Hello,

I am attempting to convince my obgyn to give me 30 days of bicalutamide for the kick it gives to the E receptors. She is not comfortable doing this due to:

"the risk of fulminant hepatitis does not outweigh the benefits of using this medication in transwomen. "

Is there anything I can present to her to get through this gate?

Thank you in advance,

Kaz

I only recently (last four to five weeks) that my aunt (late 40s early 50s) is dying of liver failure due to alcoholic hepatitis. I was not provided with clear information at the time regarding her state of health, but after seeing her tonight I am sure that it is grim. I have a medical background and am aware of her prospects. She is currently on a ventilator and likely suffering from diffuse alveolar damage due to a subdural brain bleed.

They are planning on taking her off of the ventilator tomorrow. Her children are young, 19 is her oldest. I'm having a difficult time processing her potential death and how to help her children in the best way possible...Many of my relatives are blaming my aunt for her impending death. Although I know as humans we have free will, I view alcoholism as a complex disease process...it's not as though she wanted to leave her children without a mother.

If anyone could advise it would be greatly appreciated

That’s right, kava lovers, we have yet another instance where researchers attempt to link kava to hepatotoxicity (liver damage), and they have yet again failed.

In this report they talk about liver damage in a 35 year old woman due to what they think is kava.

This case file has a number of issues, not least in that it lacks full documentation. We were given no information as to how much kava and what kind of kava was consumed. We’re only told that she drank 2 or more cups of “Kava kava tea” daily for one month. One month of consumption also makes you really question the title of the paper “Fulminant Hepatic Failure after Chronic Kava Kava Ingestion”. Last time I checked this wasn’t considered “chronic” in any way. Also, as you can see, the researchers refer to it as “Kava Kava” throughout the entire paper. This screams to me that neither author had any working knowledge of kava.

Getting picky about it, but they don’t list Forster in attribution when they list “Piper Methysticum” like every other academic paper on kava does.

They did not test the patient for any commonly known liver diseases such as CMV, EBV, HSV or VZV (group II), or Hepatitis. They simply asked the patient if they had any of those, the patient replied “no” and they went about their business.

The AST/ALT numbers presented fall outside the range of ANY other report claiming hepatotoxicity. AST was 13,222 and ALT was 10,448 almost 3 times the numbers we see in all of the other reports.

I messaged a prominent kava researcher in Germany about this article, and he added a little extra in regards to the last paragraph of this paper.

In the last paragraph the authors postulate that glutathione can open the kavalactone ring, potentially providing protection against hepatotoxicity.

His response: “The hypothesis of glutathione quenching kavalactone toxicity by destroying the kavalactone ring system is not based on sound science. There is nothing indicating a toxicity of kavalactones, and if the ring is opened, there would probably be no more effect. Natural kava contains glutathione, so with this logic kava would have no effect.”

I hope these two authors might one day drink some “Kava kava” and broaden their understanding of it.

Rahman, Samin, and Daria Falkowitz. 2021. “The Case Files: Fulminant Hepatic Failure After Chronic Kava Kava Ingestion.” Emergency Medicine News 43 (10B): https://journals.lww.com/em-news/Fulltext/2021/10191/The_Case_Files__Fulminant_Hepatic_Failure_After

Do your worst!

It really does, I swear!

For context I'm a Refuse Driver (Garbage man) & today I was on food waste. After I'd tipped I was checking the wagon for any defects when I spotted a lone pea balanced on the lifts.

I said "hey look, an escaPEA"

No one near me but it didn't half make me laugh for a good hour or so!

Edit: I can't believe how much this has blown up. Thank you everyone I've had a blast reading through the replies 😂

12 year old male with incipient acute appendicitis surgery. Three days after the surgery, he was discharged. Two weeks later, he was admitted for liver failure. Patient died and liver biopsy was taken.

What is your diagnosis?

https://preview.redd.it/67ng3ap7bx771.png?width=877&format=png&auto=webp&s=9db42afe7322da5674068506cce627f2f982a593

https://preview.redd.it/8g33rlp7bx771.png?width=1228&format=png&auto=webp&s=de6c810c4a2d0838877cbc7b3ff6c46e49e637ed

https://preview.redd.it/9stn5fp7bx771.png?width=1228&format=png&auto=webp&s=db8b21a34c878057ada97702fdc67870afbdeb7f

https://preview.redd.it/c8gj3sp7bx771.png?width=1228&format=png&auto=webp&s=b6091ef933f20e4a04944695bf983b25aaca5171

https://preview.redd.it/dbsp5op7bx771.png?width=1228&format=png&auto=webp&s=a1999f96f8033be9f585da16101464248b1706ed

https://preview.redd.it/r7pxzco7bx771.png?width=1228&format=png&auto=webp&s=b01ad434083b229c0267f47bf0f2ba81fac7667d

They’re on standbi

Buenosdillas

Pilot on me!!

Dad jokes are supposed to be jokes you can tell a kid and they will understand it and find it funny.

This sub is mostly just NSFW puns now.

If it needs a NSFW tag it's not a dad joke. There should just be a NSFW puns subreddit for that.

Edit* I'm not replying any longer and turning off notifications but to all those that say "no one cares", there sure are a lot of you arguing about it. Maybe I'm wrong but you people don't need to be rude about it. If you really don't care, don't comment.

What did 0 say to 8 ?

" Nice Belt "

So What did 3 say to 8 ?

" Hey, you two stop making out "

When I got home, they were still there.

I won't be doing that today!

You take away their little brooms

This morning, my 4 year old daughter.

Daughter: I'm hungry

Me: nerves building, smile widening

Me: Hi hungry, I'm dad.

She had no idea what was going on but I finally did it.

Thank you all for listening.

There hasn't been a post all year!

Why

It’s pronounced “Noel.”

After all his first name is No-vac

What, then, is Chinese rap?

Edit:

Notable mentions from the comments:

• Spanish/Swedish/Swiss/Serbian hits

• French/Finnish art

• Country/Canadian rap

• Chinese/Country/Canadian rock

• Turkish/Tunisian/Taiwanese rap

There hasn't been a single post this year!

(Happy 2022 from New Zealand)

Nothing, it just waved

Bob

So that I could frequently say, "I am going to walk 5 miles now."

Edit: My most popular post on Reddit! 😀 Thank you for the awards.

Just to clarify, 12345678

Me grabbing a soda from my (what I thought was) half full 12pk...

Notices there's only 2;

Me: "Awe man... This is a damn bird box!" Her: "What the hell does that mean?!" Me: (Pulls both cans out & shows them to her) "It's only got Toucans."

I'm not ashamed to admit the look on her face was glorious.

I was just sitting there doing nothing.

“BOOM”?!