Psychoactive Drug Puns

We all know the ones. They treat drug users like scum of the earth, yet they get terrible withdrawal and migraines if they don't do there own preferred drug of choice every morning. Caffeine is the most abused drug on the planet and it has become so normalized that people convince themselves they aren't addicted to the bean or leaf.

I tried kava and it gave me a good relaxing buzz similar to alcohol. Chamomile tea makes me feel nice and cozy when winding down for bed and I always have wonderful sleep with it. What other legal mildy psychoactive drugs are out there that I should try?

Music for Psychedelic Therapy, Wow.

I was just visiting /r/ireland and saw a discussion about new minimum prices on alcohol and whether it'll make people start using drugs. Made me wonder about Prohibition in the US.

Much of the franchise has had these and they are always pretty fun in my opinion

Just like the title says, I don't have problems with stopping to use weed (my current DOC), even for a longer duration and don't feel any withdrawal symptoms or craving. I simply forget about it and the drug / the desire doesn't cross my mind for quite a long time, sometimes even months.

Same applies to other substances I like to use as well, Speed and MDMA for example.

Even when I was using Mephedrone, which is famous for its compulsive redosing behavior and craving, I didn't feel any desire to extend the sessions as infinitum. After the second redose I usually decided that it's time to stop, no problems whatsoever.

On the other side, I am a master procrastinator and have huge issues keeping myself motivated with important tasks. I am simply not able to set priorities, do the important tasks first and keep myself focused on just that. This gets even worse with long-term tasks, like studying, especially now when I am supposed to work on my thesis.

The consequence is that I am quickly resorting to procrastination and constantly seek for any kind of distraction. No matter how silly, stupid, pointless and unnecessary those activities are, I am craving for instant gratification, for that quick dopamine shot. I am essentially a distraction junkie, I simply need it more than anything else, especially more than advancing in the actually important tasks to do. This leads some very illogical, unreasonable or downright stupid behavioral patterns.

It seems like those distractions and instant gratifications are the way harder drug for me than any psychoactive substance.

My Dopamine system is pretty much fucked up.

In the MCAT bros 300 pg. document/Khan Academy, it was stated that intramuscular drugs are incredibly fast acting if applied on the outer thigh (e.g. epi pen) since there are a bunch of blood vessels in that area , so why is that heroine or crack users (ones who don't care how much the injection hurts and just want the high) inject drugs intravenously instead of intramuscularly on their outer thigh?

Their personalities are too different from mine. They are very risk averse and they act out of gut feelings, rather than deliberation. No amount of information can change their minds about drugs. It pains me to think about the unrealized relationship potential when parents and their children put up a front for each others. There's too much hiding and pretending between people who are supposed to be the closest.

I have come to a point in my life where I want my mind to change. I want the way I think to change, the way I behave and everything in my head.

I know shrooms won’t do this but it might give me a better chance at obtaining that drastic change I need in order to get out of this deadly thought rope.

I heard good things about this though, and I’m willing to have a bad trip. Any advice will be appreciated in where to go to trip and what kind of low dosage to begin with since I know next to nothing about shrooms.

Please forgive me for sounding this desperate but I want some kind of change in my mind, thinking the same every day is really damaging me I think.

Any information on suppliers in St. Gallen area of Switzerland? If so I would be very lucky I think.

As title says is there any books you guys recommend that are about psychoactive substances? No drug in particular, anything from psychedelics to amphetamines to opioids.

-couldnt post this in /drugs since i dont have enough karma so i decided to post in here

"I think that actually represents one of the central problems with psychoactive drugs is you can think that they're helping you, but that's very different from them helping you. And I think that's actually one of the most important reasons to try to use them as infrequently as possible—it will aid that self-assessment because if you're constantly in the throes of it, you can easily lose track of who you are and how you relate to who you used to be and where you're going."

Full explanation here

Hello, I am trying to learn more about the GABA-B receptor and VGCC’s.

I used phenibut for 3+ years daily, I quit a year ago. After taking phenibut, no other psychoactive drugs work whatsoever - and yes, that means all of them. MDMA, opiates, stimulants, psychedelics, etc.

Phenibut is a gaba-B agonist and effects VGCC. I’ve done extensive research into the gaba-B effects, and from my research it concludes that stimulating the gaba-B receptor will inhibit other neurotransmitters.

It appears there’s many mechanisms at play that can cause this, but one of which appears to be from the fact that the gaba-B receptor inhibits adynylate cyclase, and that enzyme plays a key role in neurotransmitter release. It also appears calcium channels also play a similar role.

Does anyone else have any more information as to how this works?

Here are some studies below. I quoted the more relevant parts that talk about this.

2 Functions of GABAB Receptors GABAB receptors play a critical role in long-term inhibition of synaptic transmission (Bowery, 1993). In the brain, GABAB receptors are located both pre- and postsynaptically. Activation of presynaptic GABAB receptors inhibits neurotransmitter release from presynaptic terminals (Bowery et al., 1980; Bowery, 1993). Presynaptically, GABAB autoreceptors have been reported to control the release of GABA, whereas GABAB heteroreceptors regulate the release of glutamate, noradrenalin, dopamine, 5-hydroxytryptamine, substance P, cholecystokinin, and somatostain (Kaupmann et al., 1997)”

“GABAB receptors (GABABRs) regulate the excitability of most neurons in the central nervous system by modulating the activity of enzymes and ion channels. In the sustained presence of the neurotransmitter γ-aminobutyric acid, GABABRs exhibit a time-dependent decrease in the receptor response—a phenomenon referred to as homologous desensitization. Desensitization prevents excessive receptor influences on neuronal activity.”

https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/gabab-receptor

https://www.cell.com/neuron/fulltext/S0896-6273(00)80381-5#back-BIB27

“GABAB receptors are G protein-coupled receptors that mediate slow and prolonged inhibitory action, via activation of Gαi/o-type proteins. GABAB receptors mediate their inhibitory action through activating inwardly rectifying K+ channels, inactivating voltage-gated Ca2+ channels, and inhibiting adenylate cyclase.”

“whereas the metabotropic GABAB receptor pr

I got really high this past weekend, had an experience that was like somewhat of a memory I could physically feel.

Id like to believe it was a false memory, but don’t know if it also might be a traumatic experience I managed to bury in my subconscious

Ricaurte claims that the equivalent dosage of 1.5-1.7mg/kg of MDMA in humans is approximately 5mg in monkeys. I'm assuming he means that this would lead to roughly the same concentration of MDMA in both a human and monkey's blood, rather than it eliciting similar psychological and physiological responses from both species, but if someone knows, please confirm.

1. Would the dosage of amphetamine, morphine, diazepam and so on be approximately 3.3 times higher in monkeys? Or is it far more complicated than that, with interspecies metabolic and neurological peculiarities playing a significant role in determining analogous dosages?
2. If it's just measuring blood serum concentrations, are these are still half-decent scales when comparing it to the behavioural responses (e.g drug liking, analgesia, motor activity alterations) and physiological effects (e.g toxicity) that these doses elicit?

h

Some things I've considered:

1. They give us access to functions we don't otherwise use. (e.g., a substance might enhance physical sensations and music to the point where someone without any Se uses almost exclusively Se)

2. They change which of our 4 functions are emphasized. (e.g., a drug that enhances empathy might make a tert or inf Fe user extremely warm and caring about those around them)

3. They change our perception of our functions even though we're using the same ones as normal. (e.g., an Ne user may perceive their Ne as being very sensory-driven and thus Se-like)

4. They give us a more accurate ability to see our cognitive functions as they are. (e.g., a very introspective experience might remove the biases we have that make us type ourselves as the type we want to be, allowing us to see our true selves)

What do you guys think? From personal experience or pure speculation - either one would be great.

Bonus question: do you think any changes would persist long term, or would they only affect a person while under the influence?

Edit: you don't have to partake in or approve of drug use to speculate about how it might affect our personalities & thought processes. Maybe I should have asked this in r/ENFP or r/ENTP. All that Ne might be willing to spitball with me 😅

Sounds very cool

DREADDs (designer receptors exclusively activated by designer drugs) are going to change how psychoactive compounds interact with the brain

As far as I understand, as it is now, psychoactives interact with many of the brain's receptors, making it difficult to pinpoint the exact mechanism of action

So... rather than developing high-selectivity drugs that bind to just ONE receptor (which is very difficult to do), we turn to DREADDs (AKA high-selectivity receptors)--receptors in the brain that are exclusively activated by one drug and only one drug. Basically, reverse engineer the brain for the drug instead of the drug for the brain.

As to how those receptors get into our brains... that's still to be determined

Hamilton explains it way better than I ever could, but hopefully this provides the jist of it

Okay, so imagine that you live in a world where all nations are now one. Now again, imagine that a super government has been formed to oversee this monumental new state.

The government wages a war on drugs prohibiting the manufacturing, distribution, and possession of every psychoactive drug. In this hypothetical world, the government are successful in eradicating every single drug forever. They they do however allow people to choose one psychoactive drug that's currently available today on the market (both including the legal pharmaceutical market and the street Market) to consume legally.

What drug do you take that you would say you have the best relationship with?

At first I thought caffeine and vyvanse, but I can depend on them too much at times. And a day with no stims is characterised by lethargy, low productivity and motivation.

But I do have a super position relationship with mushies and LSD. I take them in moderation, infrequently, and use them to elicit postive change.

"I think that actually represents one of the central problems with psychoactive drugs is you can think that they're helping you, but that's very different from them helping you. And I think that's actually one of the most important reasons to try to use them as infrequently as possible—it will aid that self-assessment because if you're constantly in the throes of it, you can easily lose track of who you are and how you relate to who you used to be and where you're going."

The above quote comes from this short audio clip

As title says is there any books you guys recommend that are about psychoactive substances? No drug in particular, anything from psychedelics to amphetamines to opioids. -couldnt post this in /drugs since i dont have enough karma so i decided to post in here