I am interested in seeing peoples experiences with neuropeptides such as Cerebrolysin, Semax, and Dihexa. Are these compounds the sort of "game changer" when it comes to neuroplasticity? I would imagine increasing bdnf by such a large magnitude would seem promising. I am in my mid 20s, so I'm in the final stretch of brain development. I would like anything of use. Thanks!
I was listening to Andrew Huberman's Huberman lab podcast and there was a short segment that got me. He stated that there are (might be in humans) specific neuropeptides that are released on perceived lack of social connections/interaction. That in turn causes paranoia, fear and agression among possible other effects.
I found this study that states that this experiment was done in flies and mice (to confirm mammals having this mechanism).
I cannot really give any extra information about this, except that I looked back on my behaviour in the past months or so. It feels like I am incredibly paranoid and fearful at times when I did not recently interact with people who are already close to me.
I have to add that I might also be depressed. Going on a holiday with my family did not really elevate my mood or lack of motivation. However I feel a bit less like I am being ripped off, unequally dealt with or socially abandoned by other people.
I concluded that it might be essential for ya'll folks to be already having interacted, especially with people who you bond with, BEFORE you try to do it to people that are more like strangers to you. Maybe that is what a Wingman could do to certain people.
People who fear going out of their house might also consider whether they had personal (not through internet) interactions with any friends or relatives they like recently.
I am writing a paper on neuropeptides and am wondering if they get recycled back into the brain after they have been released like neurotransmitters. If not, what happens to them? Do the neuropeptides just float around in the intercellular matrix?
AMAZING NEUROPEPTIDE
Neurodegenerative disorders (NDDs) are characterized by neuronal death in the brain. The mechanism of the neuronal death is too complicated to be fully understood, although in many NDDs, aging and neurotoxins are known risk factors. In the central and peripheral nervous system, vasoactive intestinal peptide (VIP), a 28-amino acid neuropeptide, is released to support neuronal survival in both physiological and pathological condition. VIP can inhibit the neurodegeneration induced by the loss of neurons. The indirect protection effect is mainly mediated by glial cells through the production of neurotrophic factor(s) and inhibition of proinflammatory mediators. By remolding the structure and improving the transfer efficiency of VIP, its nerve protective function could be further improved. Its neuroprotective action and efficacy in inhibiting a broad range of inflammatory responses make VIP or related peptides becoming a novel therapeutic method to NDDs. In this review, we aim to summarize the relationship between VIP and NDDs.
https://www.researchgate.net/publication/309491952_The_effects_of_vasoactive_intestinal_peptide_in_neurodegenerative_disorders
The global neurodegenerative disorder therapeutics market was worth $13.35 billion in 2019. It is expected to grow at a compound annual growth rate (CAGR) of 8.12% and reach $18.23 billion by 2023.
https://www.globenewswire.com/news-release/2020/04/17/2017902/0/en/Neurodegenerative-Disorder-Therapeutics-Market-Global-Report-2020-to-2030-Understand-Customers-Based-on-the-Latest-Market-Research-Findings.html
There’s a product called Neuropeptide-S spray up on ReachGenius and it’s been there for a year. Just wondering if anybody has any experience with the product or the nootropic itself.
It appears to stimulate dopaminergic neurotransmission in the medial prefrontal cortex, as well as many other benefits seen in that article. So take those studies how you’d like, but i’m just surprised that nobody has reported any experiences with a product from a fairly well known company. Any thoughts/experiences?
By Changes_iv
THE AMAZING NEUROPEPTIDE and cancer———
The VIP antagonist is a hybrid peptide consisting of a portion of VIP and a portion of neurotensin, designed to change the membrane permeability of the VIP portion. The hybrid antagonist displaced 80 to 90% of [125I]VIP binding to cell cultures from cerebral cortex, hippocampus or spinal cord.
https://pubmed.ncbi.nlm.nih.gov/1646331/
The most prevalent lung cancer, non-small cell lung cancer (NSCLC) has receptors for vasoactive intestinal peptide (VIP). Here the effects of a VIP antagonist (VIP-hyb) on NSCLC growth were investigated.
https://pubmed.ncbi.nlm.nih.gov/8389448/
Vasoactive intestinal peptide inhibits human small-cell lung cancer proliferation in vitro and in vivo ———
Kaname Maruno, Afaf Absood, and Sami I. Said
https://www.pnas.org/content/95/24/14373
Hi,
so I've been researching different types of nootropics and research chemicals, and I've come across a substance by the the name of Neuropeptide S(human). What I'm curious is the (human) part. Does it mean that it's derived from human? If so, does anyone know how exactly? I'm just worried about ethcical implications here...
Thanks in advance.
Structural transitions of crucial molecular switches of the activation of the human neuropeptide Y receptor type 2 are reported from the 13C‐tryptophan labeled molecule by solid‐state NMR spectroscopy in lipid membranes. The molecule shows high structural dynamics in the apo and agonist‐bound states, which is reduced by arrestin binding.
Abstract
Dynamic structural transitions within the seven‐transmembrane bundle represent the mechanism by which G‐protein‐coupled receptors convert an extracellular chemical signal into an intracellular biological function. Here, the conformational dynamics of the neuropeptide Y receptor type 2 (Y2R) during activation was investigated. The apo, full agonist‐, and arrestin‐bound states of Y2R were prepared by cell‐free expression, functional refolding, and reconstitution into lipid membranes. To study conformational transitions between these states, all six tryptophans of Y2R were 13C‐labeled. NMR‐signal assignment was achieved by dynamic‐nuclear‐polarization enhancement and the individual functional states of the receptor were characterized by monitoring 13C NMR chemical shifts. Activation of Y2R is mediated by molecular switches involving the toggle switch residue Trp2816.48 of the highly conserved SWLP motif and Trp3277.55 adjacent to the NPxxY motif. Furthermore, a conformationally preserved “cysteine lock”‐Trp11623.50 was identified.
https://ift.tt/3kFMgsG
