Allium Porrum Puns

> Background: Common warts are the infectious viral diseases that occur in the epidermal layer of skin and are transmitted through skin contact. They are caused by a diverse range of human papillomaviruses (HPV). So, there is no vaccine or definite anti-viral medication for the prevention of this disease. Also, the treatments of common warts often have some limitations and numerous side effects as well as the risk of recurrence or superficial spreading. Persian medicine is one of the oldest traditional medicines which described common warts as a kind of skin disease and recommended several herbal medicines like Allium porrum L. for the treatment of this disease. The aim of this study was to evaluate the effect of the hydroalcoholic extract of the aerial parts of Allium porrum L. on common warts.

> Methods: In this study, five patients with common warts on their hands were included. The hydroalcoholic extract of Allium porrum L. were applied on the site of the lesion just for 2 hours every day over a three-week period. The patients were followed up for 18 weeks to check any case of recurrence.

> Results: After completing the treatment, the wart lesions in all five patients were completely healed within three weeks. During the follow-up phase (18 weeks), no case of recurrence was observed.

> Conclusion: This study shows that the topical application of hydroalcoholic extract of Allium porrum L. has therapeutic effects for common warts. Since the extract is cost-effective, without complications and highly accepted by the patients, it seems that it can be further investigated in future studies.

http://www.jkmu.kmu.ac.ir/index.php/kmus/article/view/article_63182.html

Leeks, SARS, and Mannose Binding Lectins (MBL)

A prior study on SARS-CoV found that leeks contain a mannose binding lectin (MBL), allium porrum agglutinin (APA), which binds to the SARS-CoV coronavirus. See Plant lectins are potent inhibitors of coronaviruses by interfering with two targets in the viral replication cycle.
> The plant lectins possessed marked antiviral properties against both coronaviruses with EC(50) values in the lower microgram/ml range (middle nanomolar range), being non-toxic (CC(50)) at 50-100 microg/ml. The strongest anti-coronavirus activity was found predominantly among the mannose-binding lectins.

> The most potent lectin against the SARS-CoV-induced cytopathicity is the mannose-specific plant lectin isolated from leek (APA) with an EC50 of 0.45 μg/ml

I strongly suspect that this leek MBL would work similarly against SARS-CoV-2 (more on that below).

What are Mannose Binding Lectins (MBL)?

MBL is part of our innate immune system forming our first line of defense against infections as a broad spectrum pathogen recognizer. See, e.g., The Role of the Mannose-Binding Lectin in Innate Immunity. > The innate immune system, which includes mannose-binding lectin (MBL), recognizes a broad range of molecular patterns on a broad range of infectious agents and is able to distinguish them from self.

> MBL plays an important role as a first-line host defense against certain infectious agents

Lower MBL levels were associated with a higher risk of SARS infections. See, e.g., Mannose-Binding Lectin in Severe Acute Respiratory Syndrome Coronavirus Infection > MBL contributes to the first-line host defense against SARS-CoV and that MBL deficiency is a susceptibility factor for acquisition of SARS

MBL protects us by enhancing phagocytosis by acting as an opsonin and activating the lectin pathway of our innate immune system. See, e.g., Mannose-binding lectin and the balance between immune protection and complication. > protective mechanisms of MBL include the efficient opson

Bottomless

What are your best dad jokes? Whoever tells me the funniest one will have the honor of knowing their dad joke was my first as a dad.

Edit: there are two winners.

The first is one I told to my wife. It is about him being born with 4 kidneys but two of them will become adult knees. Thank you u/cabbithunt

The second I told me son. "There are two fish in a tank. One fish looks at the other and says 'I'll drive you man the guns.'" Thank you u/kiabe1

This guy.

They XL in clothing

An under-cover cop

So i bought her a candle.

The bartender says "for you, no charge"

For all my nerds out there

They start chatting and the Gen Z kid says that social justice issues are the biggest problem facing the world, and that the white supremacist patriarchy is a plague on society. > The boomer waves this off and says the kids these days are just too sensitive, and that he fought for civil rights in the sixties and did his part.

They go back and forth on this for a while, and finally the Gen Z kid says, "we're just not gonna settle this. We don't see eye to eye. You're too old and out of touch and I'm too young and inexperienced. What we need to do is ask a Millennial with a PhD in sociology for their opinion."

The boomer says, "that's a great idea!" And yells, "HEY BARTENDER, C'MERE!"

94% of them replied “Get out of my shower!”

Married women come home, see what's in bed and go to the fridge.

Dad jokes are supposed to be jokes you can tell a kid and they will understand it and find it funny.

This sub is mostly just NSFW puns now.

If it needs a NSFW tag it's not a dad joke. There should just be a NSFW puns subreddit for that.

Edit* I'm not replying any longer and turning off notifications but to all those that say "no one cares", there sure are a lot of you arguing about it. Maybe I'm wrong but you people don't need to be rude about it. If you really don't care, don't comment.

The rest are definitely goimg to call ne a nomster.

When it's ajar

Me: "3 and 5."

Wife: "That's odd."

Other daughter: "Even when you add them."

I've done well.

Edit: Spacing.

Edit 2: Holy gold Batman! I told my family we were brief internet celebrities last night, now we're royalty! Thanks the internet!!!

It was in the middle of 9 11

I know what you're up to.

Guess who came crawling back.

*4/yo is wrestling with 11/yo.

*11/yo rolls over and pretends to die.

Mom: He's dead you don't need to keep attacking him.

4/yo to 11/yo: You're a car now! Vroom.

Mom: What? He was dead and now he's a car?

11/yo: Yeah it's reinCARnation.

A garbage truck.

2021

It's a faux pa.

They're all packed and ready to go, they're at the gate now, and they're off.

EDIT: Thankyou everyone for getting me through this Friday these puns have been ridiculously on form except the one guy that tried to offer counselling advice on a joke thread 🙈

Give me dad joke material to entertain my wife as we sit here in the hospital together! What should my first joke be when I hold my daughter?

Because the next one will be 3.14 times worse.

That's swan way to go about it.

Or Josh with them. But try not to Rob or Sue them.

She just wants a shoulder to crayon.

Eventually we realized that we were maid for each other.

I mean, he only had one Job.

My daughter and I have been trading these. Here is our current list - would love to hear more!

1. I lost my job at the chess factory. I couldn’t work knights.
2. I lost my job at the bank. A lady asked me to check her balance so I pushed her over.
3. I lost my job at the keyboard factory. I wasn’t putting in enough shifts.
4. I lost my job at the calendar factory. I took too many days off.
5. I lost my job as a maze designed. I got lost in my work.
6. I lost my job as an electrician. I was shocked!
7. I lost my job as a psychic. I didn’t see it coming!
8. I lost my job at the funeral home. Apparently, the options are “cremation” or “burial,” not “smoking” or “non-smoking.”
9. I lost my job as an astronomer. I thought my work was looking up!
10. I lost my job as a cyber criminal. I couldn’t hack it.
11. I lost my job as a human cannonball. I got fired!
12. I lost my job as a garbage collector. I had no training but I thought I would pick it up as I go.
13. I lost my job as a math teacher, same job I’ve had since 2000. That’s 46 years down the drain!
14. I lost my job in pool maintenance. It was too draining.
15. I lost my job as a fisherman. I didn’t make enough net income.
16. I lost my job as a baker. I really kneaded the dough!
17. I lost my job as a historian. There was no future in it.
18. I lost my job as a tour guide in Australia. I did not have the right koalafications.
19. I lost my job at the upholstery repair shop. I may never recover.
20. I lost my job as a massage therapist. I rubbed people the wrong way.
21. I lost my job as a seamstress. And I tried sew hard.
22. I lost my job as a musician. I just wasn’t noteworthy.
23. I lost my job at the unemployment office. And I still need to go back there tomorrow.
24. I lost my job feeding giraffes. I just wasn’t up to it.
25. I lost my job as a water slide attendant. My career is going down the tubes.
26. I lost my job at the paper shredding factory. It was a tearable job.
27. I lost my job as a drummer. I’m sure there will be repercussions.
28. I lost my job as a pole vaulter. I'll never get over it.
29. I lost my job as a pet groomer. I couldn’t make heads or tails of it.
30. I lost my job as a pastry tester. That job was a piece of cake.
31. I lost my job as a mirror inspector. I could see myself doing that for a long time.
32. I lost my job as a yoga instructor. I bent over backwards for them.
33. I lost my job at Dunkin. It’s ok, I was fed up wit

> Background: Common warts are the infectious viral diseases that occur in the epidermal layer of skin and are transmitted through skin contact. They are caused by a diverse range of human papillomaviruses (HPV). So, there is no vaccine or definite anti-viral medication for the prevention of this disease. Also, the treatments of common warts often have some limitations and numerous side effects as well as the risk of recurrence or superficial spreading. Persian medicine is one of the oldest traditional medicines which described common warts as a kind of skin disease and recommended several herbal medicines like Allium porrum L. for the treatment of this disease. The aim of this study was to evaluate the effect of the hydroalcoholic extract of the aerial parts of Allium porrum L. on common warts.

> Methods: In this study, five patients with common warts on their hands were included. The hydroalcoholic extract of Allium porrum L. were applied on the site of the lesion just for 2 hours every day over a three-week period. The patients were followed up for 18 weeks to check any case of recurrence.

> Results: After completing the treatment, the wart lesions in all five patients were completely healed within three weeks. During the follow-up phase (18 weeks), no case of recurrence was observed.

> Conclusion: This study shows that the topical application of hydroalcoholic extract of Allium porrum L. has therapeutic effects for common warts. Since the extract is cost-effective, without complications and highly accepted by the patients, it seems that it can be further investigated in future studies.

http://www.jkmu.kmu.ac.ir/index.php/kmus/article/view/article_63182.html