I got my leptin levels measured as part of a clinical trial (about Covid booster shots, nothing to do with weight loss) and mine is 139 ng/mL, the reference level is 18 ng/ mL. I haven’t been able to speak to a doctor yet - they send the numbers by email on Friday and someone will call if there’s anything to say, at some point next week.

From researching online it seems like I probably have some leptin resistance, does anyone have any experience with this? I’m very overweight (BMI 52) so I think it’s not surprising, but I have no idea if mine is unusually high given my weight or as expected. It doesn’t seem like there’s anything I can particularly do about it except lose weight, which I’m already trying to do, but also it’s supposed to make eating a calorie deficit harder. If there’s anything I can do to improve my leptin sensitivity I’d like to try it.

Leptin is like a thermostat: It sets your weight.

In contamination theory, A pollutant COULD affect this lipostat and cause some people to becomes overweight but also the same containment can cause some people to become underweight. Don't ask me how this works. It's something I read somewhere and I'd like to learn more about it.

Here's something about excess leptin:

https://www.reddit.com/r/askscience/comments/b7obfo/excess_leptin_is_that_a_thing/

Here's something about underweight animals:

https://slimemoldtimemold.com/2021/09/06/a-chemical-hunger-part-ix-anorexia-in-animals/

Now it's your turn to figure out what all this means. Good luck.

Your thoughts?

She now repeatedly swallows food, pukes it out and swallow it again, with no chance of ever satisfying her raving hunger.

I’m not really sure where to post this, so if any of you have suggestions please let me know.

I am sure being on prednisone long-term has screwed my body up, but I have been off for over three months at this point and usually this is when my body gets back to normal. I’ve had blood work twice in my leptin levels have been 1.7, at 27.5% body fat that’s a clear indication that it’s a little confused. My reverse T3 and T3 are on the lower side but still in normal range. I am trying to reverse my calories up, and I had a free meal tonight, in hopes that things like this will help me reset my leptin.

Does anyone have any experience with this or resources?

Believe it or not, your body, when it's working correctly, doesn't want you to excessively store calories. After a certain point having extra insurance against starvation in the form of body fat will put your body in more immediate danger. So your fat cells release leptin (satiety hormone) to tell your brain that they have enough fuel to last and you will naturally not overeat unless you force yourself to. That's how it normally works for most vertebrates, especially mammals. Unfortunately, something went awry. We all know overweight people -- if we're on this sub, we probably ARE one of those people -- who are getting their butts kicked by hunger and overeating, where even if they eat satiating and healthy food it's harder for them to feel satisfied.

That said:

Most people adhering to a modern diet have, in addition to insulin resistance, leptin resistance from consuming excessive linoleic acid from seed/vegetable oils, along with meats and vegetables high in Omega-6, which will also have a lot of linoleic acids. And, also in a perverse cycle, your adipose tissues (fat cells) produce leptin just by existing and having too many of them will ALSO cause and sustain leptin resistance once you get to that state.

But the cycle in leptin-sensitive people seems to be started mostly by subverting your body's hormones and getting leptin resistance in the first place. The main culprit seems to be from linoleic acids, one of the major Omega-6 fatty acid groups. Once leptin resistance starts causing you to overeat, even when you remove these leptin-subverting things from your diet your enlarged fat cells will sustain the leptin resistance cycle. Making it harder to be satisfied from meals and not overeat.

The long and short of it is that once you get down to your goal weight and improve your insulin resistance, you'll also need to work on your insulin resistance. Meaning, no seed/vegetable oils, limit the consumption of meats and vegetables high in Omega-6s. Wagyu Beef, factory-farmed (read: grain-fed and highly unsaturated) pork and chicken is really bad for you. Along with eating too many nuts, olives, avocados, and especially legumes like black beans and peanuts. They're not so bad that you need to avoid them, but you can't pig out on them, especially when you're trying to reduce the part of your leptin resistance that comes from excessive cell size.

If you're overweight, linoleic acid is bad news unless you're in that 1% of humans who are leptin-sensitive and

Seems like a study on rats shows that when taking a GHRP (Ipamorelin) and fasting that low Leptin levels can slow down GH production but high levels of Leptin seem to jump up GH production. I know high levels of Leptin are usually found in heavier people and are not considered good. Anybody else know about this or take Leptin for this reason?

How in the FUCK do you guys deal with low leptin cravings? I struggle in this area and it’s sent me on a couple of bingers. I’ve lost roughly 80 lbs and my top abs are beginning to show. I upped my calories for about a month to a maintenance level hoping to reset my leptin but it seems like cravings are hitting me harder than ever now that I’m back to cutting. Anyone got any tricks?

New findings from the 2021 American Diabetes Association (ADA) Virtual Meeting support the potential and safety of ORMD-0701, a novel oral human leptin formulation, in patients with type 1 diabetes.

“Recent understandings of the role of leptin in glucagon and glucose homeostasis, have flagged it as a target for management of type 1 diabetes,” wrote the investigative team, spearheaded by Miriam Kidron, PhD, of Oramed Pharmaceuticals.

“While historically thought to be involved in long-term regulation of appetite and energy expenditure, leptin is now known to regulate food absorption, mucus secretion, intestinal motility and inflammatory processes,” they continued.

full article: https://www.hcplive.com/view/oral-leptin-formulation-offers-short-term-benefit-type-1-diabetes-patients

https://www.nature.com/articles/ijo2017231

Abstract

Objective:

Resistance at the brain receptors for leptin and insulin has been associated with increased feeding, obesity and cognitive impairments. The causal agent for central resistance is unknown but could be derived from the blood. Here we postulate whether hypertriglyceridemia, the major dyslipidemia of the metabolic syndrome, could underlie central leptin and insulin resistance.

Design:

We used radioactively labeled triglycerides to measure blood–brain barrier (BBB) penetration, western blots to measure receptor activation, and feeding and cognitive tests to assess behavioral endpoints.

Results:

Human CSF was determined to contain triglycerides, a finding previously unclear. The radioactive triglyceride triolein readily crossed the BBB and centrally administered triolein and peripherally administered lipids induced in vivo leptin and/or insulin resistance at hypothalamic receptors. Central triolein blocked the satiety effect of centrally administered leptin. Decreasing serum triglycerides with gemfibrozil improved both learning and memory inversely proportionate to triglyceride levels.

Conclusions:

Triglycerides cross the blood–brain barrier rapidly, are found in human cerebrospinal fluid, and induce central leptin and insulin receptor resistance, decreasing satiety and cognition.

V–-V: only vehicle was injected; V–L: leptin injected without triolein; T-–L: triolein and leptin co-injected

Is Leptin Resistance the Cause of Your Weight Gain? - PCOS Diva

Hey all, I feel completely brain dead after studying all day and can't figure this out. Leptin is a hormone that decreases appetite by suppressing orexin production. Orexin increases appetite and is stimulated by ghrelin. Why is it that leptin KO mice are larger than WT? If they have a decreased appetite, wouldn't they just eat less and hence be smaller? I'm sorry if this is a dumb question, I feel like the answer is obvious but my brain is dead.

I'm in the midst of a super frustrating, months-long plateau. I track macros and calories religiously; I weigh and measure all my food; my ketones (measured with a blood meter) are consistently between 2.0 and 4.0, and my blood glucose rarely rises above 100 (it's in the low 80s when fasting). I also increased my exercise regiment about two months back (it did not break the weight plateau, and my measurements have not changed).

After pouring through my records (I trained as a research scientist; you'd think I'm documenting a mission to Mars for how meticulous my record-keeping is) and reading up on the usual causes of plateaus, I've started to wonder about leptin-receptor burnout.

Does anyone else suspect this might be playing a role for them? If so, did you plateau (and for how long)? Was there anything you did that you felt helped besides "keeping the faith" and waiting it out? TIA.

A carbohydrate-restricted diet for patients with irritable bowel syndrome lowers serum C-peptide, insulin, and leptin without any correlation with symptom reduction

10.1016/j.nutres.2020.12.001

https://sci-hub.se/10.1016/j.nutres.2020.12.001

Highlights

• Starch and sucrose-reduced diet led to lower levels of C-peptide, insulin and leptin
• Reduction of C-peptide and insulin levels correlated with reduced carbohydrate intake
• There was no correlation between hormone levels and gastrointestinal symptoms

Abstract

Alterations in gut endocrine cells and hormone levels have been measured in patients with irritable bowel syndrome (IBS). The hypothesis of the present study was that hormone levels would change after 4 weeks of a starch- and sucrose-reduced diet (SSRD) intervention corresponding to decreased carbohydrate intake and symptoms. Among 105 IBS patients from primary and tertiary healthcare, 80 were randomized to SSRD, while 25 followed their ordinary diet. Food diaries, Rome IV, and IBS-symptom severity score (IBS-SSS) questionnaires were completed, and blood samples were collected at baseline and after the intervention. Serum C-peptide, gastric inhibitory peptide, glucagon, glucagon-like peptide-1, insulin, leptin, luteinizing hormone, polypeptide YY, and glucose were measured, along with the prevalence of autoantibodies against gonadotropin-releasing hormone; its precursor, progonadoliberin-2, and receptor; and tenascin C. Carbohydrate intake was lower in the intervention group than in controls at week 4 (median: 88 [66-128] g vs 182 [89-224] g; P < .001). The change in carbohydrate intake, adjusted for weight, was associated with a decrease in C-peptide (β: 14.43; 95% confidence interval [CI]: 4.12-24.75) and insulin (β: 0.18; 95% CI: 0.04-0.32) levels. Glucose levels remained unchanged. The IBS-SSS scores were lower in the intervention group but not in controls (P < .001), without any association with changes in hormone concentrations. There was no difference in autoantibody prevalence between patients and healthy controls. In conclusion, the hypothesis that reduced carbohydrate intake corresponded to altered hormonal levels in IBS was accepted; however, there was no relationship between hormonal concentrations and symptoms.

Keywords: Carbohydrate-restricted diet; Dietary intervention; Gonadotropin-releasing hormone; Hormo

I got my leptin levels measured as part of a research study and mine is 139 ng/mL, the reference level is 18 ng/ mL. I haven’t been able to speak to a doctor yet - they send the numbers by email on Friday and someone will call if there’s anything to say, at some point next week.

From researching online it seems like I probably have some leptin resistance, does anyone have any experience with this? I’m very overweight (BMI 52) so I think it’s not surprising, but I have no idea if mine is unusually high given my weight or as expected. It doesn’t seem like there’s anything I can particularly do about it except lose weight, which I’m already trying to do, but also it’s supposed to make eating a calorie deficit harder. If there’s anything I can do to improve my leptin sensitivity I’d like to try it. I'm can lose weight if I stick to a calorie deficit but I do find it very hard to stick to, I think probably no more than anyone else though.

I’m 36, female, 328lbs, 5ft 4, white British. All my other results were normal except cholesterol towards the high end of normal and low vitamin D (26nmol/L), they tested a whole bunch of stuff. Blood pressure is fine, no PCOS that I know of, not insulin resistant. I’m asthmatic and take Clenil and I'm on Effexor 300mg for depression / anxiety. I drink alcohol once or twice a week, no smoking or recreational drugs, living in the UK.

I’m not really sure where to post this, so if any of you have suggestions please let me know.

I am sure being on prednisone long-term has screwed my body up, but I have been off for over three months at this point and usually this is when my body gets back to normal. I’ve had blood work twice in my leptin levels have been 1.7, at 27.5% body fat that’s a clear indication that it’s a little confused. My reverse T3 and T3 are on the lower side but still in normal range. I am trying to reverse my calories up, and I had a free meal tonight, in hopes that things like this will help me reset my leptin.

Does anyone have any experience with this or resources?

I’m not really sure where to post this, so if any of you have suggestions please let me know.

I am sure being on prednisone long-term has screwed my body up, but I have been off for over three months at this point and usually this is when my body gets back to normal. I’ve had blood work twice in my leptin levels have been 1.7, at 27.5% body fat that’s a clear indication that it’s a little confused. My reverse T3 and T3 are on the lower side but still in normal range. I am trying to reverse my calories up, and I had a free meal tonight, in hopes that things like this will help me reset my leptin.

Does anyone have any experience with this or resources?