I was taught that DNA is a very stable molecule which is very resistant to radiation because of the nature of the bonding and that it was only susceptible to damage when un woven . So if this teaching is correct , why isn’t the S phase of the cell cycle , the phase where the whole genome is un woven and replicated, the most radio sensitive ? But counterintuitively it is the most radio resistant phase? I couldn’t get answers at school so I would be elated if someone could help me out with this.
or at any time? or does your body have the same "level" of sensitivity at all times?
Hi ! I was wondering what resources you have used to learn more about radiosensitizers ?
Nimorazole belongs to the imidazole‐based family of antibiotics to fight against anaerobic bacteria. Moreover, nimorazole is now in Phase 3 clinical trial in Europe for potential use as a hypoxia radiosensitizer for treatment of head and neck cancers. We envision the use of [ 15 N 3 ]nimorazole as a theragnostic hypoxia contrast agent that can be potentially deployed in the next‐generation MRI‐LINAC systems. Here, we report the first but very important steps to create long‐lasting (for tens of minutes) hyperpolarized state on three 15 N sites of [ 15 N 3 ]nimorazole with T 1 of up to ~6 minutes. The nuclear spin polarization was boosted by ~67000‐fold at 1.4 T (corresponding to P 15N of 3.2%) via 15 N‐ 15 N spin‐relayed SABRE‐SHEATH hyperpolarization technique relying on simultaneous exchange of [ 15 N 3 ]nimorazole and parahydrogen on polarization transfer Ir‐IMes catalyst. The isomeric side product of [ 15 N 3 ]nimorazole synthesis was hyperpolarized too. The presented results pave the way to efficient spin‐relayed SABRE‐SHEATH hyperpolarization of a wide range of imidazole‐based antibiotics and chemotherapeutics.
https://ift.tt/3dvAZIg
Do your worst!
It really does, I swear!
For context I'm a Refuse Driver (Garbage man) & today I was on food waste. After I'd tipped I was checking the wagon for any defects when I spotted a lone pea balanced on the lifts.
I said "hey look, an escaPEA"
No one near me but it didn't half make me laugh for a good hour or so!
Edit: I can't believe how much this has blown up. Thank you everyone I've had a blast reading through the replies 😂
They’re on standbi
Pilot on me!!
Buenosdillas
Dad jokes are supposed to be jokes you can tell a kid and they will understand it and find it funny.
This sub is mostly just NSFW puns now.
If it needs a NSFW tag it's not a dad joke. There should just be a NSFW puns subreddit for that.
Edit* I'm not replying any longer and turning off notifications but to all those that say "no one cares", there sure are a lot of you arguing about it. Maybe I'm wrong but you people don't need to be rude about it. If you really don't care, don't comment.
What did 0 say to 8 ?
" Nice Belt "
So What did 3 say to 8 ?
" Hey, you two stop making out "
