Human Genome Project Puns

Can anyone please provide good websites with a lot of info on the human genome project? Preferably regarding the years: 1993-1998 and 1998-2003.

I'm very much a clueless layman, but I'm learning about genetics for the first time. I don't mean this in any sort of combative way–the Human Genome Project had countless benefits that we can't possibly track, and I'd imagine $2.7 billion is a trifle compared to its broader impact.

My question is just narrowly about the way that genome sequencing has dropped rapidly in cost. Was it fundamentally necessary to first use these exorbitantly pricey methods, which provided the foundation for the future research which would make it affordable? Or are the two questions inherently separate: the Human Genome Project gave us a first, initial glimpse at our mapped out genome, and then a decade later separate technological developments would make that same task much cheaper (as is commonly the case in science and technology).

The "could we have waited" in the title is probably misleading–I really don't mean any sort of value judgment (the project sounds enormously important), I purely mean "could" in a narrow hypothetical (not, "would it have been a good idea to wait", which I highly doubt).

https://www.christianitytoday.com/news/2020/may/francis-collins-nih-wins-templeton-prize-biologos-genome.html

“I think of God as the greatest scientist. We human scientists have an opportunity to understand the elegance and wisdom of God’s creation in a way that is truly exhilarating. When a scientist discovers something that no human knew before, but God did—that is both an occasion for scientific excitement and, for a believer, also an occasion for worship.”

• Francis Collins, 2001 (an excerpt from the CT May 2020 article I linked above)

“[Evolution] may seem to us like a slow, inefficient, and even random process, but to God—who's not limited by space or time—it all came together in the blink of an eye. And for us who have been given the gift of intelligence and the ability to appreciate the wonders of the natural world that he created, to have now learned about this evolutionary creative process is a source of awe and wonder. I find these discoveries are completely compatible with everything I know about God through the Scriptures.”

• Francis Collins, CT January 2007

Hello

I have a question about the Human genome project. Am reading about the BRAC1 and BRAC2 gene, but I want to know if the HGP as enhanced our knowledge about this genes and if there's any link with the project and this two fascinating genes?

Thanks

Hello anyone taking ap bio or even regular bio! So I found this lengthy AP Bio Pdf, and I made a copy of it with just the notes, therefore it's just a smooth read through. I also added this guide on the key words of any AP question at the bottom :D. Please use to study!!

https://docs.google.com/document/d/1VspQ_o4QvzwJen4iSvpl-0a9pf6I2d7Rwx25CdoDlD8/edit?usp=sharing

A few years later, while Death Eaters run the school and burn everything muggle, she sneaks into her hidden genetics laboratory in the dungeons and experiments on the DNA and blood of magic and nonmagical plants and animals to uncover the mysteries of inheritable magic and curses...

So, I kept thinking to myself, where have I heard the term project 863 before. It really started to bother me. Then, I remembered. You see, it was part of Human Genome Project, and it was also the name for a general slew of other projects based on tech and biology. That then got me thinking about the Lazarus Effect.

After doing some light reading I think I have a tie in.

Project Pegasus was created to study the effects of certain chemical compositions on the Human genome, I believe, both mentally and physically. Because of these experiments, Lifes Blood, was created with some government backing. Now, if we take what Deborah said about doing what was necessary to stop Syphus (which it is safe to assume at this point was burning Syntech down), what if, in doing so, she seriously or fatally injured Syphus.

What if Lifes Blood is quite literally keeping Syphus alive by way of a Lazarus effect? Injecting the serum into his bloodstream is effectively stopping the decomposition of his body and regenerating his cells at a genetic level. Deb needed a consortium of her own to investigate her theories about what Lifes Blood is/was and what it's true application is for. So, she hand-picked Sam, Mathias and Woods as her 'Project 863' and only has until today, March 5th, to see what they do with the serum.

Today, March 5th, is absolute in how the project goes. Do Mathias and crew show compassion for Nelsons plight and hand over the serum or do the give the serum to D or the detective and potentially kill Syphus in the doing so. Either way, Deb would now longer be part of the experiment as her results would be concrete and absolute. That's why she would be, from this day forth, be 'in the dark'.

Either way, I would love to see the data set appropriated for this whole event.

https://www.sidra.org/research/scientific-services-and-cores

Sidra Medicine offers researchers access to new methods for high throughput sequencing for a wide range of applications. The experimental workflow includes library preparation, cluster generation and sequencing.

We currently operate several different types of Illumina, PacBio, and Bionano sequencers, offering researchers access to sophisticated technology for high throughput sequencing that can be used in a wide range of applications.

The members of the sequencing platforms are postdoctoral research scientists, engineers, and technicians who are professionally trained and form a highly qualified team to accomplish the specialized scientific tasks of sequencing.

Single cell genomics

Single Cell Genomics is dedicated to advancing genome research of single cells. We apply Massively Parallel RNA Single-Cell Sequencing (MARSseq) to evaluate transcriptome profiles of single cells or from ultra-low input material.

To be also able to characterize the single cell genome and epigenome, we are developing new computational strategies are supported by our single cell data analysis experts with computational methods deconvolute tissue composition, determine cell type heterogeneity, identify novel cell type defining markers or track transcriptional dynamics.

We are equipped with a microfluidic device (Fluidigm C1), an automated liquid handling platform and we collaborate with our experienced FACS facility.

Proteomics and Metabolomics

The Proteomics and Metabolomics core facility uses mass spectrometry as the key technology for qualitative and quantitative protein characterization. The chemical analytics core provides customized chemical analysis, biochemical synthesis and drug screen.

Flow Cytometry and Microscopy

The deep phenotyping core has 16 color FACS analysis, cell sorting and cytokine profiling instruments.

Stem Cell Biology

The stem cell biology core provides support to develop induced pluripotent stem cells (iPSCs) and has the capacity to differentiate them into different types of adult cells.

Model Systems

The zebrafish facility provides top-quality tailor-made service for our users, combining sophisticated techniques with expert guidance and support that allow even users with no previous experience of the zebrafish system to achieve optimal results.

Zebrafish embryos are transparent and develop outside the mothe

Hi Reddit! I’m Francis Collins, the Director of the National Institutes of Health (NIH) where I oversee the efforts of the largest public supporter of biomedical research in the world. Starting out as a researcher and then as the director of the National Human Genome Research Institute, I led the U.S. effort on the successful completion of the Human Genome Project. Next week, on April 25th, the 15th anniversary of that historic milestone, we will celebrate this revolutionary accomplishment through a nationally-recognized DNA Day.

In my current role as NIH Director, I manage the NIH’s efforts in building innovative biomedical enterprises. The NIH’s All of Us Research Program comes quickly to mind. The program’s goal is to assemble the world’s largest study of genetic, biometric and health data from U.S. research volunteers, which will be available to scientists worldwide. This data will help researchers explore ways we can improve health and prevent and treat disease, as well as guide development of therapies that consider individual differences in lifestyle, environment, and biology. We also hope that this will give our volunteer research participants a deeper knowledge of their own health and health risks. Starting this spring, Americans across the country will be invited to join the All of Us Research Program as research participants. If you are 18 years or older, I hope you’ll consider joining!

I’m doing this AMA today as part of a public awareness campaign that focuses on the importance of genomics in our everyday lives. The campaign is called “15 for 15” – 15 ways genomics is now influencing our world, in honor of the Human Genome Project’s 15th birthday! Check out this website to see the 15 advances that we are highlighting. As part of the campaign, this AMA also kicks off a series of AMAs that will take place every day next week April 23-27 from 1-3 pm ET.

Today, I’ll be here from 2-3 pm ET – I’m looking forward to answering your questions! Ask Me Anything!

UPDATE: Hi everyone – Francis Collins here. Looking forward to answering your questions until 3:00 pm ET! There are a lot of great questions. I’ll get to as many as I can in the next hour.

UPDATE: I am wrapping up here. Thanks for all the great questions! I answered as many as I could during the hour. More chances to in

I was wondering if there was a document of the human genome with all the genes named and their functions explained as well as the various alleles as well as the resulting interactions between certain genes

Any information would be greatly appreciated and i'm not bothered if i have to flick through multiple documents

Sorry if my terminology is wrong the farthest i've gone until now is high school biology

“The Human Genome Project mapped the letters of the human genome, but it didn’t tell us anything about the grammar: where the punctuation is, where the starts and ends of genes are, the location of the regions that regulate them, and where and how much genes are expressed. That’s what ENCODE is trying to do.” -NIH Program Director, Elise Feingold, Ph.D.

Some of the most important parts of the human genome may not be our genes. They may be the so-called “dark matter” of the genome — the parts of our DNA that do not encode proteins.

Since 2003, the NIH’s Encyclopedia of DNA Elements (ENCODE) Project has been exploring the regions of the human genome that have biochemical activities that are, in some cases, suggestive of function. Of particular emphasis has been mapping out the locations of the many gene regulatory regions hiding there, which are harder to find than protein-coding genes.

These crucial regulatory elements — such as promoters and enhancers — coordinate the activity of thousands of genes. Differences in these regulators help explain why skin cells and brain cells are so different, despite containing exactly the same genetic sequence.

While the first rounds of the ENCODE project focused primarily on the challenging task of mapping these dark regions and finding regions that might be biologically relevant, the project’s next phase will expand to the crucial task of beginning to test some of these DNA regions to try to learn which actually impact human biology in meaningful ways.

Yesterday NIH announced its latest round of ENCODE funding, which includes support for five new collaborative centers focused on using cutting edge techniques to characterize the candidate functional elements in healthy and diseased human cells. For example, when and where does an element function, and what exactly does it do.

UCSF is host to two of these five new centers, where researchers are using CRISPR gene editing, embryonic stem cells, and other new tools that let us rapidly screen hundreds of thousands of genome sequences in many different cell types at a time to learn which sequences are biologically relevant — and in what contexts they matter.

Today’s AMA brings together the leaders of NIH’s ENCODE project and the leaders of UCSF’s partner research centers.

Your hosts today are:

• Nadav Ahituv, UCSF professor in the department of bioengineering and therapeutic sciences. Interested in gene regulation and how its alteration leads to morphological diffe

Hi reddit! I am Francis Collins, Director of the National Institutes of Health where I oversee the work of the largest supporter of biomedical research in the world, spanning the spectrum from basic to clinical research. In my role as the NIH Director, I oversee the NIH’s efforts in building groundbreaking initiatives such as the BRAIN Initiative, the Big Data to Knowledge (BD2K) Initiative, the Precision Medicine Initiative Cohort Program, and the Vice President’s Cancer Moonshot program. In addition to these programs, my colleagues and I work to promote diversity in the biomedical workforce, improve scientific policy with the aim to improve the accuracy of outcomes, continue NIH's commitment to basic science, and increase open access to data.

Happy DNA Day! We've come a long way since the completion of the Human Genome Project. Researchers are now collaborating on a wide range of projects that use measures of environmental exposure, social and behavioral factors, and genomic tools and technologies to expand our understanding of human biology and combat human disease. In particular, these advances in technology and our understanding of our DNA has allowed us to envision a future where prevention and treatment will be tailored to our personal circumstances. The President’s Precision Medicine Initiative, being launched this year, will enroll one million or more Americans by 2019, and will enable us to test these exciting ideas in the largest longitudinal cohort study ever imagined in the U.S.

Proof!

I'll be here April 25, 2016 from 11:30 am - 12:15 pm ET. Looking forward to answering your questions! Ask Me Anything!

Edit: Thanks for a great AMA! I’ve enjoyed all of your questions and tried to answer as many as I could! Signing off now.

Does anyone have a source for the percentage of each race that was used to develop the human genome project?

Hello

I have a question about the Human genome project. Am reading about the BRAC1 and BRAC2 gene, but I want to know if the HGP as enhanced our knowledge about this genes and if there's any link with the project and this two fascinating genes?

Thanks