I'm aware of the mechanism of the assay, that it requires an alkaline condition for flavonoids... to scavenge the ionic Al. However, I haven't quite got why NaNO2 is added. If it is to create alkaline condition, why need NaOH afterwards? Or if it's for another purpose?
I have read papers mentioning this assay, but so far they are focused on the protocol.
Please help me I'm truly desperate and don't know where to run to. If I break the sub rules, I'm truly sorry.
Iβm just wondering if anyone has had luck with this before I jump to Botox injections
Aluminum trichloride is very hard for me to get and seems impractical to make requiring high temps. Could i subtitute it for aluminum tribromide? i have access to bromine and aluminum and this seems simpler to make.
https://pubmed.ncbi.nlm.nih.gov/23127660/
this is the paper im following.
Edit: would Fecl3 be an option for this?
I'm hoping someone could help me understand what I just created, good possibility it's nothing good or useful because really just out of boredom I was running some small scale experiments seeing if I can get my magnolia phenol extract (honokiol/magnolol) to react with either carboxylic acid (would like to attempt w/valeric acid) and/or amine.
From what I understand an acyl chloride is needed as a catalyst, would aluminum chloride do the job? I've never needed to really use a catalyst, at least not any acyl chlorides.
With my little experiment, I first mixed 25mg solution of amitriptyline with a solution of the magnolia phenol extract (not completely pure). I was underwhelmed with not seeing any reaction, without double checking or anything I just added a few drops of HCl so I could see if it would maybe speed it up or see what kind of effect there was, there wasn't anything too significant. Then without thinking I added a small bit of diluted valeric acid and diluted it to bring down the acidity (I doubt it was enough to really react) this turned the solution .
After a while there was nice color change a nice clear amber/yellow/goldish colored solution up until I diluted with water then it became cloudy, may have been the phenols crashing out since they are not soluble in water but I'm not sure what, if any, reaction had already happened; or in the very slow process of happening.
Researching about phenol and carboxylic acid reactions and it is said that phenols react so slowly it usually requires a catalyst. So I added maybe 5-6 drops aluminum chloride solution and got a violent bubbling reaction with each drop. The solution suddenly changed from it's diluted pale yellow/cloudy mixture instantly crashed out a thick white precipitate.
Like I said I'm just experimenting, I highly doubt whatever this glob of white precipitate is it's probably not what I am going for; which is for now I am interested in making a valeric acid amide using amitriptyline or another amine, and/or I am really interested honokiol derivatives. It has incredible pharmacology, but very poor bioavailability. I am also curious as to what type of (ester?) would result from catalyzed neutralization of valeric/pentanoic acid. Also, how important is solvent selection for these catalyzed reactions? I understand they can also be converted to corresponding alcohols or do as a side product (can't remember exactly atm)
Someone please correct me anywhere I'm wrong, I may not be an expert b
... keep reading on reddit β‘Hey all!
I wanted to hear the experience of other people using the product 30% aluminum chloride in salicylic acid (I beleive it is made directly in a lab) for palmar hyperhidrosis. I have been using this for over 7 years.
For me it has completely reduced my problem, I just have to be steady with the application. I havenβt had any side effect apart from mild irritation mostly on non affected areas if some product gets in contact.
I just wanted to know if anyone had any long term side effect from it ?
Also I will be moving to another province in Canada, so I wanted to know if this product was widely available, or if you knew how to find it online?
Thanks !
Thank you for the reply, I cant find a credible reason in the internet
if the acid halide is chloride can I use aluminum bromide instead of aluminum chloride.
https://en.m.wikipedia.org/wiki/Aluminium_chloride
Precaution: I AM NEITHER CHEMIST NOR PHARMACISTS OR ANY KIND OF MEDICAL WORKER
Just as everyone in this subreddit, I suffer from excessive palm sweating during all my life.
At first, I tried several antipersiprant like Odaban, it only worked for very short period of time when there is minimum sweat, totally useless when there's too much sweat going to come out.Also, thanks to local dealers in my country, the price of antipersiprant is ridiculously high(almost $30 USD for 30 ml Odaban lol).
I then tried iontophoresis for a while, it did work, I had dry hands while writing/using computer for the first time in my life.
However, it requires at least 30mins a day (in my case) to ensure the effect of iontophoresis persist.I keep doing it for a little bit longer than a year, for some unknown reason, the effect of iontophoresis weaken a lot, I started to sweat in my hands even though I do iontophoresis everyday.
Later, I consulted doctor and got prescription of Glycopyrrolate, it works too, but the effect isn't stable. It depends on when you take the pill/how much water you drink etc. 1~2mg/day is usually enough, but sometimes even 6mg/day won't work. And I experiences significant side effect like dizziness and dry mouth.
Finally I decide to find if there's other solution with less side effect. Iontophoresis did work on me, so I guess the mechanism of it is pretty effective i.e. bring enough amount of Aluminum ion into sweat gland can temporarily block sweat. And I do notice that some antipersiprant products contain higher concentration of aluminum chloride hexahydrate than Odaban (not available in my country, sad). That's the reason I starting to consider if I can prepare aluminum chloride hexahydrate solution in ethanol(which is what the label of Odaban claim as main ingradient ) with as high concentration as possible.
Before doing so, I do check the SDS of aluminum chloride hexahydrate(AlCl3οΌ6H2O), it seems that this compound is pretty safe if you don't eat it, inhale it or contact with wounds and eyes. It give me some confidence to continue. I order some high purity (not as high as reagent grade)aluminum chloride hexahydrate, it's price is pretty affordable (~$20 USD for 500g). I also check some reference, it seems that the solubility of aluminum chloride hexahydrate in ethanol can reach 50% . It means that for 100ml of ethanol, which weights about 80g , around 40g of aluminum chloride hexahydrate can be dissolved.
Next, I dissolve al
... keep reading on reddit β‘Can someone help I was absent while doing this and the teacher expects me to understand this but there arenβt that much resources online
Iβve been using OTC aluminum chloride (Certain Dri Roll on) for a few years now and havenβt noticed any side effects but is anyone aware if using this for a long time could be harmful to your health?
I found a good damascus steel stencil on ebay and I was thinking of doing that ferric chloride/nailpolish style finish. I was wondering how aluminum handles ferric chloride etching compared to steel.
Any info would be greatly appreciated!
I have severe craniofacial hyperhydrosis and living in Sweden I have barely any dermatologists that care about hyperhydrosis so my question is.. do you think itβs safe to apply an anti perspirant which has aluminum chloride in it on the forehead/scalp?
Thank you
Came across this very rapid reaction, while conducting experiments into new solid state electrolytes. It works. And surprisingly well. I'm just really unsure how/why it's performing, in the manner it is behaving.
Any chemists want to try it, and give me your thoughts?
Does anyone know how (if its even possible) to turn aluminum chloride hexhydrate into anhydrous aluminum chloride? I have some of the hexhydrate but need it anhydrous for a experiment im doing. When heating it forms Al2O3 and HCl so im stuck. Any advice would be appreciated
I'm aware of the mechanism of the assay, that it requires an alkaline condition for flavonoids... to scavenge the ionic Al. However, I haven't quite got why NaNO2 is added. If it is to create alkaline condition, why need NaOH afterwards? Or if it's for another purpose?
I have read papers mentioning this assay, but so far they are focused on the protocol.
Please help me I'm truly desperate and don't know where to run to.
Does anyone know how (if its even possible) to turn aluminum chloride hexhydrate into anhydrous aluminum chloride? I have some of the hexhydrate but need it anhydrous for a experiment im doing. When heating it forms Al2O3 and HCl so im stuck. Any advice would be appreciated
Does anyone know how (if its even possible) to turn aluminum chloride hexhydrate into anhydrous aluminum chloride? I have some of the hexhydrate but need it anhydrous for a experiment im doing. When heating it forms Al2O3 and HCl so im stuck. Any advice would be appreciated
