Seen on the Aspen Alert...
A pre-print in BioRxiv from the biotechnology company Sinovac, describes protection of macaque monkeys from infection by SARS-CoV-2 by a vaccine candidate. The candidate is a "killed virus" vaccine prepared by inactivating live virus with beta-Propriolactone, a standard procedure used in inactivate other viruses for use as vaccines. This is possibly the first published report of protection of non-human primates by a COVID-19 vaccine candidate. The vaccine candidate administered day 0 and day 7 elicited strong antibody responses that neutralized all eleven strains of SARS-CoV-2 isolated in China and several European countries.
EDIT: Here's the official pre print. A little sparse on data but it is what it is.
Gorillas, Chimp, Orangutans and etc.
https://en.m.wikipedia.org/wiki/Yerkish
Hi Reddit,
My name is Roger Lemon, I am a just-retired Professor of Neurophysiology at the Institute of Neurology, UCL, where I worked for 22 years, after university posts in Sheffield, Melbourne, Rotterdam and Cambridge. I am a Fellow and past Council Member of the Academy of Medical Sciences.
My main research interest is the control of skilled hand movements by the brain and is prompted by the need to understand why hand and finger movements are particularly affected by damage to the cortex, and its major descending pathways, for instance as a result of stroke, spinal injury and motor neuron disease. My experiments involve the use of purpose-bred non-human primates, since these provide the best available model for the human sensorimotor system controlling the hand.
My research is complemented by parallel studies in normal human volunteers and in patients: interactions between discoveries gained from work in monkeys and understanding the effects of neurological disorders on hand function in patients has been an important part of my career, especially when working at the Institute of Neurology, a world centre for the treatment of neurological disorders. I have helped to develop better ways of studying the human motor system, to understand the process of recovery after injury and to investigate therapies that might enhance recovery.
I am firmly of the opinion that we still need some research in monkeys to understand the complex functions of the human brain. This is fundamental research aimed at understanding normal brain function in, for example, learning, memory, emotion and, my own research area, motor skill. I believe that this work should only be carried out with careful regulation that ensures responsible, high-quality research and requires the highest possible welfare standards, driven by application of the 3Rs.
I am also keen to explain that without supporting this basic type of research, we will not get the translational benefits that results from a small but important fraction of the work that leads on to impact on the clinical conditions such as those listed above.
So I am a strong advocate for better engagement between scientists and the public about how we use animals in science, which has been vital for much of my own research.
This is my first AMA, Iβm here to talk about the neuroscience of skilled movement, the miracle of the human hand, and how it is disrupted by dis
... keep reading on reddit β‘
There is a study from 2005, where they gave baboons and squirrel monkeys oral administration of Adderall like mix (3:1 dex/lev amphetamine) at human-like clinical doses for about 4 weeks. After treatment, they found a significant reduction in striatal dopamine concentration, DAT site density, and VMAT site density.
Question is, are these just temporary down-regulation or are these changes long-lasting? Are there any other studies that are done on this?
I have found one study on vervet monkeys where they injected an extremely high concentration of Methamphetamine into their bloodstream (2 x 2mg/kg, 6 hours apart). They noticed a reduction in immunoreactivity of TH, DAT, and VMAT that lasted a long time. About 1.5 years later it did mostly recover to control. Although this study shows that significant damage can be done by extreme IV acute dose, and the brain can regenerate, it's not exactly relevant to ADHD patients since prescription amphetamine (not meth) is taken orally and at a much lower dosage.
Like... The bear worship, fire worship, sun worship, etc. are probably the same exact things that amaze and mystify other primates. We are just eventually able to put them into language and expand upon them.
... yes I got high before I showered.
Can someone explain the differences of matrilinear and patrilinear social structure in non- human primates?
A pre-print in BioRxiv from the biotechnology company Sinovac, describes protection of macaque monkeys from infection by SARS-CoV-2 by a vaccine candidate. The candidate is a "killed virus" vaccine prepared by inactivating live virus with beta-Propriolactone, a standard procedure used in inactivate other viruses for use as vaccines. This is possibly the first published report of protection of non-human primates by a COVID-19 vaccine candidate. The vaccine candidate administered day 0 and day 7 elicited strong antibody responses that neutralized all eleven strains of SARS-CoV-2 isolated in China and several European countries.
I know the link is for a Forbes article. I haven't tracked down the preprint yet...
