Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce nature.com/articles/s4159…
πŸ‘︎ 61
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πŸ‘€︎ u/StoicOptom
πŸ“…︎ Oct 05 2021
🚨︎ report
Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce - Nature Medicine nature.com/articles/s4159…
πŸ‘︎ 7
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πŸ‘€︎ u/dem0n0cracy
πŸ“…︎ Oct 19 2021
🚨︎ report
Pothos leaves appear to spontaneously senesce. This is the third leaf to have this happen on this plant! What's going on here? I water once every 2-3 weeks. reddit.com/gallery/jk3rud
πŸ‘︎ 2
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πŸ‘€︎ u/moleyfeeners
πŸ“…︎ Oct 29 2020
🚨︎ report
Pothos leaves appear to spontaneously senesce. This is the third leaf to have this happen on this plant! (I've been cutting them off once it happens.) Does this look to you all like pathogenesis? Any advice? reddit.com/gallery/jk0mty
πŸ‘︎ 7
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πŸ‘€︎ u/moleyfeeners
πŸ“…︎ Oct 29 2020
🚨︎ report
Why Some Fungi Senesce and Others Do Not [PDF] files.shroomery.org/attac…
πŸ‘︎ 6
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πŸ‘€︎ u/najjex
πŸ“…︎ Jun 11 2020
🚨︎ report
Senescent cells are NOT just zombie cells that need to be destroyed to prolong life. erj.ersjournals.com/conte…
πŸ‘︎ 65
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πŸ‘€︎ u/Jleftync
πŸ“…︎ Jan 12
🚨︎ report
Rather than a β€œrejuvenating” agent, GDF11 may have a detrimental effect on liver senescence. Growth differentiation factor 11 accelerates liver senescence through the inhibition of autophagy [2021, open-access] onlinelibrary.wiley.com/d…
πŸ‘︎ 99
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πŸ“…︎ Dec 20 2021
🚨︎ report
A newly discovered anti senescence function of vitamin B2 - A group of Kobe University(Japan) researchers have revealed that adding Vitamin B2 to cells that have been exposed to aging stress increases the mitochondria's ability to produce energy and prevents cell aging medicalxpress.com/news/20…
πŸ‘︎ 211
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πŸ‘€︎ u/Dr_Singularity
πŸ“…︎ Dec 13 2021
🚨︎ report
[general] Senescence only happens when cloning or breeding, right?

Senescence only happens when cloning or breeding right? A 3rd gen clone doesn't just senesce, it doesn't just stop producing all of a sudden, right?

πŸ‘︎ 2
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πŸ‘€︎ u/Nervous-Life-715
πŸ“…︎ Jan 10
🚨︎ report
Senescent Astrocytes May Negatively Affect the Function of Neurons fightaging.org/archives/2…
πŸ‘︎ 70
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πŸ“…︎ Jan 03
🚨︎ report
In Down syndrome cells, genome-wide disruptions mimic a senescence-like state - Extra chromosome alters chromosomal conformation and DNA accessibility across the whole genome in neural progenitor cells, disrupting gene transcription and cell functions much like in cellular aging picower.mit.edu/news/down…
πŸ‘︎ 70
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πŸ‘€︎ u/bischofff
πŸ“…︎ Jan 06
🚨︎ report
Getting the garden back up and running after a catastrophic die off event from senescence. Don’t let your myc run too long before starting over again from spore.
πŸ‘︎ 23
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πŸ‘€︎ u/ShroomsandPussy
πŸ“…︎ Dec 11 2021
🚨︎ report
Removing senescent cells in human fat with senolytics alleviates signs of diabetes, suggesting that targeting aging could treat type 2 diabetes and other metabolic diseases genengnews.com/news/exper…
πŸ‘︎ 531
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πŸ“…︎ Nov 25 2021
🚨︎ report
The current state of Hyperglitch: Wireframe Wolves - Senescence soundcloud.com/wireframew…
πŸ‘︎ 5
πŸ’¬︎
πŸ“…︎ Jan 11
🚨︎ report
Showcasing my Fallen Rosemary, wielding a Limited Christmas Weapon(Senescence), Merry Christmas Captains(Everyone).
πŸ‘︎ 9
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πŸ‘€︎ u/Choi129
πŸ“…︎ Dec 25 2021
🚨︎ report
Microbiome and Human Aging: Probiotic and Prebiotic Potentials in Longevity, Skin Health and Cellular Senescence (Dec 2021) mdpi.com/2072-6643/13/12/…
πŸ‘︎ 36
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πŸ‘€︎ u/basmwklz
πŸ“…︎ Jan 02
🚨︎ report
Emerging Interrelationship Between the Gut Microbiome and Cellular Senescence in the Context of Aging and Disease: Perspectives and Therapeutic Opportunities (Jan 2022) link.springer.com/article…
πŸ‘︎ 22
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πŸ‘€︎ u/basmwklz
πŸ“…︎ Jan 06
🚨︎ report
Longevity, cellular senescence and the gut microbiome: lessons to be learned from crocodiles (Dec 2021) cell.com/heliyon/fulltext…
πŸ‘︎ 16
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πŸ‘€︎ u/basmwklz
πŸ“…︎ Jan 04
🚨︎ report
Ageing, Cellular Senescence and Senolytics: The Path to Translation | Prof James Kirkland youtube.com/watch?v=yqjuW…
πŸ‘︎ 42
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πŸ“…︎ Dec 10 2021
🚨︎ report
Removing senescent cells in human fat with senolytics alleviates signs of diabetes, suggesting that targeting aging could treat type 2 diabetes and other metabolic diseases genengnews.com/news/exper…
πŸ‘︎ 317
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πŸ‘€︎ u/StoicOptom
πŸ“…︎ Nov 25 2021
🚨︎ report
COVID-19 evokes cellular aging, causing cytokine storm and multi-organ failure. Removal of senescent cells in 194 human patients with senolytics reduces hospitalization and death in early trials nature.com/articles/s4158…
πŸ‘︎ 2k
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πŸ‘€︎ u/StoicOptom
πŸ“…︎ Sep 13 2021
🚨︎ report
My 1st science article - p53 & senescence!! youtube.com/watch?v=VPucF…
πŸ‘︎ 64
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πŸ‘€︎ u/bischofff
πŸ“…︎ Jan 05
🚨︎ report
Would you take a vaccine to treat aging-related diseases? Arterial stiffening, diabetes occur as Senescent or zombie cells stop dividing but don't die, damaging nearby healthy cells by releasing chemicals that cause inflammation. "Japanese scientists develop vaccine to eliminate cells behind aging" japantimes.co.jp/news/202…
πŸ‘︎ 2
πŸ’¬︎
πŸ“…︎ Dec 13 2021
🚨︎ report
I was thinking about how spores can survive in space and it made me wonder- Do you think psychedelic mushrooms could be senesced versions of a superpotent mushroom that could've been a hallucinogenic message from aliens?

Could the similarities in the hallucinations that people experience during trips be explained not by our chemical similarities but by us sharing different distorted fragments of that original message? And if so do you think we could ever build the genetics back up to find out whatever that original mushroom message sent via interstellar spore was? Or am I just high af?

πŸ‘︎ 5
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πŸ‘€︎ u/redditesgarbage
πŸ“…︎ Dec 15 2021
🚨︎ report
Hydra appear to be biologically immortal due to their cells’ lacking the degenerative effects of senescence. en.m.wikipedia.org/wiki/H…
πŸ‘︎ 44
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πŸ‘€︎ u/AptitudeSky
πŸ“…︎ Nov 22 2021
🚨︎ report
Profiling senescent cells in human brains reveals neurons with CDKN2D/p19 and tau neuropathology [2021] nature.com/articles/s4358…
πŸ‘︎ 47
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πŸ“…︎ Dec 12 2021
🚨︎ report
[Suggestion] Elder, Prime, and Senescent

Gielinor has a lot of trees that go unchopped, ores that go unpicked, and fishes that go unmolested – here's what we can do to revitalise them:

Elder (trees), Prime (ores), Senescent (fishes); which is a mix of other content like falling stars, giant seaweed, and farming.

For example: a yew tree that goes 24 hours without being chopped will grow into a tall elder tree that can be chopped for giant yew logs. These giant logs can be fletched or burned for several logs’ worth, in the same way giant seaweed can be cooked for several soda ash.

This principle similarly applies for mining, fishing, and other resource gathering skills. The speed remains the same, however you gain more exp per thing yielded, and the depletion rate is far slower so that other players have time to find them and to get their fill, like falling stars.

Adventurers will travel to the ends of Gielinor seeking elder trees and primed ores, and be able to harvest them like the good old days, but now in a much more viable way that breathes life into dead & lost content!

πŸ‘︎ 36
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πŸ‘€︎ u/ChefsOtherHat
πŸ“…︎ Nov 13 2021
🚨︎ report
I had my NAD+ levels and senescent cell markers measured. reddit.com/gallery/qlkwii
πŸ‘︎ 43
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πŸ“…︎ Nov 03 2021
🚨︎ report
Longevity, cellular senescence and the gut microbiome: lessons to be learned from crocodiles (Dec 2021) cell.com/heliyon/fulltext…
πŸ‘︎ 15
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πŸ‘€︎ u/MaximilianKohler
πŸ“…︎ Jan 06
🚨︎ report
Interviews of 2021: senescence, young blood and dog longevity. Five of our favourite interviews with some of the world’s leading researchers from across the aging field.

https://www.longevity.technology/interviews-of-2021-senescence-young-blood-and-dog-longevity/?utm_source=reddit&utm_medium=social&utm_campaign=youngblood

πŸ‘︎ 40
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πŸ‘€︎ u/philnewman100
πŸ“…︎ Dec 30 2021
🚨︎ report
How good is the evidence that cellular senescence causes skin ageing ? ncbi.nlm.nih.gov/pmc/arti…
πŸ‘︎ 65
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πŸ‘€︎ u/Donovan200
πŸ“…︎ Dec 03 2021
🚨︎ report
Cellular Senescence: It’s Complicated, but There’s Hope lifespan.io/news/cellular…
πŸ‘︎ 130
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πŸ‘€︎ u/ziscz
πŸ“…︎ Oct 27 2021
🚨︎ report
A vaccine for aging that eliminates senescent cells. Japanese researchers claim vaccine eliminates senescent cells.

https://www.longevity.technology/a-vaccine-for-aging-that-eliminates-senescent-cells/?utm_source=reddit&utm_medium=social&utm_campaign=vax

πŸ‘︎ 18
πŸ’¬︎
πŸ‘€︎ u/philnewman100
πŸ“…︎ Dec 14 2021
🚨︎ report
Herpetologists of Reddit , since crocs show extremely slow senescence , what if , since nature can't sustain big organisms , it kills off crocs way before they attain the so-called old age ?
πŸ‘︎ 2
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πŸ‘€︎ u/aritra_001
πŸ“…︎ Dec 11 2021
🚨︎ report
Senescent Cells And Their Impact On Aging | Prof Richard Faragher Interview Series Ep 2
πŸ‘︎ 41
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πŸ“…︎ Dec 26 2021
🚨︎ report
NIH launches $ 150 million program to study senescent cells nih.gov/news-events/news-…
πŸ‘︎ 140
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πŸ‘€︎ u/Donovan200
πŸ“…︎ Nov 24 2021
🚨︎ report
Floodland Brewing - Senescence 2021
πŸ‘︎ 15
πŸ’¬︎
πŸ‘€︎ u/ewwiccc
πŸ“…︎ Dec 17 2021
🚨︎ report
Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence [2021, open-access] nature.com/articles/s4141…
πŸ‘︎ 20
πŸ’¬︎
πŸ“…︎ Dec 18 2021
🚨︎ report
Flavonoids in Skin Senescence Prevention and Treatment ncbi.nlm.nih.gov/pmc/arti…
πŸ‘︎ 47
πŸ’¬︎
πŸ‘€︎ u/Donovan200
πŸ“…︎ Nov 28 2021
🚨︎ report
Removing senescent cells in human fat with senolytics alleviates signs of diabetes, suggesting that targeting aging could treat type 2 diabetes and other metabolic diseases genengnews.com/news/exper…
πŸ‘︎ 66
πŸ’¬︎
πŸ‘€︎ u/TheMostWanted774
πŸ“…︎ Nov 27 2021
🚨︎ report
Targeting Mitochondrial Metabolism as a Strategy to Treat Senescence

https://www.mdpi.com/2073-4409/10/11/3003/htm

Summary: The mitochondria undergoes significant changes with senescence. An increase in senescence leads to dysfunctional mitochondria which generates excessive Reactive Oxygen Species (ROS). The increase in ROS hinders the process of oxidative phosphorylation (a process in which cells generate ATP) and increases reliance on glycolysis (process of breaking down glucose to generate energy).

[The way I understand it glycolysis is a less efficient way to generate energy compared to oxidative phosphorylation and seems to be increased in cancer cells as this paper suggests: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506713/]

Anyway, so this paper is looking at how reprogramming mitochondrial metabolism can reduce senescence.

πŸ‘︎ 19
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πŸ‘€︎ u/Valuable_Ad1073
πŸ“…︎ Dec 14 2021
🚨︎ report
Researchers from Spain and UK have developed a new method to remove old cells from tissues, thus slowing down the aging process - "We now have, for the first time, an antibody-based drug that can be used to help slow down cellular senescence in humans" phys.org/news/2021-10-ant…
πŸ‘︎ 71
πŸ’¬︎
πŸ‘€︎ u/QuantumThinkology
πŸ“…︎ Oct 20 2021
🚨︎ report
Experimental Drugs That Reduce Aging by Eliminating Senescent Cells in Human Fat Alleviate Signs of Diabetes genengnews.com/news/exper…
πŸ‘︎ 7
πŸ’¬︎
πŸ‘€︎ u/newbooke
πŸ“…︎ Nov 25 2021
🚨︎ report
Cellular Senescence: It’s Complicated, but There’s Hope lifespan.io/news/cellular…
πŸ‘︎ 43
πŸ’¬︎
πŸ‘€︎ u/AtlanticBiker
πŸ“…︎ Oct 27 2021
🚨︎ report
Norma Jean - Bless The Martyr And Kiss The Child 20th Anniversary Senescent Double solidstate.merchnow.com/p…
πŸ‘︎ 29
πŸ’¬︎
πŸ‘€︎ u/xDecim8x
πŸ“…︎ Nov 04 2021
🚨︎ report

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