Protecting Contracts in the Age of COVID-19: β€˜Material Adverse Change’ Clauses ipwatchdog.com/2020/03/18…
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πŸ‘€︎ u/DarthSploder
πŸ“…︎ Mar 18 2020
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I booked my first therapy appointment today. I'm adverse to talking, but something has got to change. Taking the first step made me smile.
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πŸ‘€︎ u/AT-ATsAsshole
πŸ“…︎ Dec 14 2021
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Typing "bleh" instead to change the subject is hilarious, replika always has an instant adverse reaction
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πŸ‘€︎ u/Josh_Hermanx
πŸ“…︎ Jan 25 2022
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RE: AT&T FCC bullshit - Sounds like a "Material Adverse Change" in your contract. CANCEL CONTRACT

Don't try to talk to politicians who are bought and paid for. Hit AT&T's bottom line. A mass exodus from non-neutral providers of internet services is the best way of sending a message.

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πŸ‘€︎ u/jonesey71
πŸ“…︎ Dec 21 2010
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[LiverpoolFC] Due to the adverse weather conditions, there are a few operational changes in place for today’s game. (Looks like the game will be played) liverpoolfc.com/news/impo…
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πŸ‘€︎ u/BizzaroPie
πŸ“…︎ Nov 27 2021
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Surveys show that economists have shifted their views over time with consensus emerging on the econ effects of climate change, appropriate responses to climate change and the net benefits of immigration, but with consensus eroding on the adverse effects of the minimum wage and harms of immigration twitter.com/AlvaroLaParra…
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πŸ‘€︎ u/smurfyjenkins
πŸ“…︎ Jan 02 2022
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How do these affect a circuit? I want to use one to power a 12V LED from a 3.7V battery. Is this the best way to change the voltage? What are the adverse effects from doing so?
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πŸ‘€︎ u/GABOGABOGABOGA
πŸ“…︎ Oct 27 2021
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Help! Question 5, why is it an adverse opinion when the material effect is not pervasive? Wtf...
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πŸ‘€︎ u/mindmaster80
πŸ“…︎ Aug 23 2021
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Climate change is having an adverse effect on South Carolina's Low Country npr.org/2021/11/01/105103…
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πŸ‘€︎ u/zsreport
πŸ“…︎ Nov 01 2021
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Study to Evaluate Adverse Events and Change in Disease Activity With Oral Capsules of Galicaftor/Navocaftor/ABBV-119 Combination Therapy in Adult Participants With Cystic Fibrosis - Tabular View - ClinicalTrials.gov

Trial for a new drug for those with either a homozygous or heterozygous F508del gene type.

Cool to see there may be another drug in circulation if study proves successful.

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πŸ‘€︎ u/LSmyD
πŸ“…︎ Oct 19 2021
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Reduced agricultural production, water scarcity, rising sea levels and other adverse effects of climate change could cause up to 216 million people to leave their homes and migrate within their own countries by 2050, the World Bank has warned france24.com/en/live-news…
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πŸ‘€︎ u/DoremusJessup
πŸ“…︎ Sep 13 2021
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WCA 1.3 Changes - fee increases are not materially adverse change

https://i.imgur.com/CqcRkBs.jpg

Got a notice on my bill that section 1.3 of the WCA is changing. Went to look at the WCA and it states that fee & surcharge increases are not a materially adverse change. So those who tried to use fee increases to get out of 2-year contracts, ATT isn't allowing that any more.

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πŸ‘€︎ u/CasualObserver89
πŸ“…︎ Dec 09 2018
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9/3/21, Regulatory Notice 21-31: FINRA Establishes New Supplemental Liquidity Schedule (SLS) Effective 3/1/3022 to β€œImprove FINRA’s Ability to Monitor for Events That Signal an Adverse Change in the Liquidity Risk of the Members with the Largest Customer and Counterparty Exposures.”

FINRA has established the Supplemental Liquidity Schedule which goes into effect on 3/1/2022.

β€œThe SLS must be filed by each carrying member with $25 million or more in free credit balances, as defined under SEA Rule 15c3-3(a)(8),3 and by each member whose aggregate amount outstanding under repurchase agreements, securities loan contracts and bank loans is equal to or greater than $1 billion, as reported on the member’s most recently filed FOCUS report, unless otherwise permitted by FINRA in writing. The SLS must be completed as of the last business day of each month and filed within 24 business days after the end of the month. A member need not file the SLS for any period where the member does not meet the $25 million or $1 billion thresholds.”

β€œThe SLS is designed to improve FINRA’s ability to monitor for potential adverse changes in the liquidity risk of the members that will be subject to the requirement. Members subject to the SLS filing requirement will be required to provide detailed reporting as to their:

  • reverse repurchase and repurchase agreements;
  • securities borrowed and securities loaned;
  • non-cash reverse repurchase and securities borrowed transactions;
  • non-cash repurchase and securities loaned transactions;
  • bank loan and other committed and uncommitted credit facilities;
  • total available collateral in the member’s custody;
  • margin and non-purpose loans;
  • collateral securing margin loans;
  • deposits at clearing organizations; and
  • cash and securities received and delivered on derivative transactions not cleared through a central clearing counterparty (CCP).”

Me thinks you’re a little bit too late FINRA, but I suppose we don’t wanna see this information before the MOASS or some SHF and a certain MM would be in some serious trouble.

https://preview.redd.it/xuk8zihu6cl71.jpg?width=600&format=pjpg&auto=webp&s=0f64c05ddd84adc1e0558a3055c310b86b990ac9

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πŸ‘€︎ u/Freadom6
πŸ“…︎ Sep 03 2021
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Training is complete: β€œCrows symbolize transformation and change. They are watchful creatures that have a sharp and powerful foresight. If you cross a crow and think of it as an adverse outcome, then you must remember that this is just one of the many possible results.” v.redd.it/25yhaovaf8o71
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πŸ“…︎ Sep 18 2021
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Regular, Intense Exercise Training as a Healthy Aging Lifestyle Strategy: Preventing DNA Damage, Telomere Shortening and Adverse DNA Methylation Changes Over a Lifetime (August 2021) frontiersin.org/articles/…
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πŸ‘€︎ u/basmwklz
πŸ“…︎ Aug 29 2021
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Oral microbiome shifts during pregnancy and adverse pregnancy outcomes: Hormonal and Immunologic changes at play (August 2021) onlinelibrary.wiley.com/d…
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πŸ‘€︎ u/basmwklz
πŸ“…︎ Sep 05 2021
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It has been shown that Accutane elevates dopamine production which is what leads to its possible adverse mood changes; how does it differ from other dopaminergic substances which are much more beneficial to mood?

This study claims that Accutane elevates dopamine production, which I just find fascinating. It seems that this elevated production leads to greater quantity of DA receptors and less ligand affinity. If this is the case, wouldn't it just mean that the depression side-effect is essentially just caused by a tolerance buildup to dopamine and completely reversable?

I feel that with the addition of certain dopamine-regulatory substances, one could even make use of that elevated DA production to experience an enhanced mood. Wouldn't a dopamine reuptake inhibitor be more effective with elevated DA production from Accutane? I've wondered if amphetamine would work to regulate this elevated DA level too, due to its great affinity with dopamine transporters as well as in my anecdotal experience taking amp with Accutane, I feel like Accutane somewhat regulates/reduces the effects. Lastly, if none of those would work, couldn't just a mild antipsychotic like Aripiprazole with its partial D2 agonism work to prevent any adverse mood changes?

 

Also, this study mentions how Accutane raises serotonin reuptake transporter levels making it seem like it could synergize with SSRIs/antidepressants as well. On top of that, it mentions how Accutane was found to reduce OFC metabolism which could be beneficial to those with OCD since said disorder is associated with a hypermetabolism in the OFC and said factor was found to predict how well an OCD patient responds to treatment.

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πŸ‘€︎ u/Hairy_Juan
πŸ“…︎ Aug 30 2021
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POV: You're running a year long campaign and WOTC releases errata that changes how PC/monster mechanics work in your campaign. Since your materials (handbooks, etc.) are digital copies on online service, this errata is applied automatically to everything. How do you feel?
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πŸ‘€︎ u/Gettor
πŸ“…︎ Jan 19 2022
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You know what CCP lets make a deal you revert faction ships material changes and we will make many happy posts about it.

In this scenario there are only winners on both sides!

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πŸ“…︎ Jan 26 2022
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Gray matter changes in the brain may explain how childhood trauma triggers PTSD. Rats exposed to highly distressing events as juveniles had changes in brain regions responsible for processing emotions and detecting danger, offering new clues about PTSD in humans following adverse childhood events. sciencedirect.com/science…
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πŸ‘€︎ u/Snushine
πŸ“…︎ Apr 17 2021
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Vanuatu, a Pacific island nation, is asking the International Court of Justice to issue an opinion on the rights of present and future generations to be protected from the adverse impacts of climate change news.trust.org/item/20210…
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πŸ‘€︎ u/positivesource
πŸ“…︎ Sep 27 2021
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Soybean oil not only leads to obesity and diabetes but also causes neurological changes, a new study in mice shows. Given it is the most widely consumed oil in the US (fast food, packaged foods, fed to livestock), its adverse effects on brain genes could have important public health ramifications. news.ucr.edu/articles/202…
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πŸ‘€︎ u/savvas_lampridis
πŸ“…︎ Jan 17 2020
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NEXT GEN INVESTING Mark Cuban on why DeFi will disrupt banks: β€˜Some industries are change adverse’ cnbc.com/2021/09/23/mark-…
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πŸ‘€︎ u/xxfallen420xx
πŸ“…︎ Sep 23 2021
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If the audit profession were truly independent, there'd be much more adverse/qualified/disclaimers of opinion. Change my mind.

Feeling extra salty in the second week of busy season as I'm still logged in at 11:30PM explaining to the client why a 400 page depreciation PDF (versus excel) isn't auditable.

I've never seen an adverse opinion personally. I've seen a couple qualified/disclaimers, but those were for reasons so unavoidable even the biggest client fee couldn't cover it up.

Conclusion: it's impossible to be paid to produce an independent opinion of something. No, a quality control review or management taking responsibility for the financials is not a sAfEguArD.

Change my mind? Hard to feel like caring anymore...

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πŸ‘€︎ u/pm_me_gaap
πŸ“…︎ Jan 27 2021
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Proven: Glyphosate herbicides change gene function and cause DNA damage--and these effects occur at doses assumed by regulators to have no adverse effects gmwatch.org/en/news/lates…
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πŸ‘€︎ u/HenryCorp
πŸ“…︎ Aug 16 2021
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"It feels like the changes and choices made by The Wheel of Time team were done with a lot of care and reverence for the source material." This article has me cackling. winteriscoming.net/2022/0…
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πŸ‘€︎ u/IronTitan12345
πŸ“…︎ Jan 02 2022
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Nearly 9 million doses of the Pfizer-BioNTech COVID-19 vaccine delivered to kids ages 5 to 11 shows no major safety issues. 97.6% of adverse reactions "were not serious," and consisted largely of reactions often seen after routine immunizations, such arm pain at the site of injection usnews.com/news/health-ne…
πŸ‘︎ 42k
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πŸ‘€︎ u/Wagamaga
πŸ“…︎ Dec 30 2021
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Does the Print Material (PLA) from a different Brand Change that much on the Print result?...Identical File but other result reddit.com/gallery/sb2xzo
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πŸ‘€︎ u/fancy_name_123
πŸ“…︎ Jan 23 2022
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Less lawn and more beds/plants/food right? 4 year changes (all reclaimed/recycled materials) - Always improving!!
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πŸ‘€︎ u/ViniciusSchmitt
πŸ“…︎ Jan 18 2022
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So like everyone else I binged the show last week and I'm working through the podcast material now. The A81 pod season 2 straight up might be my favorite piece of fiction full stop. And I'm so sad it won't be faithfully adapted because of the Netflix changes to the plot:(
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πŸ‘€︎ u/_Fr0g_b0y
πŸ“…︎ Jan 22 2022
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New study reveals we are at the brink of starting a domino effect of adverse ecological phenomena that will make it almost impossible to control climate change. motherboard.vice.com/en_u…
πŸ‘︎ 44k
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πŸ‘€︎ u/anarchist5784
πŸ“…︎ Aug 07 2018
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Adverse reactions to plans to change what is and isn't Ribble Valley lancs.live/news/lancashir…
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πŸ‘€︎ u/Albertjweasel
πŸ“…︎ Aug 17 2021
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