Norepinephrine–dopamine reuptake inhibitor Puns

I'm not looking for RC's that work as releasing agents.

Does anyone know where you'd find some substances that act like NRIs or DNRIs that aren't, for example, Bupropion or nortriptyline that requires a doctor to prescribe them to you. I'm interested to see how I well I could function with one but I've been having issues finding one. Any help would be appreciated!

There are many instances online of folks with ADHD self-medicating with pseudoephedrine, generally when they've run out of their script meds and are away from home or about to travel, so need a short term solution before they can get another script. I have many symptoms of ADHD which I only came to realise in adulthood were treated - and therefore went unnoticed - during my teenage years due to recurrent sinusitis which involved very regular seasonal medicating with pseudoephedrine to treat. There was a time when pseudoephedrine was as regular to me as a multivitamin, and it was only after the sinus issues went away in my early twenties that I realised that my concentration, motivation and ability to actually finish a project are practically non-existent - I chalked this up to a couple of life changes and issues which hit me around then, and only very recently discovered pseudoephedrine's membership of the amphetamine class - and thus began to realise the correlation between my productive years, and the slide into ADHD once I stopped using the stuff. Many things now make sense which didn't before.

For reasons which are very mundane and not something I'd bore the folks here with, I don't at this time want to go down the prescription meds route (essentially, my country's mental healthcare system sucks and it's an absolute nightmare to deal with). Since I made the connection to my past productivity and my past pseudoephedrine use, I have found that self-medicating with pseudoephedrine HCL at the recommended nasal decongestant dosing schedule causes me to have some of the most productive days in living memory, but I'm also aware that many talk of pseudo as a medication with a very unpleasant crash and tolerance effect if one stays on it for too long. With that in mind, lately I've been choosing a day or two per week in which I'll go for it, and schedule things I very much want to focus on and complete for those days. It's going exceptionally well.

I'm just wondering though, can anyone anecdotally describe how far one can push this in terms of consecutive days and frequency, before hitting any of the tolerance or rebound "walls"? I'm in a position now in which I'll be completely alone for most of the next four days and I have a pile of stuff I'd like to accomplish, so I'm tentatively considering going for the full 60mg / 4 times daily for at least today and tomorrow, and possibly going on into Sunday and Monday depending on how things are going.

I unders

I've tried Ritalin, and it had no effect on me, does that mean Wellbutrin will similarly have no effects on me? I was unable to find information on this in /r/drugs/wiki/drugs.

It is already known that antidepressants such as Wellbutrin (Bupropion), which are norepinephrine-dopamine reuptake inhibitors, reduce an individual's seizure threshold. This made me wonder whether adding something like tDCS would cause a user to experience a seizure due to the reduced seizure threshold. Does anyone have any advice?

Thanks,

Bailey

What is the overall best dopamine or dopamine-norepinephrine reuptake inhibitor (DRI/DNRI)? No releasers, just reuptake inhibitors.

:)

I was wondering how these two differ, high wise. Also, which one is more/less healthy and/or addictive for the user? I know drugs like amphetamines are dopamine (as well as other neurotransmitter) agonists, and drugs like cocaine block the reuptake pump of dopamine and norepinephrine.

I understand that even highly selective serotonin releasing agents like MMAI have empathogenic effects and recreational value. Is the baseline release of serotonin simply too low to allow substantial accumulation in the synapse by reuptake inhibition?

I’ve read that Wellbutrin Dopamine Reuptake Inhibitor mechanism is too low to have any antidepressant effects. So that would mean that it comes from its NRI mechanism?

A prominent part of my depression has been lack of motivation and difficulty summoning up enough energy to focus on work.

I'm currently taking Lexapro which is amazing for my anxiety. But as is well known tends to make that lack of motivation thing even more difficult.

I know that Wellbutrin is the go to for these sort of issues. I tried it before and experienced lots of anxiety.

My question was whether there are other agents that can be used for the 'get up and go' kick that Wellbutrin gives. Perhaps NRIs?

Has anybody had any success with this class of drugs (Strattera etc) for this purpose?

The reason I ask is because after 2 years I'm suddenly starting to get bad tunnel vision and overstimulation from aderall&vyvanse despite trying the lowest and even some higher doses. For most of the past 2 years it improved my productivity but as of the last few months I'm less productive on them. I believe it may be due to getting treatment for my sleep, and it dramatically improving recently. Maybe I'm more rested and clear headed enough to where any dose of those is just overkill? Idk. While I do have diagnosed adhd and they did help a ton with jumpstarting me out of a 5 year rut to create habits&mental tools, I've tried for too long now and just can't seem to make it work. Anyways, because of this I want to talk to my doctor about trying concerta since it seems to not work the same way, but I am not 100% sure if it's a pure reuptake inhibiter, or if it will also massively boost the chemicals on its own.

Bupropion and nortriptyline for example.. I've got Nortriptyline prescribed for myself and I've seen people here on reddit using Bupropion for anxiety... How would this work ?

Hey all,

I understand how dopamine releasers like amphetamines and dopamine reuptake inhibitors like methyphenidate work and what contributes to their effect but what exactly is a dopamine agonist? How does it differ from the latter two, how does it work and what are the effects on depression and mood? Thanks!

Could someone help me understand why a drug like Stratterra, that acts primarily as a Norepinephrine Reuptake Inhibitor, would initially cause a side effect like tiredness in the first few weeks of it's use?

My understanding is that norepinephrine promotes alertness and 'vigilance', what is the mechanism that it would have an opposite effect initially?

Edit: For anyone that might come across this post with the same question, I found this response in another thread. The user didn't post any links or studies to back it up unfortunately, I might try and find some. But this being the mechanism makes a lot of sense so I might try and find some "evidence".

"There are post-synaptic alpha-2 receptors all over the brain. Some of them desensitize more readily than others, but e.g. the prefrontal receptors don't readily desensitize, which is why clonidine, guanfacine and NRIs pretty much work indefinitely, if they work at all. Yet many of the the post-synaptic alpha-2 receptors that cause side effects usually do desensitize over time, thus a reduction in side effects. Some other side effects shouldn't really be considered side effects, just an indication that the target mechanism isn't appropriate for the patient, for example of they're feeling emotionally flat and unable to get excited, then that's just the unfortunate flip side of this particular type of stimulation of the executive functioning, which inhibit emotions (including hyperactivity and anxiety)."

Part 1: Amphetamine / Speed neurologically superior to cocaine?

In respect of: Amphetamine (Levo or Dextra) & Cocaine Hydrochloride

I know from research that cocaine is a triple reuptake inhibitor of dopamine;norepinephrine ;serotonin but doesn't act as a releaser.

Amphetamine on the other hand, through a varying mechanism of action blocks the recycling of the above, in addition to reversing their transporter proteins resulting in saturation of these monoamines post-synaptic.

It seems that the intensity of euphoria and stimulation on amphetamine depends on the speed and magnitude that dopamine and adrenaline are being fired across the synapse. I suspect that in essence this means the pleasurable effects felt are dependent on your use of other dopaminergic stimulants, including MDMA which many are unaware also relies on dopamine release to exert the stimulating and part euphoria. The more one uses stimulants of this nature, I assume less dopamine etc. are being fired at less speed and magnitude and lowers the perceived euphoria - a driving factor in tolerance and diminishing returns. Receptors post-synaptic also become regulated and desensitized.

MDMA and other primary serotonin releasers appear to exert higher neurotoxicity, serotonin pathways are much less robust than dopamine (owing to the fact you can't take MDMA as regulary as other stimulants, or it won't work).

Why do I think amphetamine is superior to cocaine in two contexts?

• Cocaine is much more expensive than amphetamine, yet has an inferior mechanism of action, a ridiculously short duration unless compulsively redosing.
• Whilst cocaine is not thought to be neurotoxic either, especially relative to drugs like MDMA, amphetamine also isn't thought to be, even at recreational doses. With a mechanism of action superior to cocaine and not thought to be much worse for the brain than cocaine, what is the purpose of cocaine's popularity and availability over amphetamine?

As mentioned by a poster, cocaine is also uniquely cardiotoxic. Whilst with sensible use (the word sensible being applied in jest), and an otherwise healthy person wouldn't be likely to suffer a cardiac arrest or heart attack from irregular use, amphetamine whilst like all other stimulants are not good for the cardiac system, is thought to be considerably less dangerous - and this seems to apply to the entire amphetamine class of drugs in comparison to cocaine.

**Part 2: Is the strength of a reuptake inhibitor an

Wouldn't it be counterintuitive if it increases the levels of norepinephrine in your body?

I have 3-fpm and 4f-mph.

Thanks in advance🙏

I've been on a fair share of SSRIs with the usual side effects such as emotional blunting, lack of drive/motivation, brain fog, sexual side effects etc.

It got me thinking if there was a drug that also increased dopamine, then perhaps you could alleviate some of the symptoms mentioned above?

Why don't we use dopamine reuptake inhibitors in treating depression?

My blood pressure is fine on a daily basis. However, when I drink coffee or Yerbe, my pressure rises so that I feel uncomfortable sometimes. And he doesn't drink much of this coffee.

Is it the fault of the NRI drug I am treating? Does he have a significant influence in this situation

I have this weird phenomenon that whenever I experience a release of dopamine, be it through an orgasm, drinking or weed, I feel fine for half a day, but then my motivation and mood plummet for at least 24 hrs. Stuck in brain fog. My speech is noticeably worse (limited vocabulary, quieter, etc.).It can take between 3-5 days for me to feel leveled out again. I hardly ever drink, and I quit weed years ago. The orgasms though… that’s just a cruel neurotransmitter game my brain is playing on me.

I’d love to understand the mechanism with my dopamine release. It doesn’t get released when I work on projects that used to make me feel good (and still would if I didn’t procrastinate them). Instead I go for the dopamine rush and as a consequence need 3-5 days to be back at baseline.

This year my psychiatrist put me on Sertraline (an SSRI). It was supposed to help with social anxiety, lower cortisol / prolactin and give me the motivation to work of an ever-growing stack of projects I’ve been procrastinating. But Sertraline took away any remaining motivation and made me bed-ridden for the entire summer, even on the lowest dose. I slowly quit it after 8 weeks and experienced all the negative symptoms from brain zaps to upset stomach to increased sweating. I’ve tried other SSRIs over the past 15 years but none seemed to benefit me, and all gave me side effects.

Should I give Wellbutrin (Bupropion) a try? I used it twice over the past two decades but no longer have records on why I quit them. I recall not having sexual side effects on it, but perhaps it made me more irritable / anxious. Is there perhaps another medication that is more geared on dopamine reuptake inhibition and less so on norepinephrine? My social anxiety and general high-stress exhaustion would probably go into overdrive if I keep more norepinephrine in my system.

https://www.nice.org.uk/guidance/gid-ta10371/documents/129-2

NOTE: Edited to add continuously as I clear my brain fog to create a 'proper' post.

Some pro people looking at medical history could say: he's had 4x different anti-depressants, none have worked, indeed suicidal idealisation has got to OCD instant throat-slitting, so he's 'treatment-resistant'. Let's try ketamine...

I wish, OMG I wish.

The reason is ketamine takes my pain away. Of course I will stop being depressed if I was not in pain everyday.

Whew PEM from my venomous emotions will get me back, but what do I have to loose?

I have no quality of life and I have no medical intervention to help me. I rely on an illegal weed which has caused me to be arrested twice.

I'm getting UK legal weed, step 1, step 2 is until I die I will fight for those people right now, in the UK, who are suffering because the NHS refuse to help them effectively.

I take Quetiapine which is so unusual for neuroleptics. And it also causes the reuptake of Noradrealine. At night I take it to sleep well and in the morning it becomes a bit silted. However, during the day I am very excited, turned on, I have a lot of energy in me, but not necessarily the good one, some people think,

I got something to my nose that I am so hyperactive and I am anti-drug. After coffee (which rarely drinks) or a moment of great stress, sometimes the pressure rises unnaturally too much, I did not measure it accurately, but I feel as if it was dangerous.

Is this the fault of the effect of this Quetiapine on noradrealine?

So. I've had dissociative episodes before, but as I don't remember quite all of them I can't describe them. But I had a really bad one about...this month actually. At first it was like, I was crying because something reminded me of a bad childhood experience and I couldn't get myself out of it, and then I was so bad that I was so spaced out in the store that I was in that I fell backwards somewhere trying to back up.

Anyway, after that incident I've noticed I've had these feelings that I'm not connected to my body, or I'm not human, or I'm like a void or something and that this body is merely a shell containing the void-ness or something. It's hard to understand, and I've had major psychotic episodes since I was at least 8. Is this a dissociative episode, and if so, how do I stop it? Most of the time, my antipsychotics have prevented me from having major dissociative episodes too, mainly ones where I hear voices and the voices take over my body on occassion (but sometimes I remember so I don't know what that falls under, it's more like, when I see what I've written when my body's possessed I'm like. Wait. That's not me.) and I don't want to have any kind of episode like that sometime soon although a lot of my voices are benign. It's relevant to this thing because lately I've been typing things on the computer and then I get into an episode and it feels like a completely different person typed what I said and I'm just a completely different person than like...Francis (my name) Prime or something. Does that make sense? Sorry, I'm rambling, ADHD does that to a person. It's doubly an issue because I'm going to get outpatient therapy soon and I'm afraid if I do something like that in front of them I'll have to get bumped up to inpatient.

Anyway, how do you catch yourself in these episodes and how do you stop them? The only thing that stops/grounds me from my experience is Yuki Kajiura's music.

Bupropion is helping me a lot - I’ve been more productive in the last few days than in previous few weeks!

Household chores don’t require a big mental effort to start & I feel more energy & zest for life!

However I do feel a weird nausea on & off each day.

My face is sometimes red with a purple tint - I go check my blood pressure & it is high.

It’s normally 115/75. It’s often 130/80 on Bupropion.

I’ve been taking 300mg XR for 2 weeks. I also take 45mg mirtazapine at night and have taken that for years.

The increased Dopamine & Noradrenaline is definitely the missing piece in my mental health medication, but is there an alternative that might feel “healthier”?

The other NDRIs like Ritalin all seem to be addictive.

Thanks

I take 60 mg Cymbalta. Do I need to be off this medication for 2 weeks before M-dosing; or can I  gradually come off Cymbalta while microdosing??

One thing I don’t understand is why mainly the only meds used to treat depression (besides wellbutrin) are ssri’s or snri’s. What about dopamine? Doctors usually won’t prescribe Wellbutrin until at least a couple ssri’s are tried first. I see a major problem here. Depression is usually caused by a lack of serotonin, dopamine, or norepinephrine (or any combination of them). So if an ssri isn’t working, it’s probably because there isn’t a lack of serotonin. There’s likely a lack of dopamine and/or norepinephrine. There should be more medications to treat this. Wellbutrin shouldn’t be the only ndri available. I think cns stimulants like adderall and vyvanse should be used for depression too. Even though they are stimulants they also function as ndri’s.

I was depressed for almost a year. I was put on two different ssri’s and three different snri’s during that time. None of them helped a bit. Some made me more numb, some made me feel worse. They made it harder to concentrate and fucked up my memory. I was diagnosed with adhd shortly after stopping the meds for which I was prescribed adderall. Adderall destroyed my depression. I didn’t even expect it to but it did. My life has vastly improved since starting it. I think it could be of help to people even without adhd. So I wasted all that time trying different ssri’s and snri’s when serotonin wasn’t the problem. It was dopamine.

Just a little rant of some thoughts I have on this subject. Adderall for depression I wanna see it.

There are many instances online of folks with ADHD self-medicating with pseudoephedrine, generally when they've run out of their script meds and are away from home or about to travel, so need a short term solution before they can get another script. I have many symptoms of ADHD which I only came to realise in adulthood were treated - and therefore went unnoticed - during my teenage years due to recurrent sinusitis which involved regular seasonal medicating with pseudoephedrine to treat. There was a time when pseudoephedrine was as regular to me as a multivitamin, and it was only after the sinus issues went away in my early twenties that I realised that my concentration, motivation and ability to actually finish a project are practically non-existent - I chalked this up to a couple of life changes and issues which hit me around then, and only very recently discovered pseudoephedrine's membership of the amphetamine class - and thus began to realise the correlation between my productive years, and the slide into ADHD once I stopped using the stuff. Many things now make sense which didn't before.

For reasons which are very mundane and not something I'd bore the folks here with, I don't at this time want to go down the prescription meds route (essentially, my country's mental healthcare system sucks and it's an absolute nightmare to deal with). Since I made the connection to my past productivity and my past pseudoephedrine use, I have found that self-medicating with pseudoephedrine HCL at the recommended nasal decongestant dosing schedule causes me to have some of the most productive days in living memory, but I'm also aware that many talk of pseudo as a medication with a very unpleasant crash and tolerance effect if one stays on it for too long. With that in mind, lately I've been choosing a day or two per week in which I'll go for it, and schedule things I very much want to focus on and complete for those days. It's going exceptionally well.

I'm just wondering though, can anyone anecdotally describe how far one can push this in terms of consecutive days and frequency, before hitting any of the tolerance or rebound "walls"? I'm in a position now in which I'll be completely alone for most of the next four days and I have a pile of stuff I'd like to accomplish, so I'm tentatively considering going for the full 60mg / 4 times daily for at least today and tomorrow, and possibly going on into Sunday and Monday depending on how things are going.

I understand

Posted this to a few other related subreddits without realising this one existed, and now I feel like a complete eejit 😂 Feels like the best place for it!

There are many instances online of folks with ADHD self-medicating with pseudoephedrine, generally when they've run out of their script meds and are away from home or about to travel, so need a short term solution before they can get another script. I have many symptoms of ADHD which I only came to realise in adulthood were treated - and therefore went unnoticed - during my teenage years due to recurrent sinusitis which involved very regular seasonal medicating with pseudoephedrine to treat. There was a time when pseudoephedrine was as regular to me as a multivitamin, and it was only after the sinus issues went away in my early twenties that I realised that my concentration, motivation and ability to actually finish a project are practically non-existent - I chalked this up to a couple of life changes and issues which hit me around then, and only very recently discovered pseudoephedrine's membership of the amphetamine class - and thus began to realise the correlation between my productive years, and the slide into ADHD once I stopped using the stuff. Many things now make sense which didn't before.

For reasons which are very mundane and not something I'd bore the folks here with, I don't at this time want to go down the prescription meds route (essentially, my country's mental healthcare system sucks and it's an absolute nightmare to deal with). Since I made the connection to my past productivity and my past pseudoephedrine use, I have found that self-medicating with pseudoephedrine HCL at the recommended nasal decongestant dosing schedule causes me to have some of the most productive days in living memory, but I'm also aware that many talk of pseudo as a medication with a very unpleasant crash and tolerance effect if one stays on it for too long. With that in mind, lately I've been choosing a day or two per week in which I'll go for it, and schedule things I very much want to focus on and complete for those days. It's going exceptionally well.

I'm just wondering though, can anyone anecdotally describe how far one can push this in terms of consecutive days and frequency, before hitting any of the tolerance or rebound "walls"? I'm in a position now in which I'll be completely alone for most of the next four days and I have a pile of stuff I'd like to accomplish, so I'm tentatively considering going

What is the overall best dopamine or dopamine-norepinephrine reuptake inhibitor (DRI/DNRI)? No releasers, just reuptake inhibitors.

:)

is there a natural dopamine reuptake inhibitor?

A Dopamine reuptake inhibitor, not a dopamine+noradrenaline reuptake inhibitor