TIL Most humans see about a million colors due to three retinal cones: red, green, and blue. Some humans have a fourth cone for orange light and can see 100 million variations in color. thecut.com/2015/02/what-l…
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πŸ‘€︎ u/Papancasudani
πŸ“…︎ Dec 12 2020
🚨︎ report
TIL most birds can’t move their eyes, which are not spherical like in mammals. They are also tetrachomatic, meaning they have 4 retinal cones (primary colors) versus 3 in humans, allowing most birds to see the UV spectrum and distinguish between colors that appear identical to humans. en.wikipedia.org/wiki/Bir…
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πŸ‘€︎ u/LurkmasterGeneral
πŸ“…︎ Apr 11 2017
🚨︎ report
Researchers identify a cellular recycling process in the eye's cone cells called autophagy that they need to function and, in some cases, survive. The researchers believe that if the recycling process can be activated with drugs, the approach may be used to treat or prevent some retinal diseases. medicalxpress.com/news/20…
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πŸ‘€︎ u/drewiepoodle
πŸ“…︎ Oct 29 2015
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Is there any evidence to suggest our brains can generate new colors for wavelengths we don't presently have retinal cones for?

If these are the wavelengths our retinal cones currently respond to, I can't help but wonder what would happen if we could add new cones to respond to a broader spectrum. For instance a cone that peaks at 350 should put us in to ultraviolet, while a cone that peaks at 730 should put us into infrared.

The question then becomes, would the brain generate new colors for these added spectrums? Or is it possible that the color spectrum is complete so to say, and adding more wavelengths would just stretch out the existing color palette that we all know?

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πŸ‘€︎ u/seanalltogether
πŸ“…︎ Aug 24 2010
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In blinding, degenerative eye diseases, the retina (eye's light detector) deteriorates. Johns Hopkins scientists grow working retinal tissue from induced pluripotent stem cells complete with rods and cones that detect light and send nerve signals neomatica.com/2014/07/10/…
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πŸ‘€︎ u/cosmic8
πŸ“…︎ Jul 11 2014
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/u/randomrecombination responds to: TIL most birds can’t move their eyes, which are not spherical like in mammals. They are also tetrachomatic, meaning they have 4 retinal cones (primary colors) versus 3 in humans, allowing most birds to see the UV spectrum and distinguish between colors ... [+31] np.reddit.com/r/todayilea…
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πŸ‘€︎ u/ModisDead
πŸ“…︎ Apr 12 2017
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TIL most birds can’t move their eyes, which are not spherical like in mammals. They are also tetrachomatic, meaning they have 4 retinal cones (primary colors) versus 3 in humans, allowing most birds to see the UV spectrum and distinguish between colors that appear identical to humans. reddit.com/r/todayilearne…
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πŸ‘€︎ u/unremovable
πŸ“…︎ Apr 12 2017
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New study investigates the role of the endocannabinoid system in a rat model of retinal degeneration. A synthetic cannabinoid administered to rats showed a positive benefit (preserving rods and cones). ncbi.nlm.nih.gov/pubmed/2…
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πŸ‘€︎ u/enferex
πŸ“…︎ Feb 11 2014
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Researchers identify a cellular recycling process in the eye's cone cells called autophagy that they need to function and, in some cases, survive. The researchers believe that if the recycling process can be activated with drugs, the approach may be used to treat or prevent some retinal diseases.

This is an automatic summary, original reduced by 69%.


> They've identified in cone cells a cellular recycling process called autophagy that the cells need to function and, in some cases, survive.

> "The idea would be to stimulate the autophagy process and give cone cells more energy so that they could stay alive for as long as possible."

> "Proteins and organelles in the cell get old, and they have to be removed. Autophagy is the process that removes them so the cell can continue to function."

> "When the cells are stressed by starvation, the autophagy pathway is activated, and the cells temporarily digest their own proteins to survive. This process not only cleans out debris but allows the cell to use its own energy stores to keep sending visual signals even when there isn't any external energy to fuel it."

> "Even if you're in the Sahara Desert or some other place with intense sunlight, you can still distinguish shapes and colors. But when we took out the autophagy gene and exposed the mouse cones to bright light, the cells died."

> Ferguson said the experiments demonstrate that autophagy is important to the function and survival of cone cells and key to vision.


Summary Source | FAQ | Theory | Feedback | Top five keywords: cell^#1 cone^#2 autophagy^#3 function^#4 process^#5

Post found in /r/science.

NOTICE: This thread is for discussing the submission topic only. Do not discuss the concept of the autotldr bot here.

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πŸ‘€︎ u/autotldr
πŸ“…︎ Oct 29 2015
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During a Retinal detachment you envision fireworks as your cone cells slowly succumb to lack of oxygen. Fireworks like a final curtosy to all that you have seen during the years. Then a black draper is slowly drawn before you and you will never see again.
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πŸ‘€︎ u/64-17-5
πŸ“…︎ Sep 13 2015
🚨︎ report
Scientists used CRISPR/Cas9-mediated genome editing in situ to reprogram rod cells to become cone-like photoreceptor cells in the retina of mice with retinitis pigmentosa, a cause of blindness, to restore visual function. nature.com/cr/journal/vao…
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πŸ‘€︎ u/mvea
πŸ“…︎ Apr 22 2017
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First Contact - Resurgence- 524

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Vuxten limped into the command center, looking around for the Duty Officer. He motioned at a Treana'ad behind the desk, one Staff Sergeant Nan'Tz.

"Where's Lieutenant Grentip?" Vuxten asked.

"He stepped out to grab us all some dinner, sir," the Treana'ad said. The com clinked and he grabbed it before the second chime. "Headquarters, First Telkan Marine Division, Staff Sergeant Nan'Tz speaking. How can I help you, sir, ma'am, both or neither?"

Vuxten waited for a moment as the Treana'ad Staff Duty NCO forwarded the call to the Bravo Company HHC barracks.

"Sorry about that, sir," the Treana'ad said. "It's been hectic tonight."

"I understand. Who's handling ground to orbit commo?" Vuxten asked.

"5th Signal Brigade. They're on the other side of base, though," the Treana'ad said. "Anything I can help with, sir?"

Vuxten nodded. "I need to put a call through to General NoDra'ak as well as Division Command and whoever's handling MEDCOM out here," he said.

The Treana'ad nodded. "General NoDra'ak and his command staff are actually ground-side, right here at this base," he said. "The MEDCOM Commander is at the base hospital."

Vuxten sighed, glanced at Casey, who was standing against the wall with a neutral expression. "I think you better put me through to the General first."

"Which one?" The Treana'ad asked, putting his hand on the comlink.

"General Vrawgarkwa, she's the current Division Commander," Vuxten said.

Nan'Tz motioned at the ring on the floor by the wall. "I'll shoot it over there, sir."

Vuxten moved over and stood in the ring, activating it with his implant. The security came online. Someone would be able to tell who he was, and that he was talking to someone, but not who and not intercept any data or listen in on the conversation.

He waited while Staff Sergeant Nan'Tz put through the call.

Vrawgarkwa answered, dressed in a PT uniform, her hair messed up. "Yes, Captain?"

"Ma'am, I've just come into possession of what I think may be critical data," Vuxten said.

Vrawgarkwa narrowed her eyes, then shook her head. "You've got a devil's slice of luck, Captain. Let's hear it."

Vuxten inhaled, then launched into it. "Currently, the SUDS inoperative and the cloning banks all keep locki

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πŸ‘€︎ u/Ralts_Bloodthorne
πŸ“…︎ Jun 26 2021
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First Contact - Resurgence- 522

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Major General (Formerly Third Great Grand Most High) Ge'ermo'o stood by the holotank, which was displaying the thirty-eight tanks that had been found destroyed with the tag "IT WAS LIKE THAT WHEN WE GOT HERE" on the ground or on the side of the tank. All of them had caught on fire, had thrown tracks, and were showing massive damage.

The turbo-lift doors opened and General Trucker came in, the hiss and wheeze of his cybernetics loud in the silence of the conference room. With him was General Warkrawk, the Commander of the Corps Maintenance. Following quietly was Gunner Second Class Ha'almo'or, who looked nervous to Ge'ermo'o. General NoDra'ak exited the elevator, the robotic legs of his therapy frame clicking on the deck plating.

They silently gathered around, staring at the holotank.

"That's a lot of Confed tax payer money," NoDra'ak chuckled, lighting his cigarette.

"Indeed," General A'armo'o said.

"So who's idea was this? Speak freely," General NoDra'ak said.

There was silence a moment.

NoDra'ak sighed, puffing smoke out around his two remaining footpads. "I'm not interested in laying blame. As a matter of fact, the undeniable evidence there is something seriously wrong with our new 'supertanks' makes me more concerned about the reality that we may be fielding our troops with faulty equipment. That, gentlemen, is how you lose a war."

There was nods.

Ge'ermo'o held up one hand. "It was my idea, General."

NoDra'ak nodded. "Why?"

Ge'ermo'o pointed at the tanks in the holotank. One was showering trails of sparks like an expensive firework display. "I did not trust the tanks."

"That's it?" General Warkrawk asked, reaching up and smoothing her hair. She had a short cowlick at the front that she patted nervously. "You destroyed almost forty tanks because you 'didn't trust them'?"

Ge'ermo'o nodded. "Observational data caused an instinctive dislike to the new machines. Just the simple act of standing in front of one and staring at it during a scheduled precipitation period, to observe how it appears in the rain, made me instinctively distrust it. There was something in my observations that I was not consciously recognizing that made me distrust the machine in the same way as I would distru

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πŸ‘€︎ u/Ralts_Bloodthorne
πŸ“…︎ Jun 25 2021
🚨︎ report
Scientists used CRISPR/Cas9-mediated genome editing in situ to reprogram rod cells to become cone-like photoreceptor cells in the retina of mice with retinitis pigmentosa, a cause of blindness, to restore visual function.

This is an automatic summary, original reduced by 87%.


> Top of pageDear Editor,We report a gene therapy strategy using CRISPR/Cas9-mediated cellular reprogramming by switching a mutation-venerable/sensitive cell type to a mutation-insensitive/resistant cell type, therefore restoring tissue architecture and function.

> By reprogramming rod to cone-like photoreceptors in situ by inactivating Nrl or Nr2e3, we show an increase in cone-like cells with remarkable concomitant preservation of both cone and rod photoreceptors and retinal tissue, with restoration of visual function.

> Our approach demonstrates the feasibility of cellular reprogramming in preventing degeneration and preserving tissue and function, and points to a novel approach in treating human diseases in a gene and mutation independent manner.

> Gene therapy shows great promise in treating many human diseases, yet a major drawback of the current technology is that it can only be directed to a particular mutation or a single gene at best.

> One approach to overcome the above drawbacks in tissue repair and regeneration is therapeutic cellular reprogramming, which switches a cell type sensitive to a mutation to a functionally related cell type that is resistant to the same mutation.

> Our approach shows promise of cellular reprogramming in preventing degeneration and restoring tissue function, and points to a novel approach in treating human diseases in a gene and mutation independent manner.


Summary Source | FAQ | Theory | Feedback | Top five keywords: cell^#1 gene^#2 rod^#3 cone^#4 retina^#5

Post found in /r/science and /r/Health.

NOTICE: This thread is for discussing the submission topic. Please do not discuss the concept of the [autotldr](http://www.reddit.com/user

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πŸ‘€︎ u/autotldr
πŸ“…︎ Apr 22 2017
🚨︎ report
I was diagnosed with Retinitis Pigmentosa/Rod Cone Dystrophy, can this help?

So long story short, I was recently diagnosed with RP/RCD, and lost a good amount of my vision. Doctors tell me theres nothing I can do and will slowly go blind as I have been. Devastation is an understatement as to how I feel. I am a 26 year old male and struggled my entire life with poverty to finally have a good career and support my family. Anyways, I went to my fiance's sisters house and she invited me to try some special brownies.. 30 minutes later it felt as though someone turned on a light bulb in my eyes.. it was such a crazy experience I couldn't believe it. I felt as though for about 20 minutes, dark spots I see were more bright and easier to see. I have never tried marijuana before in my life until this moment, and the effects were so profound I am thinking about continuing. Do you guys think this will help me out? I am kind of nervous about this as I never tried marijuana before this experience. I am trying to hold on to my vision at all costs, and some research online is indicating it might help. Please let me know your thoughts, and if you have any questions.

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πŸ‘€︎ u/throwaway1sq
πŸ“…︎ Apr 25 2014
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Restoration of visual function in advanced disease after transplantation of purified human pluripotent stem cell-derived cone photoreceptors cell.com/cell-reports/ful…
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πŸ‘€︎ u/StoicOptom
πŸ“…︎ Apr 24 2021
🚨︎ report
First Contact - Fourth Wave - 472 First Telkan

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The Atrekna prepared to attempt harvesting the population of a city a million years in the past, at the very edge of their ability to pull an area that large and that populated. The last times it had been summoned, it was destroyed in a flare of explosives and the searing of chemical weapons.

Two of a Quorum had gotten too close to the city the last time.

The chemical weapons had seared the life from them, scorching nerve bundles, seeming to burn out phasic nerve endings first. They had taken nearly three minutes to die and had screamed the entire time. As it took less than sixty seconds from exposure at one part per eleven million for the cattle to die, the Atrekna suspected that the ferals had used that particular chemical weapon purposefully.

They knew when they began the shift to jungle they would be forced to defend themselves again.

Somehow the ferals were able to discover where they were, and seemed to know that when they shifted the terrain they could no longer stay a half second out of phase with reality.

They had lost nearly twenty Atrekna, each tens of thousands of years old, to those damnable low-tech spears. Normally, the Atrekna didn't care what happened to a dead body, it would be reclaimed and turned into nutrient slurry eventually.

But the last four phases had seen nearly twenty killed, and each time the ferals ran out to grab the fallen body and spirit it away.

Worse, the primitive feral that had landed first was requiring more and more attention. Rather than exhausting itself fighting the slavespawn it seemed to only become more and more active, more and more enraged. Several times it had abandoned high tech weapons to attack with a sword or a spear or a club, roaring out its rage.

So far the Atrekna had found not a single ringslave that could stand face to face with the enraged primate for longer than it took to gain the primate's attention.

Which meant there were even more working to hold the primate in place now, rewinding it through the last hour or so, with it becoming increasingly difficult to do so.

For some reason, the primate's strength was not lessening. It seemed to have a bottomless pit of resources to draw upon and no care abo

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πŸ‘€︎ u/Ralts_Bloodthorne
πŸ“…︎ Apr 14 2021
🚨︎ report
First Contact - Fourth Wave - Chapter 457 - Crying Anne

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The elevator whined as it rattled its way up. It paused, shuddered, then started moving again.

Dee gave a frustrated sigh and shook her head.

"What's wrong?" Dhruv asked, leaning against the wall.

"Your people are fucking children," she said. She pulled out her cigarettes and pulled one from the pack, staring at it for a long moment. "Half a pack. Shit."

"What do you mean?" Dhruv asked. Daxin glared at him, willing him to stop engaging with the obvious lunatic in their midst, but he just smiled back.

Dee touched the button panel, where it was all mechanical push buttons with light up rings around them. "Look at this. This was installed before my tits started sagging, and here it is," she glared at Legion. "Tell me it's the temporal dissonance problems."

Dhruv shrugged. "Could be. I've always presumed Crying Anne was temporally locked to keep the enemy from using temporal munitions against it. A temporal stabilizer would explain this."

"Hmph," Dee said, turning away. "Fucking kids."

"I don't understand why you are upset," Dhruv said, watching her light the cigarette.

"This place should be manned. There should be hundreds, thousands of specially trained military and civilian experts handing this area. It's the central defensive facility in the entire solar system and we're apparently the only living thing here," Dee snarled.

Dhruv shrugged again. "Might be inhospitable to people after a period of time. We're fine, but Daxin and I, we're immortals, and you're whatever you are. Besides, if it had been manned, the crew would have dropped dead when everyone else started dropping like flies."

"Wait, do what now?" Daxin asked, looking up from where he was scratching FIDO's neck.

"Something caused a tissue and engram mismatch in the SUDS, everyone started dying," Dhruv said.

Dee made another noise of disgust. "That's not what happened. The cerebral tissue and DNA reverted somehow to pre-Glassing, which meant the neural overlays you use when you 'reskin' burned the neural tissue. To top it off, the body's immune system went crazy and started attacking the body as well as bioware and cyberware implants," she shook her head. "For someone who's supposedly so s

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πŸ‘€︎ u/Ralts_Bloodthorne
πŸ“…︎ Mar 31 2021
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First Contact - FOURTH WAVE - Chapter 440 - Hesstla

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DAY FOUR - HESSTLA

The communications channels were full of nothing but squealing, static, pops, and hissing. It had started suddenly, a half hour before. Communication was lost almost immediately with any satellite that could not be reached by laser. Quantum communications systems were down at any range further than a hundred meters, radio was available only across certain bandwidths. Laser communication and a thin frequency of microwave was available but that wasn't something that was guaranteed to last.

Undrat had spent over two hours helping lay direct wire communication line between the fire positions. Armored pipe with internal mesh then the cable inside, buried under the ground at the standard six inches deep.

It had been good work, work Undrat was proud of as he returned to the firing position and went to the back of the firing position. There he removed his armor and cleaned off, ate, and relaxed on his bunk. Undrat used his retinal link to study the field manuals on interservice operations, taking time to look over the new section on emergency communications.

YOU BELONG TO US rang out again, as it had for the last day and a half.

THEN COME GET SOME! roared back, with DEEZ NUTZ MAYBE! following.

The last day and a half the Terran Space Force had been fighting the invaders, tentatively identified as Precursor Species Nine. Undrat had heard that there had been some landings, small forces that had managed to fight through the Space Force interdiction, get through the orbital defense systems, and then get through the ground defense systems.

Fourteen hours ago the Marines of the Third Telkan Marine Division had rolled out to start striking at the recently landed enemy. From what Undrat had heard, almost the entire Division was engaged in combat now.

Which was why Undrat was paying particular attention to the Telkan Marine section of the inter-service operations field manual.

Private Second Class Erkolt came over and sat down, wiping his hands off with a rag. He waited politely until Undrat bookmarked the section he was reading. Undrat sat up, putting his hands on his knees, and looked at Erkolt.

"Your armor is in fully serviceable condition

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πŸ‘€︎ u/Ralts_Bloodthorne
πŸ“…︎ Mar 13 2021
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First Contact - Fourth Wave - Chapter 445

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Huddled down with the babies, her face turned toward the firewall, her upper body shifted so that it was between the outside and the babies, Aunt Fenn shrieked when the white light seemed to fill the air, almost like it was streaming through the firewall. Nee and the unnamed baby took the opportunity to bite her arm, the baby just gumming and gnawing, Nee sinking her little teeth deep into Fenn's arm. There was a loud explosion, a sharp crack like a glass pane meters thick breaking in half on a cold winter's day, with another flash of white light. Then red light.

The car suddenly rocked up on the shocks, tilting slightly.

It wasn't a noise. It was a pressure that squeezed, combined with heat that made her pant and slicked her fur with sweat that ran down her face. The car slammed back down with the squeak of overstressed shocks, then rocked slightly.

"STAY IN THE CAR!" Dambree yelled.

Aunt Fenn hold the babies closer, the bite from Nee no longer hurting. The taste of blood had made Nee close her eyes, made her jaw relax, as her feral little brain released endorphins.

Fenn squeezed her eyes shut.

Don't cry! she heard her niece yell at her in her memories. Then the deadpan voice, leeched of all emotion. Let it turn to something else.

Part of her wanted to start screaming. Part of her brain kept trying to show her all the memories. The squelching sound of the sharp metal rod popping the male's eyeball as Dambree jammed it into his eye socket. The crunch of bone under the sound of the can hitting the square base the rod was attached to. The dead look on her niece's face, as if she was merely hammering a nail into a board. The way she had gone into the house alone, covered the bodies, and came out as if she had merely gone upstairs to check on a sleeping sibling.

The dead expression on the girl's face since the sirens went off.

She felt like she had failed. Not only her poor niece, who had been trapped on the surface during the long war, but her sister, dead since the initial invasion. The baby nuzzled her and she shifted to keep it from biting her chest.

There was words, painful sobbing gagging words.

THWACK!

She could hear something burning, smell burning synthetic

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πŸ‘€︎ u/Ralts_Bloodthorne
πŸ“…︎ Mar 17 2021
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DAD JOKES ARE NOT DIRTY.

Go post NSFW jokes somewhere else. If I can't tell my kids this joke, then it is not a DAD JOKE.

If you feel it's appropriate to share NSFW jokes with your kids, that's on you. But a real, true dad joke should work for anyone's kid.

Mods... If you exist... Please, stop this madness. Rule #6 should simply not allow NSFW or (wtf) NSFL tags. Also, remember that MINORS browse this subreddit too? Why put that in rule #6, then allow NSFW???

Please consider changing rule #6. I love this sub, but the recent influx of NSFW tagged posts that get all the upvotes, just seem wrong when there are good solid DAD jokes being overlooked because of them.

Thank you,

A Dad.

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πŸ‘€︎ u/Von_Bostaph
πŸ“…︎ Jun 18 2021
🚨︎ report
There are only two white people in the movie Black Panther

Martin Freeman, and Andy Serkis.

They also play roles in Lord of the Rings.

I guess that makes them the Tolkien white guys.

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πŸ‘€︎ u/jzagri
πŸ“…︎ Jun 24 2021
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ELI5: why is it that if we look at special reverse color pictures 30 seconds, then look away and blink you see the picture in color
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πŸ‘€︎ u/LarzzzLeonLove
πŸ“…︎ Feb 08 2021
🚨︎ report
What did the left eye say to the right eye when they got married?

'Eye-do'

This is my first post pls don't kill me lol.

The people in the comment section is why I love this subreddit!!

Cred once again my sis wants credit lol

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πŸ‘€︎ u/tieyz
πŸ“…︎ Jun 27 2021
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What was a very common name in the middle ages?

I heard parents named their children lance a lot.

First post please don't kill me

Edit: i went to sleep and now my inbox is dead, thank you kind strangers for the awards!

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πŸ“…︎ Jun 24 2021
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Apologies if it's a bit corn-y
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πŸ‘€︎ u/mediashiznaks
πŸ“…︎ Jun 26 2021
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so many choices
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πŸ‘€︎ u/SailorNebula
πŸ“…︎ Jun 07 2021
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He knows too much
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πŸ‘€︎ u/Potato_salad123
πŸ“…︎ Jun 24 2021
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Well that didn't cross my mind
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πŸ‘€︎ u/JasonPetreasCoach
πŸ“…︎ Jun 11 2021
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where do pirates get their hooks?

second hand stores!

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πŸ‘€︎ u/bigus-_-dickus
πŸ“…︎ Jun 25 2021
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