LEXINGTON, Mass.--(BUSINESS WIRE)--Dec. 9, 2021-- Frequency Therapeutics, Inc. (Nasdaq: FREQ), a clinical-stage regenerative medicine company focused on developing therapeutics to activate a personβs innate regenerative potential to restore function, today shared the results from its FX-322-113 study, a placebo-controlled trial evaluating the administration of FX-322 in subjects with severe sensorineural hearing loss (SNHL). In the study, FX-322 was associated with a hearing signal as shown by improvements by four subjects in a sentence-in-noise test.
FX-322-113 is a double-blind, placebo-controlled Phase 1b study designed to assess the local and systemic safety of a single dose of FX-322, and to evaluate hearing responses in a cohort of individuals with severe SNHL (pure tone average deficit between 71-90 decibel (dB) hearing level), a patient population that may have considerable damage to their inner ears and where cochlear implants may be the only potential intervention to improve hearing. Subjects were randomized 4:1 and received either FX-322 or placebo in one ear. Safety, otologic and audiologic assessments were conducted at days 30 and 90 following administration of FX-322 or placebo.
To gain a more comprehensive understanding of the potential impact of FX-322 in this population, the Company evaluated hearing function using multiple tests of speech perception in both quiet and noisy backgrounds, including the Bamford-Kowal-Bench Sentence-in-Noise exam (BKB-SIN). BKB-SIN is a validated test designed for severe SNHL populations (including cochlear implant patients), measuring the change in signal-to-noise ratios (SNR) required for a subject to correctly repeat words in a sentence.
In the FX-322-113 study, BKB-SIN test improvements were observed in four subjects, all of whom exceeded the 95 percent critical difference of 3.1 dB SNR, with two subjects showing a 6 dB response. A single placebo patient had a 3.6 dB change. In the study, subjects did not show substantial changes in speech perception measures in quiet, the safety profile in the study was favorable and there were no treatment-related serious adverse events reported.
βGiven the level of cochlear damage, identifying single words in any au
... keep reading on reddit β‘Hi, I am doing my 4th year MSci Psychology project into speech perception, and am looking for participants who are over 18. It is all online and completely anonymous, and involves a few listening tasks and a questionnaire. This study must be completed on a laptop or computer and using earphones or headphones, and should only take 30 mins to complete. Let me know if you have any questions, and click on the link to participate. Thank you!
https://research.sc/participant/login/dynamic/7770D682-D3E4-4B6A-919B-04F81B485D07
I am a PhD student at the National School of Engineers of Brest (ENIB) which is a member of Lab-STICC, a French research laboratory. I really need more responses to a survey I am conducting. We are exploring how people perceive speech coming from an emergency room leader to understand how speech affects perception of authority and how that perception affects behavior. The survey consists of thirty-three sentences that participants evaluate four times according to a short scenario.
The survey should take 10-15 minutes. If you enter your email address (which is totally optional and no personal details are collected), you will be entered to win one of five β¬ 10 prizes (winners will receive an email to find out how they would like to receive their money).
This link takes you to a random Google Forms survey (I have created random surveys to test different parameters): https://docs.google.com/forms/d/e/1FAIpQLScTaE_foifwbZEYNzVQh91Q2Stn6RSLTOu-tZwZntBLQdr1Eg/viewform?usp=sf_link
I really need more native and high-level English speakers to participate, so every response counts. Thanks!
I have been interested in the topic of palatalization a lot.
A year or so ago, I heard the creator of Interslavic talking about the dialects of IS used by different actors in The Painted Bird. For example, in this movie, he said that the priest is using the less-palatalized version of IS to sound more serious and educated while the common men use more palatelized style and sound "softer".
He is certainly not alone who sees this thing that way. I have it similar.
Perhaps it's because of the church or Latin, but when I hear street pronounced as shtreet etc. it sounds unpleasant/lazy/uneducated to me. I know, it's not right, but I feel it that way, what ever the cause for this feeling may be - but the perception is there and I evaluate it as an unpleasant dialect.
Also, if we observe people like Richard Dawkins, he prefers to say species like spiesies and not speshies. And there are more examples like that when, especially with the sh sound.
Is this perception of less palatalization = more education universal or not?
Or is this only associated with certain language families?
If you could recommend some studies or if you are studying this yourself and can chime in, that would be great.
Hello Everyone!
Iβm still currently in need of participants for my MSc Dissertation. Happy to do exchanges!
Iβm running an online experiment that can be done in your own time whenever you can. It involves listening to speech and identifying certain sounds with keyboard responses. There will be a prize draw for one of 5 Β£20 vouchers for those that participate to compensate you for your time. The experiment will take no longer than 1 hour and 30 minutes as a higher boundary, though completion times vary from participant to participant. To be eligible, you must: be a right-handed, monolingual native speaker of British English, have normal or corrected-to-normal vision, no history of hearing aids or developmental disorders.
If you are interested in participating, or simply wish to know more, please email me at b.ohanlon@lancaster.ac.uk.
Thank you for your interest and time!
Hello everyone! We are a research team from the University of Cambridge. We are looking for adult (Age 20-60) and child participants (Age 8-12) who are raised in the U.K. to take part in an online study that investigates how face masks affect how we process speech. This is highly relevant to many of us as a new routine under COVID-19.
The experiment takes no more than 30 minutes. In the experiment, you will complete a simple language game. You'll only need a laptop/PC with a speaker and microphone to complete the experiment. For child participants, a parent can keep your child company throughout the experiment and fill out a brief online questionnaire about your child's language background. All data will be completely anonymous.
If you fit the criteria below or know someone who does, please consider signing up by clicking on this link: https://forms.gle/iCe5wdRzUQqWJuh6A
- Child aged 8-12 or adults aged 20-60
- Raised in the UK
- English is one of you/your child's native languages
- No known language, hearing or learning difficulties
Adults will receive a οΏ‘5 voucher from your favourite supermarket (UK), and children (family) οΏ‘10!
Should you have any questions please contact Karina Li, permasc.cambridge@gmail.com. Thank you for your help!
Do share it with your family and friends!
Hello!
The Bilingualism, Mind, and Brain Lab at University of California Irvine is currently recruiting participants for a speech perception experiment!
Our study measures the ability to identify ethnic and regional accents in Southern California.
We are currently looking for White American, Chinese American, Hispanic/Latinx, Vietnamese American and Filipino American Bilinguals and Monolinguals who grewΒ in the San Gabriel Valley or Orange County.
This experiment includes a language background questionnaire and general speech perception questions. The experiment will take approximately 30 minutes to complete and participants will be compensated $7.50 for their time.
If interested, please contact either Research Assistants through the following emails.
Joseph Cheung: jccheun2@uci.edu
Rachel Vu: rnvu@uci.edu
Just wondering if anyone else had completed this study a few days ago? Part 1 was reading sentences aloud for about 25 minutes. Part 2 was using headphones to detect tones. I WAS wearing headphones and had no problem hearing the tone in the sample, but I did not hear a single tone after the sample.
Just trying to figure out if there was an issue with Part 2 or if something is wrong with my hearing (or my headphones) . Was told I failed Part 2 and asked to return study. I emailed the researcher with that info (i.e., that I was wearing headphones, heard the sample tone, but no tones thereafter) , but no response as of yet. Fingers crossed re getting paid for Part 1. Hopefully no issue there, but still confused about Part 2 issue. Did anyone with better headphones or hearing complete it?
Hey everyone!
For a small linguistics project of mine I'm currently looking for about 20 participants who might be interested in taking part in a short perception experiment. The focus is on how people perceive and interpret speech in different contextual settings, and the entire thing takes roughly 30 minutes to complete.
In order to participate, all you need is headphones and a desktop/laptop computer. The program doesn't run on mobile, unfortunately.
The experiment was optimized to run on Chrome or Firefox; if you use a different browser you might run into some issues.
You can access the experiment using the following link: https://pavlovia.org/run/jh730/demothesis
If some of you want to give it a try, that'd be great! Thanks in advance!
Hi everyone!
My name is Laura and I am a postgraduate Psycholinguistics student at University of Essex. I am currently looking for Lithuanian-English speakers (from 18 to 40 years of age) for my experiment. Your native language must be Lithuanian and your second language must be English. You will be asked to listen to Lithuanian and English sentences, while in the background there will be a competing Lithuanian or English talker. You will only need to attend to female voice and write down what your heard in the text box on the screen. Your participation will help us broaden our understanding why listening to second language in noise is more difficult than listening to your native language in noise. The data you provide will be anonymous.
The experiment (without breaks) will take around 40 min. I know itβs quite long but your help and patience will be greatly appreciated!
For the experiment you will need to use computer, have a real keyboard and wear headphones or earphones! Please DO NOT use Safari browser.
Here is the link to the experiment: https://www.psytoolkit.org/c/3.3.2/survey?s=UHvNb
Thank you!
Hi everyone! My team is a group of graduate students at Hunan University, China. Our project is about how to promote English speech perception and production of Chinese learners of English.
The ideal candidate should be US English native speakers with no knowledge of Mandarin (Chinese) and any other languages of Eastern countries, such as Japanese, Korean, etc. The age should be from 18 to 27 years old. Last but not least, he or she should have normal hearing and not any speech impairments.
The experiment material including instructions will be sent to the participants by email, and conducted as required of the instructions in a quiet environment (your home or any other place you like). The experiment will last about 1.5 hours (besides the preparation work, such as software installment and instruction reading, etc.) and be paid 30 dollars in total through PayPal. It will be remitted in advance upon your agreement. It is hoped to be completed before February 25, 2021.
If you would like to join the experiment, please fill in the following table and send it back to the mailbox hmmachael@hnu.edu.cn with subject line βLinguistics experiment + name.β The material is only for the experiment use and will be sealed after that. Thank you!
1.Name
2.Sex
3.Age
4.Mother tongue
5.Right-handed / left-handed?
6.Educational level
7.School
8.Major
9.Any music training? And how long (months)?
10.Any hearing problems?
-
Contact (Tel)
-
Valid PayPal email
Any questions can be directed to Michael at hmmachael@hnu.edu.cn.
Thank you in advance for your time!
Background: while Obama was giving a speech (sometime in the past when he was president) a woman behind him on the dais began to faint. Obama notices something around him and turns to help the woman while assistance comes for her.
It doesn't take long for the comments to turn into a war zone about Obama's Healthcare policies, speaking ability and of course, actions in the war.
Drone strikes. Hospitals. Weddings. Children.
Did he? Or did the US military? Similar to under Bushβs leadership?
Oh you think the Taliban is a charitable 501c3?....I got news for you...
A little sprinkling of Obama vs Trump (and someone who doesn't understand how the passage of time works):
>He is a true leader.
>>Your bar is low
>>>Getting Trump elected does that to a nation.
And of course what drama would be incomplete without the "nothing ever happens" crowd?
>That is so staged >>[How deep does this conspiracy go? Is the woman an actor, or did the deep state poison her and make her faint? Did Obama drain her of her Adrenachrome?](https://www.reddit.com/r/nextfuckinglevel/c
... keep reading on reddit β‘In my target language, my skills are always improved, people around me who are also heavily drinking more accurately perceive my speaking as good, and my memory of my command of the conversation is much better than when sober!
Should I take up alcoholism to speed up fluency??
LEXINGTON, Mass.--(BUSINESS WIRE)--Oct. 21, 2021-- Frequency Therapeutics, Inc. (Nasdaq: FREQ), a clinical-stage regenerative medicine company focused on developing therapeutics to activate a personβs innate regenerative potential to restore function, today announced that the first subject has been dosed in a new FX-322 Phase 2b study (FX-322-208) being conducted in a refined population of individuals with SNHL.
FX-322-208 is a randomized, placebo-controlled, multi-center study designed to evaluate the impact of a single administration of FX-322 on speech perception in approximately 124 subjects with SNHL. The studyβs primary endpoint is speech perception, a measure of sound clarity and understanding speech. The Phase 2b studyβs inclusion criteria are designed to enroll subjects with the same hearing loss severities and etiologies as those subjects in which statistically significant improvements in speech perception were observed in prior FX-322 clinical studies. FX-322-208 will include subjects with hearing loss associated with either noise-induced or sudden SNHL.
The U.S. Food and Drug Administration (FDA), in a recent Type-C meeting with the Company, agreed that speech perception is an acceptable primary efficacy endpoint. A variety of other listening tests, including multiple measures of speech perception and pure tone thresholds, will also be assessed.
βThe FX-322-208 Phase 2b study incorporates learnings from all of our prior studies, enabling us to identify targeted patient populations and prior responder groups for evaluation. We are testing FX-322 in subjects with hearing loss severities and etiologies where we have seen improvements in past trials. We have also applied key additional design elements to the study to mitigate potential bias and help ensure the consistency of baseline hearing assessments,β said David L. Lucchino, Frequencyβs Chief Executive Officer. βMoreover, we are very pleased to have obtained alignment with the FDA on speech perception as the primary endpoint for our upcoming studies, given the important need for treatments that can provide greater hearing clarity. In a recently held externally-led Patient Focused Drug Development program with FDA, sponsored by the Hearin
... keep reading on reddit β‘I hope this kind of post is allowed. I am a PhD student at the National School of Engineers of Brest (ENIB) which is a member of Lab-STICC, a French research laboratory. I really need more responses to a survey I am conducting. We are exploring how people perceive speech coming from an emergency room leader to understand how speech affects perception of authority and how that perception affects behavior. The survey consists of thirty-three sentences that participants evaluate four times according to a short scenario.
The survey should take 10-15 minutes. If you enter your email address (which is totally optional and no personal details are collected), you will be entered to win one of five β¬10 prizes (winners will receive an email to find out how they would like to receive their money).
I really need more native and high-level English speakers to participate, so every response counts. Thanks!
I am a PhD student at the National School of Engineers of Brest (ENIB) which is a member of Lab-STICC, a French research laboratory. I really need more responses to a survey I am conducting. We are exploring how people perceive speech coming from an emergency room leader to understand how speech affects perception of authority and how that perception affects behavior. The survey consists of thirty-three sentences that participants evaluate four times according to a short scenario.
The survey should take 10-15 minutes. If you enter your email address (which is totally optional and no personal details are collected), you will be entered to win one of five β¬ 10 prizes (winners will receive an email to find out how they would like to receive their money).
This link takes you to a random Google Forms survey (I have created random surveys to test different parameters):https://docs.google.com/forms/d/e/1FAIpQLScTaE_foifwbZEYNzVQh91Q2Stn6RSLTOu-tZwZntBLQdr1Eg/viewform?usp=sf_link
Sometimes the link doesn't work on phones where the first page shows but you can't go to the second. If this is the case and you would like to participate, tell me and I will DM you a link directly to the Google form.
I really need more native and high-level English speakers to participate, so every response counts. Thanks!
Hi everyone! My team is a group of graduate students at Hunan University, China. Our project is about how to promote English speech perception and production of Chinese learners of English.
The ideal candidate should be US English native speakers with no knowledge of Mandarin (Chinese) and any other languages of Eastern countries, such as Japanese, Korean, etc. The age should be from 18 to 27 years old. Last but not least, he or she should have normal hearing and not any speech impairments.
The experiment material including instructions will be sent to the participants by email, and conducted as required of the instructions in a quiet environment (your home or any other place you like). The experiment will last about 1.5 hours (besides the preparation work, such as software installment and instruction reading, etc.) and be paid 30 dollars in total through PayPal. It will be remitted in advance upon your agreement. It is hoped to be completed before February 25, 2021.
If you would like to join the experiment, please fill in the following table and send it back to the mailbox hmmachael@hnu.edu.cn with subject line βLinguistics experiment + name.β The material is only for the experiment use and will be sealed after that. Thank you!
1.Name
2.Sex
3.Age
4.Mother tongue
5.Right-handed / left-handed?
6.Educational level
7.School
8.Major
9.Any music training? And how long (months)?
10.Any hearing problems?
-
Contact (Tel)
-
Valid PayPal email
Any questions can be directed to Michael at hmmachael@hnu.edu.cn.
Thank you in advance for your time!
Hi everyone! My team is a group of phD students at Hunan University, China. Our project is about how to promote English speech perception and production of Chinese learners of English**.**
The ideal candidate should be US English native speakers with no knowledge of Mandarin (Chinese) and any other languages of Eastern countries, such as Japanese, Korean, etc. The age should be from 18 to 27 years old. Last but not least, he or she should have normal hearing and not any speech impairments.
The experiment material including instructions will be sent to the participants by email, and conducted as required of the instructions in a quiet environment (your home or any other place you like). The experiment will last about 1.5 hours (besides the preparation work, such as software installment and instruction reading, etc.) and be paid 30 dollars in total through PayPal. It will be remitted in advance upon your agreement. It is hoped to be completed before February 25, 2021.
If you would like to join the experiment, please fill in the following table and send it back to the mailbox hmmachael@hnu.edu.cn with subject line βLinguistics experiment + name.β The material is only for the experiment use and will be sealed after that. Thank you!
| No. | Items | Content |
|---|---|---|
| 1 | Name | |
| 2 | Sex | |
| 3 | Age | |
| 4 | Mother tongue | |
| 5 | Right-handed / left-handed? | |
| 6 | Educational level | |
| 7 | School | |
| 8 | Major | |
| 9 | Any music training? And how long (months)? | |
| 10 | Any hearing problems? | |
| 11 | Contact | Tel: |
Any questions can be directed to Michael at hmmachael@hnu.edu.cn.
Thank you in advance for your time!
Hi everyone! My team is a group of phD students at Hunan University, China. Our project is about how to promote English speech perception and production of Chinese learners of English**.**
The ideal candidate should be US English native speakers with no knowledge of Mandarin (Chinese) and any other languages of Eastern countries, such as Japanese, Korean, etc. The age should be from 18 to 27 years old. Last but not least, he or she should have normal hearing and not any speech impairments.
The experiment material including instructions will be sent to the participants by email, and conducted as required of the instructions in a quiet environment (your home or any other place you like). The experiment will last about 1.5 hours (besides the preparation work, such as software installment and instruction reading, etc.) and be paid 30 dollars in total through PayPal. It will be remitted in advance upon your agreement. It is hoped to be completed before February 25, 2021.
If you would like to join the experiment, please fill in the following table and send it back to the mailbox hmmachael@hnu.edu.cn with subject line βLinguistics experiment + name.β The material is only for the experiment use and will be sealed after that. Thank you!
1.Name
2.Sex
3.Age
4.Mother tongue
5.Right-handed / left-handed?
6.Educational level
7.School
8.Major
9.Any music training? And how long (months)?
10.Any hearing problems?
-
Contact (Tel)
-
Valid PayPal email
Any questions can be directed to Michael at hmmachael@hnu.edu.cn.
Thank you in advance for your time!
