Epinephrine Puns

Epinephrine inhaler helps my breathing problems

That’s my number one symptom is tightness in chest and feeling like I can’t take a full breath. It flairs up starting around mid day and towards the end of the day. It really does feel almost how an allergic reaction would feel. It feels more how I would imagine asthma feels.

I tried the over the counter inhaler I have and it improves my breathing almost immediately. On good days I only have to use it once. Epinephrine is fast acting so not so long lasting, so it does wear off eventually.

I have a history of allergies and breaking out in hives for seemingly no reason. I’ve been reading about the parallels between MCAS and long covid. I have an appointment with my allergist but couldn’t get in until April.

In the mean time i am trying to eat a low histamine diet and bought some enzyme vitamins that are supposed to help with MCAS.

Has anyone found anything that really worked for them?

Also, I really want to get back to exercising, but I keep reading this is a big no. Has anyone returned to exercise without adverse effects?

Hello, my social anxiety and GAD is causing unpleasant physical symptoms when im in fear.

Are there vitamins-minerals, amino acids, herbs, derivative... which can help to prevent epinephrine spikes or some to lower base epinephrine or any mechanism which can help when my fear pop up.

I am not looking for prescription drugs.

Let's talk Epinephrine dosing strategies in cardiac arrest. You may not care for it being used at all, but the AHA is smarter than me and they want it so whatever. I'm just a paramedic, not a vast international body of science people.

We have a shortage of prefilled Epi 1:10k syringes in our region and as we were coming up with strategies with what we should do I mentioned the idea of using a loading dose of 1mg 1:10k and then an Epi infusion. If I were to make a bet I'd wager that this will eventually be the new way forward, or maybe an upcoming fad that will ultimately prove less than stellar like everything else... but that's the jaded part of me that has seen a lot of fads come and go.

I like the idea of a continuous Epi infusion at a lower dose than the stock 1mg every 3-5min. I'd like to try it. Regardless, we've got to do something, we don't have much 1:10k Epinephrine left in stock. In the past we have used 1:1k and have diluted it at the patient's side, but I'd like a better answer this time.

Your thoughts? What do y'all do? If we do the drip, how do we present it to our medical directors.

https://aquestive.com/aquestive-therapeutics-receives-written-response-to-pre-ind-submission-for-aqst-109-epinephrine-prodrug-sublingual-film-and-begins-recruitment-for-its-epinephrine-film-pharmacokinetic-and-safety-tri/

NOT A SQUEEZE PLAY - FDA APPROVAL PLAY - SIMILAR TO $CALT

Aquestive Therapeutics Receives Written Response to Pre-IND Submission for AQST-109 (epinephrine prodrug sublingual film) and Begins Recruitment for its Epinephrine Film Pharmacokinetic and Safety Trial (EPIPHAST)

• FDA confirms 505(b)(2) pathway is acceptable for the development of AQST-109
• FDA indicates AQST-109 has the potential for Fast Track designation
• Health Canada provides clearance to commence the adaptive design crossover study.

WARREN, N.J., Dec. 13, 2021 (GLOBE NEWSWIRE) -- Aquestive Therapeutics, Inc. (NASDAQ: AQST), a pharmaceutical company focused on developing and commercializing differentiated products that address patients’ unmet needs and solve therapeutic problems, today reported that it has received a written response from FDA to its pre-investigational new drug (pre-IND) meeting submission confirming that the development of AQST-109 for the treatment of anaphylaxis under the 505(b)(2) pathway is acceptable.

The FDA’s written response to Aquestive indicates that, pending review, Aquestive has performed sufficient clinical and nonclinical activity to support the opening of an Investigational New Drug (IND) application for AQST-109. In addition, the FDA provided comments on both Aquestive’s toxicology plan and clinical development plan. The FDA confirmed its agreement that (i) the 505(b)2 pathway is appropriate for the development of AQST-109 and (ii) AQST-109 has the potential to meet the regulatory criteria for Fast Track designation. Aquestive plans to file its IND for AQST-109 early in the first quarter 2022.

In addition, Health Canada has provided clearance for Aquestive’s crossover study, known as the EPIPHAST study, of AQST-109. Patient recruitment has begun and the Company expects the first dosing to occur before the end of the year. The EPIPHAST study is a randomized, open-label, three-part adaptive design, crossover study intended to compare the pharmacokinetics and pharmacodynamics of epinephrine fol

I am currently enrolled in an EMS academy to obtain my EMT certification, and this debate with my instructors raised a question.
We were taking turns taking a mock medical assessment 1 on 1 with an instructor, which will be graded as if it was an official NREMT. I had a patient that was experiencing an anaphylactic shock and happened to be asthmatic. I performed every step I thought fitted, acknowledging my field impression as main priority: anaphylactic shock. I finished my primary assessment and went to my secondary, and for my interventions, I called med control and wanted permission to administer him epinephrine THEN albuterol due to the fact of wheezing being present but most importantly, he was also asthmatic.
I reasoned with this logic because even though I know wheezing will be present in most anaphylactic patients, I thought it was appropriate to administer said asthmatic patient with albuterol after giving epinephrine because his asthma might've been a secondary medical illness. The constant excessive extortion of the patient's asthmatic lungs, tightening of the chest and lungs, etc can flair up the patient's asthma.
Also, our class textbook states allergic reactions and anaphylaxis will present with asthma to an asthmatic patient, ALSO had a written scenario where the EMT administered both epi and albuterol.
So as a result, the test was a critical failure due to "inappropriate intervention". I accepted my result but try to reason with my instructors with what the textbook said. In the end, they informed me anaphylactic does not in fact cause asthma and will be calling the publisher of our textbook to fix the error.
I would love to hear what yall say! Is it dangerous to administer both medications? If so, how so? Do you think it's reasonable to also administer epi then albuterol? ALSO: please leave citation of work/proof! I would love to do personal studying and show my instructor if I was right or even wrong! Thanks guys for reading this, have a good day. (:

I had to schedule an appointment for allergy testing. There are no appointments until mid March, but the scheduler said that even if there was something sooner, epinephrine stays in your system for six weeks. I had never had epinephrine until last week in the ER. Is this true? I am not understanding how it can stay in your system that long but you can still have another allergic reaction in the meantime.

I went to the dentist today and they gave me a local anesthetic that had epinephrine in it. immediately heartrate went up, i got the bad shakes and my teeth were clattering for 20 minutes. its been 4 hours wnd im still so dizzy and nauseous i cant stand.

im guessing its because of the epinephrine but i have no idea.

anyone else had any problems with it?

EDIT: this is how i feel after reading ur response this is how i feel

https://preview.redd.it/5igkb3zoyb781.jpg?width=1200&format=pjpg&auto=webp&s=36c3a9be251750bd5dd465442948311b6ce0586a

Woman Dies Waiting for Epinephrine at Disney World, Firefighters Say Staffing Puts Guests in Danger

Please learn from this tragedy: NEVER rely on emergency services to provide the epinephrine that will keep you alive in an anaphylactic emergency. Take two epinephrine auto-injectors with you everywhere... every time!

https://preview.redd.it/slc2j11ryb781.jpg?width=1200&format=pjpg&auto=webp&s=9e996fb5eced78fbedf8d03cecfca1d94a2b93c4

Woman Received Microdoses of COVID-19 Vaccine to Avoid Anaphylaxis

Here is one woman's story about receiving a COVID-19 mRNA vaccine via microdoses to avoid anaphylaxis. If concern about reactions is keeping you from getting vaccinated, consider talking to your allergist about this strategy.

https://preview.redd.it/qvjno2yryb781.jpg?width=1200&format=pjpg&auto=webp&s=51ef9b2eb7797286ac38b9f41902a8dee791a148

Viaskin Peanut Patch Therapy Delayed Further as DBV Readies Another Phase 3 Trial

More disappointing news regarding DBV Technologies' Viaskin Peanut "patch" therapy for peanut allergy. The company also has Viaskin therapies for milk and eggs in their pipeline.

https://preview.redd.it/wyczznyxyb781.jpg?width=1200&format=pjpg&auto=webp&s=14b077a25fa638756c04da5b73ccb6bfd5a374fb

Food Allergy 101: What That Customer Service Response REALLY Tells You

You know those "may contain" allergen warnings are entirely voluntary, so you contact the manufacturer and receive a canned response designed by lawyers that seems to tell you the product is fine. But is that what they're REALLY saying? We dissect a real customer service response to show you what they are and are not telling you.

https://preview.redd.it/7ecd7wsuyb781.jpg?width=3300&format=pjpg&auto=webp&s=eb3373b0de4e6bd1117ba14b85c33c39db6ac336

[Download Our Santa Naughty List “Take 2” Reminder](https://snac

Curious about how epinephrine affects glycolysis, fatty acid synthesis, glycogen degradation and synthesis. Which does it activate/inhibit? Why?

Just saw this come across my trading platform

Get Reimbursed For Your EpiPen/Epinephrine Injector Out-of-Pocket Costs

[Kraft]

You'll have to provide details like your name, address and the amount you paid out-of-pocket for your epinephrine injectors. You will also need to provide a receipt. There is a limit of one reimbursement submission per person.

https://www.protectionforpeanuts.com/

https://www.reddit.com/r/SweetDealsCA/comments/r245gj/get_reimbursed_for_your_epipenepinephrine/

Does anyone know if an over the counter epinephrine inhaler for asthma can be used as an epipen? It has the same active ingredient. The inhalers have 0.125 mg of epinephrine.

Hey guys, I was just wondering if any of you had information on getting an Epipen here.

I have some food allergies and I like to have one just in case. I brought one but they're expired so it's time to re-up.

​ I live in Bundang - I went to my doctor and he said they don't really prescribe them here, but I've read some things that said otherwise. I'm not sure if "here" was Korea or just his office hahah ​

Any ideas?

*Edit* PLEASE don't change your medication or stop taking medication without speaking to your physician first!

I have hypertension and I've had physicians overlook this. Beta blockers interfere with the effectiveness of epinephrine shots. YOu don't want to be in a life threatening situation and have an interaction that interferes.Some common Rx names are:

• acebutolol (Sectral)
• atenolol (Tenormin)
• betaxolol (Kerlone)
• bisoprolol/hydrochlorothiazide (Ziac)
• bisoprolol (Zebeta)
• metoprolol (Lopressor, Toprol XL)
• nadolol (Corgard)
• propranolol (Inderal)
• sotalol (Betapace)
• carvedilol (Coreg)

If you do carry a pen and are taking beta blockers, talk to your physician asap.

That’s my number one symptom is tightness in chest and feeling like I can’t take a full breath. It flairs up starting around mid day and towards the end of the day. It really does feel almost how an allergic reaction would feel. It feels more how I would imagine asthma feels.

I tried the over the counter inhaler I have and it improves my breathing almost immediately. On good days I only have to use it once. Epinephrine is fast acting so not so long lasting, so it does wear off eventually.

I have a history of allergies and breaking out in hives for seemingly no reason. I’ve been reading about the parallels between MCAS and long covid. I have an appointment with my allergist but couldn’t get in until April.

In the mean time i am trying to eat a low histamine diet and bought some enzyme vitamins that are supposed to help with MCAS.

Has anyone found anything that really worked for them?

Also, I really want to get back to exercising, but I keep reading this is a big no. Has anyone returned to exercise without adverse effects?

https://aquestive.com/aquestive-therapeutics-receives-written-response-to-pre-ind-submission-for-aqst-109-epinephrine-prodrug-sublingual-film-and-begins-recruitment-for-its-epinephrine-film-pharmacokinetic-and-safety-tri/

Aquestive Therapeutics Receives Written Response to Pre-IND Submission for AQST-109 (epinephrine prodrug sublingual film) and Begins Recruitment for its Epinephrine Film Pharmacokinetic and Safety Trial (EPIPHAST)

• FDA confirms 505(b)(2) pathway is acceptable for the development of AQST-109
• FDA indicates AQST-109 has the potential for Fast Track designation
• Health Canada provides clearance to commence the adaptive design crossover study.

WARREN, N.J., Dec. 13, 2021 (GLOBE NEWSWIRE) -- Aquestive Therapeutics, Inc. (NASDAQ: AQST), a pharmaceutical company focused on developing and commercializing differentiated products that address patients’ unmet needs and solve therapeutic problems, today reported that it has received a written response from FDA to its pre-investigational new drug (pre-IND) meeting submission confirming that the development of AQST-109 for the treatment of anaphylaxis under the 505(b)(2) pathway is acceptable.

The FDA’s written response to Aquestive indicates that, pending review, Aquestive has performed sufficient clinical and nonclinical activity to support the opening of an Investigational New Drug (IND) application for AQST-109. In addition, the FDA provided comments on both Aquestive’s toxicology plan and clinical development plan. The FDA confirmed its agreement that (i) the 505(b)2 pathway is appropriate for the development of AQST-109 and (ii) AQST-109 has the potential to meet the regulatory criteria for Fast Track designation. Aquestive plans to file its IND for AQST-109 early in the first quarter 2022.

In addition, Health Canada has provided clearance for Aquestive’s crossover study, known as the EPIPHAST study, of AQST-109. Patient recruitment has begun and the Company expects the first dosing to occur before the end of the year. The EPIPHAST study is a randomized, open-label, three-part adaptive design, crossover study intended to compare the pharmacokinetics and pharmacodynamics of epinephrine following administration of AQST-109 and epinephrine administered as intramuscular injection in healthy adult subjects. This study will be used to determine the final product configuration that will be used to manufacture registration batches and conduct pivotal studies planned for the

I am currently enrolled in an EMS academy to obtain my EMT certification, and this debate with my instructors raised a question.
We were taking turns taking a mock medical assessment 1 on 1 with an instructor, which will be graded as if it was an official NREMT. I had a patient that was experiencing an anaphylactic shock and happened to be asthmatic. I performed every step I thought fitted, acknowledging my field impression as main priority: anaphylactic shock. I finished my primary assessment and went to my secondary, and for my interventions, I called med control and wanted permission to administer him epinephrine THEN albuterol due to the fact of wheezing being present but most importantly, he was also asthmatic.
I reasoned with this logic because even though I know wheezing will be present in most anaphylactic patients, I thought it was appropriate to administer said asthmatic patient with albuterol after giving epinephrine because his asthma might've been a secondary medical illness. The constant excessive extortion of the patient's asthmatic lungs, tightening of the chest and lungs, etc can flair up the patient's asthma.
Also, our class textbook states allergic reactions and anaphylaxis will present with asthma to an asthmatic patient, ALSO had a written scenario where the EMT administered both epi and albuterol.
So as a result, the test was a critical failure due to "inappropriate intervention". I accepted my result but try to reason with my instructors with what the textbook said. In the end, they informed me anaphylactic does not in fact cause asthma and will be calling the publisher of our textbook to fix the error.
I would love to hear what yall say! Is it dangerous to administer both medications? If so, how so? Do you think it's reasonable to also administer epi then albuterol? ALSO: please leave citation of work/proof! I would love to do personal studying and show my instructor if I was right or even wrong! Thanks guys for reading this, have a good day. (:

(I'm posting this on a few other subreddit, and I'm hoping I can also get pharmaceutical advice too!)

I am currently enrolled in an EMS academy to obtain my EMT certification, and this debate with my instructors raised a question.
We were taking turns taking a mock medical assessment 1 on 1 with an instructor, which will be graded as if it was an official NREMT. I had a patient that was experiencing an anaphylactic shock and happened to be asthmatic. I performed every step I thought fitted, acknowledging my field impression as main priority: anaphylactic shock. I finished my primary assessment and went to my secondary, and for my interventions, I called med control and wanted permission to administer him epinephrine THEN albuterol due to the fact of wheezing being present but most importantly, he was also asthmatic.
I reasoned with this logic because even though I know wheezing will be present in most anaphylactic patients, I thought it was appropriate to administer said asthmatic patient with albuterol after giving epinephrine because his asthma might've been a secondary medical illness. The constant excessive extortion of the patient's asthmatic lungs, tightening of the chest and lungs, etc can flair up the patient's asthma.
Also, our class textbook states allergic reactions and anaphylaxis will present with asthma to an asthmatic patient, ALSO had a written scenario where the EMT administered both epi and albuterol.
So as a result, the test was a critical failure due to "inappropriate intervention". I accepted my result but try to reason with my instructors with what the textbook said. In the end, they informed me anaphylactic does not in fact cause asthma and will be calling the publisher of our textbook to fix the error.
I would love to hear what yall say! Is it dangerous to administer both medications? If so, how so? Do you think it's reasonable to also administer epi then albuterol? ALSO: please leave citation of work/proof! I would love to do personal studying and show my instructor if I was right or even wrong! Thanks guys for reading this, have a good day. (:

(I'm posting this on a few other subreddit, and I'm hoping I can also get pharmaceutical advice too!)

I am currently enrolled in an EMS academy to obtain my EMT certification, and this debate with my instructors raised a question.
We were taking turns taking a mock medical assessment 1 on 1 with an instructor, which will be graded as if it was an official NREMT. I had a patient that was experiencing an anaphylactic shock and happened to be asthmatic. I performed every step I thought fitted, acknowledging my field impression as main priority: anaphylactic shock. I finished my primary assessment and went to my secondary, and for my interventions, I called med control and wanted permission to administer him epinephrine THEN albuterol due to the fact of wheezing being present but most importantly, he was also asthmatic.
I reasoned with this logic because even though I know wheezing will be present in most anaphylactic patients, I thought it was appropriate to administer said asthmatic patient with albuterol after giving epinephrine because his asthma might've been a secondary medical illness. The constant excessive extortion of the patient's asthmatic lungs, tightening of the chest and lungs, etc can flair up the patient's asthma.
Also, our class textbook states allergic reactions and anaphylaxis will present with asthma to an asthmatic patient, ALSO had a written scenario where the EMT administered both epi and albuterol.
So as a result, the test was a critical failure due to "inappropriate intervention". I accepted my result but try to reason with my instructors with what the textbook said. In the end, they informed me anaphylactic does not in fact cause asthma and will be calling the publisher of our textbook to fix the error.
I would love to hear what yall say! Is it dangerous to administer both medications? If so, how so? Do you think it's reasonable to also administer epi then albuterol? ALSO: please leave citation of work/proof! I would love to do personal studying and show my instructor if I was right or even wrong! Thanks guys for reading this, have a good day. (:

(I'm posting this on a few other subreddit, and I'm hoping I can also get pharmaceutical advice too!)

I am currently enrolled in an EMS academy to obtain my EMT certification, and this debate with my instructors raised a question.
We were taking turns taking a mock medical assessment 1 on 1 with an instructor, which will be graded as if it was an official NREMT. I had a patient that was experiencing an anaphylactic shock and happened to be asthmatic. I performed every step I thought fitted, acknowledging my field impression as main priority: anaphylactic shock. I finished my primary assessment and went to my secondary, and for my interventions, I called med control and wanted permission to administer him epinephrine THEN albuterol due to the fact of wheezing being present but most importantly, he was also asthmatic.
I reasoned with this logic because even though I know wheezing will be present in most anaphylactic patients, I thought it was appropriate to administer said asthmatic patient with albuterol after giving epinephrine because his asthma might've been a secondary medical illness. The constant excessive extortion of the patient's asthmatic lungs, tightening of the chest and lungs, etc can flair up the patient's asthma.
Also, our class textbook states allergic reactions and anaphylaxis will present with asthma to an asthmatic patient, ALSO had a written scenario where the EMT administered both epi and albuterol.
So as a result, the test was a critical failure due to "inappropriate intervention". I accepted my result but try to reason with my instructors with what the textbook said. In the end, they informed me anaphylactic does not in fact cause asthma and will be calling the publisher of our textbook to fix the error.
I would love to hear what yall say! Is it dangerous to administer both medications? If so, how so? Do you think it's reasonable to also administer epi then albuterol? ALSO: please leave citation of work/proof! I would love to do personal studying and show my instructor if I was right or even wrong! Thanks guys for reading this, have a good day. (: