Motility Puns

Hi all. I wanted to know if there is any hope for me to continue Nardil. Im having severe chronic gastrointestinal issues:

• Chronic constipation
• Slow/absent gut motility
• Outlet obstruction/pelvic floor issues
• Severe bloating

I never feel the urge to have a bm anymore. Only way i can is by using stimulant laxatives/enema once a week. I have tried pretty much everything to no avail; Miralax, prune juice, magnesium, fiber, drinking more water, Linzess and Motegrity to induce better motility/peristaltism. None of it has worked besides laxatives. Is there anything else i might try? Or am i doomed to come off? Even at 45mg i have these issues, and below that Nardil becomes ineffective for me. Fyi Im on 60mg Nardil and i have ibs.

I thought I had IBS my whole life. I’m 22 now. I’ve never been able to gain weight despite lifting weights obsessively on tons of different workout plans including ones made specifically for me by professionals, I’ve always been fatigued all day, I’ve slept in for most of life way past an acceptable healthy time (2-5pm on weekends), nearly every meal has caused me pain despite trying month long (in most cases way over a month) obsessive diets including counting exact calories (still no weight gain in 1k surplus), lactose free, gluten free, vegan, vegetarian, carnivore, and others I can’t remember right now. No one has ever been able to figure it out. I’ve been on my worst bout of my life for about 140 days now after 3-4 months of what I thought was complete remission with an 18 lb weight gain. I’ve lost over 20 pounds, I’ve been sleeping 18 hours a day bc I have no energy, and every meal has been causing me to feel nauseous, light headed, and completely bed ridden sick afterward.

Finally, I went to a specialist at John’s Hopkins after multiple GI specialists and doctors and tons of tests (endo and colonoscopy, HIDA test, 20 blood tests, SIBO test, MRI, X-ray, 2x CT with contrast, and multiple ER hospital visits). I’ve always been athletic despite these stomach issues but for the first time I was no longer able to power through a lift or exercise. Mentally and physically I’ve been at the lowest point in my life. Thankfully my gf and friends have all stayed with me besides isolating myself bc of the pain and stress/anxiety. Then my new doctor prescribed a gastric motility test which revealed I have severe gastroparesis. I’m writing all this to hopefully help someone else who is going through what I have been going through. Now I’m figuring out how to deal with this with diet (getting a nutritionist) and possibly medication (motilium shipped from Canada) and attempting to figure out what has caused this by doing parasite tests and a POTS test since I also have blood pooling in my extremities. Really hope this helps someone. I’m encouraging anyone with IBS or IBD or any GI issues to get tested for this just in case. It’s a very simple test, you eat 2 slices of bread and an egg filled with nuclear medicine and then take MRI pictures every hour for 4 hours. It might be for nothing but it also might save you from a life of confusing pain and malnutrition.

https://imgur.com/a/Z3S1e0o

I am diagnosed with no motility and went through IVF but the first attempt failed now waiting for more attempts any Idea what else need to get a baby when your motility is Zero.

When I’m pregnant my bowels slow down so much!! TMI but normally I have a bm 1-2x a day which is ideal. But when I get pregnant I go like once every 2-3 days. It makes me feel so constipated and increases nausea etc. I’m already taking gallbladder support, anyone else find any helpful tips?

So it’s been like three months now and something shifted out of nowhere I can go to the bathroom like once a day in the morning. But for some reason I’m not able to empty my stomach at all. I’m not sure why, is it because of my poor diet? I use laxatives and everything and I’m able to poop but not empty my stomach completely. I’m also in the Depo-Provera shot, can this mess with my hormones in some way? I told my doctor but she told me to increase my fiber and water intake. And she even gave me this SIBO test kit for some reason I’m not sure why. Forgot to mention I’ve taken Metamucil and it’s not working like before. None of the laxatives and fiber have worked like before when they cleaned me out.

We have been TTC for 10 months now, no pregnancies. Both of us are undergoing fertility testing. Husband had an SA done and count was great but everything else was on the low end with a very high round cell and agglutination count. Urologist discovered a varicocele but did not grade it, he will have an ultrasound to confirm in 2 weeks. I noticed the varicocele long before we even started the TTC process, just by touch, so I assume it’s at least a grade 2.

Here are his numbers, note the morphology is based on the old criteria (30% threshold) not the strict 4% criteria.

Total count: 292 mil

Concentration: 68 mil/mL

Progressive motility: 30% (0% rapid, 30% slow)

Morphology: 20%

Round cells: 6 to 10 mil

I am still going through my side of testing but so far everything is normal. Assuming everything checks out as normal on my side, and ultrasound confirms varicocele for husband, should we pursue the surgery? Or embolization? I can’t help but feel like his numbers are good enough that we should have had a pregnancy by now.

Has anyone been told they have slow motility in their gut, but the doctor can’t figure out why?

I tried Motegrity which worked the first day but nothing after that.

I had a colonoscopy endoscopy done with biopsies and she didn’t find anything that would contribute to the slow motility.

I’m not necessarily constipated because I go every day / other day but half the time I’ll have super rock hard stools with lots of straining, the other half the time my I’m having loser stools

I was prescribed omeprazole and carafate which have really helped with stomach pain but no word on the motility issue yet

TIA

I live near the Stanford motility center. My constipation started about six weeks ago. My digestive system nearly shut down suddenly. I get some relief from MiraLAX but I am nowhere near normal. I just had a colonoscopy and the doctor found a couple of small polyps but otherwise everything else is normal. Except, of course, I am not normal like I was before the constipation started. Based on the experience of those of you who have gone to a motility clinic, if I get my doctor to do a referral to the clinic, what tests will they run and what can they do about my constipation?

I thought motility testing was the last resort, that for sure it would show something... but nope, "results showed nothing of significance." So now what?

I've done motility testing, a colonoscopy and endoscopy, I've scooped my own poops into test tubes, and dropped two thousand dollars on an ER visit just to have a nurse stick a finger up my butt, give me a Xanax, and send me home.

I'm just. So sad and tired and angry. Not a single test has showed anything except constipation.

Symptoms: I'm still experiencing very hard stools, hemorrhoids, prolapsing, bleeding, bloating, belching, sharp cramping, coughing, lower back pain.

Meds and treatments: I've been taking daily magnesium and colase for like a year, and I feel like I'm soon going to have to increase my dosages, again. I've yet to find a probiotic that seems to do anything, or a fiber supplement that doesn't make things worse. Suppositories and enemas help for a day or two, sure, but I can't do them all the time, and besides that, they burn and sting like a [redacted].

I have literally no idea what to do now. Except for the Low Fodmap Diet, but there are no nutritionists in my network and no local ones who take my insurance; and with my history of disordered eating habits, I don't think I should attempt it alone.

Disclaimer, my symptoms are worse right now because I'm stressed, but a major part of the reason I'm stressed is that the motility test turned out to be useless. So you know, vicious cycles and whatever.

I don't even know if I'm looking for advice in this post. I just want to hear that I'm not totally alone.

My current GI is not responding to my requests for a referral to Mayo or Cedars-Sinai. I believe motility is my main problem, and it’s reflected in my family as well. I really think my next step is a motility specialist. Does anyone see any in CA or AZ that didn’t require a prior GI referral?

So I've just been told that it's possible to have fast motility with SIBO. This usually presents in people with fast transit time/diarrhea (that is not caused by constipation). Does anyone know if a prokinetic like ginger is still advised in these cases? What is the approach to handling a case like this?

I have been a long time sufferer of IBS-C and am in the middle of a severe bout of constipation (gas, bloating, soft stool which I am having trouble passing naturally).

I’ve tried laxatives, suppositories and an enema (which I can barely hold in for a minute) for short term relief over Christmas but am feeling more concerned than I have in the past.

I am new to London and was hoping someone might be able to recommend a motility specialist? Getting desperate and worry these symptoms might be a sign of something more serious

TIA

I understand that the most common cause of SIBO is slow motility. However my main digestive issue is diarrhea. I never get constipated. Could I still have slow motility if this is the case?

Anybody been told that when you tell them having oral intake which you can’t barely even manage (I barely have 600 cals a day currently and I’m getting pretty active with my new job and school), that you shouldn’t have a feeding tube because it will just cause you more pain and make you end up in the hospital more than you already are even though you need nutrition and hydration which you can’t get enough of orally? Like this doctor said I’ll just end up with constant infections and pain from the tube (talking surgical tubes not nasal) so he’s going to refer me back to my old GI and highly recommend I don’t get a tube that I need. Although I’m going to request my old and now current GI gives me a NJ anyways to start with and for other serious reasons I am reporting this other GI to the college of physicians… anyways, thoughts?

So, I (34 M) was diagnosed with severe oligoasthenoteratozoospermia 2 years ago. The doctor basically said there is no treatment except insemination or IVF.

But then I have also heard that lifestyle can significantly affect sperm count and motility, and at the time I was working a high-pressured job, smoking, drinking, and taking drugs.

Is it possible to change lifestyle enough to conceive without insemination or IVF?

I've been looking into various things this week, and one was 5-HTP as a way to maybe increase serotonin in the gi tract and potentially improve motility and constipation. I have not been able to find any studies with trials on humans for gastrointestinal effects. But I have seen 5-HTP mentioned on here on a post of IBS treatments for constipation, and I've seen people mentioning relief of constipation from a slow release 5-HTP supplement Natrol 5-HTP Plus Time Release Tablets - it was mentioned in this post.

The only study I have found on gastrointestinal effects was this: Effects of Serotonin and Slow-release 5-HTP on Gastrointestinal Motility in a Mouse Model of Depression. The study used a slow release version of 5-HTP.

And this article mentioning that study and possible applications: A moody gut often accompanies depression: New study helps explain why

I would imagine 5-HTP would have more benefit if too little serotonin in the gut was contributing to your specific situation. And in general since 5-HTP relates to serotonin, I would guess usage with antidepressants or medicines that affect serotonin would need to be done carefully to make sure serotonin syndrome issues wouldn't happen (like why using multi antidepressants together should be done carefully).

Not 5-HTP, but some other interesting supplements I've been looking into:

For those with MTHFR gene mutations, the supplement L-methylfolate may have some benefits. This supplement mostly comes up when looking into treatment resistant depression. From here, "The use of L-methylfolate allows the clinician to bypass a critical metabolic step in folate’s transformation to L-methylfolate, specifically the reduction of methylenetetrahydrofolate to L-methylfolate by the enzyme methylenetetrahydrofolate reductase (MTHFR). MTHFR is the rate limiting step in this process, and significantly, MTHFR enzymatic activity has a wide range of fu

After perfusion school, let’s say a masters program for instance, is there any other education you can pursue to further your career? I’m assuming a doctorate for teaching? Besides teaching and clinical work, are there other common perfusion roles? Also, are there any sort of fellowships or specialized training?