Tumor Suppressor Gene Puns

Hi labrats. This is a bit of a strange request because it's purely fictional, but cancer is a big theme in a weird little short story I'm writing. I've already managed to sneak in two oncogenes, Jun and Ras, as names for characters that will ultimately be corrupted by the cancer stand-in character. I want to get one more science reference into the story, this time a character who will oppose the cancer, so I'm looking to name them after a tumor suppressor gene or the like. Got any suggestions?

Which one of these can the tumor suppressor gene produce?

1. DNA repair protein
2. apoptosis inducing ligands
3. protein that inhibits cell cycle
4. antibodies that inhibit growth factors

I watched the pathoma, have that and my FA out with me going through the anki but man some of these are just NOT sticking. For some of them (eg, CDKN2A; SMAD4 (DPC4), these seemingly random names do not stick with 1) their associated condition, 2) gene product, and 3) function/mechanism (eg, KIT is a stem cell growth factor w/ MOA point mutation).

Any way to get these to stick?

Which Sketchy Video Discusses Tumor Suppressor Genes (P53, Etc.) And Proto-Oncogenes?

Ugh just came across an Anking Step 2 card that asks for mechanism of neurofibromin in NF1. Is this kind of information still needed for Step 2? This sounds too "sciency" to me.

I am struggling with keeping those in mind tbh. I know that Anki makes it easier but i am looking for something that smoothes me into anki eg: sketchy or any mnemonics. Does anything like that exist

Hi, I’m Vinny Lynch, assistant professor in the Department of Human Genetics at the University of Chicago.

A while back, I got interested in Peto’s Paradox: the observation that big and long-lived organisms like elephants and whales don’t get cancer as often as we think they should. If all cells have a similar risk of developing cancer, then really large animals should be at really high risk.

But there’s absolutely no correlation between body size or lifespan and cancer rates.

So we studied elephant genomes, and now we think we’ve found the mechanism that explains the paradox. Elephants have 20 copies of the very well-known p53 tumor suppressor gene (to be precise: one p53 gene and 19 p53 retrogenes).

We looked in 60+ other animals, including whales, fish, birds, and humans, but found that only elephants (and maybe bats) have more than one p53 gene. We looked in woolly mammoth and mastodon genomes as well, and shed some light onto the evolutionary origins of p53 expansion (if you’re curious about mammoth genomes I did another AMA a few months ago). Lastly, we transferred one of the extra p53 genes from elephants into mouse cells that we grew in the lab and made some pretty interesting observations.

We released our findings on the open-access preprint server BioRxiv, and another group, which came to pretty much the same conclusion but focused mostly only on elephants and humans, independently released theirs in JAMA. You can read an article about our two studies in the New York Times.

Edit: Well, it’s been a lot of fun but I have to run. Thanks for all the questions Reddit!

Like, hypermethylation (and excess folate supplementation) is associated with higher cancer risk, even though methylation tends to turn off genes rather than turn them on (and TET enzymes the reverse,. and lowered TET also associated with higher cancer). So this seems to imply that tumor suppressor genes are just uniquely susceptible to methylation

eg https://www.crsociety.org/topic/17436-reversal-of-epigenetic-age-with-diet-and-lifestyle-in-a-pilot-randomized-clinical-trial/

https://www.futuremedicine.com/doi/10.2217/epi-2017-0021?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0www.ncbi.nlm.nih.gov&

Please can anyone share mnemonic to remember important oncogenes and tumor suppressor genes and associated cancers?? Thanks in advance :)

Getting confused between the similarities/differences between all of these in cancer and gene regulation. Thanks!

Hello,im 23 years old and 2 years ago I got a strange lesion in my palate, after a biopsy it was classified as "inconclusive" the pathologist explained me that it was either a reactive lesion or a dysplasia, and we can't know! I have an appointment in the end of January to gather more explanations

My mother got breast cancer at 51 years old and died of it at 65 years old The lesion apparead few month after her death, I think it's probably related, my immun system is strongly related to my mental health : I got shingles after a traumatic event and I have multiple deficiencies since childhood due to poor diet

Oral cancer in young are very rare, if I really had a dysplasia it would be terrible

Now all I can do is sequence my genome to see if I'm predisposed to cancer

I want to know if tumor suppressor gene are present in promethease? (Brca, check2, nb1...)

Is the test reliable? Is the whole gene tested? Or I should get color genetic test instead

I live in France so getting a test here would be difficult and very long because of the strict law about genetic testing

Researchers found extravirgin olive oil upregulates cannabinoid CB1 receptor coding gene, which is involved in the body's protection mechanisms against colon cancer^[1] .

What do you think about it? I'm considering to start consuming more olive oil.