Each sessions cost about $150-200 and I'd like to do them about 2-4x a month for an illness I'm struggling with because I don't feel like the meds are working. However since these infusions aren't technically FDA approved, My PCP most likely won't sign off on them and refer to a place. Is there any other way I can bypass him to get this paid for? I'm rated at 80% and have no tricare insurance.

There is apparently a possible autoimmune component of gastroparesis (of course there is!). Has anyone had immunoglobulin treatment? Does anyone had diagnoses of autoimmune gastrointestinal dysmotility (AGID)? what about autoimmune gastrointestinal neuropathies (GAIN) or other dysautonomia?

Which clinics are the best for getting a diagnosis for these? Anyone have experience getting insurance to cover this type of therapy?

TIA!

https://doi.org/10.1016/j.braindev.2021.11.005

https://pubmed.ncbi.nlm.nih.gov/34863613

Abstract

BACKGROUND

Pyruvate dehydrogenase complex (PDHC) deficiency is an inborn error of metabolism that causes lactic acidosis and neurodevelopmental changes. Five causative genes have been identified: PDHA1, PDHB, DLAT, DLD, and PDHX. Four neurological phenotypes have been reported: neonatal encephalopathy with lactic acidosis, non-progressive infantile encephalopathy, Leigh syndrome, and relapsing ataxia. Of these, neonatal encephalopathy has the worst mortality and morbidity and there is no effective treatment.

SUBJECTS AND METHODS

We studied two girls who were clinically diagnosed with PDHC deficiency as neonates, they were subsequently found to have PDHA1 mutations. The clinical diagnosis was based on white matter loss and a lateral ventricular septum on fetal MRI, spasticity of the lower extremities, and lactic acidosis worsening after birth. Intravenous ketogenic diets were started within 24 h after birth. The ketogenic ratio was increased until the blood lactate level was controlled, while monitoring for side effects.

RESULTS

In both cases, the lactic acidosis improved immediately with no apparent side effects. Both children had better developmental outcomes than previously reported cases, neither exhibited epilepsy.

CONCLUSIONS

Intravenous ketogenic diet therapy is a treatment option for neonatal-onset PDHC deficiency. Further studies are needed to optimize this therapy.

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Open Access: False

Authors: Takehiko Inui - Yoichi Wada - Moriei Shibuya - Natsuko Arai-Ichinoi - Yukimune Okubo - Wakaba Endo - Toshihiko Uchida - Noriko Togashi - Etsuo Naito - Kazuhiro Haginoya -

Additional links: None found

I am looking to compile a list of IV protocols that individuals have used which have resulted in marked improvement. Please provide as much detail as you have in terms of components, doses and number of treatments. I have no seen this organized before, but if it has already been done please link to it.

https://doi.org/10.3389/fmed.2021.740374

https://pubmed.ncbi.nlm.nih.gov/34621766

Abstract

Therapeutic ketosis is traditionally induced with dietary modification. However, owing to the time delay involved, this is not a practical approach for treatment of acute conditions such as traumatic brain injury. Intravenous administration of ketones would obviate this problem by rapidly inducing ketosis. This has been confirmed in a number of small animal and human studies. Currently no such commercially available product exists. The aim of this systematic review is to review the safety and efficacy of intravenous beta-hydroxybutyrate. The Web of Science, PubMed and EMBASE databases were searched, and a systematic review undertaken. Thirty-five studies were included. The total beta-hydroxybutyrate dose ranged from 30 to 101 g administered over multiple doses as a short infusion, with most studies using the racemic form. Such dosing achieves a beta-hydroxybutyrate concentration >1 mmol/L within 15 min. Infusions were well tolerated with few adverse events. Blood glucose concentrations occasionally were reduced but remained within the normal reference range for all study participants. Few studies have examined the effect of intravenous beta-hydroxybutyrate in disease states. In patients with heart failure, intravenous beta-hydroxybutyrate increased cardiac output by up to 40%. No studies were conducted in patients with neurological disease. Intravenous beta-hydroxybutyrate has been shown to increase cerebral blood flow and reduce cerebral glucose oxidation. Moreover, beta-hydroxybutyrate reduces protein catabolism and attenuates the production of counter-regulatory hormones during induced hypoglycemia. An intravenous beta-hydroxybutyrate formulation is well tolerated and may provide an alternative treatment option worthy of further research in disease states.

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Open Access: True

Authors: Hayden White - Aaron J. Heffernan - Simon Worrall - Alexander Grunsfeld - Matt Thomas -

Additional links:

https://www.frontiersin.org/articles/10.3389/fmed.2021.740374/pdf

[https://research-repository.griffith.edu.au/bitstream/10072/409193/2/White516639-Published.pdf](https://research-repository.griffith.edu.a

Almost 12 months into long haul. Recently found out I have high levels of S100B indicative of inflammation in the brain and/or CNS. Negative ANA and CRP is normal. Had brain MRI, heart MRI and CT scan of the abdomen.

Currently taking prednisone and the antihistamine stack, but my GP also suggested we try IVIG.

Open to it but interested in hearing any experiences.

Only remaining symptoms are fatigue and PEM. The former much alleviated with prednisone.

Hi everyone.

My story: grew up with drug addicted father and hectic, anxious depressed mother.

So i have suffered with low self-esteem for large parts of my life. I am and almost 30 year old man. Been through the psychedelic search with use of substances from psilocybin, LSD, 5-meo-DMT and Ayahuasca once. I have been searching for a long time for more relief and peace inside myself. And establishing firmer and stronger boundaries and being more happy with my self from day to day.

My childhood i survived mainly through dissociation into video games, intense weight lifting/bodybuilding and i had my spiritual awakening/breakdown approximately around 26-27 years old.

I started seeing a therapist in the beginning of 2020 and he has helped me massively. I have also tried ketamine nasally dozens of times at home, at parties and combined with LSD and MDMA. And i think it is quite a remarkably substance.

Now they have gotten a clinic in my hometown here i Norway. And i have signed up for three sessions with Ketamine being pumped into my veins and blood intravenous. The psychologist i talked to seemed really professional, and i talked about my depressive, anxious episodes and intense desire to escape my hometown, and travel away from everything everytime i feel really down.

I have been struggling with an intense split on the inside. One part of me wants to stick around with my family, girlfriend and friends, and another part wants to get the hell out of here.

Soi am wondering what you guys think about this ketamine therapy i signed up for now. Being my session this monday, and tuesday the day after. And the last one on monday 22.02.2021 i will combine this Ketamine therapy combined with going to my therapist and still working on the repressed childhood traumas inside of me.

Since i have tried Ketamine a bunch of other times nasally, been in K-hole lot´s of times and done it recreationally with friends and on my own. How different will this be for me doing it intravenous in a clinical setting? Is this something i must do for a long period of my life? Since it is quite expensive (and i have the money atm) i aim at this as another tool helping me along the way to better and better life quality. I have been getting more and more life quality the last months. More light coming in through my eyes!

I can also mention that i am an intense seeker. Been delving in philosophy, psychedelics like mentioned, using floatation therapy a lot (since my brother owns a float

Here's survey about if you've ever has an IV before.

https://docs.google.com/forms/d/e/1FAIpQLSfMNIDe7PS49jrsEUYIIGwecuNF2m1O8RDVizTyhbL0hRm_Rg/viewform?usp=sf_link

Hi guys! I was wondering for the use of Intravenous needles for pediatric cancer patients aged 4 - 10 Years old , in which part of their arm are the most common spot for the IV needle insertion?

Thanks for replying!