Agriculture hit our diet hard. Only until the (2nd?) industrial revolution did it start to improve.
Hello people, I hope all of you are safe and okay. I was suffering from an autoimmune condition for two years and 7 months ago I knew that it's Guillain-Barré syndrome. I'm still on prednisone and I really not comfortable with it. I tried lots of things that could help, but I didn't get any better.
But I found a great video on Youtube, a conversation between Dr Berg and Dr. Zsófia, they were talking about treating autoimmune conditions and even cancer with only diets and few other non-chemical ways.
Dr. Zsófia and Dr. Berg were talking about the interesting relationship between intestinal permeability (leaky gut) and autoimmune disease, and more.
I will just write some of the interesting notes in that conversation, so you get an idea about it.
Summary of this conversation:
Dr Berg: First of all i want to know exactly what is a neurologist and in addition to that how did you get involved in what you're doing right now. Did you have a personal health problem that led you into this or how do you get so involved in what you're doing?
Dr. Zsófia: Originally i am a biologist, specifically I'm a neuroscientist but I have always been working in a clinical setting, in top institutes in Hungary for neurology epilepsy psychiatry; so
this was my environment but I was always get involved in doing research work in clinical settings in patients and then got involved analyzing brain activity, brain electrical activity in epilepsy patients, sleep and how this relates to memory processes, sleep related memory consolidation for example.
Then, I stepped forward and I became interested in nutrition as a whole and I know that there is a lot of interest around vitamins; specifically like vitamin D but I had to realize that the nutritional context as a whole is is much more important than single nutrients singular vitamins for example.
Dr Berg: That's one of the reasons why I brought you here; because you're in clinical practice which is a huge difference between someone just doing research in a lab and never had any experience
they just graduated in their phd and then they've never worked with actual patients so until you do that you really have not applied these ideas.
I want to dive right into a very specific topic , intestinal permeability and exactly what that is and maybe you can call generally speaking leaky gut. And in the relationship to autoimmune disease since a good portion of our
- Original Contribution
- Open Access
- Published: 21 October 2021
A score appraising Paleolithic diet and the risk of cardiovascular disease in a Mediterranean prospective cohort
- Víctor de la O,
- Itziar Zazpe,
- Leticia Goni,
- Susana Santiago,
- Nerea Martín-Calvo,
- Maira Bes-Rastrollo,
- J. Alfredo Martínez,
- Miguel Á. Martínez-González &
- Miguel Ruiz-Canela
European Journal of Nutrition (2021)Cite this article
- 1 Accesses
- 4 Altmetric
- Metricsdetails
Abstract
Purpose
To assess the association between a score appraising adherence to the PaleoDiet and the risk of cardiovascular disease (CVD) in a Mediterranean cohort.
Methods
We included 18,210 participants from the Seguimiento Universidad de Navarra (SUN) cohort study. The PaleoDiet score comprised six food groups promoted within this diet (fruit, nuts, vegetables, eggs, meat and fish) and five food groups whose consumption is discouraged (cereals and grains, dairy products, legumes, culinary ingredients, and processed/ultra-processed foods). CVD was defined as acute myocardial infarction with or without ST elevation, non-fatal stroke and cardiovascular death. Cox proportional hazards models adjusted for potential confounders were fitted to assess the association between the PaleoDiet score and CVD risk, and the PaleoDiet and MedDiet indices to explore differences between both diets.
Results
During 12.2 years of fol
... keep reading on reddit ➡ncbi.nlm.nih.gov/pmc/articles/PMC7073984
1. Introduction
> Diabetes is a chronic disease and one of the most prevalent public health concerns globally. The current number of people suffering from diabetes exceeds 425 million in the world, and there is still a large number of people who remain undiagnosed [1].
> The American Diabetes Association’s (ADA) recommendations strongly emphasize that there is no single eating pattern that is best for those with diabetes; however, they do suggest that the diet should mainly be based on products with a low glycemic index and should exclude refined sugars and processed food [2].
> The Paleolithic diet, also known as a hunter–gatherer diet or stone-age diet, is an estimated nutritional pattern considered to be typical of people living during the paleolithic era, from approximately 2.5 million to 10,000 years ago. It encourages the consumption of meat, fish, eggs, vegetables, fruits, roots, and nuts, while many cultivated products, such as dairy products, oils, cereals, and legumes (as well as salt and refined sugars) are excluded [6]. [...] Therefore, the Paleolithic diet typically resembles a low-carbohydrate diet. However, the hunter–gatherer diet provides a higher amount of dietary fiber (up to 45–100 g per day) than a low-carbohydrate diet [7].
> Therefore, the aim of this meta-analysis was to compare the effect of the Paleolithic diet with other types of diets commonly perceived as healthy on glucose and insulin homeostasis in studies conducted in adults with altered glucose metabolism.
2. Methods
n = 4 studies
> Sensitivity analyses were also performed by removing each study one by one and recalculating the pooled estimates.
3. Results
4. Discussion
Limitations
>Firstly, the nu
... keep reading on reddit ➡
I am not really well informed about nutrition. I was just wondering about both diets. The Paleolithic seems to rely a lot on proteins and as I see it, animal protein. I know that there are other sources for proteins, but would they be enough to fullfil the necessary proportions demanded by Paleolithic diet? I'm sorry if I am saying some nonsense
I would like to know where I can read more about both topics.
Abstract
Objective: Several randomized clinical trials (RCTs) have investigated the effects of the Paleolithic diet (PD) in adult patients suffering from metabolic disorders. However, the results of these RCTs are conflicting. Therefore, we conducted a systematic review and meta-analysis to assess the effects of the PD in patients with metabolic disorders.
Methods: We searched the PubMed/Medline, Scopus, Cochrane Databases, Google Scholar, Web of Science, and Embase databases up to June, 2020. The data were pooled using a random-effects model. From the eligible publications, 10 articles were selected for inclusion in this systematic review and meta-analysis. The meta-analysis was performed using a random-effects model. The heterogeneity was determined using the I2 statistics and the Cochrane Q test.
Results: The pooled results from the random-effects model showed a significant reduction of the homeostatic model assessment of insulin resistance (HOMA-IR) (weighted mean difference, WMD: -0.39, 95% CI: -0.70, -0.08), fasting insulin (WMD: -12.17 μU/mL, 95% CI: -24.26, -0.08), total cholesterol (WMD: -0.32 mmol/l, 95% CI: -0.49, -0.15), triglycerides (WMD: -0.29 mmol/L, 95% CI: -0.42, -0.16), low-density lipoprotein cholesterol (WMD: -0.35 mmol/L, 95% CI: -0.67, -0.03), blood pressure (BP)(WMD - 5.89 mmHg; 95% CI - 9.973 to - 1.86 for the systolic BP and WMD - 4.01 mmHg; 95% CI - 6.21 to - 1.80 for the diastolic BP values) and C-reactive protein (CRP) levels (WMD: -0.84, mg/L, 95% CI: -1.62, -0.06) in the PD group versus control group.
Conclusions: Our findings provide better insights into the effect of the PD on the modulation of the glucose and lipid metabolism factors in patients with metabolic disorders, providing comprehensive information for the development of future RCTs with a high quality design.
38-Month Long Progression-Free and Symptom-Free Survival of a Patient With Recurrent Glioblastoma Multiforme: A Case Report of the Paleolithic Ketogenic Diet (PKD) Used As a Stand-Alone Treatment after Failed Standard Oncotherapy
How to cite: Tóth, C.; Dabóczi, A.; Chanrai, M.; Schimmer, M.; Clemens, Z. 38-Month Long Progression-Free and Symptom-Free Survival of a Patient With Recurrent Glioblastoma Multiforme: A Case Report of the Paleolithic Ketogenic Diet (PKD) Used As a Stand-Alone Treatment after Failed Standard Oncotherapy. Preprints 2019, 2019120264 (doi: 10.20944/preprints201912.0264.v1). Tóth, C.; Dabóczi, A.; Chanrai, M.; Schimmer, M.; Clemens, Z. 38-Month Long Progression-Free and Symptom-Free Survival of a Patient With Recurrent Glioblastoma Multiforme: A Case Report of the Paleolithic Ketogenic Diet (PKD) Used As a Stand-Alone Treatment after Failed Standard Oncotherapy. Preprints 2019, 2019120264 (doi: 10.20944/preprints201912.0264.v1).Copy
Abstract
Studies in animal models have suggested that the ketogenic diet may be effective in the treatment of cancer. However, human cohort studies on the ketogenic diet have, thus far, failed to show benefits in cancer survival or in any other hard clinical endpoints of the disease. This paper presents a case report of a patient with glioblastoma multiforme. The patient had initially been treated with standard oncotherapy including surgery, radiotherapy and chemotherapy. Despite standard treatment, the patient experienced a recurrence of the glioblastoma seven months later. Subsequently, the patient refused radiotherapy and chemotherapy and opted to use the paleolithic ketogenic diet (PKD) as a stand-alone therapy. Following the adoption of the PKD, progression of the disease has been completely halted. At the time of writing, the patient has remained in remission for 38 months, is without side-effects and experiences an excellent quality of life without the use of any drugs.
Subject Areas
glioblastoma; brain tumor; paleolithic diet; ketogenic diet; paleolithic ketogenic diet; metabolic therapy; intestinal permeability; cancer treatment
Paleolithic ketogenic diet
In agreement with the patient, we started the PKD in September 2016. The PKD is an animal fat-meat based diet with a fat:protein ratio of approximately 2:1 (in grams). The diet excludes cereal grains, dairy products, nightshades, legumes, plant oils (including coconut oil and olive oil), nuts, refined sugars, art
... keep reading on reddit ➡“Objective
To determine the association between dietary intake, markers of colonic health, microbiota, and serum trimethylamine-N-oxide (TMAO), a gut-derived metabolite associated with cardiovascular disease.
Design
In a cross-sectional design, long-term (n = 44, > 1 year) self-reported followers of a Paleolithic diet (PD) and controls (n = 47) consuming a diet typical of national recommendations were recruited. Diets were assessed via 3-day weighed diet records; 48-h stool for short chain fatty acids using GC/MS, microbial composition via 16S rRNA sequencing of the V4 region using Illumina MiSeq. TMAO was quantified using LC–MS/MS. Conclusions
Although the PD is promoted for improved gut health, results indicate long-term adherence is associated with different gut microbiota and increased TMAO. A variety of fiber components, including whole grain sources may be required to maintain gut and cardiovascular health.” https://link.springer.com/article/10.1007/s00394-019-02036-y
Paleolithic Ketogenic Diet sustains sufficient Magnesium levels.
A common concern with Ketogenic Diets and particularly highly carnivorous low plant based diets is magnesium (mag) deficiency. Animal food sources of mag are relatively low, while plant sources are relatively high.
100g of beef contains roughly 25mg of of mag. The RDI of mag is roughly 300-420mg per day. In contrast, hunter gatherer societies/highly carnivorous populations with low/absent plant intake do not demonstrate mag deficiency symptoms and have thriving health. This phenomena contradicts mag concerns and suggested RDI.
This hypothesis was tested with a Paleolithic Ketogenic Diet (PKD).
Method:
67 patients were identified whom had diagnosis of epilepsy, type 1 diabetes, type 2 diabetes, hypertension,obesity, hypothyroidism, cancer and other diseases.
PKD was composed of >70% Animal Food, fat:protein gram ratio 2:1. Diet prioritized fatty meat, regular intake of offal (liver, brain, marrow), and included options for fruit/vegetables or small amounts of honey for sweetening. Herbal/black tea were restricted but coffee was allowed in moderation. It can be inferred that total calorie ingestion was ab libtium.
Dairy/grain/seed oil/legumes/nightshades/fruit oil (coconut/olive)/refined sugar/sweeteners/food with additives were removed. No supplements/vitamins were included.
6 patients did not consume vegetables, fruit or honey at all.
Results:
50 selected patients adhered for an average of 2.75 months (range: 0.2 months to 32 months). Mag levels were normal in 49 out of 50 patients. There was significant negative correlation between glucose and mag levels.
Sample daily menu of mag intake was 64mg far below RDI requirements. Patients typically only consumed 2 meals a day. Food was preferably obtained from organic sources which may skew USDA database statistics.
High glucose levels and lowered mag levels prompt likely relationship of mag displacement or mal-absorption due to elevated carbohydrate load. Patients whom took medicine were excluded from the study to eliminate variance due to medicines that causing mag excretion via kidneys.
It is hypothesized that hypomagnesemia is likely due to western diet high in carbohydrate. Normalization of mag levels are due to shift from carbohydrate to fat based metabolism.
Mag is involved with enzyme reactions in glycolysis for glucose breakdown. Inve
... keep reading on reddit ➡ABSTRACT Paleolithic nutrition can optimize serum lipids in adults with hyperlipidemia who have been on a heart-healthy diet based on the current recommendations by the Academy of Nutrition and Dietetics (the Academy) or the American Heart Association (AHA). Twenty subjects (10 male and 10 female) age 40 to 62 were selected based on the criteria of a diagnosis of hypercholesterolemia. Subjects were not taking any cholesterollowering medication and had followed a calorie-controlled diet, based on either the dietary principles of the Academy or the AHA, for at least four months followed by a Paleolithic diet for four months. Multivariate analysis using repeated measures ANOVA was performed using SPSS version 21. The data reveal that the mean total cholesterol (P <.001), LDL (P <.001) and triglycerides (P<.001) were significantly lowered and HDL (P < 0.001) significantly elevated following four months of a Paleolithic diet relative to the Academy/AHA diet.
In a Hungarian clinic their is a group of M.Ds and scientist working on changing peoples lives with specific diet known as the Paleolithic ketogenic diet or PKD for short, I came accross their articles in the past but never gave it much thought untill I start looking into low carb I am interested in how their studies show a benefit of the diet. I am not a doctor/nutrionist and I am sharing these studies to create discussion and appreciate their work.
Here is a list to some of the conditions they are curing/ treating using the PKD
•T1 diabetes. https://www.researchgate.net/publication/267810000_Type_1_diabetes_mellitus_successfully_managed_with_the_paleolithic_ketogenic_diet
• Absence Epilepsy https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389034/
• Cervical Intraepithelial Neoplasia http://pubs.sciepub.com/jcrt/6/1/1/index.html
•Rectal Cancer http://pubs.sciepub.com/ajmcr/5/8/3/
•Chrons disease 27s_disease_successfully_treated_with_the_paleolithic_ketogenic_diet
They also have a study on magnesium levels whilst on the diet. https://scholar.google.com/scholar?client=ms-android-samsung&um=1&ie=UTF-8&lr&q=related:Xw9h_u1mE67BOM:scholar.google.com/#d=gs_qabs&p=&u=%23p%3DXw9h_u1mE64J
Discussion. Could this be an optimal diet? When I see people say their is no perfect human diet it annoys me because every animal has it's optimal diet just because were classed as omnivores doesn't mean she should live off fried food and processed foods and put it down to moderation with a hint of appeal to futility. I feel their is an optimal human diet that doesn't result in lifetime sickness, What other animals have such high rates of cancer, autoimmune disease, metabolic issues maybe you could say dogs eating a Std human diet of pastries, bread, processed food etc but I'm talking about wild animals.
Also this diet is interesting in that is called the KetoPaleo diet similar to the popular carnivore diet but that wording always makes me cringe no offence I personally would associate a carnivore with a ferocious animal that eats raw meat soon after it's kill. human meat eating habits sound a lot more like scavengers/necrovores and I've never seen a lion crack eggs or cook and chop it's meat so the PlaeoKeto for me has a nicer ring to it. Also please if you are uniformed about the specific topic of Eskimos diet please please do not mention them most of the studies are old and conflicting and there's a lot of fallacy and anecdotes so please do
... keep reading on reddit ➡Seems any write ups on this subject in my searches shows the diet generally summed up of most people of that era world wide only.
Anything I've seen tailored to Northern Europeans covers more the Mesolithic era.
Best I've found that is diet related shows different animals consumed pre-glacier (tundra landscape) or post glacier (forested), and hazelnuts.
Call me selfish, but my Ancestry results showed Northern European descent so curious about that. Thanks in advance.
Open letter to Professor Loren Cordain about Ketogenic and Paleolithic Diet(s)
Free download of full 12 page PDF at the following Research Gate Link:
Dear Professor Loren Cordain,
One should only grab a pen or, in this case, a keyboard and write an open letter if they want to make a clear and meaningful point. Competence in the subject is an advantage. We hope we meet both criteria. First of all, please let us express our appreciation for your work in the field of human nutrition science. We particularly appreciate your work as we have learned a lot from you. We are convinced that the changes your work has triggered will result in a considerable shift in nutrition science and help return to a reasonable and healthy diet which conforms to human evolution, or at least it will help with its scientific and exact description. As you suggest, there must be a single, optimal diet for all Homo Sapiens: an authentic Paleolithic Diet. We are writing this open letter because we want to respond to the recent criticism you expressed regarding Ketogenic Diets. We chose to publish an open letter, because thus we can inform laypeople about a professional debate which may be of public interest. You are a distinguished professional in the field of nutrition science and recently have expressed opinions on Ketogenic Diets, which have reached a wide range of people. We would like to address some of the points you made, which, in our opinion, contain scientific mistakes. This is necessary as, on the one hand, we are the founders and operators of the medical center with the most experience of Paleolithic, Ketogenic, Carnivore and PaleoKetogenic (PKD), etc.diets; on the other, our institute has applied and perfected your theoretical work, and, as a result, has been successfully treating incurable diseases, e.g. type 1 diabetes and cancer. We do not primarily talk about theories, we talk about clinical practice. We are writing our letter in hope of informing those who might feel uncertain because of the mentioned mistakes, and we also would like to encourage you to revisi
... keep reading on reddit ➡Anyone here experienced with this diet? I want to try it for few months but not sure what exactly to eat
“Objective
To determine the association between dietary intake, markers of colonic health, microbiota, and serum trimethylamine-N-oxide (TMAO), a gut-derived metabolite associated with cardiovascular disease.
Design
In a cross-sectional design, long-term (n = 44, > 1 year) self-reported followers of a Paleolithic diet (PD) and controls (n = 47) consuming a diet typical of national recommendations were recruited. Diets were assessed via 3-day weighed diet records; 48-h stool for short chain fatty acids using GC/MS, microbial composition via 16S rRNA sequencing of the V4 region using Illumina MiSeq. TMAO was quantified using LC–MS/MS. Conclusions
Although the PD is promoted for improved gut health, results indicate long-term adherence is associated with different gut microbiota and increased TMAO. A variety of fiber components, including whole grain sources may be required to maintain gut and cardiovascular health.” https://link.springer.com/article/10.1007/s00394-019-02036-y
