Osteoclast in bone marrow aspiration (MGG, x500)
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📅︎ Dec 12 2021
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osteoblast and osteoclast

I thought osteoclasts break down bone? is that what this card means by maintaining, the wording is confusing

https://preview.redd.it/fzrxo9siis381.png?width=1778&format=png&auto=webp&s=24bfd7fcb6239324d1f568a44ebe571a7a3bfb63

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📅︎ Dec 05 2021
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Antibody-induced pain-like behavior and bone erosion - links to subclinical inflammation, osteoclast activity and ASIC3-dependent sensitization journals.lww.com/pain/Abs…
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📅︎ Dec 24 2021
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ELI5 Why do osteoclasts break down bone matrix?

What is the purpose of breaking down bone?

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📅︎ Dec 04 2021
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Hydroxyproline levels to measure osteoclast activity?

First aid for step 1 2021 p50 says, "Hydroxyproline is used for lab quantification of collagen. "

Uworld step 1 QID 638 says that elevated urine levels of Hydroxyproline means there is excess osteoclast activity (collagen is broken down).

So my interpretation is that Hydroxyproline is used for lab quantification of osteoclast activity. Is that correct?

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📅︎ Nov 30 2021
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This c in osteoclasts is my greatest life achievement
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📅︎ Oct 03 2021
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How osteoclasts (bone cell) develop youtu.be/nPflPnTpCTE
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👤︎ u/Dolosus19
📅︎ Oct 12 2021
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Do Osteoclasts breakdown only Cortical Bone, or do they also breakdown Trabacular Bone?
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📅︎ Jun 25 2021
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Osteopetrosis literally means "stone bone". This hereditary disorder results from defective osteoclasts and overgrowth of bone which makes bones to become sclerotic and thick, but their abnormal structure results in them being both weak and brittle... medizzy.com/feed/102549
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👤︎ u/Surgeox
📅︎ Jul 17 2021
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How osteoclasts (bone cell) develop

Hi Folks!

This is a video from my YouTube series summarizing scientific papers. These are meant to be easier to digest for non-specialist audiences to help make primary scientific articles more accessible to everyone.

I am excited to share my latest video! This is a summary of the paper: Developmental origin, functional maintenance and genetic rescue of osteoclasts.

It outlines how osteoclasts are generated, how they function throughout life, and how they share genetic material from other cells by using a mouse model of osteopetrosis.

Any thoughts on the video are greatly appreciated. I hope that you enjoy learning about this interesting topic!

https://youtu.be/nPflPnTpCTE

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👤︎ u/Dolosus19
📅︎ Oct 12 2021
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Should i use osteoclast instead of primigenus(idk how to spell his name)

I have him hatching

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📅︎ Jun 18 2021
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How osteoclasts (bone cell) develop

Here is an interesting paper from Dr. F. Geissmann's lab from the Sloan Kettering Institute, New York, NY, USA. This paper shows a really cool development in understanding how osteoclasts are generated and elucidating how they can uptake genetic material from other cells.

Background:

-Osteopetrosis is a rare bone disease that causes bones to become denser and not develop fully that affects 1 out of every ~200 000 adults and 1 out of ~25-250 000 infants.
-This disease is characterized by deficient osteoclast (multi-nucleated resident macrophages in the bone) activity
-This disease can be treated by hematopoietic stem cell transplants in infants but has a 6-year survival rate of 48%.

Summary:

-The authors found that osteoclasts arise from erythro-myeloid progenitor cells that colonize the fetus during development as tissue-resident macrophages.
-Cells derived from Hematopoietic stem cells (HSCs) (monocytes) can be incorporated into osteoclasts after birth.
-This incorporation of cells derived from HSCs allows for genetic material sharing with osteoclasts.
-Sharing of genes that rescue the ones absent in osteoclasts reverses the symptoms of osteopetrosis.

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👤︎ u/Dolosus19
📅︎ Oct 12 2021
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Does vibration affect jaw osteoclasts? Like sonicare?

I had braces as a kid, got them off at 13, wore my retainer for a year, then nothing and my teeth were totally stable for 30 years.

Then in my early 40 (I'm 48 now), my teeth started moving all of the sudden. It's nuts, both uppers and lowers started shifting. It's to the point that I had to get braces (smile direct club) again. Why did this happen? It isn't happening to anyone else my age I know.

Also in my early 40s, I bought a sonicare. Id never have thought to connect my teeth moving to sonicare, but when I was searching for at home braces I did find ads for a rapid at home trays that use vibrating things to speed up the tooth alignment process. Is this at all scientific, that you can speed up tooth movements using vibrations? How would that work? Like stretching periodontal ligaments or activating osteoclasts?

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📅︎ Sep 30 2021
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Does PTH stimulate Osteoclast Production/Activity directly by itself, or does it stimulate Vitamin D to stimulate Osteoclasts?

Hi, my book is confusing me with these two lines:

  1. Vitamin D is Activated by PTH to increase Blood Ca²⁺
  2. PTH increases calcium when it is low in the blood by stimulating osteoclasts and depressing osteoblasts. Vitamin D also increases calcium in the blood by increasing the number of osteoclasts. Additionally, it stimulates the secretion of more PTH from the parathyroid gland

Does then PTH activate Vitamin D or does Vitamin D activate PTH and which one then works on the Osteoclasts? Because one says Vitamin D is activated by PTH but the other says that Vitamin D is needed for PTH to be secreted

Edit: Thank you Everyone for your Help!

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📅︎ May 28 2021
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What breaks down Cartilage? Is it the Osteoclasts or is there a cell called Chondroclast that does this?

Asking because there are cells called Chondroblasts and Chondrocytes, but are there then such thing as Chondroclasts or is the degradative Cartilage process done by Osteoclasts? I could not really find anything on google about Chondroclasts but maybe im not looking hard enough since the chondrocytes and blasts exist.

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📅︎ Jun 04 2021
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SARS-CoV-2 can alter bone marrow macrophage (BMM)-to-osteoclast differentiation, study finds news-medical.net/news/202…
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👤︎ u/shallah
📅︎ Apr 19 2021
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Bone Marrow Aspirate with Osteoclasts imgur.com/a/zVnPmuN
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👤︎ u/Nheea
📅︎ Oct 12 2020
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eli5: If osteoclasts and osteoblasts restructure bone density while wearing braces, why do teeth shift back to their original positions if a retainer isn't regularly worn? Why isn't the change in bone density permanent?
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📅︎ Nov 18 2020
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[Shitpost] Medical students of reddit, which one is your favorite: Osteoclast VS Osteoblast? And why?
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👤︎ u/txhrow1
📅︎ Aug 27 2020
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Osteoclast vs Osteoblast
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👤︎ u/_peeves
📅︎ Sep 15 2020
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TIL:how the process of shedding antlers work. Deer grow their impressive antlers in approx. 120 days. ~1.27cm/day. They grow inside a layer of skin commonly called "velvet" which provides nutrients for fast growth. Antlers fall off because of cells called osteoclasts, which split the antlers at base texashunterproducts.com/b…
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📅︎ Jul 31 2020
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How does calcium from osteoclasts reach effector "organs" like muscles to use? Does calcium stay in extracellular fluid

So I know osteoclasts break down calcium. So how does it reach the effector organs that use calcium? Is it through the blood vessels? So lets say it goes through the blood vessels. How does it get into the various cells to actually to be used? I guess in context of calcium is just stays in extracellular fluid till some voltage gated shit opens so it can go in or something like that?

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👤︎ u/FallsZero
📅︎ Sep 18 2020
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Bone Marrow Aspirate with Osteoclasts imgur.com/a/zVnPmuN
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👤︎ u/Nheea
📅︎ Oct 12 2020
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How osteoclasts (bone cell) develop

Hi Folks!

This is a video from my YouTube series summarizing scientific papers. These are meant to be easier to digest for non-specialist audiences to help make primary scientific articles more accessible to everyone.

I am excited to share my latest video! This is a summary of the paper: Developmental origin, functional maintenance and genetic rescue of osteoclasts.

It outlines how osteoclasts are generated, how they function throughout life, and how they share genetic material from other cells by using a mouse model of osteopetrosis.

Any thoughts on the video are greatly appreciated. I hope that you enjoy learning about this interesting topic!

https://youtu.be/nPflPnTpCTE

👍︎ 4
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👤︎ u/Dolosus19
📅︎ Oct 12 2021
🚨︎ report

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