Steroidal hormones such as testosterone or cortisol as described as "hormones" and "signalling agents" of the body. Yet that's a category that's covered as well by neurotransmitters (responsible for signalling) and insulin (a peptide that also a signalling agent, and a hormone).
So what's the function of a hormone which makes it "steroidal" as opposed to other hormones like insulin?
I've only tried BPC, TB and Ipamorelin/CJC. I'm looking at trying S9009 soon and maybe injectable L-carnitine and NAD+, what are some things you tried that were actually notable in terms of how good they made you feel or a benefit they provided?
I noticed there are no discussions regarding GHRP and cardiovascular health.
GHRP has profound effects that people with heart failure may potentially benefit from.
I don't want to cite all the studies. Just Google "ghrp heart" and you will see some promising information.
I figured I'd bring some awareness to some.
I kind of heard that some hormones are peptides of different sizes (from 3 or more). For example, the hormone oxytocin stimulates uterine contraction, or bradykinin suppresses tissue inflammation. At the same time, the free amino acids that make up these polypeptides do not perform such a role. Is this due to the fact that peptides specifically react with cell receptors than free amino acids?
I'm confused on the difference between the 2. Arent all peptides made up of amino acids so why are they listed in different categories
similarly, whats the difference between a amino acid neurotransmitter and a peptide neurotransmitter?
question is above!
but also, what is the difference between hormones and neurotransmitters in terms of binding? I was reading something about oxytocin being a hormone and a neurotransmitter- the fact that it is released into the blood stream from the anterior pituitary = hormone; when it is released from the hypothalamus in the brain = neurotransmitter
thanks!
Hi everyone. I’m an epileptologist and i have a patient I’ve diagnosed with non epileptic events based on two independent long term video eegs capturing her typical events that actually brought this up to me. I had not heard of it before, so I did some digging and I found this article:
Predicting psychogenic non-epileptic seizures from serum levels of neuropeptide Y and adrenocorticotropic hormone Alessandro Miani et al. Acta Neuropsychiatr. 2019 Jun.
The TL;DR version is that in those patients that don’t have convulsive events during EMU admission, these two hormones being elevated predicted NEEs with over 90% accuracy. Color me surprised. I’m wondering if anybody uses this routinely when they admit to the EMU?
Took it for about 5 months. Initially had great results. Now having a few issues to say the least.
Would like to know your dose/duration + experience if so.
Thanks.
P.S. please no negative comments of "you're an idiot for doing that!" (I've beat myself up enough on it at this point)
Because their are a few of them and a thread for each one wouldn’t have a lot of traction, I decided to combine them into one thread to make info gathering easier.
For those unaware, each week we have a specific steroid or PED up for discussion. This week we are discussing GHRPs. The goal of these threads is to generate discussion about the posted compound and get a wide variety of user experiences and feedback about it. These threads are extremely useful as an archive for new users, and for experienced users researching a new compound. This is all anecdotal, of course, and you should take these reviews with a grain of salt.
Stuff to discuss could include:
- Benefits/gains you experienced
- Side effects you experienced, physically or mentally (good or bad)
- Details of the cycle you included the compound in
- Whether you liked the compound or not and whether you’d use it again
What this thread ISN'T for:
- General questions about the compound that are answered by the wiki, or would be better suited for the Ask Anything thread
- Spitballing your next cycle
- Non-constructive criticism of other users cycles
- General questions about compounds that aren't directed at a user who has shared their experiences
Note: Comments violating these few simple guidelines will be removed
As always, read the entry in the wiki (if applicable) and follow the rules. Please, discuss away.
what do we need to know about secretory hormones
Why growth hormone
There are a lot of reasons why one might not want to use growth hormone, but it also has a myriad of positives such as:
- do more exercise
- have higher bone capacity
- look younger
- keep your hair
- build muscles
- get lean
- mental clarity
- prevent a lot of diseases
- advantages for your children
How does it work?
Well, short answer? we don't fucking know.
We have some ideas though, as you can read in this paper [Growth hormone-releasing peptides - PubMed (nih.gov)](https://pubmed.ncbi.nlm.nih.gov/9186261/#:~:text=Growth%20hormone%2Dreleasing%20peptides%20(GHRPs,secretion%20in%20animals%20and%20humans.&text=The%20GHRP%20receptor%20has%20recently,coupled%20receptors%20known%20so%20far.) , it might inhibit a hormone callled somatostatin, or GHIH. GHIH inhibits growth hormone, and thus should be minimized if you want to increase your growth hormone. You might be thinking, doesnt GHRP just release growth hormone, like the name suggests?
While that might be the case, right now it seems unlikely since we studied the exact form of the GHSR (growth hormone secretagogue receptor) and they don't seem to be related to the form of GHRP at all. Usually, what we know is GHRH, the growth hormone releasing hormone, which binds to the GHSR and then stimulates a release of growth hormone.
How to take it
First off, it should always be stored in the fridge, to preserve it.
In order to take it, many longevity experts say it should be injected into fat, aka subcutaneous, but others claim they have had the best results by injecting into muscle. Personally, I use it in the delts, where I feel like I get best results.
For mixing it with the bacteriostatic water, you should usually find the instructions on the package, without knowing your exact contents and amounts I can't help you.
Kinds of GHRP
Basically, there are a couple of forms of GHRP, but only GHRP6 and more recently GHRP2 have been used widely to increase growth hormones.
GHRP2 and GHRP6 have different structures, but they both have similar effects on animals.
GHRP6 is longer available and thus studies more extensively, although GHRP2 also has been subject of a couple of studies. The c
... keep reading on reddit ➡
there was a question where you needed to know that tryptophan is the precursor to serotonin. are there any other peptide hormone precursors we should know about? I had no idea we even needed to know this.....
The preservation of biological samples in formaldehyde induces intra‐ and inter‐crosslinking of peptides, which hampers the mass spectrometric detection of those analytes. Chemical reversal of formaldehyde‐induced peptidyl crosslinking permits mass spectrometry imaging of intact peptides, while protecting the spatiochemical characteristics of analytes in formalin‐fixed paraffin‐embedded tissues.
Abstract
Linking molecular and chemical changes to human disease states depends on the availability of appropriate clinical samples, mostly preserved as formalin‐fixed paraffin‐embedded (FFPE) specimens stored in tissue banks. Mass spectrometry imaging (MSI) enables the visualization of the spatiotemporal distribution of molecules in biological samples. However, MSI is not effective for imaging FFPE tissues because of the chemical modifications of analytes, including complex crosslinking between nucleophilic moieties. Here we used an MS‐compatible inorganic nucleophile, hydroxylamine hydrochloride, to chemically reverse inter‐ and intra‐crosslinks from endogenous molecules. The analyte restoration appears specific for formaldehyde‐reactive amino acids. This approach enabled the MSI‐assisted localization of pancreatic peptides expressed in the alpha, beta, and gamma cells. Pancreatic islet‐like distributions of islet hormones were observed in human FFPE tissues preserved for more than five years, demonstrating that samples from biobanks can effectively be investigated with MSI.
https://ift.tt/30DfvEN
I just encountered a question on the question bank which required that I know FSH was a peptide hormone. I wasn't aware of this and was wondering if there's some chart or pneumonic or something that breaks down what we have to know in regards to this.
The main example Kaplan gives of a peptide hormone's signal cascade is cAMP causing changes in transcription/gene expression via the phosphorylation of CREB protein.
From what I understand, hormone effects that influence gene transcription are slow because it takes a while for the transcription, translation, and then the new protein to do its thing. This explains slow - I also thought the effects were long-lived/not transient, but I actually don't know why.
However Kaplan says that peptide hormones (and thus cAMP) effects are usually rapid and short-lived/transient. From what I understand, hormone effects are rapid when they turn on/off already-existing proteins in the cytoplasm. However the main example they give, where cAMP causes CREB to change gene transcription, is literally the opposite of that.
So I had a couple questions:
-
Why are peptide hormone effects usually rapid and short-lived? Does cAMP just phosphorylate already-existing proteins more often than it phosphorylates transcription factors?
-
What makes an effect short-lived or long-lived? Do the second messengers get degraded quickly or something? Thanks.
Looking solely as a means for muscle growth. Been lifting for 8 months now. Can anyone chime in with the gains and results youve gotten from a simple GHRP-6/GHRH stack?
And do you think its a good idea when size/strength is my main goal? I've recently had to quit marijuana due to probation and I'm really keen on the appetite effects of GHRP.
Should I try this out for a while or should I go back to r/steroids and do the yourfirstcycle?
My doc just tested my hormones and found I'm very low in testosterone so I got testosterone pellets placed, I'm also on biest cream and progesterone and have started HGH peptide injections. Does anyone have any experience with this cocktail they can share - specifically with body composition changes? The past year I have still been working out like crazy but have gained a LOT of body fat and have been dealing with insane sugar cravings.
Steroidal hormones such as testosterone or cortisol as described as "hormones" and "signalling agents" of the body. Yet that's a category that's covered as well by neurotransmitters (responsible for signalling) and insulin (a peptide that also a signalling agent, and a hormone).
So what's the function of a hormone which makes it "steroidal" as opposed to other hormones like insulin?
Linking molecular and chemical changes to human disease states depends on the availability of appropriate clinical samples, mostly preserved as formalin‐fixed paraffin‐embedded (FFPE) specimens stored in tissue banks. Mass spectrometry imaging (MSI) is an established technique that enables visualization of the spatiotemporal distribution of molecules in biological samples. However, MSI is not effective for imaging FFPE tissues because of the chemical modifications of analytes, including complex crosslinking between nucleophilic moieties. Here we used an MS‐compatible inorganic nucleophile, hydroxylamine hydrochloride, to chemically reverse inter‐ and intra‐crosslinks from endogenous molecules. The analyte restoration appears specific for formaldehyde‐reactive amino acid residues. This approach enabled the MSI‐assisted localization of pancreatic peptides expressed in the alpha, beta, and gamma cells. Pancreatic islet‐like distributions of islet hormones were observed in human FFPE tissues preserved for more than five years, demonstrating that the rich repertoire of samples from biobanks can effectively be investigated with MSI.
https://ift.tt/30DfvEN
For those unaware, each week we have a specific steroid or PED up for discussion. The goal of these threads is to generate discussion about the posted compound and get a wide variety of user experiences and feedback about it. This is all anecdotal, of course, and you should take these reviews with a grain of salt.
Stuff to discuss could include:
- Benefits/gains you experienced
- Side effects you experienced, physically or mentally (good or bad)
- Details of the cycle you included the drug in
- Whether you liked the compound or not and whether you’d use it again
- Each ester you have used and if your experience varied (if applicable)
This week’s Compounds/PEDs is:
- Growth Hormone Releasing Peptides (GHRP)
& - Growth Hormone Releasing Hormones (GHRH)
Wiki's Growth Hormone Peptides Section: Here
As always, read the entry in the wiki (if applicable) and follow the rules. Please, discuss away.
