Somnolence Puns

So, when I take my parnate dose in the morning I can count down the hours to know when the “afternoon fatigue” is going to hit me.

One thing I always found remarkable is how damn tired parnate makes me feel then, it can really rival most of the standard sleeping pills. When I cannot help it and lay down somewhere, I almost never fall asleep though. I’m just “dozing” in a vegetative, semi-conscious state for maybe one hour or even longer.

The drowsiness during that phase is intense, I get these “microsleeps” with loss of muscle tonus for some seconds and probably also enter longer bouts of light sleep. It just doesn’t feel like a “normal nap” that I remember from pre-parnate times, where I fall unconsciousness, maybe dream, and feel overall more mentally “refreshed” afterwards.

I can hardly believe that this perceived inability to nap is independent from my experience of insomnia (especially sleep onset insomnia) on parnate. I did a sleep study while taking the med: a very interesting result for me was, that I entered light phases of sleep after just 10 minutes (recorded by the EEG) where I subjectively perceived to lie awake for a least one hour.

So maybe parnate is triggering some form of paradoxical insomnia (sleep state misperception), maybe just by preventing a rapid onset of deep sleep that normally occurs after falling asleep. I have some questions and would be very interested to hear back from you guys:

Do you also experience this feeling of not being able to nap during that bout of MAOI afternoon somnolence?

Do you think this could be caused by mechanisms that are related to the well-documented MAOI-insomnia, where you lie awake in the bed for hours?

Since Xywav is so newly approved in the states, I’m really not very educated on it other than it’s a non-stimulant wake promoting agent like modafinil, etc. Can anybody share an easily digestible breakdown of the pharmacology/how it works and if it would be a decent medication to pair with an MAOI to combat daytime sleepiness? Would this only be helpful to someone with narcolepsy since it’s a sleep medication and CNS depressant? I’m really not familiar with this type of medication.

https://www.ajmc.com/view/fda-approves-jazz-pharmaceuticals-xywav-for-idiopathic-hypersomnia

This shit knocks me tf out! Anyone else? How can I combat that? Tia

I am asking here because I don't know where to ask this. I am currently on Invega 6 mg/day, I am using it off label for a condition other than schizophrenia. It costs me over 800 every month, if I switched to Risperdal I would be only paying 100 or less. But I am afraid of the sleeping side effect, I stopped Zyprexa before because it made me sleepy all day. Are they really that different in terms of side effects? I also tried abilify and it doesn't work for me, and Latuda isn't available in my country so I have no choice but Risperdal/Invega for now.

Contexte: j'ai été un très gros fumeur il y a des années.

Je suis un fumeur très anecdotique depuis que je suis père de deux enfants bas age (anecdotique = une fois par mois max un joint lors d'une promenade dehors quand tout le monde dort à la maison).

Je me dis que les gélules ou huiles pourraient être une bonne alternative pour de temps en temps, lorsque la maison dort, pouvoir prendre un petit high en écoutant de la musique au casque mais pas me retrouver à baver devant des videos youtube.... (l'aspect gélule ou huile étant pour éviter d'avoir à sortir fumer pour préserver ma famille de la fumée).

Auriez-vous des recommandations dans ce sens?

merci d'avance.

It's not even somnolence, I won't be drowsy, but < 1.8g and a few hours in, if sitting down doing something I'll just black out for a sec and wake up. Still lucid, while stimulated I'll be in a great geeked out mood, but if I try to watch something and turn my brain off, straight to snooze. But the sleep is INCREDIBLE and gives me the most insanely lucid dreams

So I started lexapro probably a few months ago I take 10mg at night before bed doesn’t effect my sleep or ability to sleep buuuut I have the hardest time staying awake when I drive. It could be 330am when I leave for work it 12pm. The weird thing is it kinda only happens when I drive. It’s so bad that I start to fall sleep driving my eyes cross trying to keep them open and I swerve. I have had to pull over and try and nap for 15 mins just so I don’t crash. I have no problems sleeping or waking up. My doc suggested I stop but it’s been two weeks and my anxiety is back in full swing. Had this happened to anyone else and is there a solution or different medication to replace it

previous

There was so much to decipher in that sentence. My chronicler? and more importantly, mage?

"I'm not a mage, and I don't have a 'chronicler' whatever that is."

My captor made an exasperated sound.

"Well, your people may have different words. What do your people call what you do? What would they call you?"

Ah. She was talking about the water bottle and the air pearls. So she considered this as magic, and thus, me as a mage. It's not the direction I thought my mind would go with this, but it's understandable.

My mind had clearly decided that in the face of the unlikeliness of what I had done, that it must be 'magic'. This is probably my fault for reading too many fantasy novels over the years. My rational mind knew there was no such thing, but if that helped my subconscious accept the changes I made in the hallucination, then fine.

I felt like being a bit facetious though, so I wasn't going to give her a straight answer.

"I'm an engineer"

"Fine, engineer. Now please do not attempt any spell casting, or 'engine-ing' while we talk. The draught you just drank should prevent you from doing so, but it can be quite unpleasant to try while under its effects."

So that's why she was willing to have me healed. She couldn't wiggle the arrow anymore, so she had to stop me from 'spell casting' by another means.

I immediately tried another air pearl anyway.

Everything seemed to be going fine. The air in the room began to move, but after a few seconds my concentration slipped, and I was struck by a strong wave of vertigo. I threw up. If I had eaten anything in the last few days it would have been much worse.

"Ugh, I asked you not to do any of your 'engine-ing', and you did it anyway. Now we have to have the rest of our talk with the smell of your vomit as a backdrop."

My nausea began to subside.

"I wanted to make this as pleasant for you as it is for me. And it's engineering by the way"

She sighed.

"Your sense of humour is remarkably intact, for a rogue mage. Usually they're too far gone for much conversation."

"Well there you are then. Seems like I'm not who you're looking for after all. I'm not a mage, and I'm too funny. I'd appreciate it if you could let me down now. Also, I'd like an apology for, you know, shooting me."

This interrogation was hopefully not going quite as she had hoped. I had to keep her off bala

Exerting as much effort as possible in writing this in spite of a quite foggy, weary state of mind, so apologies in advance for any inconveniences - I'm happy to offer more clarity in the comments.

Recently began a usual routine of Magnesium glycinate, as I had lapsed a month in taking it - usually took it 2-3 times a week.

1: Tried at 400MG a day for 4-5 days, and noticed a ridiculous degree of somnolence (+brain fog) the next day each time + some after cessation, dissociation, along with blunted caffeine/ADD efficacy - hardly felt a thing from 2-3 cups of strong coffee or my prescription. To be clear, it did result in a great deal of relaxation: lowered heart rate, minimal subjective stress, etc, and improved sleep quality, but this was hardly worth the price, and I was confused as to why daily intake within reasonable bounds of RDA guidelines induced such horrid side effects.

2: Tried again recently along similar dosing patterns as the first bout (daily), and similar nuisances recurred - hyper-somnolence, dissociation, profound attenuation of both caffeine + ADHD med efficacy. This time I had been admittedly somewhat sleep deprived and did recently recover from it thanks to the relaxing effects - but even so, the negative effects still linger after sleep recovery, and were amplified relative to the typical daytime sedation associated with past bouts of chronic sleep loss. I am wondering if I had and have entered a state of Hypermagnesia considering I have also occasionally felt slightly nauseous and have never experienced this degree of blunted efficacy in caffeine/add med intake (both of which were independent of tolerance seeing as they had returned to a normal range eventually following the first bout.)

Now, it's possible that A. I was deficient, and Magnesium restoration induced these sedative effects which would eventually disappear. Also entirely possible that sleep deprivation attenuates stim efficacy (it does) but it wouldn't explain why the efficacy declined so sharply with Magnesium ingestion even in parallel with restorative, quality sleep! So presumably, the loss of action in the stimulants and dissociation would be due to NMDA antagonism + glycine's effect on serotonin, which checks out.

But surely normal levels of magnesium wouldn't be that inhibitory, no? Seems much more likely to me I was already within a normal range (due to diet) and took too much, leading to the somnolence, possible nausea, etc. There are a myriad of intera

This might sound like a dumb question. Maybe it is.

How or why can certain medications cause both Somnolence and Insomnia? For example, the package insert for Fluoxetine lists Insomnia as 19% vs 10% with placebo and Somnolence as 12% vs 5% with placebo.

In theory pharmaceutical products are supposed to have one effect since they have one target. Is this an overly simplistic explanation? It looks like Fluoxetine may also increase Norepinephrine (link), but if we look at Citalopram, which is supposed to be more selective for Serotonin, it too can cause both Insomnia and Somnolence.

Could the explanation be the individual? Everyone has slightly different chemistry and a molecule that makes one person sleepy makes one person awake? I know of people having paradoxical reactions to medications, such as getting "wired" from Codeine cough syrup or kids getting hyperactive after taking Diphenhydramine.

Interested to hear how others conceptualize this. I used Insomnia and Somnolence as an example, but I think there are many other drugs that can cause conflicting or opposite effects, like Diarrhea and Constipation. I often feel like when I'm counseling a patient I'm basically telling them this is a crapshoot, we don't really know what will happen to you when you take this drug.

Hey guys, I've decided, in order to avoid future confusion, to depart from my original plan of somewhat mirroring 'this has not gone well'.

Without explicitly being in the same universe, it was just causing issues, and best to nip it in the bud while the story is still in its early stages.

While I'm taking the time to write in a more original direction, I am going to leave the first 2 chapters as they are for now. The comments on those threads should she'd some light on the reasons for this change. Anyway, without further ado, here is part 3.

previous

__________

I woke up to darkness. I had slept long past sunset, and the temperature had dropped significantly. Not to say it was cold, It was actually a pleasant temperature. If I had a water supply, It would probably be a good idea to travel at night. The stars provided a good amount of light, this far away from any sources of light pollution.

My lips were dry and cracked, my foot was raw and on fire, and a circular section on my chest and between my shoulder blades felt very, very sunburned. I laughed internally at thinking I might look like a Japanese flag if I took my boiler suit off. I sat up and groaned as my whole body protested. I felt a wave of dizziness and saw stars. OK, I definitely needed to take a drink now. I couldn't put it off any longer.

I slowly stumbled to the shoreline, and retrieved my beverage. As I walked back to my nook, I couldn't get rid of the thought that something was wrong. Well, a lot was wrong, I was probably going to die in a desert, and of piss toxicity no less. So I chalked up the feeling to the strangeness of my situation.

I sat down, and opened the canteen. If I sit and think about it I'll just make it worse, best just to get on and do it. I unscrewed the cap, held my breath, and took a sip.

I'd like to say it wasn't as bad as I thought it would be, but it was. The internal conflict of my thirst demanding I chug it, with the protests from my stomach and sense of disgust just made it worse. Maybe it was better to just forget it. I'm not even sure it's a good idea anyway, I'm basing this whole thing off some guy doing it in a survival tv show, and a half remembered news story I read somewhere.

I knew that the next bottle would be even worse, as this stuff I was drinking now came out of me later, even more concentrated. Ugh, I didn't want to think about it anymore. I'll just

I've had chronic sleep paralyis for as long as I can remember, even sometimes having it multiple times a day (I've had it 10+ times a day before). Including the hallucinations in which I've embaressed myself multiple times due to people witnessing me act out during these hallucinations when I'm falling asleep/waking up. I experience brain fog, my memory has decreased drastically where I often forget conversations I was just having - Everyday I feel as if I'm a zombie floating through my day, I don't feel fully there. I experience excessive daytime sleepiness, I can sleep for extremely long amounts of time and still feel extremely tired, I often go through my day drinking excessive amounts of caffeine and fighting myself to stay awake. I have no energy, no motivation, I feel constantly burned out due to constanly battling the struggle. I have taken naps before but due to my job I have to fight myself in fear of getting in trouble, and have had times where I suddenly wake up and just realized I went out for a short time. When I think about it I feel like I've had experiences of cataplexy. The worst was one time when I fell to my knees from laughing. Usually what happens is when I laugh my speech become sluggish and disoriented, or randomly one of my knees will give out for a second (I use to have been told I had weak knees as a kid due to how many times theyd give out randomly). I slightly remember having light weakness in my arms before.

I have extremely vivid dreams to where I get my dreams and reality confused. I've had my experience with insomnia as well, Sometimes I can fall asleep easily other times I just can't initally fall asleep, or I wake up during the night. Anyways, I finally was able to get a overnight sleep study after 8 months of waiting and doctors not taking me serious or dismissing me, I can say that the sleep study was pretty horrible for me because I could not fall asleep for the life of me. I know I was overthinking to the max and was uncomfortable, and I knew it didn't show the full extent of my actual sleep experiece but since it was just to see if there was a possibility of OSA, I didn't think too harshly of it. I then saw on my medical file that a doctor diagnosed somnolence, which confused me. They were going to give me a MSLT based on the overnight sleep study but because of COVID, my follow up appointment was pushed back months so I won't know the results. What does somnolence mean exactly? Do you think I will get a MSLT? I have

Previous

The canteen was filling slowly, as the condensation gathered on the blade of my pocketknife. The pain was gone, and there was something subtly different about the world.

It had been 10 minutes since the first drop, and they had settled into a steady rhythm. I had looked in the bottle, and there was even a small amount of ice at the tip of the knife. I wish I'd figured this out before I drank the piss.

I had water. I wanted to pull the knife out and drink the small amount that had accumulated in the bottle, but i didn't want to upset the process.

I sat, licking my dry lips, watching the bottle.

The knife didn't seem to be warming up. It seemed like I had successfully shifted the train onto a new track, and the universe had given way, adopted the change, and ploughed on regardless. This knife was now cold, and that was the way of things. If that was the case, I should be able to have a drink and replace it. My resolve was rapidly fading anyway.

I pulled out the knife, and raised the bottle to my lips, it felt about a quarter full.

Heaven. Pure, ice cold water. No food, sex, or drug I have ever had was as satisfying as that first mouthful, hydrating my mouth, throat, and stomach as I swallowed it. I may have made some indecent noises.

Over the next few hours, my thirst was sated.

__________

There was an orange glow appearing on the horizon. It was probably worth waiting out the day, and travelling at night now that I had a water source. In any case, although I was no longer dehydrated, my body still ached from the beginnings of heat exhaustion.

If I was remembering the 'rule of two' correctly, a person could go two minutes without air, two days without water, and two weeks without food. Given that food was now my most pressing concern, I could afford the day to recuperate. Curled up in my nook, I dozed fitfully, waking frequently to drain the canteen.

By mid afternoon, I could sleep no more. My muscles ached from the cramped sleeping position, and I was as rested as I was going to get. The canteen was still producing water at the same rate. The change seemed to be permanent. Could I do something similar for food?

What had worked in the end to produce water had been an application, of sorts, of principles I understood. A 'bending' of the rules, not an outright conjuration of water from nothing. What energy had been put into the system had cost me in pain. It wasn't the