Who is putting the orders in for immunoglobulin products like Atgam or Asceniv?
I know this is Acute rejection as it says 1 month and also saying that biopsy shows inflammatory infiltrates affecting the small arterioles. According to FA it says that CD8+ T cells and or CD4+ T cells both play a role in acute rejection. Why isnt it D also then?
https://preview.redd.it/y5igb40zmbd81.png?width=1866&format=png&auto=webp&s=e974bfb164e9b85f8f8a6c0e5312fd1895f06778
F28 Height 5’2 Weight 125 Medications: (all recent and for the infection) PHMB drops 8x, chlorhexidine drops 8x, cyclosporine 4x moxafloxine 4x, prednisone tablet 20mg. Valcylovir 200mg 1x Non smoker
Diagnosed with acanthamoeba keratitis infection in the left eye in July 2021.
I was given an emergency therapeutic full corneal transplant in September with a “hot eye”. My infection of acanthamoeba parasite had gotten too difficult to treat with only medications.
Unfortunately I have had a reoccurrence of the acanthamoeba infection in the new cornea. I’m extremely worried about the graft rejection and the fact the oral steroids I’m on are “feeding” the parasitic infection.
I was on steroid eye drops and was told to immediately stop. However I’m still on oral steroids 20mg a day. I’m also on compounded cyclosporine drops 2% 4 times a day. I’m wondering what my other anti rejection treatment options are that I can suggest to my doctor.
Had anyone treated this infection reoccurrence in a transplanted cornea?
Hi y’all Over the last year I’ve had a series of problems after having been given plasmapheresis. I had an episode of kidney transplant rejection last summer (after 10 healthy years) and was in the hospital for a little over two weeks and had out patient work for almost another two weeks. I had problems constantly because I had the catheter in my heart and a PICC line in my arm; my veins aren’t good because I’m a transplant recipient, and I had to have multiple put in surgically. I was often ignored when I complained of pain or discomfort, including when the line was sticking out a few inches than it should’ve been. During my hospital stay and outpatient treatment, my sleep and physical health got worse as I couldn’t walk almost anywhere in the hospital in part due to COVID, and had to sleep sitting straight up at home as well to make sure the line was safe. As I started walking again, I realized that I started having pain in the arm where the line had been anytime I made any physical effort, walking up and down stairs and hills or trying to run were the worst; although the places where it’d been inserted hurt quite a bit, I was also getting pain in my wrist, the joints and bones in my fingers, and sometimes my elbow. My heart, especially on the side where my catheter had been, also has similar pain. It all feels like a heavy strain but also burns. I’ve also been in a much worse mood and generally a bit hostile.A stress test came back negative, and I was told I had a “minor” case of diastolic relaxation delay. A scan of my arm showed nothing wrong with my bones or muscles. Does anyone have any idea what I should do or what the problem may be? Is it likely to be related to the treatment? Is there a type of doctor I should talk to? I’ve been in a lot of pain and my doctors don’t take it seriously. I’ve tried CBD which is only somewhat helpful.
Is it a type II(when it is due to humoral damage) or type IV(when it is due to cellular damage) HSR
my anki card says it as type II HSR overall
need confirmation
thanks :))
Hey just wanted to ask some questions as I feel totally in the dark at the moment. I'm just about 21 years post liver transplant I'm 23 years old so I have no memory of this and my liver has been super healthy ever since. Today I had a call from the docs and the liver transplant coordinators saying my liver function tests are really bad. Basically they want to see me straight away get tests done and come up with a plan. Just want to know if any of you have ever experienced rejection after transplant what happens? Do you usualy need another transplant or is there anyway to sort it before it gets to that point ? I'm in a stage of super worried but also kinda chill because I have no idea what's happening or how to feel about it. Thanks in advance :)
This is the best tl;dr I could make, original reduced by 78%. (I'm a bot)
> Finding has the potential to eliminate need for drugs on which transplant recipients rely to prevent their immune systems from attacking a new organ as a foreign object.
> UBC researchers have made a discovery that might lead to eliminating the need for transplant recipients to take drugs to stop their immune systems from attacking a new organ as a foreign object.
> The process could also potentially extend the life of transplanted organs so a second and even third transplant is not necessary, a professor of medicine at UBC's Centre for Blood Research and Life Sciences Institute said.
> Kizhakkedathu and his team found that by using a special polymer to coat blood vessels on the organ to be transplanted, organ rejection in mice was substantially reduced, results confirmed by collaborators at Simon Fraser and Northwestern University in Illinois.
> Caigan Du of UBC and Jenny Zhang of Northwestern University got similar results from a kidney transplant between mice.
> More than 3,000 Canadians received a transplanted organ in 2019 to avert end-stage organ failure.
Summary Source | FAQ | Feedback | Top keywords: organ^#1 transplant^#2 polymer^#3 UBC^#4 Blood^#5
Post found in /r/worldnews.
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Watching an old episode of MASH and they're taking an artery out of one guy and putting it into another. How can they do this without fear of rejection when things like kidneys or lungs need to have anti rejection drugs for life?
Has anyone on here had a transplant that has rejected? I had a full transplant in Jan 2020 and was doing really good and then 2 weeks ago, when dr was taking out last stitch, I flinched and it tore the cornea. I had emergency surgery and he ended up putting in 13 more stitches. Now I can't see anything out of the eye, and he said it's rejecting. From what I read, the 2nd transplant has a much less chance of success. Anyone had more than one transplant in same eye? Success stories? Other options? Any advice is appreciated. I go back tomorrow, but not sure I trust this doctor anymore.
Hi, a friend of mine has had a lung transplant almost four years ago. She is now experiencing chronic rejection of the BOS type. Her lung capacity is at 32%. What are the treatment options she’s got left? Would a treatment like ECP be useful? I am worried about her. Thanks.
I just recently was diagnosed with Antibody Mediated Rejection (AMR), I’ve been doing month IVIG infusions for the past year but my donor specific antibody level these last couple months kept coming back high. Along with having a bad cough and just feeling crummy, they did a bronch and found the AMR.
I will now start Bortezomib subcutaneous injections (chemotherapy), I will do 4 doses spread out over the course of 11 days with 500 mg of Solumedrol infusion when receiving the chemo shots. Then a larger than my normal dose of IVIG on day 12 with 100 mg Solumedrol. On day 19 I will start Rituximab infusions once a week for 3 weeks. They will recheck lung functions along with possibly doing more biopsies to see if the problem is solved.
My question is, have any of you done these rounds of treatment individually or all together in combination and if so, what was your experience like? I’m 23, so my doctor said when all my treatment is complete i will need to not go to bars and avoid public places as much as possible which is probably smart anyways with covid but will still be hard not working or finishing school.
Does you have any advice?
Company Aims to Leverage Immune Modulatory Technology to Alleviate Need for Immune Suppressants after Transplantation
PHOENIX, Feb. 16, 2021 /PRNewswire/ (OTC – CELZ)
Creative Medical Technology Holdings, Inc. announced today filing of a patent application covering the use of ImmCelz® regenerative cell therapy for preventing rejection of transplanted organs. ImmCelz® is a cellular therapy that prevents pathological immunity and inflammation while at the same time inducing regeneration of damaged tissue. Mechanistically ImmCelz® has been shown to function through stimulation of T regulatory cells1 and producing the regenerative protein Hepatocyte Growth Factor (HGF)2. The patent demonstrates that ImmCelz® may have the potential to inhibit chronic graft rejection, which is the major cause of organ loss.
"The concept of immunological tolerance has been around for more than a Century since the days of Peter Medawar," said Dr. Amit Patel, Board Member of the Company and co-inventor of the patent. "Unfortunately, transplant recipients, which include some of my patients, need to take global immune suppressive medication to reduce immune-mediated rejection of the organ. These medications, despite having made organ transplantation a reality, have potential side effects including various infections due to suppression of immunity. ImmCelz® is being developed to induce immunological tolerance, which if achieved would allow for organ transplantation without need for continuous immune suppression."
Sales of immune suppressants, which are used after transplants to prevent patients from rejecting their organs exceeded 4 billion dollars in 20183.
"To date the Company has reported therapeutic activity of ImmCelz® in models of rheumatoid arthritis4, stroke5, type 1 diabetes6, kidney failure7 and liver failure8," said Timothy Warbington, President and CEO of the Company. "Demonstration of enhancing graft survival in organ transplantation allows for a whole new area of medical progress. Our scientists suggest the superior efficacy of ImmCelz® for organ transplantation is that the cellular therapy suppresses rejection, while at the same time regenerates the organ after transplantation. It is known that the process of transplantation causes harm to the organ."
"It is our goal to continue to broaden our intellectual property portfolio by patenting technologies that our scientific team determines to be worthwhile and in the area of our core concentration," Mr. Warbingt
... keep reading on reddit ➡Why can’t T cells differentiate between a transplanted organ and an infected self cell?? Thank you
In Novavax trial still unblinded. But I had reactions to both shots moderate to severe arm pain in vaccinated arm for 4-5 days, fatigue, body aches and added moderate itching after 2nd shot. So I am sure I got vaccine
I have corneal transplants in both eyes week and a half after second shot I notice blurred vision and dull pain in one eye. Went to my specialist who told me that there was a mild corneal rejection going on in one of the eyes and the first question he asked me was: "Have you been vaccinated for Covid yet"
Seems that mild corneal transplant rejection is a thing with vaccines in general. However he suspects that Covid vaccines in general, not just Novavax, might be more of an issue because they appear to have been ramped up to the max to be as effective as possible.
Talked to the doctor at the research center gave them the name of my specialist so he can unblock me to him.
The specialist will not let me know if I am on the placebo or the vaccine(treatment is identical) unless I ask him, but I am not going to do that.
Not expecting this and it is concerning obviously rare but interesting
Published February 17, 2021: The Major Players in the Bone Marrow Transplant Rejection Treatment Market include: ● Cytodyn Inc. https://www.marketwatch.com/press-release/bone-marrow-transplant-rejection-treatment-market-2021-top-manufacturers-strategy-industry-share-growth-factors-development-trends-and-2027-forecast-industry-research-biz-2021-02-17?siteid=bigcharts&dist=bigcharts&tesla=y
now
Mainz, Germany, 02. March 2021 - ActiTrexx GmbH, a new biotech spin-off from the University Medical Center Mainz, Germany, has successfully closed its Series A financing. A consortium led by LBBW Venture Capital GmbH with participation from MediVentures GmbH, High-Tech Gründerfonds (HTGF) and Investitions- und Strukturbank Rheinland-Pfalz (ISB) invested a total of € 3.5 million.
ActiTrexx develops ATreg, activated regulatory T cells (Tregs), which are stimulated using a proprietary process, to prevent rejection reactions in transplanted patients and excessive immune responses in autoimmune diseases. For this purpose, the regulatory T cells, natural guardian cells of the immune system, are activated outside the body via a patent-protected method and administered to patients intravenously. The team led by Prof. Andrea Tüttenberg and Dr. Helmut Jonuleit from the Department of Dermatology will use the funds raised to further optimize and clinically test the novel cell therapy.
The first clinical trials for the treatment of leukemia patients who have undergone stem cell transplantation and are at particularly high risk of a life-threatening transplant rejection, graft-versus-host disease (GvHD), is particularly high, are due to start as early as 2021.The trial will run in cooperation with the III. Medical Clinic of the University Medical Center Mainz. Preclinical data demonstrated that ATreg can significantly attenuate an already existing GvHD, and even prevent, largely, the development of the disease when given early after transplantation as a prophylactic treatment. "Should these observations be confirmed in patients in the clinic, ATreg could be the cornerstone of a new, effective GvHD therapy with few side effects," said Prof. Tüttenberg, CEO of ActiTrexx.
In the past, regulatory T cells have been successfully used in academic studies for GvHD therapy. "However, the approach used by ActiTrexx means a significant improvement of already existing protocols due to the unique activation of Tregs. The product ATreg shortens the manufacturing process for Treg-based cell therapies from weeks to hours and thus, the cell preparation can be administered within a very short time," said Dr. Jonuleit, CSO of ActiTrexx. This is of particular benefit to patients with acute GvHD who are in urgent need of therapy.
"The development of therapeutics to suppress an undesired immune response in stem cell and organ transplantation as well as autoimmune diseases is curren
... keep reading on reddit ➡F28 Height 5’2 Weight 125 Medications: (all recent and for the infection) PHMB drops 8x, chlorhexidine drops 8x, cyclosporine 4x moxafloxine 4x, prednisone tablet 20mg. Valcylovir 200mg 1x Non smoker
Diagnosed with acanthamoeba keratitis infection in the left eye in July 2021.
I was given an emergency therapeutic full corneal transplant in September with a “hot eye”. My infection of acanthamoeba parasite had gotten too difficult to treat with only medications.
Unfortunately I have had a reoccurrence of the acanthamoeba infection in the new cornea. I’m extremely worried about the graft rejection and the fact the oral steroids I’m on are “feeding” the parasitic infection.
I was on steroid eye drops and was told to immediately stop. However I’m still on oral steroids 20mg a day. I’m also on compounded cyclosporine drops 2% 4 times a day. I’m wondering what my other anti rejection treatment options are that I can suggest to my doctor.
Had anyone treated this infection reoccurrence in a transplanted cornea?
