https://tweedlefarms.com/blog/why-is-my-hemp-purple/
https://preview.redd.it/k5ud1r3bcq881.png?width=1909&format=png&auto=webp&s=18136e9187e4b63f7d48e53249c5267bcb0252ff
Blueberries, blackberries, purple carrots, eggplants, acai berries, forbidden rice, and⦠cannabis? What do these plants have in common? One very important thing - anthocyanins.
Great, but what are anthocyanins?
They are a type of polyphenol compound that is responsible for the purple, red, or blue color in plants. The color exhibited is determined by the level of acidity in the plant. When ingested, they can act as antioxidants; or, molecules that fight free radicals in your body.
Why do anthocyanins develop in plants?
Over time, various species of plants have developed the ability to exhibit these striking colors for a variety of reasons.
- The coloration provided by the accumulation of anthocyanins can help to attract pollinators, while simultaneously protecting the plants from being eaten by herbivores usually attracted to the color green.
- They play a protective role against extreme temperatures.
- They protect photosynthetic tissues, essentially acting as sunscreen for the plants.
Why do anthocyanins develop in cannabis?
Anthocyanins develop in cannabis for some of the same reasons that they develop in other plants - as a protective role against extreme temperatures and certain spectrums of light. In fact, many indoor cannabis growers will manipulate the environment of their grow room to encourage the development of anthocyanins; either by adjusting the temperature or the spectrum of their lights. Additionally, during the breeding process, specific phenotypes of cannabis will be selected based on their ability to exhibit high amounts of anthocyanins (i.e. they turn very purple), sometimes with or without environmental triggers.
Now, once those specific phenotypes have been selected and stabilized, the cannabis world is treated to the distinct colors and flavors of purple cannabis seen in strains like Granddaddy Purple, Purple Kush, Purple Emperor, Painted Lady, Pink Panther, and more.
Why are anthocyanins important?
Apart from the fact that they are responsible for producing some o
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The studies i have read on anthocyanin are done with a very high concentration and pure extract. Which is practically not possible to consume. The concentration shown benificial in vitro experiments are not even closer to the tissue concentration in humans. Now a days we have supplements to consume higher concentration of anthocyanins which are pragmatically not possible. I wounder what significance anthocyanin had made in ancient human. I really dont think these phytochemicals are significantly enough in an individual diet to show any favorable outcome.
Anthocyanins are bioactive compounds exclusively found in plants (and especially in berries) that may be protective against cardiovascular and neurodegenerative disease.[1] However, in aging Western populations, the dietary intake of anthocyanins is declining[2] while the risk of neurodegenerative diseases is rising. Consequently, supplementation with anthocyanins (e.g., as berry extracts) could be helpful to sustain or even improve cognitive function. Are the anthocyanins in berry extracts as good as those in unprocessed berries? The study: This systematic review analyzed 49 randomized controlled trials to examine the effects of anthocyanin supplementation on cognitive performance (18 studies), vascular function, (22 studies), and cardiometabolic risk factors (32 studies). The results: In both short-term and long-term studies, anthocyanins improved cognitive performance in specific dimensions such as memory and, in some cases, attention and executive function as well. The researchers also found consistent evidence that anthocyanins improved vascular function and blood pressure but not cardiometabolic risk markers. Note: The included studies differed in the types and doses of anthocyanin supplements. Most studies used berry extracts with doses of 10β500 mg of anthocyanins. Future studies need to assess the safety and efficacy of different types and doses of available anthocyanin supplements.
https://examine.com/members/summaries/issue/july-2021/summary-9Lb7P1/?utm_source=examine-insiders&utm_medium=email&utm_campaign=2021-08-19
Neurogenesis promotes neuron growth, which MAY improve brain performance. It's well known that the following supplements support adult neurogenesis: Curcumin, Anthocyanins. [5]. Furthermore, Bacopa is known to be a well studied nootropic that has positive effects on memory. I have been taking all three in the hopes of the effect being synergistic; however, I am worried about a potential herb drug interaction with Adderall. Adderall is metabolized by CYP2D6 [1]. Adderall itself inhibits this enzyme a bit [1].
Curcumin is also known to inhibit CYP2D6. [2] This article (https://jphcs.biomedcentral.com/articles/10.1186/s40780-017-0083-x) seems to state that Curcumin's inhibition is potent, while I have found others that state it's not and that the interactions won't be. I am unsure if it's potent enough as I don't fully understand the values provided. I Researched CI50 but don't know how to correlate that to the 500mg I am taking of Curcumin.
Bacopa M. is also shown to inhibit this enzyme, although it's described as "weak inhibition of CYP2D6". [3]. But again, I don't know how to quantify the results and translate them to meaningful data to make a decision on stopping the consumption of the supplement.
Anthocyanins also seem to inhibit this enzyme, but very very very weakly. "As the tested anthocyanins and anthocyanidins were shown to be about 1,000-fold less potent, they are unlikely to interfere with drug metabolism by CYP2D6." [4]
Could the mix of these three supplements inhibit the enzyme in a compounding way?
Would it be effective to take these at night, before bed, such that we minimize the interaction? It would be good to know how long the inhibition lasts.
My final concern is whether it's causing Adderall to be more toxic, or just less effective? If we are inhibiting the enzyme that Adderall is metabolized by, it sounds like it's just making it less effective. Correct?
1- https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/011522s043lbl.pdf
2- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2574793/
3- https://pubmed.ncbi.nlm.nih.gov/24566323/
4- https://pubmed.ncbi.nlm.nih.gov/19357792/
5- [https://www.ncbi.nl
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