Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 nature.com/articles/s4146…
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πŸ‘€︎ u/Peeecee7896
πŸ“…︎ Jan 22
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Cross-Talk Between Extracellular Matrix and Skeletal Muscle: Implications for Myopathies

Skeletal muscle (SM) comprises around 40% of total body weight and is among the most important plastic tissues, as it supports skeletal development, controls body temperature, and manages glucose levels. Extracellular matrix (ECM) maintains the integrity of SM, enables biochemical signaling, provides structural support, and plays a vital role during myogenesis. Several human diseases are coupled with dysfunctions of the ECM, and several ECM components are involved in disease pathologies that affect almost all organ systems. Thus, mutations in ECM genes that encode proteins and their transmembrane receptors can result in diverse SM diseases, a large proportion of which are types of fibrosis and muscular dystrophy. In this review, we present major ECM components of SMs related to muscle-associated diseases and discuss two major ECM myopathies, namely, collagen myopathy and laminin myopathies, and their therapeutic management. A comprehensive understanding of the mechanisms underlying these ECM-related myopathies would undoubtedly aid the discovery of novel treatments for these devastating diseases.

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πŸ‘€︎ u/ahmadk001
πŸ“…︎ Jan 15
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Can someone explain me about sodium potassium pump in a simple way? How can it said that this process is maintaining the membrane potential by letting sodium out to to extracellular cell and let potassium in the cytoplasm?
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πŸ‘€︎ u/LengZaiL
πŸ“…︎ Dec 27 2021
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Dr. Collin Ewald | Collagen Protein & Extracellular Matrix During Aging youtu.be/r1Y5wGSqKWA
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πŸ‘€︎ u/Valuable_Ad1073
πŸ“…︎ Jan 18
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Mycorrhiza of eucalyptus have been shown to export RNA to plant part genetic expression: what is this called, and does this closer resemble a retrovirus or extracellular vesicle?

I'm super interested but not particularly well read in mycorrhizal interactions but I've never seen findings like these before and my cellular microbiology and o-chem knowledge is extremely lacking, but I dont understans how this differs from "GMO" with a retrovirus or interspecific extra cellular vesicles.

I'd also be happy with articles to read if there's not an easy answer for tgis, i'm just wondering what this phenomenon is called and how normal it is expected to be.

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πŸ‘€︎ u/throwawaybreaks
πŸ“…︎ Jan 10
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Does extracellular matrix aging occur at similar rates across species?

In human development, ECM is laid down, and that which isn't turned over accumulates damage such as crosslinks (AGEs) or breakdown of components (elastin), leading to stiff arteries and weak skin, and affecting cell behavior.

This process takes decades in humans, and I assume it's driven by spontaneous chemical reactions, not some biological clock, so it seems like it should happen at the same speed across species with similar ECMs. Does it? This would cause short-lived animals to die with good ECM and long-lived animals to die with very damaged ECM. Alternatively, does the rate of damage adjust to the species lifespan, and if so, how?

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πŸ‘€︎ u/user_--
πŸ“…︎ Jan 24
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Glycine can prevent and fight virus invasiveness by reinforcing the extracellular matrix (2021) sciencedirect.com/science…
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πŸ‘€︎ u/LungsOfSteel
πŸ“…︎ Nov 30 2021
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Real time imaging of single extracellular vesicle pH regulation in a microfluidic cross-flow filtration platform. This is the first mechanistic description of EV function on the single vesicle level. nature.com/articles/s4200…
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πŸ‘€︎ u/mauleon2
πŸ“…︎ Jan 10
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What role do extracellular vesicles "decoys" play in the immune system? "Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2"

A recent publication (El-Shennawy et al 2022) suggests that people infected with SARS-CoV-2 release extracellular vesicles (EVs) that have the ACE2 receptor on their membranes, acting as a decoy for the virus to infect instead of cells.

Has this been seen in any other viral diseases? I've never heard of this before, not sure if it even falls under the "immune system" label or not.

Maybe decoy vesicles with receptors targeted by viruses are going to be produced as antivirals?

πŸ‘︎ 4
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πŸ‘€︎ u/thecorndogmaker
πŸ“…︎ Jan 21
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Strong SARS-CoV-2 N-specific CD8+ T immunity induced by engineered extracellular vesicles associates with protection from lethal infection in mice. biorxiv.org/content/10.11…
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πŸ‘€︎ u/icloudbug
πŸ“…︎ Jan 11
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The interplay of fibroblasts, the extracellular matrix, and inflammation in scar formation sciencedirect.com/science…
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πŸ‘€︎ u/MarcHerb
πŸ“…︎ Dec 27 2021
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Fetal Bovine Serum RNA Interferes with the Cell Culture derived Extracellular RNA - Fetal Bovine Serum is use in all virus isolation cell cultures. nature.com/articles/srep3…
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πŸ‘€︎ u/BenzDriverS
πŸ“…︎ Jan 25
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Extracellular Matrix and the Production of Cultured Meat mdpi.com/1406578
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πŸ‘€︎ u/ahmadk001
πŸ“…︎ Jan 09
🚨︎ report
Effects of high extracellular fluid calcium ion concentration - what's the reason behind it?

The Guyton and Hall Textbook of Medical Physiology, p. 76, says: > For example, a high extracellular fluid calcium ion concentration decreases membrane permeability to sodium ions and simultaneously reduces excitability.

Why does this hold?

Naively, a high extracellular concentration of calcium ions should facilitate their flow through the calcium channels. Since the flow contributes to the action potential, the neurons should actually become hyperexcitable in the such a situation.

Is it possibly the case that a high extracellular concentration of calcium increases the extracellular potential, thus causing hyperpolarization of the cell? This doesn't make too much sense either because, then, a high extracellular concentration of Na+ would also decrease the excitability in a similar way.

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πŸ‘€︎ u/mrrmarr
πŸ“…︎ Dec 18 2021
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Extracellular vesicle function is shown at the single EV level for the first time

Real time imaging of single extracellular vesicle pH regulation in a microfluidic cross-flow filtration platform

https://preview.redd.it/pdtfm0tevxa81.jpg?width=685&format=pjpg&auto=webp&s=b2c5410a57d7feb18ff369fa6451c0928b9db335

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πŸ‘€︎ u/mauleon2
πŸ“…︎ Jan 10
🚨︎ report
China-Italy team demonstrated that lipid droplets, dynamic structures that naturally exist in cells, can act as intracellular microlenses for real-time monitoring of subcellular structures and detection of extracellular signals
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πŸ‘€︎ u/Dr_Singularity
πŸ“…︎ Dec 27 2021
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Plant Cunning Podcast interview with Matthew Wood on Holistic Medicine and the Extracellular Matrix anchor.fm/plantcunning/ep…
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πŸ‘€︎ u/eyesaque
πŸ“…︎ Dec 25 2021
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Plant Cunning Podcast interview with Matthew Wood on Holistic Medicine and The Extracellular Matrix anchor.fm/plantcunning/ep…
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πŸ‘€︎ u/eyesaque
πŸ“…︎ Dec 25 2021
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How does increased extracellular potassium affect action potential?

Hi! I don't get why increased extracellular potassium does not lead to an action potential? I know that the resting potential is decreasing due to this variation but I don't know if or how it is linked to it ? Thank you in advance!

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πŸ‘€︎ u/bibimbap-11
πŸ“…︎ Nov 29 2021
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Artificial sweeteners stimulate horizontal transfer of extracellular antibiotic resistance genes through natural transformation nature.com/articles/s4139…
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πŸ‘€︎ u/PHealthy
πŸ“…︎ Sep 03 2021
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Classification of Preeclamptic Placental Extracellular Vesicles Using Femtosecond Laser-fabricated Nanoplasmonic Sensors and Machine Learning biorxiv.org/content/10.11…
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πŸ‘€︎ u/sburgess86
πŸ“…︎ Dec 29 2021
🚨︎ report
Extracellular Matrix protein gelatin provides higher expansion, reduces size heterogeneity, and maintains cell stiffness in a long-term culture of mesenchymal stem cells. biorxiv.org/content/10.11…
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πŸ‘€︎ u/sburgess86
πŸ“…︎ Dec 21 2021
🚨︎ report
What role do extracellular vesicles "decoys" play in the immune system? "Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2"

A recent publication (El-Shennawy et al 2022) suggests that people infected with SARS-CoV-2 release extracellular vesicles (EVs) that have the ACE2 receptor on their membranes, acting as a decoy for the virus to infect instead of cells.

Has this been seen in any other viral diseases? I've never heard of this before, not sure if it even falls under the "immune system" label or not.

Maybe decoy vesicles with receptors targeted by viruses are going to be produced as antivirals?

πŸ‘︎ 2
πŸ’¬︎
πŸ‘€︎ u/thecorndogmaker
πŸ“…︎ Jan 21
🚨︎ report

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