Iβve been taking bupropion XL 150 mg and it makes me feel both better and worse in different ways. It improves my energy, motivation, cognition, enjoyment and interest, but it also gives me extremely tense muscles that are impossible to relax, insomnia, racing thoughts, excessive sweating, increased heart rate and sometimes shortness of breath.
Basically it feels like a constant adrenaline rush for no reason. This makes sense to me since it blocks the reuptake of norepinephrine which is almost the same as epinephrine (adrenaline), and I donβt want this but I want the positive effects that Iβm getting, which Iβm pretty sure are from the dopamine reuptake inhibition aspect of the drug. This is because all the positive effects Iβm experiencing are things that, according to my research, are affected by dopamine.
So based on this my logical conclusion is that a medication that affects dopamine but not norepinephrine would be the right one for me. But when I asked my psychiatrist about this she said that such a medication doesnβt exist, and when I asked why she wouldnβt give me a straight answer. Does anyone here have any thoughts as to why this might be, and whether a pure dopamine reuptake inhibitor does in fact exist? I just canβt understand why it wouldnβt.
The reason I ask is because after 2 years I'm suddenly starting to get bad tunnel vision and overstimulation from aderall&vyvanse despite trying the lowest and even some higher doses. For most of the past 2 years it improved my productivity but as of the last few months I'm less productive on them. I believe it may be due to getting treatment for my sleep, and it dramatically improving recently. Maybe I'm more rested and clear headed enough to where any dose of those is just overkill? Idk. While I do have diagnosed adhd and they did help a ton with jumpstarting me out of a 5 year rut to create habits&mental tools, I've tried for too long now and just can't seem to make it work. Anyways, because of this I want to talk to my doctor about trying concerta since it seems to not work the same way, but I am not 100% sure if it's a pure reuptake inhibiter, or if it will also massively boost the chemicals on its own.
I've seen that caffeine increases norepinephrine indirectly and that tyrosine may marginally increase it as well. Would there be anything a tad more potent for norepinephrine, without getting into the research chemical side of things?
First Aid 2020 says it doesn't while BnB claims that it does because of B1 effect (a point of comparison with phenylepinephrine in which CO is not altered).
Please help
Are there links with meditation and neurotransmitters like dopamine and norepinephrine in the long run
My brain seems to like dopamine; norepinephrine (and adrenalin) not so much. Wikipedia says "Dopamine is converted into norepinephrine by the enzyme dopamine Ξ²-hydroxylase (DBH), with O2 and L-ascorbic acid (vitamin C) as cofactors". I don't think it's realistic to deprive myself of vitamin C, so perhaps there is some way to inhibit DBH.
Hi all,
Does trintellix increases dopamine and norep levels like ndri( bupropion ) does?
I was before on zoloft and bupropion combo but unable to get bupropion here in ireland ( just few weeks as smoking cessation)
I am currently on 10 mg trintellix for one month with good results and wondering if moving to 20 mg will increase dopamine and norep action mirroring my previous combo
Best of luck to all and happy new year
I'm not looking for RC's that work as releasing agents.
Does anyone else seem to have this imbalance? I can't be sure what's going on but I react badly to supplements that raise dopamine/NE, I react badly to TMG (choline boosts dopamine?), I become irritable.
I also have the MAO warrior gene, if I get too irritable I will have to mega dose B2 to feel relaxed, but I think it also lowers serotonin.
I react better to SAM-E and DMG than TMG, I assume becuase sam-e raises serotonin, but it also increases epinephrine which makes me jittery. B12 seems to raise dopamine/norepinephrine, P5P seems to boost all neurotransmitters.
Any workarounds for this?
I was under the impression that Diastolic BP was due to Systemic vascular resistance; and Systolic blood pressure was due to Stroke Volume.
Thus Arteriolar constriction should lead to Increase Diastolic BP, and Venous constriction should lead to increased Preload which should in turn lead to Increased SV and Systolic BP.
Two questions:
- If dopamine is converted into norepihephrine, doesn't that mean that it's impossible for a medication to agonize the dopamine system without also agonizing norepinephrine and thus causing noradrenergic effects? Is there any such thing as a DRI? Or are all DRIs necessarily actually NDRIs?
- If there are medications that only work on dopamine - but not norepinephrine - (or there somehow could be) what kind of effects would they be expected to have that would differ them from NDRIs? Would they have a clinical advantage in the treatment of depression and ADHD over, say, Wellbutrin?
After the roller coaster ride of the past few years I'm beginning to see that as my hormones began to feel out of control, I became afraid of them, to the extent that whenever I felt my body begin to produce these "energy" hormones, I would panic and want to hide. However, without these hormones I cannot function function and cannot have any energy to do the things I want to do.
I feel excited to have this awareness... Yesterday I did a few things I had been terrified of doing... and felt both fear and at the same time some joy that I am moving into a space in which I can allow my hormones to work with me and not just frighten me. Instead of trying to hide from them I think I'll see if I can begin to make friends with them.
I realize it's a process... It's already been many years!
God damn for the fucking life of me I just want to raise all three.
At what point does like effexor do this?
Title says pretty much it, also my body can't metabolize any amphetamine like or type substance. Eutylone?
Layperson understanding:
Strattera is an NRI.
Norepinephrine is associated with vigilance and alertness.
However patients commonly report fatigue as a side effect.
Why would this be?
We have tried a TON of meds that have all failed Iβd list them all out here but I feel too awful right now to even concentrate well enough to remember, ssris, snris, one trycyclic exc so maybe heβs grasping at straws but I asked to try mirtazapine based on what Iβve read about it, it seems like maybe worth a try at this point but he instead wanted to try straterra. I donβt get it cause I thought noradrenaline is involved in fight or flight so a NRI would just worsen my anxiety? Any thoughts or anyone actually had success with their anxiety with an nri? Thanks
So, I decided to try the methylfolate route of trying to treat my histamine intolerance. After taking my methylfolate and methylcobalamin, I feel less anxious, but a lot of anhedonia. This strikes me as a decrease in activity of dopamine and norepinephrine.
I currently regularly take ALCAR, bupropion, and fexofenadine, which puts me in a lot better state than I was a year ago with depression and anxiety.
It occurs to me that when I previously tried B vitamins for depression and anxiety, something similar happened. I was taking folic acid, methylcobalamin, and pyridoxine. It was somewhat effective, but only if I took the highest amount of pyridoxine (100mg), which I ended up getting neurotoxicity symptoms from. I stopped the B6, but continued the B9 and B12. It was during the few months after this that I experienced severe anhedonia and derealization, but no anxiety due to the feeling that consequences weren't real lol. I thought it was a withdrawal symptom from the neurotoxic levels of B6, but I started to notice that I improved a bit when I didn't take the B9 and B12. However, I didn't want the anxiety to return so I kept taking them. I was then prescribed bupropion, which took care of the anhedonia and derealization, as well as other issues (I also ran out of B9 and B12 soon after this and didn't continue them). However, I've noticed that when I stop the bupropion for a week or so, the derealization starts to return.
Given this, I'm now wondering if I messed something up long term with that B9 and B12, and if there's something I can do to fix it?
I did my first fast, 72 hours, about a month ago. After those 72 hours, for about 3 weeks, I felt much more alert, focused, and just overall great. My depression reduced by about 70%, I stopped having suicidal thoughts, I was much better and happier socially, and I actually felt very focused and task oriented for the first time in a long time. (I have adhd) I felt as if I truly found an answer to a lot of my problems.
I attributed this newfound focus and drive to the adrenaline and norepinephrine in my brain that was released while fasting, as well as the dopamine reset some ppl talk about. Because it felt similar for about 3 weeks to the focus I would get from taking an adderall a few years back, because adderal also releases norepinephrine, except w/o all the downsides and comedown. I really felt amazing for those 3 weeks.
Fast forward to today and I am back to feeling like my old self before I ever did the fast. Last week I smoked weed for the first time in a good while for a couple days, and then I woke up one morning feeling the same way I used to feel before the 2 fasts Iβve done in the past month. I am now on a 5 day fast, looking to get that same adrenaline and norepinephrine release in my brain that I got from the 72 hour fasts, but I am over 96hrs in and I donβt have any of that focused feeling, strangely I feel completely normal, not even hungry.
So my question is, does adrenaline and norepinephrine release decrease over time if you do multiple fasts within a month? Or could it have been the weed that messed with my dopamine receptors?
If anyone has any experience with this Iβd be very greatful to hear from you. Iβd do just about anything to get that focused and non depressed feeling back that I got from my first fast.
Curious
Looking for a molecule that increases norepinephrine, selectively if at all possible, in the brain.
Nothing prescription, although I am aware of a number of drugs on that market which do what Iβm looking for.
Should increase focus, physicality of self, spatial intelligence, world building, and social dominance and eye contact.
Thanks for any tips or leads.
Basically, I get these intermittent rushes of a cool, tingly feeling up my back and into my head, followed by improved mental clarity and focus - it only started after I went on Strattera (a NRI) and it feels similar to the phenomenon of frisson, which is known to be linked to norepinephrine, so that's what I've decided it most likely is.
They mostly come on seemingly at random after taking my meds, but there are three reliable triggers I've identified:
-
Meditation
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Going outside and getting fresh air
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And the weirdest: peeing
So, anyone who needs to de-scatter your thoughts or lift some brain fog... consider one of these activities!
I've tried SSRIs, SNRIs, TCAa, Wellbutrin, St. Joh's Wort, Concerta (methylphenidate), maybe something else.. Anyway, whenever there is a letter "S" in there, meaning increasing serotonin in some way (St. Johns Wort included), I always get this inner tension and "bad butterflies" that never go away. It feels like "akathisia" and it's a terrible thing, and it resolved right after the cessation. Yet, it is a fact that boosting serotonin helps my depression. For example, Wellbutrin or just a plain coffee, they boost norepinephrine and I can feel a "boost" in energy, yet I remain depressed.
So I don't know what to do, it seems that there is nothing that works for me because the only things that work also have this nasty side effect, making me tense all the time which drives me nuts very soon. In the end, I actually might prefer stimulants because they actually made me feel pretty ok, but made me into an insomniac. Just terrible. :)
Does anyone have idea as to what might be going on here, "chemically" speaking, like, why would I be so sensitive to increasing serotonin, and is there any way I can find something useful that doesn't do this to me?
Norepinephrine is related to arousal , energy , working memory and attention..
Many supplements focus excessively on increasing dopamine function and forgets about norepinephrine..
Supplements like tyrosine and phenylaniline increase dopamine ...No doubt ... but that doesn't mean it automatically increase norepinephrine also ... even though pathway is connected ...
Apart from copper and vitamin c ... are there other ways to increase this neurotransmitter....
I've noticed last couple of months my fatigue levels are sky high. This makes no sense as I'm on high dose Ritalin and have also recently started Modafinil (to no effect).
I vaguely remember reading somewhere that MAOIs increase levels of other neurotransmitters like Octopamine that displace Norepinephrine - acting as 'false neurotransmitters'.
Could this mean that the MAOI is actually decreasing my norepinephrine or dopamine levels?
EDIT: There is at least one study which documents MAOIs causing inexplicable daytime somnolence. So it looks like I'm not the only one:
Avoiding numbing emotions, sleep problems, and as much erectile dysfunction as possible?
Hi guys! I'm one week into Nardil and I'm noticing some surprising side effects that people don't seem to usually talk about. My watch is detecting an elevated (+10 BPM) resting heart rate compared to before starting Nardil, and I also noticed my sinuses are wide open.
After some research, I realized both of these effects are likely caused by increased norepinephrine and epinephrine. I also found out that most decongestants work by increasing these two neurotransmitters.
While the constantly decongested nose feels quite nice, the elevated heart rate doesn't seem ideal. I would prefer to have a lower resting heart rate. Also, I think the elevated norepinephrine and epinephrine likely contributes to the insomnia and REM surpression that occurs in MAOI.
Does anyone know if these side effects of elevated norepinephrine/epinephrine subside over time?
