I'm reading conflicting info
Like which molecules do they actually hydrolyse in these places?
Is it still cAMP? How is that relevant to these places?
Hi, it's your friendly neighborhood dumbass here asking a question again
This question basically says that hypercalcemia interferes with sodium transport as it competes with the sodium transportor --> inhibits neuronal depolarization --> impaired smooth muscle contraction --> reduced colonic motility (eg constipation)
Now I am confused because I thought calcium = smooth muscle CONTRACTION
According to a SDN thread on a similar topic, it explains that calcium interfering with the voltage-gated sodium channels means a higher action potential threshold, so that results in more smooth muscle relaxation and constipation??
According to BnB, smooth muscle doesn't rely that much on action potential and that calcium + calmodulin activates MLCK which phosphorylates myosin and you get contraction.
Am I misunderstanding something or is there some huge physiology concept that I am missing here? Or is it because the excess calcium has some other effect (neuronal depression) that overrides its usual action??
Any help would be great because I am really dumb
Edit: the SDN thread I read through but am still confused: https://forums.studentdoctor.net/threads/constipation-in-hypercalcemia.647220/
All I know is that it's a Warlord thing
I have very disturbing symptoms for the last 2 months - it started with little reflux which was felt by me as heartburn and about 3 weeks later - muscle twitches in the legs, chest, arms and neck. These twitches sometimes get stronger very suddently, which makes me scared totally.
However, they only happen inside my home - the less ventilated or heated it is, the worse symptoms.
When i go outside - these twitches slowly go away. I suspect, lower oxygen or less humidity inside my home - but can it trigger smooth muscle twitches? Sometimes i feel only reflux, sometimes only twitches, but the worst is when they both happen at the same time.
Blood tests regarding heart, EKG, Sodium, Potassium, Magnesium, D-Dimer, X-Ray of chest, kidneys are all fine.
ALL doctors told me its 100% anxiety and panic attacks. But, when i dont have these twitches I sleep like a baby, my life is the same as 6 months ago, 1 year ago etc....
I may have ongoing stress from various issues, but I got used to it. Could it be nervous system burn out? I work a lot and have relatively little relaxation.
Can my condition originate from the GERD? When it started I ate a lot of chocolate and citrus fruits, other than that my diet is rather on a healthy side - not too much or too little of all kinds of foods...
I will be grateful for your help.
Thanks in advance.
Hello! 28 F here. Just reaching out for advice or any knowledge as I have some health anxiety. I had a weak positive for smooth muscle antibody (SMA) back in early July (titer of 1:40). Was also diagnosed with fatty liver and a gallstone that grew to 2.3 cm (via sonogram) and had liver enzymes of ALT 41 and AST 28. I was just retested last week and now my smooth muscle antibodies titer has risen to 1:80. ALT is now 31 AST 28. I am worried about autoimmune hepatitis although I have no symptoms and my doctor’s do not seem too worried (although I haven’t been to a hematologist yet). Thanks so much for any info!
I know it's low yield. I was just hoping to clarify the concept. I thought sarcomeres were just actin and myosin. It looks like smooth muscle contains both actin and myosin. Is there some defining characteristic outside of actin and myosin that is necessary to be defined as a sarcomere?
Thanks in advance!
I notice this especially in my split practice: It seems like every day I'm starting from zero.
Obviously that is not the reality and I do realize how far I've come since actively working on them, but it does seem like it takes an incredible amount of warm up and stretching to get to the point where I can actually work on improving where I was at the day before.
I know every body is different and so is each yoga journey, but I was wondering whether I am doing something wrong? Is there a trick to keep muscles smooth after stretching as to not feel like they are all stiff the next day?
Different sources say different things so i was just a bit confused.
So i've read this source, talking about how muscles contract, talking about sarcomeres and actin and myosin and all that jazz, but strangely, it constantly seems to imply that the sarcomere structure and function is exclusive to skeletal muscles, every image is of skeletal, it keeps mentioning skeletals, etc.
So is sarcomere also present in smooth muscles and heart muscles? If not then how do they work, and if yes, why don't smooth muscle cells have the same stripy appearance of skeletal ( and kind of, heart) muscles?
Thanks in advance
23 year old hispanic male, currently have nafld, no fibrosis and alt at normal range. I just got my most recent lab results and I saw that my smooth muscle ab screen came out as positive and my smooth muscle ab titer came out as “1:20 H” and I have no idea what those two mean, can someone help me interpret those results? Thanks.
Do both ↑ cGMP and ↑ cAMP cause vascular smooth muscle cell relaxation thus vasodilation? I am wondering that bc nitrates cause vasodilation by increasing cGMP while beta-2 adrenergic receptors cause vasodilation by increasing cAMP.
TIA!!
Finally received the results of the fine needle aspirate done for an intestinal mass on my kitty!
After an ultrasound, the large mass (5cm) seen on xray was actually on my boys small intestine! Ofcourse myself & the vet go into worst case scenario thinking it's most likely lymphoma or a carcinoma. The ultrasound did not see any inflammation on any lymph nodes so the vet was saying 60/40 it was either a carcinoma v lymphoma. We did a biopsy regardless & it indicated neither cells describing the two above cancers.
Instead it was something my dr described as super rare with very little info on it. The oncologyist believes it is smooth muscle tumor & recommends surgery for removal and maybe chemo after that.
I'm so happy that we have options to treat my best friend. Even if it only gives him a year it's much more time together than the month estimates we were given before. The best news I've received in ages, even in such a terrible situation 💙💙💙💙
My husband and I have recently decided to see a secondary fertility specialist. The first clinic I went to diagnosed me with PCOS, endometriosis (without a laparoscopy) and possible adenomyosis, calcifications and cysts on my ovaries.
We went through 3 rounds of IUI and were told if we want a more successful route to move to IVF. I got a quote for IVF at this clinic and found it was wildly outside of our means.
A friend referred me to a different clinic out of state that is within our financial limits. After meeting with this doctor he’s wanting to see if instead of the laundry list of issues I’ve been told I have, if it’s an issue with the smooth muscle in my body.
Has anyone else dealt with this or been down the route of testing smooth muscle function?
I've read that smooth muscle is under involuntary control, and striated muscle is under voluntary control. But this doesn't make sense to me, because don't both of them simply act on signals from elsewhere in the body? Voluntary vs. involuntary sounds like a characteristic of whatever sends the signal, not of the muscle that receives and acts on it.
So, is smooth muscle only called involuntary because all smooth muscle in the human body happens to be wired that way, or is smooth muscle somehow inherently incapable of acting on voluntary signals? If the latter, what exactly is different about these signals?
