Concatenation of molecular docking and molecular simulation of BACE-1, Ξ³-secretase targeted ligands: in pursuit of Alzheimer's treatment - PubMed pubmed.ncbi.nlm.nih.gov/3…
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πŸ‘€︎ u/FlyingTabla
πŸ“…︎ Dec 13 2021
🚨︎ report
Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-Ξ³ coactivator 1Ξ± regulated Ξ²-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models pubmed.ncbi.nlm.nih.gov/2…
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πŸ‘€︎ u/greyuniwave
πŸ“…︎ Dec 20 2020
🚨︎ report
Biogen halts study of Alzheimer’s drug, once pinned as β€œthe last great hope for AD”. At this point, 4 Anti-AΞ² mAbs have failed 9 big Ph3 trials, 3 Ξ³-Secretase inhibitors showed cognitive worsening, 4 BACE inhibitors showed cognitive worsening. Global pipeline for AD looks bleak. statnews.com/2019/03/21/b…
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πŸ‘€︎ u/SirT6
πŸ“…︎ Mar 21 2019
🚨︎ report
Biogen halts study of Alzheimer’s drug, once pinned as β€œthe last great hope for AD”. At this point, 4 Anti-AΞ² mAbs have failed 9 big Ph3 trials, 3 Ξ³-Secretase inhibitors showed cognitive worsening, 4 BACE inhibitors showed cognitive worsening. Global pipeline for AD looks bleak. statnews.com/2019/03/21/b…
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πŸ‘€︎ u/SirT6
πŸ“…︎ Mar 21 2019
🚨︎ report
"Protein shredder regulates fat metabolism in the brain" Importance of Ξ³-secretase in the regulation of liver X receptor and cellular lipid metabolism. medicalxpress.com/news/20…
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πŸ‘€︎ u/RockerSci
πŸ“…︎ May 09 2020
🚨︎ report
A first-in-human study of the safety and efficacy of a new drug, a gamma secretase inhibitor, to treat people with sensorineural hearing loss

Participant inclusion criteria

  1. Male or female between 18 and 80 years of age
  2. A primary complaint of hearing loss of Λ‚ 10 years in duration, the history suggesting this hearing-loss to be of age-related, noise-induced or idiopathic origin
  3. A bilateral, symmetrical (<15 dBHL difference) SNHL with a pure-tone average threshold across the frequencies 0.5, 1, 2, 4 and 8 kHz of between 25 and 60 dBHL with 2 or more frequencies less than 60 dBHL

Participant exclusion criteria

  1. Presenting with a primary complaint of tinnitus
  2. A β€˜true’ air-bone gap >15 dBHL in 3 or more contiguous frequencies between 0.5, 1, 2, 4 kHz
  3. History of suspected or diagnosed genetic cause of hearing loss
  4. Suspected or known diagnosis of inner ear pathology, congenital hearing loss, fluctuating hearing loss, MΓ©niΓ¨re’s disease, or secondary endolymphatic hydrops, perilymph fistula, cochlear barotrauma, autoimmune hearing loss, radiation-induced hearing loss, retro-cochlear lesion
  5. Evidence of acute or chronic otitis media or otitis externa on examination; or a history of middle ear pathology and/or surgery
  6. Any therapy known as ototoxic within 12 months of screening

http://www.isrctn.com/ISRCTN59733689

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πŸ‘€︎ u/ecipch
πŸ“…︎ May 21 2017
🚨︎ report
Merck halts late-stage trial of anti-Alzheimer’s drug verubecestat (a beta-secretase-1 inhibitor) due to lack of effect in mild-to-moderate disease [CNN, 15 Feb 2017] edition.cnn.com/2017/02/1…
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πŸ‘€︎ u/isosafrole
πŸ“…︎ Feb 15 2017
🚨︎ report
Biogen halts study of Alzheimer’s drug, once pinned as β€œthe last great hope for AD”. At this point, 4 Anti-AΞ² mAbs have failed 9 big Ph3 trials, 3 Ξ³-Secretase inhibitors showed cognitive worsening, 4 BACE inhibitors showed cognitive worsening. Global pipeline for AD looks bleak. statnews.com/2019/03/21/b…
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πŸ‘€︎ u/SirT6
πŸ“…︎ Mar 21 2019
🚨︎ report
Merck halts late-stage trial of anti-Alzheimer’s drug verubecestat (a beta-secretase-1 inhibitor) due to lack of effect in mild-to-moderate disease [CNN, 15 Feb 2017] edition.cnn.com/2017/02/1…
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πŸ‘€︎ u/isosafrole
πŸ“…︎ Feb 15 2017
🚨︎ report
Lilly Voluntarily Terminates Phase II Study for LY2886721, a Beta Secretase Inhibitor, Being Investigated as a Treatment for Alzheimer's Disease (NYSE:LLY) newsroom.lilly.com/releas…
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πŸ‘€︎ u/jube01
πŸ“…︎ Jun 16 2013
🚨︎ report
New Alzheimer's Trial with Solanezumab, Gantenerumab, and a beta secretase inhibitor wftv.com/news/news/local/…
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πŸ‘€︎ u/hithazel
πŸ“…︎ Oct 10 2012
🚨︎ report
Alzheimer's Ξ²-Secretase (BACE1) Regulates the cAMP/PKA/CREB Pathway Independently of Ξ²-Amyloid

Hey guys. I would be grateful if someone could find me this article!

http://www.jneurosci.org/content/32/33/11390.full.pdf+html

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πŸ‘€︎ u/Montinho
πŸ“…︎ Sep 13 2012
🚨︎ report
SERIOUS: This subreddit needs to understand what a "dad joke" really means.

I don't want to step on anybody's toes here, but the amount of non-dad jokes here in this subreddit really annoys me. First of all, dad jokes CAN be NSFW, it clearly says so in the sub rules. Secondly, it doesn't automatically make it a dad joke if it's from a conversation between you and your child. Most importantly, the jokes that your CHILDREN tell YOU are not dad jokes. The point of a dad joke is that it's so cheesy only a dad who's trying to be funny would make such a joke. That's it. They are stupid plays on words, lame puns and so on. There has to be a clever pun or wordplay for it to be considered a dad joke.

Again, to all the fellow dads, I apologise if I'm sounding too harsh. But I just needed to get it off my chest.

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πŸ‘€︎ u/anywhereiroa
πŸ“…︎ Jan 15 2022
🚨︎ report
Blind Girl Here. Give Me Your Best Blind Jokes!

Do your worst!

πŸ‘︎ 5k
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πŸ‘€︎ u/Leckzsluthor
πŸ“…︎ Jan 02 2022
🚨︎ report
This subreddit is 10 years old now.

I'm surprised it hasn't decade.

πŸ‘︎ 14k
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πŸ‘€︎ u/frexyincdude
πŸ“…︎ Jan 14 2022
🚨︎ report
Dropped my best ever dad joke & no one was around to hear it

For context I'm a Refuse Driver (Garbage man) & today I was on food waste. After I'd tipped I was checking the wagon for any defects when I spotted a lone pea balanced on the lifts.

I said "hey look, an escaPEA"

No one near me but it didn't half make me laugh for a good hour or so!

Edit: I can't believe how much this has blown up. Thank you everyone I've had a blast reading through the replies πŸ˜‚

πŸ‘︎ 20k
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πŸ‘€︎ u/Vegetable-Acadia
πŸ“…︎ Jan 11 2022
🚨︎ report

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