Denosumab vs Bisphosphonate?

Is Denosumab ever indicated as first line therapy? If not, when would a patient need to be switched to it from Bisphosphonates?

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πŸ‘€︎ u/PunMuffin909
πŸ“…︎ Nov 15 2020
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mastocytosis and bisphosphonates

Whats a opinion of giving bisphosphonates with systematic mastocytosis and about a year after dental implants ??? Any opinions?

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πŸ‘€︎ u/craycraypelirroja
πŸ“…︎ Feb 22 2021
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Bisphosphonates Safe but May Not Improve Bone Marrow Lesion Volume drugs.com/news/bisphospho…
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πŸ‘€︎ u/anonymous-shad0w
πŸ“…︎ Aug 14 2020
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Any one on bisphosphonates?

Please reply if you have osteoporosis and been on bisphosphonates?

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πŸ‘€︎ u/Fah84
πŸ“…︎ Dec 28 2020
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The deception and fallacies of sponsored randomized prospective double-blinded clinical trials: the bisphosphonate research example ncbi.nlm.nih.gov/pubmed/2…
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πŸ‘€︎ u/tarkay
πŸ“…︎ Feb 01 2020
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How hard would it be to make Liposomal Bisphosphonate?

A PhD student invented this stuff 5 years ago now. How hard would it be for anyone to make it? Or why isn’t a Chinese pharma making a generic rip off already?

Not that I don’t want the inventor to profit from the idea. I just want this tattoo removal cream ASAP. Don’t we all?

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πŸ‘€︎ u/waffenwolf
πŸ“…︎ Sep 22 2019
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Bisphosphonates show promise for improving SNHL hms.harvard.edu/news/dram…
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πŸ‘€︎ u/prancingbeans
πŸ“…︎ Aug 09 2020
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Being argued today before the US Supreme Court: Merck's liability for failure to warn of fracture risk of Bisphosphonates scotusblog.com/2019/01/ar…
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πŸ‘€︎ u/victorkiloalpha
πŸ“…︎ Jan 07 2019
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"ATRAID" gene: Osteoporosis is commonly treated with Bisphosphonates, which inhibit bone resorption. But these drugs are associated with serious adverse effects, including osteonecrosis and fractures. Researchers have now identified a gene known as "ATRAID" that is linked with these adverse effects. nature.com/articles/s4157…
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πŸ“…︎ Jun 18 2020
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When can we expect that removal cream to be on the market? (Liposomal Bisphosphonate)

Having read the patent for this product (link below). It has successfully removed tattoos on pigs and rats in lab testing. However it still remains in pre-clinical trials. It has not yet been tested on human volunteers. How long will the FDA and regulations process take?

You can read all about the science of it here.

Its so fustrating that this actually exists but we cannot use it yet.

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πŸ‘€︎ u/waffenwolf
πŸ“…︎ Aug 15 2019
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Removing bisphosphonates for osteoporosis ppx and treatment from hospital formulary

My institution is looking at the idea to remove bisphosphonates used for osteoporosis from the hospital formulary under the rationale that they have a slow onset of action, long terminal elimination half life, and they're expensive. The idea is that patient's should be able to bring their own med from home if they'd like to take it but we won't be providing it to them in-house. This won't affect bisphosphonates used for hypercalcemia of malignancy.

Has anyone seen similar efforts at their institution?

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πŸ‘€︎ u/Dan137exe
πŸ“…︎ Mar 12 2015
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How do you counsel patients taking both levothyroxine and a bisphosphonate on administration?

Google searches show patients discussing how they incorrectly do it

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πŸ‘€︎ u/5-325
πŸ“…︎ Mar 22 2017
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Osteogenesis Imperfecta Medication: Bisphosphonates emedicine.medscape.com/ar…
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πŸ‘€︎ u/palmerwife2010
πŸ“…︎ Jul 13 2017
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Epic scientific fraud. Studies on bisphosphonates and Vitamin K for bone fractures was faked. science.sciencemag.org/co…
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πŸ‘€︎ u/BillTowne
πŸ“…︎ Aug 21 2018
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Bisphosphonates and the like

When is the earliest age they can be (ethically) prescribed?

I mean, is "post-menopausal" and "increasingly creepy DEXA results" a solid argument?

I'm sick of being worried about stress fractures if I decide to take a detour on my morning walk. And I'm REALLY FUCKING SICK of waiting for this orthopedic implant in my foot to make a commitment

I am in my early 40s.

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πŸ‘€︎ u/melatonia
πŸ“…︎ Feb 18 2018
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Canadian PhD Candidate Uses Bisphosphonate Topical Cream to Remove Tattoos on Mice globalnews.ca/news/183209…
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πŸ‘€︎ u/Gewehr98
πŸ“…︎ Feb 19 2015
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X-rays Help Predict Permanent Bone Damage From Bisphosphonates sciencedaily.com/releases…
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πŸ‘€︎ u/29bobby
πŸ“…︎ May 18 2009
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Osteonecrosis of jaw (Alendronate and other bisphosphonates) [Osteoporosis]
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πŸ‘€︎ u/3MinuteHero
πŸ“…︎ Jun 12 2014
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Bisphosphonates found to increase bone density in patients with rheumatoid arthritis (sub-analysis of the 10-year prospective cohort) medivizor.com/blog/Sample…
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πŸ‘€︎ u/medivizor
πŸ“…︎ Jul 13 2017
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