I'm a PhD specialized in genetics and cellular biology who is discovering the metabolism of fatty acid for a new project, so I'm not very keen on metabolism and organic chemistry and I would need some help on something I don't understand. Please don't use too much enzyme abreviation to be sure I can follow you, thank you very much.
So basically, I understood that generating a triglycerid can be done by linking together a glycerol with three fatty acid-CoA. The first two can be done without further manipulation, giving a Phosphatidic Acid. Then, you need to remove the phosphate group on the third alcohol residue of the glycerol before adding the third fatty acid-CoA, giving you diacylglycerol first.
And here is my problem, I'm using a review (Currie & al., Cellular Fatty Acid Metabolism and Cancer, Cell Press, 2013, 10.1016/j.cmet.2013.05.017) which focus on triglycerids and fatty acids. The main figure shows that diacylglycerol can either become a triglycerid by adding the third fatty acid-CoA or go to the pool of phospholipids of the cell. However, if I understood correctly, diacylglycerol IS NOT a phospholipid since it has lost its phosphate group.
Can someone describe to me or give me a clear reference to understand what happens to diacylglycerol if it doesn't become a triglycerid ? Unfortunately I don't manage to find this answer by myself. Thank you very much.
https://www.ncbi.nlm.nih.gov/pubmed/31562840 ; https://sci-hub.tw/10.1016/j.brainres.2019.146484
Nakajima S1, Gotoh M2, Fukasawa K3, Murakami-Murofushi K3, Kunugi H4.
Abstract
Astrocytes exhibit an important role in neural lipid metabolism for the regulation of energy balance to supply fatty acids (FAs) and ketone bodies to other neural cells. Lipid droplets (LDs) consisting of neutral- and phospho-lipids increase in the brains of patients with neurodegenerative diseases, such as Alzheimer's disease and multiple sclerosis. However, the role of LDs and its lipid source remains largely unexplored. Here, we found that oleic acid (OA) was a potent inducer of astrocytic LD accumulation among various FAs. Lipidomic analysis using liquid chromatography equipped with tandem mass spectrometry revealed that the cellular triacylglycerol and phospholipid compositions in astrocytes during LD accumulation reflected the condition of extracellular FAs. Furthermore, the inhibition of diacylglycerol acyltransferase blocked OA-induced LD accumulation and caused lipotoxicity-induced cell death in astrocytes. The present study demonstrated that the formation of LDs, caused due to the increased extracellular OA, facilitated survival against lipotoxic condition.
Highlights
• Oleic acid strongly induced astrocytic lipid droplet (LD) accumulation.
• Lipid composition of cellular LDs reflected to extracellular fatty acids.
• Inhibition of LDs accumulation caused lipotoxicity in astrocytes.
Do your worst!
For context I'm a Refuse Driver (Garbage man) & today I was on food waste. After I'd tipped I was checking the wagon for any defects when I spotted a lone pea balanced on the lifts.
I said "hey look, an escaPEA"
No one near me but it didn't half make me laugh for a good hour or so!
Edit: I can't believe how much this has blown up. Thank you everyone I've had a blast reading through the replies 😂
It really does, I swear!
They’re on standbi
Pilot on me!!
Dad jokes are supposed to be jokes you can tell a kid and they will understand it and find it funny.
This sub is mostly just NSFW puns now.
If it needs a NSFW tag it's not a dad joke. There should just be a NSFW puns subreddit for that.
Edit* I'm not replying any longer and turning off notifications but to all those that say "no one cares", there sure are a lot of you arguing about it. Maybe I'm wrong but you people don't need to be rude about it. If you really don't care, don't comment.
What did 0 say to 8 ?
" Nice Belt "
So What did 3 say to 8 ?
" Hey, you two stop making out "
When I got home, they were still there.
I won't be doing that today!
You take away their little brooms
This morning, my 4 year old daughter.
Daughter: I'm hungry
Me: nerves building, smile widening
Me: Hi hungry, I'm dad.
She had no idea what was going on but I finally did it.
Thank you all for listening.
There hasn't been a post all year!
Buenosdillas
It’s pronounced “Noel.”
After all his first name is No-vac
What, then, is Chinese rap?
Edit:
Notable mentions from the comments:
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Spanish/Swedish/Swiss/Serbian hits
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French/Finnish art
-
Country/Canadian rap
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Chinese/Country/Canadian rock
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Turkish/Tunisian/Taiwanese rap
