Aldosterone: increase volume with no change in osmolarity (bc it is only causing solvent (water) to follow the solute (Na+) aka not bringing in more water like ADH)
ADH: increase volume but decrease osmolarity (bc ADH causes increased water permeability due to collecting duct)
I am having trouble figuring this out. Aldosterone seems to increase uptake of NA+ ions and increase secretion of K+ ions. Water follow Na+ ions yes, but can't it also be the same for water following K+ ions? And if that's the case, how does water retention increase of sodium ions go in but at same time potassium ions go out. Sort of confused by all this water retention business for aldosterone
Like its effects on blood pressure and in the kidney??
it tends to confuse the life out of me lmao
I’m 29 year old female. Over the last 6 months, I’ve had severe chest pain lasting for about 7 days. My doctor narrowed this down to high blood pressure causing my issues.
I’m in the process of being tested for secondary hypertension. I just received my blood work back and the Aldosterone/Renin Activity ratio was 64, where normal range was less than 25. My aldosterone level was 19.2 ng/dL and my renin was 0.3 ng/dL
My main question is if this is going to be enough information to diagnose secondary hypertension? Are these results conclusive or what more information would be required?
Hi,
For almost two years now, I've had high aldosterone and no one seems to be able to work out why.
For a while it was thought that my diet might be too low in salt, so I upped my salt intake, which caused me to have hypokalemia and an increase in heart palpitations (and my aldosterone and renin levels stayed the pretty much the same as they were before)
My aldosterone is always between 1000 and 1500 pmol/l and my last renin was 8 pg/ml though I don't have the other renin values.
My blood pressure is not high, I do not have low magnesium, and I tested negative for gitelmans.
I've had a CT scan which didn't show a tumour.
If I eat a lot of salt, my potassium gets too low, but it seems to stay at the low end of normal if I follow a really low salt diet. And regardless of whether I have a normal or low salt diet my spot urine sodium is always <5 mmol/l and my spot urine potassium has ranged between 11 and 26 mmol/l.
Has anyone got any ideas what could be going on with me? My endocrinologist seems a bit stumped at the moment.
Thanks!
47F , 220lbs, 5ft 9 in. No health history except for sudden onset hypertension and some strange symptoms along with it such as occasional very intense feelings of adrenaline rush when I am not doing anything. Increased HR with these episodes and very high blood pressure.
I have been to the ER twice in the last 6 months for this and the last time they did a CT of my abdomen and said that my adrenal glands look normal.
Saw cardiologist and heart checks out but I saw these results in my endocrinology chart. I am waiting to hear from the doctor but do these results look like I have hyperaldosteronism?
Aldosterone 12.9 ng/dl
Renin Activity 3.0 ng/dl/hr
Aldosterone/Renin Ratio 4.3
- Sodium and water loss -> hypo-osmolar volume contraction -> reduced blood pressure -> sensed at by granular cells of JGA -> increased renin
BUT...
- Decreased sodium reabsorption at thick loop of Henle -> more sodium presented to macula densa cells -> DECREASED renin production
Are we saying here that reduction in volume trumps increase in sodium delivery to macula densa cells with regards to renin release?
Thank you.
Activation of Renin Angiotensin Aldosterone System (RAAS), leads to an increase of aldosterone levels in COVID-19 patients which may be associated with increased mortality due to cardiac arrest in COVID-19 infected patients. Aldosterone regulates the innate and adaptive immune response by promoting the activation of inflammatory mediators and cells such as monocytes, macrophages, dendritic cells (DCs), and lymphocytes.
I'm a 35 relatively healthy woman. I had my renin, cortisol, DHEA, and aldosterone tested a couple weeks ago. The reason for testing was severe waves of fatigue- sleeping 15 hours some days-, hypertension (sitting at 160/105 daily. Some days in the AM it'll be normal. Seems to come in waves.), anxiety for no apparent reason, high pulse (resting hr is 100-145 bpm), sweating, abdominal and flank pain, and constant dehydration, among other symptoms. I drink an electrolyte mix in my water daily because I feel so thirsty all the time.
The worst part is the fact that my doctor said he thinks it's just depression. He said "when your adrenal labs come back normal, are you going to let me put in a consult with mental health?" Seems the blanket diagnosis for everyone in the care of the VA is depression and PTSD. I do have those issues- but this is so far from depression it's ridiculous. This is physiological exhaustion, pain, and feeling sick day in and day out. When depression hits me, I just take a day to myself and recoup, coming out fine on the other side. I am gainfully employed with the post office, and have a great life. Depression isn't what's causing this.
Labs-
Renin was at 0.85 ng/mL/h (ref range 0.52 to 5.82)
Aldosterone was <1 ng/dL (ref range for time drawn @ 1530 was < or = 21)
Cortisol was 6.3 ug/dL (ref range 2.9-17.2)
DHEA sulfate was 182 mcg/dL (ref range 23-266)
Sodium was normal- 141
Potassium was normal- 4
Got a call from my doc saying all labs were normal this morning. He admitted that he doesn't know much about endocrinology before ordering these. He had no idea what DHEA was and put it in as ADHE in my soap note. I feel that because my sodium and potassium were normal he thinks that's the end all be all. Here's the kicker- they pulled a report from an abdominal CT from 8 YEARS AGO and said it was normal so I'm good..... 😤
I am service connected for a partial disability from the military from adrenal disease that wasn't fully diagnosed and worked up while I was active duty. Now it's in the VA's hands. And they aren't doing anything about it.
I feel awful all day every day. Some days I feel like my body is trying to shut down. If I do any physical exertion it takes me days to recoup my energy- I've been an athlete my entire life, so this isn't normal for me. There has been some talk in the past about adrenal tumors/pheochromocytoma, but that apparently isn't a concern for them now due to the normal CT from 2013.
I feel li
... keep reading on reddit ➡I have been posting a lot on this sub since getting covid back in June '21 and this community have been very supportive so thanks a ton.
As some of you may be aware, I have been complaining of debilitating lightheadedness/vertigo and trouble maintaining balance while walking. I even posted on covid damaging ACE 2 receptors and causing blood pressure/blood flow/circulation issues. I had 24-hour urine test for cortisol and aldosterone, I received my results yesterday. Cortisol turned out extremely high (like 3X maximum level) and aldosterone very low.
Aldosterone is also involved in regulation of blood pressure and electrolytes. This could be why my BP keeps fluctuating all day and gets low BP after eating and having BM.
Did anyone have similar problem post covid? Any suggestions? I'm theorizing that cortisol may be very high due to high inflammation from covid because my gut still hurts or possibly covid disrupting HPA/ACTH. I tried walking for 45 minutes last night and my legs felt very heavy and I was so imbalanced.
Any help is highly appreciated.
Aldosterone & Hearing - Parsemus Foundation One can only hope, at the bottom of the article Parsemus says the people with the patent are working with a pharma company to develop a drug . You can see the patent through a link on the article. Like the old saying, hope springs eternal. Just putting this on here as I find it interesting and someone else may too. article is only 3 days old
Al-DOS-terone helps TWO molecules get reabsorbed (both sodium and water).
Antidiuretic hormone only helps reabsorb water.
I always get the 2 mixed up and coming up with this really helped me lol!
Someone asked if anyone was experiencing low potassium and if it could be related to endo so I did some research and found some interesting articles. I made a post on my profile breaking it down (I still don't understand reddit that much sorry) which I'm linking here in case anyone else is curious.
I’ve had primary AI for almost 13 years and I’ve been on fludrocortisone/florinef and dex all these years (although I was on hydro for the first 8 years) and I’m getting weird aldosterone labs again like I did when I was first diagnosed. My renin and angiotensin II were both very high and my sodium is low both in urinalysis and blood which is normal for me). Does this just confirm that I am “salt wasting” or what else have you guys noticed in your treatment with Florinef over your diagnosis? I need to do a blood pressure reading because I haven’t in a while and will add an edit… just looking for some real life experiences if any one else has faced this.
Hello i was lately reading on rp forum and someone said that sodium/potassium intake must be 1:1 or sodium always little higher than potassium. With other words: if potassium intake is higher than sodium, than aldesterone increase.
The problem is i can't find anywere that rp is saying this or studys that confirm this theory. rp is only saying about the benifits of sodium but nothing about ratio's.
Now i am not sure if this theory word to consider in my diet. can someone back this up?
someone else said: "Don't drink too much liquid (a pint or so consumed quickly causes serotonin release which increases aldosterone which increases water retention and inflammation"
Can someone back this up to?
I am a past steroid abuser. I quit when always getting hypoglycemia and nocturnal seizures. All tests pointed to hypoglycemia. Only have issues afterwards when being a pot head. So I quit that too. Now my labs are showing almost zero renin and aldosterone and 100 dhea. I am on trt at 8mg per day and have in range ultra sensitive estradiol without a ai. When I wear a cgm my bg curve is still showing adrenal insufficiencies. Would taking a 25 mg dhea make anything worse in terms of the adrenal response. I recently found that magnesium glycinate negativity impacted my mood and was causing adrenalized rushes like hypoglycemia but my bg was normal. It improved my 3am sleep maintenance Insomnia . I use acv and figure that's why my renin is low. My bp is normal.
Is low renin and aldosterone a bad thing?
I know low dhea at 46 years old isn't a great thing.
I still carry a shit load of muscle.. like Duane Johnson size. Little more roid gut. I'm 6'2 280 lb with a 36-in waist.
I am completely straight edge do not even use caffeine or alcohol and I drink 2 gallons of water a day and that keeps my urine just that straw color.
All of my endocrinologists are all clueless I've gone to Stanford and UCSF and most of them are just blaming my past steroid use.
I normally go 3 to 4 years between seizures unless I'm using marijuana and generally I'll begin getting hot flashes and tingly lips and shaky hands within about 2 months.
If anybody could give me some insight on what DHEA is going to do I'm getting the delivery from Amazon today and I'm just wondering if it's going to make anything substantially worse.
Hopefully you guys are all having a good day and I appreciate your help.
My regular doctor ordered some blood work...
My aldosterone levels were .9 ng/dL on a scale of 0-30 !!!
My aldos/renin ratio levels was .5 ng/dL on a scale of 0-30 !!!
** I am being referred to an endocrinologist but my appointment is not for another 2 months so I'm trying to learn a little on my own about this.
I haven’t been feeling great so my dr ordered a bunch of different tests. Everything came back normal except for high Aldosterone. Potassium and renin were normal and I actually have low blood pressure so my dr wanted me to retake the aldosterone test since I don’t really fit those symptoms. When I retook the test the results were even higher. Any idea why my aldosterone could be high but I don’t fit the symptoms? Should I be worried? Any tips on how to lower aldosterone levels?
Thanks!
Hi, I was wondering if anyone has any idea why someone may present very high aldosterone but normal blood pressure, and I also have many symptoms of LOW ALDOSTERONE? (like very strong fatigue, salt cravings, lots of thirst)
I also have hypothyroidism, high prolactin, high estrogen, low Testosterone, low progesterone... in case this gives some clues
Dose aldosterone increase or decrease blood pressure?
Someone asked if anyone was experiencing low potassium and if it could be related to endo so I did some research and found some interesting articles. I made a post on my profile breaking it down (I still don't understand reddit that much sorry) which I'm linking here in case anyone else is curious.
how does ADH help with water retension where aldosterone can help with BOTH water and sodium?
My regular doctor ordered some blood work...
My aldosterone levels were .9 ng/dL on a scale of 0-30 !!!!!!!
My aldos/renin ratio levels was .5 ng/dL on a scale of 0-30!!!
** I am being referred to an endocrinologist but my appointment is not for another 2 months so I'm trying to learn a little on my own about this.
Male, 5'10", 170 pounds, main symptoms: insomnia, anxiety, debilitating fatigue, hair loss, brain fog, confusion, low appetite, cortisol levels/ACTH pretty normal though....
I haven’t been feeling great so my dr ordered a bunch of different tests. Everything came back normal except for high Aldosterone. Potassium and renin were normal and I actually have low blood pressure so my dr wanted me to retake the aldosterone test since I don’t really fit those symptoms. When I retook the test the results were even higher. Any idea why my aldosterone could be high but I don’t fit the symptoms? Should I be worried? Any tips on how to lower aldosterone levels?
Thanks!
