I’m 29 year old female. Over the last 6 months, I’ve had severe chest pain lasting for about 7 days. My doctor narrowed this down to high blood pressure causing my issues.
I’m in the process of being tested for secondary hypertension. I just received my blood work back and the Aldosterone/Renin Activity ratio was 64, where normal range was less than 25. My aldosterone level was 19.2 ng/dL and my renin was 0.3 ng/dL
My main question is if this is going to be enough information to diagnose secondary hypertension? Are these results conclusive or what more information would be required?
Is it western blot?
https://doi.org/10.3390/nu13103357
https://pubmed.ncbi.nlm.nih.gov/34684358
Abstract
BACKGROUND
Obesity increases the severity of SARS-CoV-2 outcomes. Thus, this study tested whether obesogenic and ketogenic diets distinctly affect SARS-CoV-2 entry proteins and the renin-angiotensin system (RAS) in rat pulmonary and cardiac tissues.
METHODS
Male Sprague-Dawley rats were fed either standard chow (SC), a high-fat sucrose-enriched diet (HFS), or a ketogenic diet (KD) for 16 weeks. Afterwards, levels of angiotensin converting enzyme 2 (ACE2), transmembrane protease serine 2 (TMPRSS2), RAS components, and inflammatory genes were measured in the lungs and hearts of these animals.
RESULTS
In the lungs, HFS elevated ACE2 and TMPRSS2 levels relative to SC diet, whereas the KD lowered the levels of these proteins and the gene expressions of toll-like receptor 4 and interleukin-6 receptor relative to HFS. The diets did not alter ACE2 and TMPRSS2 in the heart, although ACE2 was more abundant in heart than lung tissues.
CONCLUSION
Diet-induced obesity increased the levels of viral entry proteins in the lungs, providing a mechanism whereby SARS-CoV-2 infectivity can be enhanced in obese individuals. Conversely, by maintaining low levels of ACE2 and TMPRSS2 and by exerting an anti-inflammatory effect, the KD can potentially attenuate the severity of infection and migration of SARS-CoV-2 to other ACE2-expressing tissues.
------------------------------------------ Info ------------------------------------------
Open Access: True
Authors: Daniel Da Eira - Shailee Jani - Rolando B. Ceddia -
Additional links:
Hi,
For almost two years now, I've had high aldosterone and no one seems to be able to work out why.
For a while it was thought that my diet might be too low in salt, so I upped my salt intake, which caused me to have hypokalemia and an increase in heart palpitations (and my aldosterone and renin levels stayed the pretty much the same as they were before)
My aldosterone is always between 1000 and 1500 pmol/l and my last renin was 8 pg/ml though I don't have the other renin values.
My blood pressure is not high, I do not have low magnesium, and I tested negative for gitelmans.
I've had a CT scan which didn't show a tumour.
If I eat a lot of salt, my potassium gets too low, but it seems to stay at the low end of normal if I follow a really low salt diet. And regardless of whether I have a normal or low salt diet my spot urine sodium is always <5 mmol/l and my spot urine potassium has ranged between 11 and 26 mmol/l.
Has anyone got any ideas what could be going on with me? My endocrinologist seems a bit stumped at the moment.
Thanks!
I haven’t been feeling great so my dr ordered a bunch of different tests. Everything came back normal except for high Aldosterone. Potassium and renin were normal and I actually have low blood pressure so my dr wanted me to retake the aldosterone test since I don’t really fit those symptoms. When I retook the test the results were even higher. Any idea why my aldosterone could be high but I don’t fit the symptoms? Should I be worried? Any tips on how to lower aldosterone levels?
Thanks!
I am a past steroid abuser. I quit when always getting hypoglycemia and nocturnal seizures. All tests pointed to hypoglycemia. Only have issues afterwards when being a pot head. So I quit that too. Now my labs are showing almost zero renin and aldosterone and 100 dhea. I am on trt at 8mg per day and have in range ultra sensitive estradiol without a ai. When I wear a cgm my bg curve is still showing adrenal insufficiencies. Would taking a 25 mg dhea make anything worse in terms of the adrenal response. I recently found that magnesium glycinate negativity impacted my mood and was causing adrenalized rushes like hypoglycemia but my bg was normal. It improved my 3am sleep maintenance Insomnia . I use acv and figure that's why my renin is low. My bp is normal.
Is low renin and aldosterone a bad thing?
I know low dhea at 46 years old isn't a great thing.
I still carry a shit load of muscle.. like Duane Johnson size. Little more roid gut. I'm 6'2 280 lb with a 36-in waist.
I am completely straight edge do not even use caffeine or alcohol and I drink 2 gallons of water a day and that keeps my urine just that straw color.
All of my endocrinologists are all clueless I've gone to Stanford and UCSF and most of them are just blaming my past steroid use.
I normally go 3 to 4 years between seizures unless I'm using marijuana and generally I'll begin getting hot flashes and tingly lips and shaky hands within about 2 months.
If anybody could give me some insight on what DHEA is going to do I'm getting the delivery from Amazon today and I'm just wondering if it's going to make anything substantially worse.
Hopefully you guys are all having a good day and I appreciate your help.
https://doi.org/10.3390/nu13020480
https://pubmed.ncbi.nlm.nih.gov/33572630
Abstract
The brain renin-angiotensin system (RAS) has been recently involved in the homeostatic regulation of energy. Our goal was to analyse the influence of a diet rich in saturated fatty acids (butter) against one enriched in monounsaturated fatty acids (olive oil) on hypothalamic RAS, and their relationship with the metabolism of fatty acids. Increases in body weight and visceral fat, together with an increase in aminopeptidase A expression and reductions in AngII and AngIV were observed in the hypothalamus of animals fed with the butter diet. In this group, a marked reduction in the expression of genes related to lipid metabolism (LPL, CD36, and CPT-1) was observed in liver and muscle. No changes were found in terms of body weight, total visceral fat and the expression of hepatic genes related to fatty acid metabolism in the olive oil diet. The expressions of LPL and CD36 were reduced in the muscles, although the decrease was lower than in the butter diet. At the same time, the fasting levels of leptin were reduced, no changes were observed in the hypothalamic expression of aminopeptidase A and decreases were noted in the levels of AngII, AngIV and AngIII. These results support that the type of dietary fat is able to modify the hypothalamic profile of RAS and the body energy balance, related to changes in lipid metabolism.
------------------------------------------ Info ------------------------------------------
Open Access: True
Authors: Ana Belén Segarra - Germán Domínguez-Vías - José Redondo - Magdalena Martínez-Cañamero - Manuel Ramírez-Sánchez - Isabel Prieto -
Additional links:
For hormonal regulation for blood pressure, in my notes I have that when there’s a decrease in blood volume, then there’s a decrease in blood pressure so the kidneys will release renin which then gets converted into angiotensiogen. Angiotensinogen then converts ? To AT1 then AT2 which is active. It then will Vasoconstrict arteries to increase blood pressure or release aldosterone from the adrenals. The kidneys will retain sodium and water to increase blood volume and blood pressure. Is my pretty basic understanding correct or am I leaving stuff out? Also will AT2 vasoconstrict AND release aldosterone or will it do one or the other? Thanks!
in response to a drop in BP, angiotensin II stimulates the adrenal glands to secrete aldosterone which will then cause the distal convoluted tubule to RETAIN sodium and water, meaning they are kept in the tubules and not reabsorbed back into the blood. how does this then result in blood volume increasing, and therefore BP too? no water is being reabsorbed.
Hello,
I've had a few blood tests now which have all showed that my aldosterone is high, but my renin is in the normal range. (Most recent test: Aldosterone 1350 pmol, renin 55.7)
My endocrinologist just wants to keep doing it again to see if it changes at any point, but that seems strange and my potassium is always borderline low, and I try to keep it up with eating a potassium rich diet.
Does anyone know what could be causing this?
I haven’t been feeling great so my dr ordered a bunch of different tests. Everything came back normal except for high Aldosterone. Potassium and renin were normal and I actually have low blood pressure so my dr wanted me to retake the aldosterone test since I don’t really fit those symptoms. When I retook the test the results were even higher. Any idea why my aldosterone could be high but I don’t fit the symptoms? Should I be worried? Any tips on how to lower aldosterone levels?
Thanks!
I haven’t been feeling great so my dr ordered a bunch of different tests. Everything came back normal except for high Aldosterone. Potassium and renin were normal and I actually have low blood pressure so my dr wanted me to retake the aldosterone test since I don’t really fit those symptoms. When I retook the test the results were even higher. Any idea why my aldosterone could be high but I don’t fit the symptoms? Should I be worried? Any tips on how to lower aldosterone levels?
Thanks!
