I made a post on here in search of the perfect supplement to use in order to induce the ability to learn absolute pitch. In the research I have been doing as to how the epileptic drug Valproate produced the plasticity akin to a 5 yo and generated the ability for adults to learn something that only a child could learn.
The conclusion is that the mechanism behind this miracle is a DNA transcription process which is made a lot easier, due to the fact that valproate inhibits HDAC-I. Histone deacetylase(HDAC) does exactly what it says it does. It removes acetyl groups from histones and other proteins, consequently, suppressing the transcription of the DNA.
This is not what is desired. What we really want is acetyl groups attached to proteins for easier transcription. And that is to, either inhibit the deacetylase enzyme. or to up-regulate histone acetylation transferase. ALTHOUGH the HDAC inhibitor has more literature backing itβs plasticity element.
Question is: does anyone know how to come across HDAC inhibitors without sacrificing your wallet to the devil?
Iβve come across thymoquinone as a promising HDAC enzyme inhibitor but I donβt really know how much I am supposed to dose it for desired effect.
Same goes for butyrate. This is a lesser HDAC inhibitor and is also generated in the body by different bacteria. One could eat a fiber rich diet to increase the butyric acid production OR eat supplements. Supplementation would be the route in terms of cost. The problem here is the same with quinone. I am not sure of the dosages to take.
There is a study on butyric acid that would compare it to Trichostatin-A only that the paper didnβt include the methodology or dosages so I emailed the research team for the full report in hopes of getting a little closer to the level of HDAC-I inhibition butyrate has compared to established, pharmaceutical HDAC inhibitors. Weird thing is is that I remember seeing a title for a study along the lines of Butyrate and VPA.. but I am not able to find it so I suppose I dreamt it.
So itβs hard to parse out data for quinone/butyrate amount that corresponds in level of HDACI inhibition to pharmaceutical brands like valproate.
I cannot handle conflict. At all. It makes me feel sad and confused and frightened; the same way I felt about it when I was a child. In the face of conflict, I want to run away, hug one of my stuffies, crawl into a pillow fort, and hide until itβs over. Iβve actually done this at home when thereβs conflict between me & my husband (which is fairly rare), or between me & my husband & his toxic high-conflict mother. She blew up at my husband last nightβepic conflict, epic rageβand itβs still escalating; and while I understand my husband needs a supportive partner, all I want to do is hug my stuffie and curl into a ball and hide. It feels like the end of the world, and it makes me scared.
Does anyone else feel this way?
I have never ever experienced this from any drug. Itβs almost like I feel like I did when I was 7 again maybe even better I cannot explain it. Itβs so strange Iβm no longer high and didnβt trip for long but I have 0 anxeities something I have never experienced on anything not even strong opiates.
So, I really love stuffed toys ( specifically jellycat bunnies lol) I love the texture and the softness, and I also like small little toys that are just cute. Iβve had quite a few people tell me I need to grow up or tell me Iβm weird, which I can understand, most people my age are interested in a lot more different things. But because I have autism, itβs just one of my special interests, and I kind of feel like Iβm younger in my head anyway, is it a problem I still enjoy things like this? if anyone could just give me their opinions it would be interesting to know
This just occurred to me when watching a clip someone posted of the scene where Joey is hiding in a box as Chandler enters the room.
In this scene, Joey isn't stupid, rather he's childlike, and I think this is an important distinction that the writers lose in some of the later episodes.
It's when Joey goes from childlike to stupid where the writers lose so many of us. Stupid people are a liability and typically end up hurting the people around them because of it. If Joey was stupid from the beginning, he would have also lacked emotional intelligence. But he displays relatively good emotional intelligence over and over again, as he is truly compassionate and a good friend to every one in the group (and when he does wrong his friends, he has the emotional intelligence to repair the relationship. If he was stupid, he wouldn't be able to do that).
If he was stupid, he would be more of a liability and less likeable. Because he's childlike, we adore him and like him in spite of this. But this is why it upsets some of us when Joey is portrayed this way in later episodes. We know he's not just dumb. He's certainly not arrogant. So that's why it doesn't make sense to us when these behaviours emerge sometimes.
Anyways, a bit of a ramble and I don't have the energy to make a concrete case with evidence, but acknowledging this kind of 'clicked' in my mind after reading so many posts about Joey's apparent 'dumbing down.'
Welcome to r/FireEmblemHeroesβs official banner salt thread!
People are eager to express their opinions on any new banner trailer that releases, and that's great! However, /new/ can get pretty crowded when there are 10 people complaining about the newest banner. Due to this, we create megathreads for each banner trailer - Salt and Hype. Until the Banner is live in-game, salt fueled threads should be redirected here, so report any if you see them.
Vent your frustrations with the game here, but that is not an excuse to attack others who may disagree. Please civil towards fellow Summoners, and remember that this is a thread specifically for salt so downvoting negative comments would be counterproductive.
Weekly/Important Megathreads:
Somewhere I read this: "The most powerful shamans are childlike".
What does powerful mean in this context? Why are the most powerful ones childlike?
For the people who aren't exactly salty or hyped, just confused.
I wouldn't talk about this, at least in detail to my IRL friends, but I know I can talk about this here, as I figured you'll understand.
Like many kids, I loved Christmas and Father Christmas always brought me presents. plus, my mother always used to decorate the tree when I went to bed when I was little. That stopped after sometime when I was older and I help decorate things. This part, I didn't mind. Anyway, I, like many kids, believed in Father Christmas, that is, until it was forcibly taken away from me at age 14. I moved schools at that age, mainly for academic reasons, as I wanted to be challenged (for context, I was educated in a special school and moved to a mainstream school). Sometime on the run up until Christmas, everyone treated me well and when I told them about Father Christmas, they were nice about it, that is, until mum decided to tell me, out of the blue that he wasn't real. Her reasoning is that she didn't want me to be bullied, which is fine, but alas, the mythos was no more, and it was never the same again. I just was zombified and had to face that I was older. The magic was gone. It still pains me when Father Christmas is mentioned to me and I hear kids and parents talk about him and it takes all my strength to fight back tears and/or tell the truth. The one thing you need to know about me, is that I HATE LIES and will kill you, if you so much as lie to me. I often feel very angry that many kids are lied to, but at the same time, I want to believe again. It's a very weird one.
I even avoid Polar Express as that movie often more times than not, sends me into depression and turns me into a blubbering mess, (it's not because of the ropey motion-capture) in particular, because it reminds me of a negative aspect of myself, which is the fact that I will not be fooled and am in a sense, distrusting. I disprove things that aren't reality and am factual. There was even an episode of Born Naughty (a docusode where there were phycologists that were either diagnosing the 2 kids participating of either playing up, or have a disorder) and one episode involved a 9 year old who was basically very hyperactive and just overwhelmed (later diagnosed as autistic). At one point, they were in a shopping center going to a Santa's grotto and the narration then read out "Thomas has a hard time letting go of childlike beliefs" and his little brother stated that (older kid) believed in Santa still and (younger one) didn't. I remember having to stop the video
... keep reading on reddit β‘... at least in the novel. The movie (who btw only adepts the first half of the novel) portrays her rather as a damsel in disstress who must ask Bastian if he could pretty please call her Moon child. In the Book however she's a Lovecraftian entity who sacrifices a child's mind once in the while to renew her powers.
So first of all, The childlike empress is discribed as being super alien and not able to expirence human emotions - not only is she neutral in all conflicts Happening in her Empire (which includes slavery and war) it is also hinted that she has no concept of good and evil at all. Every being is only allowed to meet her one time in their life, and if you try to do it another time she disappear from her pavilion where she spends all of her time alone unless she needs a New name.
A major thing that the movie changes from the book is that in the novel Bastian is to much afraid to give the Empress a New name, since he is ashamed of himself. The empress doesn't accept this wanders to another godly being called the old man of wandering moutian (who is more or less a persona for Michael Ende himself) whom she forces to create a time loop starting with Bastian finding the book. Bastian is at this point unable to stop reading and the only thing he can do is say her name, which stops the loop and bring him to Phantasia. A 10 year old boy is literary forced into a parallel dimension against his will, unable to escape the godly force of the empress once he read past the point of no return.
And you think ok now she got her name, now Bastian will live though adventures in Phantasia and return home at the end of the day, your wrong. Now comes the Part that the movie didn't Adept. After Bastian is sucked into Phatasia, the Empress is giving him AURYN (the amulett Atreyu was wearing in the first half). The AURYN is able to grant him any wish, every desire but by doing so he loses a memory every time. There is a part of the novel where he is genuinely mad with Power and Atreyu tries to stop him even acknowledging that by doing so he must defy the Empress since it was her will that Bastian has his power: She knew, that this would Happen and gave him AURYN anyway because she does not care for Bastian - she is unable to care for anyone.
But it gets more creepy. At the end, Bastian comes to a villiage-sized insane asylum full of Mute people playing with wood-crafted Letters. The keeper of this villiage explains that all of these were humans brought to Phanta
... keep reading on reddit β‘Iβm a 17 year old male and when Iβm in my middle register my voice has some weight to it but the moment I go higher all of the weight leaves and the sound becomes very bright and childlike. Is this solely due to my age or am I not doing something right?
Like, anything is interesting and you find happiness in it. Like bro, that's the best thing ever.
I mean, this is coming from someone who hasn't had many experiences, so yeah no wonder I got a ton of it left, but still, it's sooooo good.
Basically, just acting dumb enough so anything you find is interesting. Best shit ever. 10/10
So i personally feel like the way Enfps are typed doesnβt always align with how I feel and sometimes leaves me to question if I am even a Enfp which as lead to 7 retests all the same result. I feel as most enfps are typed as very positive,outgoing,carefree,naive ,too lazy/undisciplined,warm, welcoming nice goofy peaceful and youthful personality when on the other hand I feel pretty cynical often. I can be a socialite one week and a recluse for the next.Iβve had to go to therapy to stop overthinking the stupidest things.I donβt feel the least bit naive I feel like Iβm wise and well attuned with people and there agendas and generally feel like I know whatβs going on. I love to seek knowledge Iβm definitely lazy when it comes to a 9-5job but Iβm the only person in my family or friend group who works-out consistently(now for 7 years). I always try to be and like to be nice warm and welcoming,but if I feel like someone is being malevolent or a bully even as much as not showing common courtesy or basic respect doing something i consider morally bad or wrong.I will turn cold in a heartbeat and treat them how they are treating others wether that be a cold stare,ignoring them a tongue lashing or violence I feel obligated to stand against immoral acts and people. And will call someone out if they take there behaviors to far. So I necessarily donβt like to fight though it can be enjoyable I feel like fighting is inevitable due to there being evil in the world therefore fighting is necessary and you may not always be allowed to be peaceful.I do love to laugh and be goofy but there is way more to life then just positive emotions. Is this just me or do others feel this way too?
From socks to sleepers, pjs and robes all I can find has hearts, kittens and flowers and most definitely the word LoVe . Also really fuzzy fabrics.
If its anything monochromatic, it will be black or pink satin or lace.
I'm so sick of trying to find anything in a simple colour or fabric that is in between those two styles and isn't overpriced. I'm baced in Europe.
Do you think I'm overeacting?
So i personally feel like the way Enfps are typed doesnβt always align with how I feel and sometimes leaves me to question if I am even a Enfp which as lead to 7 retests all the same result. I feel as most enfps are typed as very positive,outgoing,carefree,naive ,too lazy/undisciplined,warm, welcoming nice goofy peaceful and youthful personality when on the other hand I feel pretty cynical often. I can be a socialite one week and a recluse for the next.Iβve had to go to therapy to stop overthinking the stupidest things.I donβt feel the least bit naive I feel like Iβm wise and well attuned with people and there agendas and generally feel like I know whatβs going on. I love to seek knowledge Iβm definitely lazy when it comes to a 9-5job but Iβm the only person in my family or friend group who works-out consistently(now for 7 years). I always try to be and like to be nice warm and welcoming,but if I feel like someone is being malevolent or a bully even as much as not showing common courtesy or basic respect doing something i consider morally bad or wrong.I will turn cold in a heartbeat and treat them how they are treating others wether that be a cold stare,ignoring them a tongue lashing or violence I feel obligated to stand against immoral acts and people. And will call someone out if they take there behaviors to far. So I necessarily donβt like to fight though it can be enjoyable I feel like fighting is inevitable due to there being evil in the world therefore fighting is necessary and you may not always be allowed to be peaceful.I do love to laugh and be goofy but there is way more to life then just positive emotions. Is this just me or do others feel this way too?
Welcome to r/FireEmblemHeroesβs official banner hype thread!
People are eager to express their opinions on any new banner trailer that releases, and that's great! However, /new/ can get pretty crowded when there are 10 people fawning over the newest banner. Due to this, we create megathreads for each banner trailer - Salt and Hype. Until the Banner is live in-game, all hype fueled threads should be redirected here, so report any if you see them outside.
Share your excitement for the new banner here, even if it's just a small detail! This probably isnβt necessary to say, but please remain civil towards other Summoners, and enjoy!
Weekly/Important Megathreads:
