Dedifferentiated parosteal osteosarcoma

30f Caucasian 5'4" 185lbs non-smoker no recreational drug use. Occasional alcohol use. Diagnosed with grade 3 dedifferentiated parosteal osteosarcoma of the right leg with medullary involvement good margins. Started in May recurred twice. First time grew between 3-4cm in 6 weeks. Second time grew over 5cm in 4 weeks. Also diagnosed with ADHD taking 36mg Concerta for that and depression taking 300mg welbutrin for that. Also taking Cymbalta and nurotin(sp?) For never pain. My most recent surgery was an amputation of my right leg.

I'm still trying to understand a good deal concerning my diagnosis since this all happened so fast but mostly I want to know what the recommendation is as far as chemo goes. The decision has been left up to me but I could use advice on what to advocate for.

I'm also curious to know about the difference of using methotrexate vs not using it. Like what are the benefits and should I advocate for using the tri cocktail of methotrexate, doxyirubin, and cisplatin? Or would doxyirubin and cisplatin be enough. Is there any advantage to not using methotrexate such as will it give another option if I do grow another time agree reviving

I do know I don't feel comfortable waiting for another tumor to grow given how aggressive the one in my leg was. I'm concerned that I'll lose another appendage or one will grow somewhere it can't be cut out or off. And this kind of cancer is rare so studies show chemo is controversial.

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πŸ‘€︎ u/Tatsuhime
πŸ“…︎ Dec 18 2021
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Co-expression of MDM2 and CDK4 in transformed human mesenchymal stem cells induces dedifferentiated liposarcoma potency biorxiv.org/lookup/conten…
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πŸ‘€︎ u/sburgess86
πŸ“…︎ Apr 02 2018
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Cellular Reprogramming, and the Goal of Separating Dedifferentiation from Epigenetic Rejuvenation fightaging.org/archives/2…
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πŸ“…︎ Sep 18 2021
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Cellular Reprogramming, and the Goal of Separating Dedifferentiation from Epigenetic Rejuvenation fightaging.org/archives/2…
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πŸ“…︎ Sep 18 2021
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Blind Girl Here. Give Me Your Best Blind Jokes!

Do your worst!

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πŸ‘€︎ u/Leckzsluthor
πŸ“…︎ Jan 02 2022
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This subreddit is 10 years old now.

I'm surprised it hasn't decade.

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πŸ‘€︎ u/frexyincdude
πŸ“…︎ Jan 14 2022
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Dropped my best ever dad joke & no one was around to hear it

For context I'm a Refuse Driver (Garbage man) & today I was on food waste. After I'd tipped I was checking the wagon for any defects when I spotted a lone pea balanced on the lifts.

I said "hey look, an escaPEA"

No one near me but it didn't half make me laugh for a good hour or so!

Edit: I can't believe how much this has blown up. Thank you everyone I've had a blast reading through the replies πŸ˜‚

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πŸ‘€︎ u/Vegetable-Acadia
πŸ“…︎ Jan 11 2022
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What starts with a W and ends with a T

It really does, I swear!

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πŸ‘€︎ u/PsychedeIic_Sheep
πŸ“…︎ Jan 13 2022
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What do you call quesadillas you eat in the morning?

Buenosdillas

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πŸ‘€︎ u/FarronKeepSucks
πŸ“…︎ Jan 14 2022
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What is a a bisexual person doing when they’re not dating anybody?

They’re on standbi

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πŸ‘€︎ u/Toby-the-Cactus
πŸ“…︎ Jan 12 2022
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Geddit? No? Only me?
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πŸ‘€︎ u/shampy311
πŸ“…︎ Dec 28 2021
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I wanna hear your best airplane puns.

Pilot on me!!

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πŸ‘€︎ u/Paulie_Felice
πŸ“…︎ Jan 07 2022
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E or ß?
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πŸ‘€︎ u/Amazekam
πŸ“…︎ Jan 03 2022
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i Karenough to
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πŸ‘€︎ u/Amazekam
πŸ“…︎ Jan 14 2022
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No spoilers
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πŸ‘€︎ u/Onfour
πŸ“…︎ Jan 06 2022
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Covid problems
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πŸ‘€︎ u/theincrediblebou
πŸ“…︎ Jan 12 2022
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These aren't dad jokes...

Dad jokes are supposed to be jokes you can tell a kid and they will understand it and find it funny.

This sub is mostly just NSFW puns now.

If it needs a NSFW tag it's not a dad joke. There should just be a NSFW puns subreddit for that.

Edit* I'm not replying any longer and turning off notifications but to all those that say "no one cares", there sure are a lot of you arguing about it. Maybe I'm wrong but you people don't need to be rude about it. If you really don't care, don't comment.

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πŸ‘€︎ u/Lance986
πŸ“…︎ Dec 15 2021
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πŸ‘€︎ u/bouvard1
πŸ“…︎ Oct 29 2019
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I had a vasectomy because I didn’t want any kids.

When I got home, they were still there.

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πŸ‘€︎ u/demotrek
πŸ“…︎ Jan 13 2022
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What did 0 say to 8 ?

What did 0 say to 8 ?

" Nice Belt "

So What did 3 say to 8 ?

" Hey, you two stop making out "

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πŸ‘€︎ u/designjeevan
πŸ“…︎ Jan 03 2022
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