Diffuse Sky Radiation Puns

https://academic.oup.com/neuro-oncology/article-abstract/21/Supplement_2/ii77/5466793?redirectedFrom=fulltext ; https://booksc.xyz/book/75694979/d50d4b (there is nothing else but the abstract)

Alex P Rossi, Nelofer Syed, Cynthia Wetmore, Adrienne C Scheck

Abstract

Diffuse Intrinsic Pontine Glioma (DIPG) is a highly infiltrative pediatric tumor with a median survival of approximately 9 months. Due to its location, the tumor is generally considered inoperable and there are few therapeutic options. Radiation is the only primary treatment for these tumors; however, this provides only short-term benefits. New therapeutic modalities are critically needed, and recent publications have suggested that a more effective treatment regime may involve multiple concurrent therapies that also potentiate radiation. A variety of combination treatments are under investigation, particularly those including histone deacetylase inhibitors (HDACi). Unfortunately, the use of multiple pharmaceutical agents often leads to unacceptable toxicity and side effects. One potential non-toxic therapy is metabolic ketosis which can be achieved using a therapeutic ketogenic diet (KD). The KD causes an increase in blood ketones and a decrease in blood glucose and has been used to safely treat refractory pediatric epilepsy. We have previously used human and murine high-grade glioma cells and a mouse model of high grade glioma to demonstrate that therapeutic ketosis has pluripotent anti-tumor activity alone and in combination with radiation. BHB has been shown to act as an endogenous HDACi. As such, the potential therapeutic underpinnings of the KD may involve the epigenetic-modifying capabilities of BHB. We now report that BHB causes significant growth inhibition in a DIPG cell line (SU-DIPG33; a generous gift from M. Monje, Stanford U.). In addition, BHB increases radiation induced DNA damage as measured by γH2AX western blot analysis. These data suggest that therapeutic ketosis may be a non-toxic adjuvant therapy that both potentiates radiation and inhibits the growth of DIPG cells. (supported by Students Supporting Brain Tumor Research and the Jaydie Lynn King Program in Neuro-oncology).

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I have been struggling with the text that I have and was wondering if anyone could simplify the 1990 or the 1986 version of the diffuse radiation perez models?

1986 : D(c) = D(h)((.5(1+cos(s))(1-f1-f2)+f1(a/c) + f2(b/d)

1990 : D(c) = D(h)((.5(1+cos(s))(1-f1) + (f1(cos(theta)/cos(z))) + f2sin(s)

Any help would be appreciated. Im kinda lost on what F1 f2 and abcd are..

A normal day at the office.

Working when suddenly a thought enters my mind. Thought develops and runs free. Turns into a thought about my past. Said thought makes me angry.

Usually I’d be stuck in a thought-train and continue to feed my anger.

Not this time. I felt in control. I observed my anger and my thoughts and it went away.

I felt calm and at peace.