I thought osteoclasts break down bone? is that what this card means by maintaining, the wording is confusing
https://preview.redd.it/fzrxo9siis381.png?width=1778&format=png&auto=webp&s=24bfd7fcb6239324d1f568a44ebe571a7a3bfb63
What is the purpose of breaking down bone?
First aid for step 1 2021 p50 says, "Hydroxyproline is used for lab quantification of collagen. "
Uworld step 1 QID 638 says that elevated urine levels of Hydroxyproline means there is excess osteoclast activity (collagen is broken down).
So my interpretation is that Hydroxyproline is used for lab quantification of osteoclast activity. Is that correct?
Hi Folks!
This is a video from my YouTube series summarizing scientific papers. These are meant to be easier to digest for non-specialist audiences to help make primary scientific articles more accessible to everyone.
I am excited to share my latest video! This is a summary of the paper: Developmental origin, functional maintenance and genetic rescue of osteoclasts.
It outlines how osteoclasts are generated, how they function throughout life, and how they share genetic material from other cells by using a mouse model of osteopetrosis.
Any thoughts on the video are greatly appreciated. I hope that you enjoy learning about this interesting topic!
I have him hatching
Here is an interesting paper from Dr. F. Geissmann's lab from the Sloan Kettering Institute, New York, NY, USA. This paper shows a really cool development in understanding how osteoclasts are generated and elucidating how they can uptake genetic material from other cells.
Background:
-Osteopetrosis is a rare bone disease that causes bones to become denser and not develop fully that affects 1 out of every ~200 000 adults and 1 out of ~25-250 000 infants.
-This disease is characterized by deficient osteoclast (multi-nucleated resident macrophages in the bone) activity
-This disease can be treated by hematopoietic stem cell transplants in infants but has a 6-year survival rate of 48%.
Summary:
-The authors found that osteoclasts arise from erythro-myeloid progenitor cells that colonize the fetus during development as tissue-resident macrophages.
-Cells derived from Hematopoietic stem cells (HSCs) (monocytes) can be incorporated into osteoclasts after birth.
-This incorporation of cells derived from HSCs allows for genetic material sharing with osteoclasts.
-Sharing of genes that rescue the ones absent in osteoclasts reverses the symptoms of osteopetrosis.
I had braces as a kid, got them off at 13, wore my retainer for a year, then nothing and my teeth were totally stable for 30 years.
Then in my early 40 (I'm 48 now), my teeth started moving all of the sudden. It's nuts, both uppers and lowers started shifting. It's to the point that I had to get braces (smile direct club) again. Why did this happen? It isn't happening to anyone else my age I know.
Also in my early 40s, I bought a sonicare. Id never have thought to connect my teeth moving to sonicare, but when I was searching for at home braces I did find ads for a rapid at home trays that use vibrating things to speed up the tooth alignment process. Is this at all scientific, that you can speed up tooth movements using vibrations? How would that work? Like stretching periodontal ligaments or activating osteoclasts?
Hi, my book is confusing me with these two lines:
- Vitamin D is Activated by PTH to increase Blood Ca²⁺
- PTH increases calcium when it is low in the blood by stimulating osteoclasts and depressing osteoblasts. Vitamin D also increases calcium in the blood by increasing the number of osteoclasts. Additionally, it stimulates the secretion of more PTH from the parathyroid gland
Does then PTH activate Vitamin D or does Vitamin D activate PTH and which one then works on the Osteoclasts? Because one says Vitamin D is activated by PTH but the other says that Vitamin D is needed for PTH to be secreted
Edit: Thank you Everyone for your Help!
Asking because there are cells called Chondroblasts and Chondrocytes, but are there then such thing as Chondroclasts or is the degradative Cartilage process done by Osteoclasts? I could not really find anything on google about Chondroclasts but maybe im not looking hard enough since the chondrocytes and blasts exist.
So I know osteoclasts break down calcium. So how does it reach the effector organs that use calcium? Is it through the blood vessels? So lets say it goes through the blood vessels. How does it get into the various cells to actually to be used? I guess in context of calcium is just stays in extracellular fluid till some voltage gated shit opens so it can go in or something like that?
Hi Folks!
This is a video from my YouTube series summarizing scientific papers. These are meant to be easier to digest for non-specialist audiences to help make primary scientific articles more accessible to everyone.
I am excited to share my latest video! This is a summary of the paper: Developmental origin, functional maintenance and genetic rescue of osteoclasts.
It outlines how osteoclasts are generated, how they function throughout life, and how they share genetic material from other cells by using a mouse model of osteopetrosis.
Any thoughts on the video are greatly appreciated. I hope that you enjoy learning about this interesting topic!
