Intercellular Matrix Puns

#Possible ways of a spike shedding after vaccination

Back in the the spring of 2021, when a lot of vaccinations were happening, there were some concerns about the vaxxinated potentially 'passing the spike protein to others around them.' This supposition was fueled by an internal Pfizer document that devoted an entire section to the possibility of "mRNA vaccine shedding," whereby people who were exposed to it near vaxxinated ones could potentially suffer an adverse reaction. A new study now suggests a way to do just that:

Introductory Explanation:

>Exosomes:

>Exosomes are small, single-membrane, secreted organelles of ∼30 to ∼200 nm in diameter that have the same topology as the cell and are enriched in selected proteins, lipids, nucleic acids, and glycoconjugates. Exosomes contain an array of membrane-associated, high-order oligomeric protein complexes, display pronounced molecular heterogeneity, and are created by budding at both plasma and endosome membranes. Exosome biogenesis is a mechanism of protein quality control, and once released, exosomes have activities as diverse as remodeling the extracellular matrix and transmitting signals and molecules to other cells. This pathway of intercellular vesicle traffic plays important roles in many aspects of human health and disease, including development, immunity, tissue homeostasis, cancer, and neurodegenerative diseases. In addition, viruses co-opt exosome biogenesis pathways both for assembling infectious particles and for establishing host permissiveness. On the basis of these and other properties, exosomes are being developed as therapeutic agents in multiple disease models.

>Source: https://pubmed.ncbi.nlm.nih.gov/31220978/

> See also: Exosome (vesicle): https://en.wikipedia.org/wiki/Exosome_%28vesicle%29

In section 8.3.5 of the internal Pfizer document:

https://cdn.pfizer.com/pfizercom/2020-11/C4591001_Clinical_Protocol_Nov2020.pdf

it was described that exposure during pregnancy or breastfeeding to a recipient of a Pfizer mRNA shot during the study period should be reported to Pfizer's safety department within 24 hours of the investigator becoming aware of it. Thus, Pfizer apparently assumed the possibility of spike shedding.

A study titled:

Circulating Exosomes with COVID Spike Protein Are Induced by BNT162b2 (Pfizer-BioNTech) Vaccination Prior to Development of Antibodies: A Novel Mechanism for Immune Activation by mRNA Vaccines

could provide an explanation for path

I don't want to step on anybody's toes here, but the amount of non-dad jokes here in this subreddit really annoys me. First of all, dad jokes CAN be NSFW, it clearly says so in the sub rules. Secondly, it doesn't automatically make it a dad joke if it's from a conversation between you and your child. Most importantly, the jokes that your CHILDREN tell YOU are not dad jokes. The point of a dad joke is that it's so cheesy only a dad who's trying to be funny would make such a joke. That's it. They are stupid plays on words, lame puns and so on. There has to be a clever pun or wordplay for it to be considered a dad joke.

Again, to all the fellow dads, I apologise if I'm sounding too harsh. But I just needed to get it off my chest.

Continuation of mTORC1 p2: Mast cells.... p1 --> Link

2. Overview and activation of MCs

Although the role of MCs is overlooked compared with microglia, MCs remain an important factor in the immune signaling pathway (29). MCs, the effector cells of the innate immune system, are derived from hematopoietic stem cells and multifunctional antigen-presenting cells and have a pivotal role in immunoglobulin type E (IgE)-associated allergic and inflammation-associated diseases (35). Despite their low numbers in most organs, MCs are present in both healthy and disease states. MCs are the first line of defense against invading pathogens and are distributed in almost all organs and vascularized tissues (36). Blood MCs express CD34 and contain cytoplasmic granules filled with heparin and histamine, the latter of which is released after binding to IgE. Unlike other myeloid-derived cells, tissue MCs have a hematopoietic developmental lineage (37,38). During MC development, immature lineage progenitors enter the circulation and are recruited to peripheral tissues by endothelial cells, regulating the appearance of granules with proteases (37,38). Human MCs may be classified into mucosal and connective tissue types according to the type of proteases present in their cytoplasmic granules; the mucosal type contains tryptase, whereas the connective tissue type contains both tryptase and chymase (39). MCs act as first responders and environmental ‘sensors’ to interact with other cellular elements involved in physiological and immune responses, promoting the neuroinflammation process (40). MCs are present in various areas of the brain and meninges. Although less distributed in the brain, they are generally found in the subthalamic nucleus, choroid plexus and the parenchyma of the hypothalamic region (41). The pathogenic roles of MCs were indicated to extend from allergic disease to autoimmune diseases and carcinogenesis (42-47).

The most common way through which MCs perform their function is degranulation. The activation of the inflammatory process results in a rapid release of MC granules into the interstitium. MC granules contain pre-formed and newly synthesized reactive chemicals known as MC mediators. These mediators include histamine, tryptase, chymase, interleukin families, tumor necrosis factor-α (TNF-α), serotonin, heparin, proteoglycans, vascular endothelial growth factor (VEGF), prosta

Alot of great jokes get posted here! However just because you have a joke, doesn't mean it's a dad joke.

THIS IS NOT ABOUT NSFW, THIS IS ABOUT LONG JOKES, BLONDE JOKES, SEXUAL JOKES, KNOCK KNOCK JOKES, POLITICAL JOKES, ETC BEING POSTED IN A DAD JOKE SUB

Try telling these sexual jokes that get posted here, to your kid and see how your spouse likes it.. if that goes well, Try telling one of your friends kid about your sex life being like Coca cola, first it was normal, than light and now zero , and see if the parents are OK with you telling their kid the "dad joke"

I'm not even referencing the NSFW, I'm saying Dad jokes are corny, and sometimes painful, not sexual

So check out r/jokes for all types of jokes

r/unclejokes for dirty jokes

r/3amjokes for real weird and alot of OC

r/cleandadjokes If your really sick of seeing not dad jokes in r/dadjokes

Punchline !

Edit: this is not a post about NSFW , This is about jokes, knock knock jokes, blonde jokes, political jokes etc being posted in a dad joke sub

Edit 2: don't touch the thermostat

Do your worst!

They were cooked in Greece.

I'm surprised it hasn't decade.

Ants don’t even have the concept fathers, let alone a good dad joke. Keep r/ants out of my r/dadjokes.

But no, seriously. I understand rule 7 is great to have intelligent discussion, but sometimes it feels like 1 in 10 posts here is someone getting upset about the jokes on this sub. Let the mods deal with it, they regulate the sub.

Don't you know a good pun is its own reword?

Two muffins are in an oven, one muffin looks at the other and says "is it just me, or is it hot in here?"

Then the other muffin says "AHH, TALKING MUFFIN!!!"

For context I'm a Refuse Driver (Garbage man) & today I was on food waste. After I'd tipped I was checking the wagon for any defects when I spotted a lone pea balanced on the lifts.

I said "hey look, an escaPEA"

No one near me but it didn't half make me laugh for a good hour or so!

Edit: I can't believe how much this has blown up. Thank you everyone I've had a blast reading through the replies 😂

It really does, I swear!

And now I’m cannelloni

Because she wanted to see the task manager.

But that’s comparing apples to oranges

And boy are my arms legs.

Heard they've been doing some shady business.

but then I remembered it was ground this morning.

Edit: Thank you guys for the awards, they're much nicer than the cardboard sleeve I've been using and reassures me that my jokes aren't stale

Edit 2: I have already been made aware that Men In Black 3 has told a version of this joke before. If the joke is not new to you, please enjoy any of the single origin puns in the comments

BamBOO!

They’re on standbi

A play on words.

My daughter, Chewbecca, not so much.

Pilot on me!!

Christopher Walken

Nothing, he was gladiator.

Dad jokes are supposed to be jokes you can tell a kid and they will understand it and find it funny.

This sub is mostly just NSFW puns now.

If it needs a NSFW tag it's not a dad joke. There should just be a NSFW puns subreddit for that.

Edit* I'm not replying any longer and turning off notifications but to all those that say "no one cares", there sure are a lot of you arguing about it. Maybe I'm wrong but you people don't need to be rude about it. If you really don't care, don't comment.

Or would that be too forward thinking?

#Possible ways of a spike shedding after vaccination

Back in the the spring of 2021, when a lot of vaccinations were happening, there were some concerns about the vaxxinated potentially 'passing the spike protein to others around them.' This supposition was fueled by an internal Pfizer document that devoted an entire section to the possibility of "mRNA vaccine shedding," whereby people who were exposed to it near vaxxinated ones could potentially suffer an adverse reaction. A new study now suggests a way to do just that:

Introductory Explanation:

>Exosomes:

>Exosomes are small, single-membrane, secreted organelles of ∼30 to ∼200 nm in diameter that have the same topology as the cell and are enriched in selected proteins, lipids, nucleic acids, and glycoconjugates. Exosomes contain an array of membrane-associated, high-order oligomeric protein complexes, display pronounced molecular heterogeneity, and are created by budding at both plasma and endosome membranes. Exosome biogenesis is a mechanism of protein quality control, and once released, exosomes have activities as diverse as remodeling the extracellular matrix and transmitting signals and molecules to other cells. This pathway of intercellular vesicle traffic plays important roles in many aspects of human health and disease, including development, immunity, tissue homeostasis, cancer, and neurodegenerative diseases. In addition, viruses co-opt exosome biogenesis pathways both for assembling infectious particles and for establishing host permissiveness. On the basis of these and other properties, exosomes are being developed as therapeutic agents in multiple disease models.

>Source: https://pubmed.ncbi.nlm.nih.gov/31220978/

> See also: Exosome (vesicle): https://en.wikipedia.org/wiki/Exosome_%28vesicle%29

In section 8.3.5 of the internal Pfizer document:

https://cdn.pfizer.com/pfizercom/2020-11/C4591001_Clinical_Protocol_Nov2020.pdf

it was described that exposure during pregnancy or breastfeeding to a recipient of a Pfizer mRNA shot during the study period should be reported to Pfizer's safety department within 24 hours of the investigator becoming aware of it. Thus, Pfizer apparently assumed the possibility of spike shedding.

A study titled:

Circulating Exosomes with COVID Spike Protein Are Induced by BNT162b2 (Pfizer-BioNTech) Vaccination Prior to Development of Antibodies: A Novel Mechanism for Immune Activation by mRNA Vaccines

could provide an explanation for path

#Possible ways of a spike shedding after vaccination

Back in the the spring of 2021, when a lot of vaccinations were happening, there were some concerns about the vaxxinated potentially 'passing the spike protein to others around them.' This supposition was fueled by an internal Pfizer document that devoted an entire section to the possibility of "mRNA vaccine shedding," whereby people who were exposed to it near vaxxinated ones could potentially suffer an adverse reaction. A new study now suggests a way to do just that:

Introductory Explanation:

>Exosomes:

>Exosomes are small, single-membrane, secreted organelles of ∼30 to ∼200 nm in diameter that have the same topology as the cell and are enriched in selected proteins, lipids, nucleic acids, and glycoconjugates. Exosomes contain an array of membrane-associated, high-order oligomeric protein complexes, display pronounced molecular heterogeneity, and are created by budding at both plasma and endosome membranes. Exosome biogenesis is a mechanism of protein quality control, and once released, exosomes have activities as diverse as remodeling the extracellular matrix and transmitting signals and molecules to other cells. This pathway of intercellular vesicle traffic plays important roles in many aspects of human health and disease, including development, immunity, tissue homeostasis, cancer, and neurodegenerative diseases. In addition, viruses co-opt exosome biogenesis pathways both for assembling infectious particles and for establishing host permissiveness. On the basis of these and other properties, exosomes are being developed as therapeutic agents in multiple disease models.

>Source: https://pubmed.ncbi.nlm.nih.gov/31220978/

> See also: Exosome (vesicle): https://en.wikipedia.org/wiki/Exosome_%28vesicle%29

In section 8.3.5 of the internal Pfizer document:

https://cdn.pfizer.com/pfizercom/2020-11/C4591001_Clinical_Protocol_Nov2020.pdf

it was described that exposure during pregnancy or breastfeeding to a recipient of a Pfizer mRNA shot during the study period should be reported to Pfizer's safety department within 24 hours of the investigator becoming aware of it. Thus, Pfizer apparently assumed the possibility of spike shedding.

A study titled:

Circulating Exosomes with COVID Spike Protein Are Induced by BNT162b2 (Pfizer-BioNTech) Vaccination Prior to Development of Antibodies: A Novel Mechanism for Immune Activation by mRNA Vaccines

could provide an explanation for path

#Possible ways of a spike shedding after vaccination

Back in the the spring of 2021, when a lot of vaccinations were happening, there were some concerns about the vaxxinated potentially 'passing the spike protein to others around them.' This supposition was fueled by an internal Pfizer document that devoted an entire section to the possibility of "mRNA vaccine shedding," whereby people who were exposed to it near vaxxinated ones could potentially suffer an adverse reaction. A new study now suggests a way to do just that:

Introductory Explanation:

>Exosomes:

>Exosomes are small, single-membrane, secreted organelles of ∼30 to ∼200 nm in diameter that have the same topology as the cell and are enriched in selected proteins, lipids, nucleic acids, and glycoconjugates. Exosomes contain an array of membrane-associated, high-order oligomeric protein complexes, display pronounced molecular heterogeneity, and are created by budding at both plasma and endosome membranes. Exosome biogenesis is a mechanism of protein quality control, and once released, exosomes have activities as diverse as remodeling the extracellular matrix and transmitting signals and molecules to other cells. This pathway of intercellular vesicle traffic plays important roles in many aspects of human health and disease, including development, immunity, tissue homeostasis, cancer, and neurodegenerative diseases. In addition, viruses co-opt exosome biogenesis pathways both for assembling infectious particles and for establishing host permissiveness. On the basis of these and other properties, exosomes are being developed as therapeutic agents in multiple disease models.

>Source: https://pubmed.ncbi.nlm.nih.gov/31220978/

> See also: Exosome (vesicle): https://en.wikipedia.org/wiki/Exosome_%28vesicle%29

In section 8.3.5 of the internal Pfizer document:

https://cdn.pfizer.com/pfizercom/2020-11/C4591001_Clinical_Protocol_Nov2020.pdf

it was described that exposure during pregnancy or breastfeeding to a recipient of a Pfizer mRNA shot during the study period should be reported to Pfizer's safety department within 24 hours of the investigator becoming aware of it. Thus, Pfizer apparently assumed the possibility of spike shedding.

A study titled:

Circulating Exosomes with COVID Spike Protein Are Induced by BNT162b2 (Pfizer-BioNTech) Vaccination Prior to Development of Antibodies: A Novel Mechanism for Immune Activation by mRNA Vaccines

could provide an explanation for path

#Possible ways of a spike shedding after vaccination

Back in the the spring of 2021, when a lot of vaccinations were happening, there were some concerns about the vaxxinated potentially 'passing the spike protein to others around them.' This supposition was fueled by an internal Pfizer document that devoted an entire section to the possibility of "mRNA vaccine shedding," whereby people who were exposed to it near vaxxinated ones could potentially suffer an adverse reaction. A new study now suggests a way to do just that:

Introductory Explanation:

>Exosomes:

>Exosomes are small, single-membrane, secreted organelles of ∼30 to ∼200 nm in diameter that have the same topology as the cell and are enriched in selected proteins, lipids, nucleic acids, and glycoconjugates. Exosomes contain an array of membrane-associated, high-order oligomeric protein complexes, display pronounced molecular heterogeneity, and are created by budding at both plasma and endosome membranes. Exosome biogenesis is a mechanism of protein quality control, and once released, exosomes have activities as diverse as remodeling the extracellular matrix and transmitting signals and molecules to other cells. This pathway of intercellular vesicle traffic plays important roles in many aspects of human health and disease, including development, immunity, tissue homeostasis, cancer, and neurodegenerative diseases. In addition, viruses co-opt exosome biogenesis pathways both for assembling infectious particles and for establishing host permissiveness. On the basis of these and other properties, exosomes are being developed as therapeutic agents in multiple disease models.

>Source: https://pubmed.ncbi.nlm.nih.gov/31220978/

> See also: Exosome (vesicle): https://en.wikipedia.org/wiki/Exosome_%28vesicle%29

In section 8.3.5 of the internal Pfizer document:

https://cdn.pfizer.com/pfizercom/2020-11/C4591001_Clinical_Protocol_Nov2020.pdf

it was described that exposure during pregnancy or breastfeeding to a recipient of a Pfizer mRNA shot during the study period should be reported to Pfizer's safety department within 24 hours of the investigator becoming aware of it. Thus, Pfizer apparently assumed the possibility of spike shedding.

A study titled:

Circulating Exosomes with COVID Spike Protein Are Induced by BNT162b2 (Pfizer-BioNTech) Vaccination Prior to Development of Antibodies: A Novel Mechanism for Immune Activation by mRNA Vaccines

could provide an explanation for path

#Possible ways of a spike shedding after vaccination

Back in the the spring of 2021, when a lot of vaccinations were happening, there were some concerns about the vaxxinated potentially 'passing the spike protein to others around them.' This supposition was fueled by an internal Pfizer document that devoted an entire section to the possibility of "mRNA vaccine shedding," whereby people who were exposed to it near vaxxinated ones could potentially suffer an adverse reaction. A new study now suggests a way to do just that:

Introductory Explanation:

>Exosomes:

>Exosomes are small, single-membrane, secreted organelles of ∼30 to ∼200 nm in diameter that have the same topology as the cell and are enriched in selected proteins, lipids, nucleic acids, and glycoconjugates. Exosomes contain an array of membrane-associated, high-order oligomeric protein complexes, display pronounced molecular heterogeneity, and are created by budding at both plasma and endosome membranes. Exosome biogenesis is a mechanism of protein quality control, and once released, exosomes have activities as diverse as remodeling the extracellular matrix and transmitting signals and molecules to other cells. This pathway of intercellular vesicle traffic plays important roles in many aspects of human health and disease, including development, immunity, tissue homeostasis, cancer, and neurodegenerative diseases. In addition, viruses co-opt exosome biogenesis pathways both for assembling infectious particles and for establishing host permissiveness. On the basis of these and other properties, exosomes are being developed as therapeutic agents in multiple disease models.

>Source: https://pubmed.ncbi.nlm.nih.gov/31220978/

> See also: Exosome (vesicle): https://en.wikipedia.org/wiki/Exosome_%28vesicle%29

In section 8.3.5 of the internal Pfizer document:

https://cdn.pfizer.com/pfizercom/2020-11/C4591001_Clinical_Protocol_Nov2020.pdf

it was described that exposure during pregnancy or breastfeeding to a recipient of a Pfizer mRNA shot during the study period should be reported to Pfizer's safety department within 24 hours of the investigator becoming aware of it. Thus, Pfizer apparently assumed the possibility of spike shedding.

A study titled:

Circulating Exosomes with COVID Spike Protein Are Induced by BNT162b2 (Pfizer-BioNTech) Vaccination Prior to Development of Antibodies: A Novel Mechanism for Immune Activation by mRNA Vaccines

could provide an explanation for path

#Possible ways of a spike shedding after vaccination

Back in the the spring of 2021, when a lot of vaccinations were happening, there were some concerns about the vaxxinated potentially 'passing the spike protein to others around them.' This supposition was fueled by an internal Pfizer document that devoted an entire section to the possibility of "mRNA vaccine shedding," whereby people who were exposed to it near vaxxinated ones could potentially suffer an adverse reaction. A new study now suggests a way to do just that:

Introductory Explanation:

>Exosomes:

>Exosomes are small, single-membrane, secreted organelles of ∼30 to ∼200 nm in diameter that have the same topology as the cell and are enriched in selected proteins, lipids, nucleic acids, and glycoconjugates. Exosomes contain an array of membrane-associated, high-order oligomeric protein complexes, display pronounced molecular heterogeneity, and are created by budding at both plasma and endosome membranes. Exosome biogenesis is a mechanism of protein quality control, and once released, exosomes have activities as diverse as remodeling the extracellular matrix and transmitting signals and molecules to other cells. This pathway of intercellular vesicle traffic plays important roles in many aspects of human health and disease, including development, immunity, tissue homeostasis, cancer, and neurodegenerative diseases. In addition, viruses co-opt exosome biogenesis pathways both for assembling infectious particles and for establishing host permissiveness. On the basis of these and other properties, exosomes are being developed as therapeutic agents in multiple disease models.

>Source: https://pubmed.ncbi.nlm.nih.gov/31220978/

> See also: Exosome (vesicle): https://en.wikipedia.org/wiki/Exosome_%28vesicle%29

In section 8.3.5 of the internal Pfizer document:

https://cdn.pfizer.com/pfizercom/2020-11/C4591001_Clinical_Protocol_Nov2020.pdf

it was described that exposure during pregnancy or breastfeeding to a recipient of a Pfizer mRNA shot during the study period should be reported to Pfizer's safety department within 24 hours of the investigator becoming aware of it. Thus, Pfizer apparently assumed the possibility of spike shedding.

A study titled:

Circulating Exosomes with COVID Spike Protein Are Induced by BNT162b2 (Pfizer-BioNTech) Vaccination Prior to Development of Antibodies: A Novel Mechanism for Immune Activation by mRNA Vaccines

could provide an explanation for path

#Possible ways of a spike shedding after vaccination

Back in the the spring of 2021, when a lot of vaccinations were happening, there were some concerns about the vaxxinated potentially 'passing the spike protein to others around them.' This supposition was fueled by an internal Pfizer document that devoted an entire section to the possibility of "mRNA vaccine shedding," whereby people who were exposed to it near vaxxinated ones could potentially suffer an adverse reaction. A new study now suggests a way to do just that:

Introductory Explanation:

>Exosomes:

>Exosomes are small, single-membrane, secreted organelles of ∼30 to ∼200 nm in diameter that have the same topology as the cell and are enriched in selected proteins, lipids, nucleic acids, and glycoconjugates. Exosomes contain an array of membrane-associated, high-order oligomeric protein complexes, display pronounced molecular heterogeneity, and are created by budding at both plasma and endosome membranes. Exosome biogenesis is a mechanism of protein quality control, and once released, exosomes have activities as diverse as remodeling the extracellular matrix and transmitting signals and molecules to other cells. This pathway of intercellular vesicle traffic plays important roles in many aspects of human health and disease, including development, immunity, tissue homeostasis, cancer, and neurodegenerative diseases. In addition, viruses co-opt exosome biogenesis pathways both for assembling infectious particles and for establishing host permissiveness. On the basis of these and other properties, exosomes are being developed as therapeutic agents in multiple disease models.

>Source: https://pubmed.ncbi.nlm.nih.gov/31220978/

> See also: Exosome (vesicle): https://en.wikipedia.org/wiki/Exosome_%28vesicle%29

In section 8.3.5 of the internal Pfizer document:

https://cdn.pfizer.com/pfizercom/2020-11/C4591001_Clinical_Protocol_Nov2020.pdf

it was described that exposure during pregnancy or breastfeeding to a recipient of a Pfizer mRNA shot during the study period should be reported to Pfizer's safety department within 24 hours of the investigator becoming aware of it. Thus, Pfizer apparently assumed the possibility of spike shedding.

A study titled:

Circulating Exosomes with COVID Spike Protein Are Induced by BNT162b2 (Pfizer-BioNTech) Vaccination Prior to Development of Antibodies: A Novel Mechanism for Immune Activation by mRNA Vaccines

could provide an explanation for path

#Possible ways of a spike shedding after vaccination

Back in the the spring of 2021, when a lot of vaccinations were happening, there were some concerns about the vaxxinated potentially 'passing the spike protein to others around them.' This supposition was fueled by an internal Pfizer document that devoted an entire section to the possibility of "mRNA vaccine shedding," whereby people who were exposed to it near vaxxinated ones could potentially suffer an adverse reaction. A new study now suggests a way to do just that:

Introductory Explanation:

>Exosomes:

>Exosomes are small, single-membrane, secreted organelles of ∼30 to ∼200 nm in diameter that have the same topology as the cell and are enriched in selected proteins, lipids, nucleic acids, and glycoconjugates. Exosomes contain an array of membrane-associated, high-order oligomeric protein complexes, display pronounced molecular heterogeneity, and are created by budding at both plasma and endosome membranes. Exosome biogenesis is a mechanism of protein quality control, and once released, exosomes have activities as diverse as remodeling the extracellular matrix and transmitting signals and molecules to other cells. This pathway of intercellular vesicle traffic plays important roles in many aspects of human health and disease, including development, immunity, tissue homeostasis, cancer, and neurodegenerative diseases. In addition, viruses co-opt exosome biogenesis pathways both for assembling infectious particles and for establishing host permissiveness. On the basis of these and other properties, exosomes are being developed as therapeutic agents in multiple disease models.

>Source: https://pubmed.ncbi.nlm.nih.gov/31220978/

> See also: Exosome (vesicle): https://en.wikipedia.org/wiki/Exosome_%28vesicle%29

In section 8.3.5 of the internal Pfizer document:

https://cdn.pfizer.com/pfizercom/2020-11/C4591001_Clinical_Protocol_Nov2020.pdf

it was described that exposure during pregnancy or breastfeeding to a recipient of a Pfizer mRNA shot during the study period should be reported to Pfizer's safety department within 24 hours of the investigator becoming aware of it. Thus, Pfizer apparently assumed the possibility of spike shedding.

A study titled:

Circulating Exosomes with COVID Spike Protein Are Induced by BNT162b2 (Pfizer-BioNTech) Vaccination Prior to Development of Antibodies: A Novel Mechanism for Immune Activation by mRNA Vaccines

could provide an explanation for path