Hi,
I suffer from something called dissociation and I have been taking Melatonin for over 2 years now ( I know, way too long), but since of yesterday I told myself that Im going to quit it. Now I read online that Melatonin actually blocks the NMDA Receptors which then can lead to dissociation and malfunctioning of some brain parts (just like Ketamine). And I wanted to ask you whether someone has any idea on how to open up the NMDA receptors, which then might make me dissociate less (I think?)
Hey everyone,
Iβm a behavioral neuroscience major and Iβm really interested in sleep medications and how they affect the brain. But to be completely honest, Iβm not too sure about the technical terms behind some of the literature Iβm reading. Iβm familiar with benzos, non benzos, antipsychotics, SSRIs and those similar to them to a degree. I recently read that melatonin can actually inhibit long term potentiation by affecting MT1 and MT2, and I canβt find too much information about dual orexin receptor agonists in my university database. I think I read that the dual orexin receptor antagonists affect working memory negatively, but Iβm not sure. Could you guys help me understand these two medications a bit more in regards to how they affect memory, learning, and cognition?
Thank you in advance and I look forward to reading your responses!
I have read that using melatonin supplements affect the bodies own ability to produce natural melatonin. Agomelatine being a melatonin receptor agonist, could it cause the same problem after drug discontinuation?
Study's have suggested the use of melatonin is antidopamineic within specific areas in the brain. There have also been study's showing that if protects your brain from dopamine downregulation associated with heavy stim abuse, but what about speeding up the recovery period (specifically upregulation of dopamine receptors). Or perhaps even more exciting is upregulation of dopamine within the regular healthy person? Is it possible that these effects could be harnessed to almost act in a nootropic sense aside from benefits of sleep? What if someone dosed melatonin every several hours to keep dopamine receptors continuously suppressed? They would probably feel pretty bad but once they stopped would they not feel great for an extended period of time??
So I have been experiencing extreme fatigue, falling asleep easily and very vivid dreams each night as well as other symptoms since taking Melatonin and saw a sleep specialist today. A sleep study was ordered on me as they could not explain what was going on.
I was wondering if anyone knows much about melatonin receptors and if they got desensitized could they cause the sleep cycle to get out of whack. I have described my symptoms in past posts and can post here if people are interested.
Hey guys!
I've decided to find out why do we may feel sleepy after lunch. Read a ton of articles about circadian rhythms, discovered how adenosine works, and it was very clear, but didn't find any clear evidence that tryptophan, serotonin, melatonin and carbohydrates affect some sort of receptors or stuff that can put us to sleep. Also the whole internet is contradictory on that topic.
Can you please help me to deal with the issue? Thanx!
It's from my understanding, that Melatonin binds to the appropriate receptors specifically because it's chemical structure is appropriate to that type of receptor and because it's the endogenous chemical produced by the body specifically for that receptor. It should have the have the highest affinity and efficacy at that receptor.
However, a drug company made Rozerem for the treatment of insomnia. I would assume, and correct and explain to me the reason I'm wrong please, that it's going to have to be chemically similar to the melatonin structure such that the binding can take place. My question is why would Rozerem be marketed as superior to Melatonin because it can't be a 1 to 1 match and would have a slightly different molecular structure and bind at what I would assume is a weaker effect.
It's obviously used for a reason. Probably because it's stronger and better. That means my understanding is incorrect and requires correction. I would appreciate that a lot. Thanks
I have a sleep disorder where I do not enter deep sleep properly (my sleep study showed I dipped moved from light sleep to REM with little stage 3 or 4). After years of research I discovered glycine promotes these stages of sleep that I was missing. Now I have almost completely managed to control it with high doses of glycine (15g, twice nightly, 30g total). I buy AjiPure since it's the only pharmaceutical grade glycine I can find. I assumed it was safe since glycine is commonly found in high amounts in foods. Any reason to think I might be wrong?
I think my recent COVID diagnosis triggered this, but I'm not sure. I take lamictal and adderal for ADD/depression, but I've never had issues with lack of sleep. I cannot go to bed for the life of me lately.
I take ashwagandha in the AM and PM, and that's it besides regular vitamins. I've been trying valerian root tea at night the past few days but I feel like it's only making it worse. Same with CBD/CBN gummies - it's even more triggering. I don't know what to do. Any advice helps.
Took 400 mg and I know Iβll be Tired for the comedown. Am I fine to take these to fall asleep?
