Senescence only happens when cloning or breeding right? A 3rd gen clone doesn't just senesce, it doesn't just stop producing all of a sudden, right?
Could the similarities in the hallucinations that people experience during trips be explained not by our chemical similarities but by us sharing different distorted fragments of that original message? And if so do you think we could ever build the genetics back up to find out whatever that original mushroom message sent via interstellar spore was? Or am I just high af?
Gielinor has a lot of trees that go unchopped, ores that go unpicked, and fishes that go unmolested – here's what we can do to revitalise them:
Elder (trees), Prime (ores), Senescent (fishes); which is a mix of other content like falling stars, giant seaweed, and farming.
For example: a yew tree that goes 24 hours without being chopped will grow into a tall elder tree that can be chopped for giant yew logs. These giant logs can be fletched or burned for several logs’ worth, in the same way giant seaweed can be cooked for several soda ash.
This principle similarly applies for mining, fishing, and other resource gathering skills. The speed remains the same, however you gain more exp per thing yielded, and the depletion rate is far slower so that other players have time to find them and to get their fill, like falling stars.
Adventurers will travel to the ends of Gielinor seeking elder trees and primed ores, and be able to harvest them like the good old days, but now in a much more viable way that breathes life into dead & lost content!
https://www.longevity.technology/interviews-of-2021-senescence-young-blood-and-dog-longevity/?utm_source=reddit&utm_medium=social&utm_campaign=youngblood
https://www.longevity.technology/a-vaccine-for-aging-that-eliminates-senescent-cells/?utm_source=reddit&utm_medium=social&utm_campaign=vax
https://www.mdpi.com/2073-4409/10/11/3003/htm
Summary: The mitochondria undergoes significant changes with senescence. An increase in senescence leads to dysfunctional mitochondria which generates excessive Reactive Oxygen Species (ROS). The increase in ROS hinders the process of oxidative phosphorylation (a process in which cells generate ATP) and increases reliance on glycolysis (process of breaking down glucose to generate energy).
[The way I understand it glycolysis is a less efficient way to generate energy compared to oxidative phosphorylation and seems to be increased in cancer cells as this paper suggests: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506713/]
Anyway, so this paper is looking at how reprogramming mitochondrial metabolism can reduce senescence.
