Found out through a incidental find that I had a 1.7 cm mass on my right kidney. Through a partial nephrectomy, found out it was clear cell carcinoma. It is localized in the mass as of now.
Just hit me hard today, had my both my parents already died both from lung cancer. Curious to know who has beaten this ? Definitely could use some positive news or stories. I just found out yesterday so been trying my best not to stress.
well i have papillary thyroid carcinoma doctor said microcarcinoma due to size. They are gonna talk to me tomorrow about what we should do next. Im scared and i thought i.was preparred mentally but i am not. One thing that scares me is the mention of hurthl cell feature which is confusing me. Does that mean its hurthl cell cancer? does it mean that it could be i do not know. The internet us full of information and many things are scaring me. I read conflicting info. I cant talk to.do tor until tomorrow and even then im not sure its going to bring my anxiety down. I got people pushing for second opinions but i dont see what good it will do. I went to mass general i dont think i will do better than mass general. im afraid it will be uncurable or come back if successfuly removed. I just wish i could wake up from this.
Hello, I have been recently diagnosed with triple positive, invasive ductal carcinoma which has reached my lymph nodes. Looking for positive stories from people who have been through it.
I don’t even know what to say. I just need to vent.
I had a partial thyroidectomy about two weeks ago, and was supposed to hear back about the pathology report within 5-7 days. I didn’t, which I wrote off to it being right around the holidays. My biopsy was Bethesda 3 back in October so I’ve been in “maybe/maybe not” land for a while now. I saw my surgeon for a post-op eight days after the surgery and he assured me this was normal, and that thyroid pathology takes a long time. It felt weird, but I took his word for it.
It’s Hürthle Cell Carcinoma. That really rare one that scared me to read about. How the hell? I am a 33 year old woman with no other health issues. (Well, they also found a teeny PTC microcarcinoma on the lobe they took out, so I guess there’s another one.)
I just don’t get it. He was so reassuring going into this, saying that I really didn’t have anything to worry about and that he didn’t feel or see anything in my lymph nodes. None of my symptoms seemed, to him, to indicate malignancy. I was honestly expecting a call as such, and I had been feeling really relaxed and carefree. After all of the false reassurance my doctor gave me, I don’t know whether or not to trust him when he says he’s pretty sure it’s stage 1. (Ultrasound tomorrow and a TT scheduled regardless.) There’s extensive vascular invasion, according to the report I got back… so how does that even make any sense??
I don’t know, you guys. I’m rambling. I’m scared. If one more person tells me how l lucky I am to have “an easy cancer” I’m going to punch them in the throat.
All I could find online is that the lower lip is more exposed to the "precipitating factors"—as vague as that. There was not expansion on what those factors are.
Could an important one be sunlight? Sure, but it's hard to argue that the lower lips get more sun exposure than the upper lips. Also***,*** if we take that argument, basal cell carcinoma should also more frequently happen at the lower lip—but it doesn't.
Does sporadic, intense exposure to sunlight somehow specifically affect the upper lip while chronic low intensity exposure to the sun affects the lower lip? How?
I’m extremely dark skin and I just got a BCC diagnosis for a bump on my face. I’m quite shocked by this. Should get a second opinion for the biopsy interpretation? Are biopsies 100% accurate?
Full paper: https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC6316561/
This study found Zinc supplementation tends to reduce liver enzymes in chronic liver disease, and to reduce the risk of developing hepatocellular carcinoma (liver cancer).
Zinc is known to have anti-inflammatory and antioxidant effects, making it protect against the damage caused by fat buildup in the liver - excess fatty acid accumulation in the liver causes inflammation and oxidative stress, and Zinc decreases the intensity of these two processes, ultimately protecting the liver.
That being said, long-term Zinc supplementation also carries the risk of Copper deficiency, as the former inhibits the absorption of the latter from the stomach. Copper is essential for red blood cell function and for the nervous system, so high-dose Zinc supplementation can cause anemia and spinal cord nerve damage (Copper-deficiency myelopathy).
The daily value (DV) of Zinc is 11mg/day for adults and children aged 4 and over, according to the FDA (Source) - supplementation with this amount is unlikely to cause Copper deficiency.
Hi all,
So my diagnosis has been a mess. I originally had a 9cm tumor on my right thigh, first identified in October 2020. At first they thought it was a Sarcoma because of the location. But biopsy came back as possibly a Neuroendocrine Tumor (NET). Had surgery to remove it in March 2021 (in the interim, it only grew 1cm), and they took out 2 of my quad muscles to ensure clear margins margins. From there I was considered NED, they said nothing else should be done, and several other hospitals I went to for a second opinion agreed to just wait and see. Pathology of the tumor specified this to be a Paraganglioma, a rare type of NET.
I sent samples to the NIH Paraganglioma department since it was very odd for Paragangliomas to occur in the thigh. I also saw an Endocrinologist who did a CT scan of my liver and a colonoscopy, all clear. Had clear 3 month scans.
Then in November 2021, just before my 6 month scans, the NIH contacted me and said after several analyses, they don't believe it's a Paraganglioma. They are not sure what is either, but their best guess is that it's an ectopic adrenal cortical neoplasm, whatever that means... Then on my 6 month scan they found a 9cm tumor in my abdomen, mets in my lungs, right thigh and even bone mets that gave me a micro fracture of my right femur. It was a shock how something seen as low grade could have gone from zero to this in just 6 months!
I just had femur nailing for my bone mets, and will start chemo (etoposide and cisplatin) next week. In the meantime I've ordered some genomic testing, and seeking second opinions at Mayo, MSK, and Sunnybrooke research institute in Toronto (I'm based in Canada).
But in the meantime I'm wondering what else to do? My current oncologist seems a bit cryptic and slow to react and I'm looking for other options but I don't want to delay treatment in the meantime. Genomic testing and second opinions will take at least a month to provide answers, so hopefully they give more insights. Current oncologist sees this as a High Grade Neuroendocrine Carcinoma.
Has anyone dealt with something similar? Or had a cancer go from low grade to high grade?
BTW, I've posted on all the FB groups, but thought I'd post here as well.
Thanks for reading!
Had a lumpectomy on 12/21 and woke up to my pathology results in my email Christmas Eve morning. I was shocked to say the least. I finally spoke to someone at the doctors office today and was told my treatment will be hormone blocking pills and radiation. What can I expect from this?
In April I suffered a spontaneous subcapsular hematoma on my right kidney. It was about the size of a lime & therefore blocked most of my kidney. I had a few CT, my drs weren’t the best, changed my PCP who ordered an mri. Well 2 MRI’s later I have a lesion & several areas “of concern”. I guess typically they don’t like to biopsy kidneys bc they’re so vascular. And where this is located in on the pole. So probably I’ll need the whole thing removed- idk. I have two appts within the next 8 days to go over “next steps”. Anyone have a similar experience?
32/Female 5’ 6” 160lbs, non smoker MRI results came in this past weekend and confirmed a 3.5cm tumor in my right kidney. Cellular walls encompassed signs of being malignant but no biopsy yet obviously. tumor round in shape. No other abnormalities found on other kidney or other major organs. They’re saying it’s Renal Cell Carcinoma. I’ve always been a very healthy person and in shape. Im really blind sighted by this diagnosis. They found the tumor by a freak accident from a CT scan given to me in the ER because I was in a MVA recently. I haven’t started any appointments yet. Im really looking for what to expects as far as surgery goes and maybe what I can do now as far as life style changes go and diets to stick by. Any questions I should ask my doctor? What are my odds with fighting this? Survival rates look like they depend on stages of the cancer. I don’t think im in stage 1 yet. I haven’t spoken to an Oncologist or Nephrologist. Just looking for more solid info on what’s to come. I’m just scared because I have 2 kids to worry about too. Any advice would help
I was recently diagnosed with Neuroendocrine high grade small cell carcinoma stg. 4. It spread to parts of my stomach & lungs, I don’t have any problem breathing, just severe stomach pains that hurt 24/7 but am taking pills to mask the pain every 6 hours. Currently on chemo, my question is what’s on the horizon, please be honest & if there’s treatments you can suggest that’ll be great. Thank you for your time.
I hope this doesn’t breach the rules, my mother recently got diagnosed with grade iii invasive ductal carcinoma, she still has to undergo some tests to figure out which stage it is and if it spread and I just want to hear some of your guys’ stories if you’ve had a similar experience, to comfort both her and I.
This post is very brief but if you want more details I’ll reply with them and any information about this would be much appreciated, I just stumbled upon this sub and saw all the posts made by people in remission and it makes me so happy! Both her and I would love to hear some people’s stories :)
Edit: Update! After a full body x-ray, the cancer has not spread to any organs! She’s feeling a lot better and so am I. Benign lumps are forming in her breasts though, the doctors suspect that thats hormonal.
Edit 2: She’s gonna take meds to shrink the tumour and then do chemo
https://www.mdpi.com/2227-9059/10/2/234/htm
Abstract
Tyrosine is an essential ketogenic and glycogenic amino acid for the human body, which means that tyrosine is not only involved in protein metabolism, but also participates in the metabolism of lipids and carbohydrates. The liver is an important place for metabolism of lipids, carbohydrates, and proteins. The metabolic process of biological macro-molecules is a basis for maintaining the physiological activities of organisms, but the cross-linking mechanism of these processes is still unclear. Here, we found that the tyrosine-metabolizing enzymes, which were specifically and highly expressed in the liver, were significantly down-regulated in hepatocellular carcinoma (HCC), and had a correlation with a poor prognosis of HCC patients. Further analysis found that the reduction of tyrosine metabolism would activate the cell cycle and promote cell proliferation. In addition, we also found that the solute carrier family 27 member 5 (SLC27A5) regulates the expression of tyrosine-metabolizing enzymes through nuclear factor erythroid 2-related factor 2 (NRF2). Therefore, the SLC27A5 and tyrosine-metabolizing enzymes that we have identified coordinate lipid and tyrosine metabolism, regulate the cell cycle, and are potential targets for cancer treatment.
Authors:
https://preview.redd.it/9egwle282q981.png?width=359&format=png&auto=webp&s=0fe793fe2b94f35d917cfaf4075dd4a4cd2ae6f1
Hello everyone I am a medical student in my 4th year. I have been involved in a medical project with a pathologist regarding the role that IHC played in reclassifying lung tumors . I am due to present at a student congress after tomorrow and I am having trouble understanding two things. I have already asked my pathologist and unfortunately due to a language barrier I cant understand her.
briefly, the morphological diagnosis of the lung resection specimen was poorly differentiated sqcc. But after the use of IHC the final diagnosis was LCC
1- why did we pick these specific markers? (ck7, ttf1, ki67, p63, napsine)
2- why ck7 and ki67 being p+ meant that the final diagnosis is LCC?
I apologize if my question is not plausible. I can also provide pictures from our lab if it helps.
please take in consideration my enthusiasm for pathology. I have worked really hard throughout the summer and this is my last question to complete my presentation at my very first student congress.
edit: biopsy -> resection specimen
https://twitter.com/hardytskagimoto/status/1473142704595152899?s=21
