https://www.frontiersin.org/articles/10.3389/fnut.2021.682243/full

> # Ketogenic Metabolic Therapy, Without Chemo or Radiation, for the Long-Term Management of IDH1-Mutant Glioblastoma: An 80-Month Follow-Up Case Report > > > Background: Successful treatment of glioblastoma (GBM) remains futile despite decades of intense research. GBM is similar to most other malignant cancers in requiring glucose and glutamine for growth, regardless of histological or genetic heterogeneity. Ketogenic metabolic therapy (KMT) is a non-toxic nutritional intervention for cancer management. We report the case of a 32-year-old man who presented in 2014 with seizures and a right frontal lobe tumor on MRI. The tumor cells were immunoreactive with antibodies to the IDH1 (R132H) mutation, P53 (patchy), MIB-1 index (4–6%), and absent ATRX protein expression. DNA analysis showed no evidence of methylation of the MGMT gene promoter. The presence of prominent microvascular proliferation and areas of necrosis were consistent with an IDH-mutant glioblastoma (WHO Grade 4). > > Methods: The patient refused standard of care (SOC) and steroid medication after initial diagnosis, but was knowledgeable and self-motivated enough to consume a low-carbohydrate ketogenic diet consisting mostly of saturated fats, minimal vegetables, and a variety of meats. The patient used the glucose ketone index calculator to maintain his Glucose Ketone Index (GKI) near 2.0 without body weight loss. > > Results: The tumor continued to grow slowly without expected vasogenic edema until 2017, when the patient opted for surgical debulking. The enhancing area, centered in the inferior frontal gyrus, was surgically excised. The pathology specimen confirmed _IDH1-_mutant GBM. Following surgery, the patient continued with a self-administered ketogenic diet to maintain low GKI values, indicative of therapeutic ketosis. At the time of this report (May 2021), the patient remains alive with a good quality of life, except for occasional seizures. MRI continues to show slow interval progression of the tumor. > > Conclusion: This is the first report of confirmed IDH1-mutant GBM treated with KMT and surgical debulking without chemo- or radiotherapy. The long-term survival of this patient, now at 80 months, could be due in part to a therapeutic metabolic synergy between KMT and the IDH1 mutation that simultaneously target the glycolysis and glutaminolysis pathways

I have been dealing with thyroid cancer for about five years now. I've had three surgeries to the neck and have gone through radioactive iodine twice. After this most recent surgery I was directed to receive radiation therapy instead. I had the mask made, with some difficulty, and when the day came to do a dry run simulation... the moment they put the mask on me I panicked and they had to reschedule me to try again in a couple days.

It was so tight that I felt like I couldn't breathe, not to mention how restrictive it is. I understand that preventing movement is the entire point, but feeling like I'm going to choke at any second... only being able to breathe out of one nostril... I don't know if I can do this once, let alone for six weeks. Do any of you that have gone through this have anything that they did that could help? Suggestions, things they asked their doctor for, alternatives... anything?

My mother has stage 2 oral cancer and finished her chemotherapy just yesterday. From 4th of July she will start her radiation therapy. The doctors recommended inserting a feeding tube during her course of radiation.

I’m kinda worried about it. Are they helpful during the treatment ? Are they temporary ?

I need some insights about it since I have no clue.

Hello! I've been a long-time member of this subreddit, and recently I've found myself in need of some guidance. I'm a fairly recent graduate (December 2020), and have been working in the field for a little over 6 months. The clinic I work at has two Locum therapists, due to the therapist shortage where I live. I actually just moved to the area because of the shortage and their staffing needs.

Anyway, I got to talking with one of the Locums and I realized that I have a great interest in doing travel work myself. I've moved around a fair amount in my adult life, and so I'm familiar with what that entails. I also love the challenge of encountering new clinics, new staff, and new ways of approach.

I'm pretty fortunate because my current clinic does a lot--SRT-100 superficial treatments, brachytherapy, external beam via TruBeam, SBRTs (no SRTs because there's a gamma knife nearby, however), PET/CT sim, and they're currently putting in a proton therapy machine and integrating MRI into their sim planning--I will gain a lot of valuable experience here.

My thoughts are to get a year or two of experience under my belt, then seriously look into traveling. I am married to an awesome dude who is very supportive and would work remotely, and we have two cats. I know the biggest hurdle would likely be housing because of the cats. I'm up for the challenge though!

Anywho, I've come to you all to ask if there are any travel therapists among you willing to share your experiences, the pros and cons. I would very much appreciate any advice!

I was just dx with DCIS and IDC on left side (plus another mass was found during MRI...biopsy is on 30th) and atypical cells requiring a good size of tissue removal on the right side. I just found out on Monday. My surgeon highly recommended partial mastectomies with radiation therapy and cosmetic reconstruction and lifts to be done at the same time. She will also be removing 3-4 sentinent lymph nodes as well.

So to occupy my brain I am starting to figure out what I need to buy for my recovery.

I've read about a cream with calendula to help with radiation that I plan on getting, but what else do you recommend?

Certain pillows, bras or camis for radiation therapy, what type of tops should I wear right after surgery? Anything else?

TIA

A few weeks ago I was diagnosed with brain cancer a Stage 4 Glioblastoma to be exact. They got out 97% of it during a operation, which if I survive safed me. And on Monday I've started my chemo and radiation therapy and it seems to be going fine I didn't have had any big problems except for Monday when I threw up. I am quite happy right now and I hope that fucker gets his ass grilled from the radiation

So I live in Canada and my doctor said he does refer people to the USA for proton therapy, but he said that it wouldn't be beneficial in my case because the dose of radiation that will hit my heart is 9GY which is within the limit and it wouldn't be approved.

He also said that a lot of the push for proton radiation in the USA is a marketing tactic and that it really isn't much more beneficial for people with lymphoma.

Is this true?

Dads currently undergoing radiation therapy and we are looking to find some foods he can actually taste anyone got any ideas i know its a stretch.

I was just wondering if anyone knows about the job market in Toronto for radiation therapists. I saw that there were less hospital partners within the radiation therapy program than with rad technology and nuclear medicine. I am worried that I am going to have a harder time finding work within Toronto as their are only a few hospitals that have a radiation therapy sector. Is there anyone from Rad therapy who could let me know how many spots are allocated to each hospital and if they usually got their first or 2nd choice hospital?

I am planning to go to El Camino College for their radiologic technology program to become an MRI tech. I was just wondering if that's a good idea or are there better programs I should look into?

Hello guys. I hope everyone is healthy and prospering. I start radiation therapy today for 4 weeks. Is there any tips and tricks you guys can share with me? I’m a little nervous about my skins reaction and the fatigue I heard comes with it, I workout 6 times a week and don’t want to stop my lifestyle because of this.

Hello. I worked as a card dealer for a Native American casino. I used Intermittent Leave to cover absences caused by chemotherapy treatment over the course of 4 months. After chemo came radiation, every weekday. My Intermittent Leave expired. During the period I was receiving radiation treatment I made an ER visit and was diagnosed with a blood clot in my internal jugular vein, put on blood thinning medication and told by my oncologist not to return to work until he said to. This was conveyed in writing to the casino HR department.

The blood clot was a result of having an access port in my chest for chemotherapy treatment. The removal surgery was re-scheduled because they would not perform the procedure while I am on blood thinners. It was performed later that week. It was during this week of waiting for the surgery and going to radiation every weekday afternoon that I was terminated. I wasn’t notified my absences would affect my job standing and later found out I was terminated when I received the papers in the mail. I was under the assumption I was to stay home as ordered by my oncologist, plus I had the surgery planned then re-scheduled during that same week.

I elected to appeal my termination and evidently the General Manager has ten (10) working days to respond to my grievance but it has been a month and I haven’t heard from the casino. In my appeal letter I made no demands but rather stated I made a mistake by not knowing my schedule better and asked for forgiveness.

Until I was terminated I had minimal absences from work and was tardy two (2) times but not since around 2019 (I would have to look that up. It wasn’t recent, for sure). I wasn’t disciplined, as per the employee handbook, for any of the three (3) days on which I didn’t call in. I missed those days during that week and was terminated.

My radiation is now done. I am still on blood thinners and will be for at least another few months according to my radiologist. My health insurance coverage expired at the end of February. I don’t know what do do next because I have not heard the decision regarding my appeal. I did enroll in an insurance program through the marketplace yesterday as I am almost out of medication and a lapse may not be good for me.

This was at a Native American casino on their land. I have no idea how state or federal laws apply. I am not a Native American.

Can anything be done? Please ask if you need more details; it’s a lot to unpack given my condition a

Hi there, I’m deciding between these two careers. So far, I have a bit of a grasp on certain differences between the two in terms of lifestyle (RRT more 9-5 and long term patient care vs RT more OT, weekends and night shifts, no long term patient care), But I’m interested in knowing more about salaries and opportunities for promotion between the two? From what I understand, it seems like with radiology tech, you have more opportunity to learn and grow in different specializations like MRI, PET, CT, etc. BUT, it apparently pays less (right out the gate at least)?

Whereas, radiation pays a bit more right out the gate but it seems like there’s not a ton of room for growth? I could be totally wrong about this, so I’m wondering if anyone here has experience with these two professions and if they could help clear up the differences for me? Thank you.

Edit: TECHNOLOGIST** I apologize for that error in the subject line.

I have been dealing with thyroid cancer for about five years now. I've had three surgeries to the neck and have gone through radioactive iodine twice. After this most recent surgery I was directed to receive radiation therapy instead. I had the mask made, with some difficulty, and when the day came to do a dry run simulation... the moment they put the mask on me I panicked and they had to reschedule me to try again in a couple days.

It was so tight that I felt like I couldn't breathe, not to mention how restrictive it is. I understand that preventing movement is the entire point, but feeling like I'm going to choke at any second... only being able to breathe out of one nostril... I don't know if I can do this once, let alone for six weeks. Do any of you that have gone through this have anything that they did that could help? Suggestions, things they asked their doctor for, alternatives... anything?

Ketogenic Metabolic Therapy, Without Chemo or Radiation, for the Long-Term Management of IDH1-Mutant Glioblastoma: An 80-Month Follow-Up Case Report

Case Reports Front Nutr

. 2021 May 31;8:682243. doi: 10.3389/fnut.2021.682243. eCollection 2021.

Ketogenic Metabolic Therapy, Without Chemo or Radiation, for the Long-Term Management of IDH1-Mutant Glioblastoma: An 80-Month Follow-Up Case Report

Thomas N Seyfried 1, Aditya G Shivane 2, Miriam Kalamian 3, Joseph C Maroon 4, Purna Mukherjee 1, Giulio Zuccoli 5Affiliations expand

• PMID: 34136522
• PMCID: PMC8200410
• DOI: 10.3389/fnut.2021.682243

Free PMC article

Abstract

Background: Successful treatment of glioblastoma (GBM) remains futile despite decades of intense research. GBM is similar to most other malignant cancers in requiring glucose and glutamine for growth, regardless of histological or genetic heterogeneity. Ketogenic metabolic therapy (KMT) is a non-toxic nutritional intervention for cancer management. We report the case of a 32-year-old man who presented in 2014 with seizures and a right frontal lobe tumor on MRI. The tumor cells were immunoreactive with antibodies to the IDH1 (R132H) mutation, P53 (patchy), MIB-1 index (4-6%), and absent ATRX protein expression. DNA analysis showed no evidence of methylation of the MGMT gene promoter. The presence of prominent microvascular proliferation and areas of necrosis were consistent