I can name any number of politicians, past and present, whose policies were so repugnant to me that I found even the mention of their names highly upsetting; but there are also some whose presentation just grates on me, whether it’s their voice, their use of language, the cadence of their speech - to the point where I just have to turn them off when they appear in the media.
I just want to add that sometimes this reaction has no relationship to their correspondence with my own political positions: there are a few particularly vocal types on “my side” whom I find so supremely annoying that I just want to tell them to shut up already.
There are also a number of performers who just make my skin crawl, often for no discernible reason. There are movies, TV shows, etc that I haven’t seen simply because they are in it - or, if I’m really interested in the writer, the story, the rest of the cast, etc I might watch it in spite of their part in it.
On the other hand, there are those in public life, whether in politics or art, that I will go out of my way to keep abreast of - or at the very least, be excited to encounter them in a news briefing or programme. Certain performers have to be in something pretty dire for me to not want to watch their performances, because I take so much pleasure in their talent.
I’m sure that everyone has intense likes or dislikes, but some of mine actually trigger a fight-or-flight response: I have to turn them off, or plug my ears, or just yell obscenities over what they’re saying (it helps to live alone). Even, like I said, if I happen to agree with some of what they’re saying.
Does anyone else have this experience? How do you work around it?
And if so, dare I ask - stirrer that I am - who is on your list?
Type 4 HSR can occur via 2 mechanisms - one involving CD8+ and the other involving CD4+ cells(inflammatory reaction). Do both of them require previous exposure of antigen?
i am 23 and i am shaking and feel like i got parkinson disease iam hypersensitive to heat and cold does anybody else experience this?!
https://www.tandfonline.com/doi/full/10.1080/08830185.2021.1939696?s=09
From my understanding, wegener involves PR3-ANCA/c-ANCA, which are antibodies, and they trigger neutrophilic cell destruction/damage.
Hi,
B&B mentioned that there's IgE Dependent and IgE Independent Type I Hypersensitivity reactions. Can someone give an example of an IgE Independent Type I Hypersensitivity reaction? In my mind, even mast cell/basophil activation is via bound IgE receptors. Thank you.
Hey guys, I know you’re not doctors but I was wondering if any of you have had a delayed hypersensitivity reaction to infliximab?
I had my 6th or so infliximab infusion on Monday (today is Friday) and I’m wondering if I’m currently experiencing a delayed hypersensitivity reaction or if I’m overthinking it.
My symptoms are:
- Aching pain in my legs
- Slight raised rash on arms (kind of a light pink colour, I don’t think it’s meningococcal)
- Dry mouth
- Slight headache (could be dehydration)
If anyone has experienced something similar, did you take antihistamines? Did you go to the ER?
I’ve had a hypersensitivity reaction before (to azathioprine) and they weren’t very helpful in the hospital, just told me to stop taking the meds after being unable to figure out what else was wrong with me lol. The symptoms were similar, but I also had a fever and chills.
My other ideas are just a standard allergic reaction (I have no known allergies except azathioprine, so maybe a new allergy? Maybe from a type of hand san or cleaning product I haven’t used before?) or some kind of anxiety or stress thing.
Any experiences or advice is helpful. Thanks in advance :)
Hello,
My mother (69 years old) was diagnosed with stage 4 lung cancer (NSCLC) . She had severe pain on her torax. She tested negative for ALK, EFGR and ROS1 biomarkers but tested positive for PD-L1 so her doctor started her with Keytruda (Pembrolizumab) 2mg/kg every 3 weeks.
The first cycle went great, her torax pain disappeared completely after 2 weeks and her appetite increased so it was clearly working. However, during the second cycle, just after starting the infusion she experienced shortness of breath, red face and severe chills so she had to go the emergency room. The doctor said she had a severe hypersensitivity infusion reaction. He said we would like to try again by giving her antihistamines before the next infusion.
So one week later we tried again with the antihistamines. This time the full dosage went through almost completely. We thought everything was going to be ok, however just before finishing she developed the same reaction again.
Her doctor decided to stop keytruda and start treatment with chemotherapy instead using Carboplatin, Pemetrexed and Avastin (Bevacizumab).
According to everything that I have read she had pretty survival good chances with immunotherapy but not so much with chemotherapy.
Does anyone have any advice or experience with this type of reactions to immunotherapy? What makes me sadder is that the treatment was clearly working.
I was finally able to pinpoint exactly what I'm allergic to with my current allergist after 1.5 years of sinus congestion and countless different meds and allergy tests and doctors. I had a delayed reaction to intradermel testing where 2 new bumps showed up 24 hrs after injection. The reaction was also confirmed by a bloodtest. I am officially allergic to my cat and house dust! My allergist told me that only 10% of his patients exhibit that sort of delayed t-cell reaction, and that explains why I have had so little success with conventional drugs (I've tried montelukast, zafirlukast, allegra, zyrtec, claritin, all providing little relief). My question to my type IV people out there is, what do you do to manage your condition?
I have this Zanki card on autoimmune gastritis that I would like someone to clarify for me. This refers to AI Gastritis as a T4 HSR which is T-cell mediated. Through our didactics we only talked about AI gastritis as a form of chronic gastritis that involves anti-IF or anti-parietal cell antibodies.
If AI Gastritis is a T4 HSR, how are the anti-IF and anti-parietal cell antibodies formed as a result of mucosal damage.
Thank you for your help!
https://preview.redd.it/5eo2ygqj9v141.png?width=1896&format=png&auto=webp&s=9846e204c728fcf2bcdc5ca6eae07d428c6f2b33
Link on Pubmed Authors Lee Y1, Shin YS, Park HS. Author information 1 Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea. Citation Curr Opin Allergy Clin Immunol. 2019 Aug;19(4):302-307. doi: 10.1097/ACI.0000000000000541.
So, I am somewhat confused on the difference between an actual immune reaction and hypersensitivity reactions. I understand hypersensitivity reactions are exaggerated response. I got a question on Kaplan talking about how a toxoid vaccine can result in Arthus reaction (type 3). So, is that what happens in an actual immune response when we get exposed to tetanus?
My mother has been taking chemo for the past 14 months now for her now fourth stage pancreatic cancer. This January we started with GEMOX, and things were going fine until in her sixth session in the end of March, she had a hypersensitivity reaction to Oxaliplatin, just minutes after it started.
This included severe pain in the stomach - she says it's more than she's ever experienced, sweating, body feeling hot, feeling light headed. The docs immediately paused it, gave her a couple of painkillers, and resumed the chemo after an hour. It went smoothly after that.
Yesterday she started with her second GEMOX cycle, and had the same reaction to Oxaliplatin, with the same actions following, and it again ended smoothly.
Now even the doctor is evaluating whether we should continue with this medicine, or try something else.
The sad part is that she was responding very well to GEMOX.
Between Dec and April, her PET scans showed that a new lesion that was spotted in the lymph nodes had almost disappeared, and the one in the Pancreas had significantly reduced in size.
Has anybody experienced such hypersensitivity reactions before? How did you and your medical team deal with it?
