Glyceryl Trinitrate is found in various medications. How does this cause headaches when applied to the skin or ingested?
I was watching Falling Skies recently and one of the characters was using nitroglycerin as a medicine. After a quick glance of the Wikipedia article, I was wondering which use came first, the weaponization or the medical treatment. No matter what the order is, I'm sure it was an interesting discussion.
Did a doctor give it as a medicine for heart disease and then someone caught it on fire or was it the other way around where someone was playing with their medication? Furthermore, is there a history of combustible compounds having other uses that are surprising or is nitroglycerin an anomaly?
Hello everyone, I am 30 yr old male from the UK and this is the first time ive ever posted on this website at all.
First off, this thread helped me so much through the darkest, hardest days. I spent many an hour with my face in a pillow, screaming, arse in the air and when I could I would look up and scroll through the posts on this to reassure myself I wasn't the only one.
So, I am now 8 weeks tomorrow absolutely pain free and I know this because I kept a diary of literally everything that was going. I thought now would be a good time to make my first ever reddit post to offer some hope to those who are going through the same hell that I did.
My story started on 3rd November 2020. I had a horrible case of norovirus (chronic diarrhea) for about 5 days before, after that i was pretty clogged up and ended up passing a massive BM after not being able to go to the toilet for about three days. I properly forced it out, worrying that if I left the poo in me any longer, I would make myself ill again or something. How wrong I was. What followed was what we all here have been through, tear, blood, pain. I have had haemorrhoids pretty much on and off for the last decade or so, so at first I just thought I had a real bad case of that. A few days after the initial tear and still thinking it was haemorrhoids I went for a walk, which usually helps me with discomfort. This pain though was so bad that I had to run home and thus began the daily cycle of screaming into a pillow for 2 hours.
Another thing is the pain schedule was a little different for me. I felt a small amount of pain during a BM, say that was at 10am, but it wasn't until around 2pm that the real pain would kick in, rendering me immobile until about 8pm. The only silver lining of this was that due to the pandemic I wasn't in work, because having to serve people in a cafe and spending all day on my feet during this would have been horrendous. God bless my girlfriend for helping me through this as well. I literally couldnt do anything. The amount of times I would have to give up on walks, or leave her to do the grocery shopping is outrageous. It is 100% the hardest thing so far in my life I have had to get through medically. Basic things become such a horrible chore.
Anyway, sorry if this is a bit of a ramble, ill try and cut to the chase of what really helped me. I tried all sorts, aloe vera gel, vaseline, haemorrhoid cream etc, but over time and reading this website A LOT, I managed to figure o
... keep reading on reddit ➡Shouldn’t be surprising that TRT isn’t healthy
“ The endothelium is integral to the maintenance of vascular health in humans, and advancing age and low testosterone levels are associated with endothelial dysfunction in men. We compared the impacts of testosterone and exercise training, alone and in combination, on endothelium-dependent flow-mediated dilation % and endothelium-independent glyceryl trinitrate % responses. In this 2×2 factorial 12-week randomized controlled trial, 80 men aged 50 to 70 years with waist girth ≥95 cm and low-normal serum testosterone levels (6–14 nmol/L) were randomized to transdermal AndroForte5 (testosterone 5.0% w/v, 100 mg/2 mL; testosterone), or matching placebo; and to supervised centre-based exercise or no additional exercise. Testosterone increased serum testosterone levels (testosterone×time, P=0.003) to the extent that 62% of subjects in testosterone groups increased levels to >14 nmol/L, whereas placebo treatment had no impact on testosterone levels. Exercise training increased flow-mediated dilation % (exercise×time, P=0.033; testosterone+exercise: +0.5, placebo+exercise: +1.0 versus testosterone+no additional exercise: −0.7, placebo+no additional exercise: +0.2%), whereas testosterone did not impact flow-mediated dilation, nor was it additive to exercise (all P>0.05). There were no significant exercise or drug main effects on glyceryl trinitrate responses (all P>0.05). Exercise training improved endothelium-dependent vasodilator function, whereas administration of testosterone at therapeutic doses did not impact flow-mediated dilation % or add to the exercise benefit. Vascular smooth muscle sensitivity to nitric oxide was not modified by exercise, testosterone, or their combination. In middle-to-older-aged men with central adiposity and low/normal testosterone levels, we observed no evidence that testosterone added to the beneficial impact of exercise on vascular function and health.”
https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.120.16411
Hey guys! Last Tuesday I woke up with the worst pain in my butt and pelvic region, scheduled an appointment for the next day, and the surgeon diagnosed it as an anal fissure. I have all the symptoms you guys are describing, including now after a few days some constipation and dysuria due to being so scared to have BM, and honestly it feels like I’m constantly being stabbed. The doctor said it was so bad that it wouldn’t be worth it to go down the glyceryl trinitrate / Rectogesic route although I’d be free to do so if I wished.
LASER SURGERY: He suggested I get a new kind of treatment which is laser fissurectomy. It doesn’t even touch the inner sphincter so chances of incontinence are zero. I’ve read a research paper on it and the results sound amazing. The pain would immediately improve (please!) and over a few months the fissure would completely be healed. I’m gonna go through with it, considering the alternative is a recurring chronic fissure that never fully heals.
LIS VS Sphincteromy: By the way, from what I’ve gathered, the lateral internal sphincterotomy (LIS) and procedures which involve cutting the inner sphincter have pretty much been phased out in most western countries. To quote a research paper, “in countries like France, the fissurectomy has been the standard of care for a chronic anal fissure for a long time”. So even without the “laser” component of the surgery, a fissurectomy seems to be a better choice than an LIS.
Thankfully I live in a country with a relatively great, but importantly free healthcare system. I don’t know what I’d do if I lived in the US, and I feel so sorry reading all your posts. :(
INITIAL MISDIAGNOSIS: Around last November I noticed a skin tag on my butthole, went to a surgeon who said it was nothing at all and gave me a hemorrhoid creme which probably made things worse. NEVER use hemorrhoids creme on fissures, it restricts blood flow. I also frequently suffer from diarrhea and my eating habits have not been the best. Other than the skin tag and discomfort during anal play, the fissure gave me absolutely no symptoms. So really the misdiagnosis made things worse because I assumed everything was fine with my butthole and just went ham with it.
ANAL: I’m bisexual 21M. I’ve only started properly trying anal a year ago, never got through with it more than a few times cause I always had pain during sex and bleeding post-anal which I attributed to just being normal (not true, anal is not supposed to hur
... keep reading on reddit ➡Go post NSFW jokes somewhere else. If I can't tell my kids this joke, then it is not a DAD JOKE.
If you feel it's appropriate to share NSFW jokes with your kids, that's on you. But a real, true dad joke should work for anyone's kid.
Mods... If you exist... Please, stop this madness. Rule #6 should simply not allow NSFW or (wtf) NSFL tags. Also, remember that MINORS browse this subreddit too? Why put that in rule #6, then allow NSFW???
Please consider changing rule #6. I love this sub, but the recent influx of NSFW tagged posts that get all the upvotes, just seem wrong when there are good solid DAD jokes being overlooked because of them.
Thank you,
A Dad.
Martin Freeman, and Andy Serkis.
They also play roles in Lord of the Rings.
I guess that makes them the Tolkien white guys.
She said apple-lutely
'Eye-do'
This is my first post pls don't kill me lol.
The people in the comment section is why I love this subreddit!!
Cred once again my sis wants credit lol
Hey Gang. I've mentioned before that most drugs contain APIs (Active Pharmaceutical Ingredients) produced in China.
Also, here is a current list of Current and Resolved Drug Shortages and Discontinuations Reported to FDA. This list is actively updated by the FDA:
https://www.accessdata.fda.gov/scripts/drugshortages/default.cfm
If you rely on any of these medications, please talk to your Doctor and make sure you have enough to cover yourself for 60 days. Supply chains are starting to have issues. In a few weeks you may not be able to get your medication when you need it.
This is a list of 150 drugs that are sourced from China:
Aciclovir – (Zovirax) – antiviral drug
Advair – asthma medicine
Adrenaline Hcl – treatment for cardiac arrest
Albendazole – treatment for worms
Alfuzosin – (Uroxatral) treatment for enlarged prostate
Allopurinol – gout treatment
Alprazolam – (Xanax) – treatment for anxiety disorders
Amikacin sulfate – treatment for bacterial infections
Aminophyline -treatment for cerebral ischemia
Amiodarone Hydrochloride -treatment for irregular heartbeat
Amlodipine – treats high blood pressure & angina
Ampicillin – antibiotic
Amodiaquine – treatment of malaria
Amoxicillin – antibiotic
Aniracetam – (Draganon, Sarpul, Ampamet) a congnition enhancer
Artemether – treats drug resistant malaria
Artesunate – malaria treatment
Aspirin – anti-inflammatory painkiller
Artemether – treats malaria
Atenolol – high blood pressure medicine
Atropine – antidote against nerve agents
Avandia – (Avandia) treatment of diabetes
Budesonide – (Entocort) treatment of allergy & asthma
Bupropion (Wellbutrin) antidepressant
Calcifediol – treats vitamin D deficiency
Candesartan – (Blopress, Atacand, Amias, Ratacand) treats hypertension
Captopril – (Capoten, Inhibace) treatment for hypertension & congestive heart failure
Carbamazepine – treatment of epilepsy, ADD & ADHD
Carnosine – treatment for autism
Cefixime – antibiotic
Cefotaxime – (Claforan) antibiotic
Cefsulodin – also, cephalosporin – antibiotic
Cephealexin – (Keflex, Keftab) – antibiotic
Chloramphenicol – antibiotic
Chlorpheniramine Maleate – (Chlor-Trimeton, Piriton) Antihistamine
Chlorpromazine Hydrochloride
Chloroquine Phosphate – treatment of malaria
Cilexetil – (Atacand) treats high blood pressure
Cilostazole – (Pletal) treats peripheral vascular disease
Cimetidine – (Tagame
... keep reading on reddit ➡I heard parents named their children lance a lot.
First post please don't kill me
Edit: i went to sleep and now my inbox is dead, thank you kind strangers for the awards!
Well, toucan play at that game.
second hand stores!
Old Neeeeiiiiighvy
it's Hans free now..
10+10 is twenty and 11+11 is twenty too
A buck-an-ear!
I Thank ye kind Matey for the booty! I be truly overwhelmed! Thank you!
Holy cow! Thank you everyone for the upvotes and awards! I wasn’t expecting this!
He should have a good vowel movement. His next diaper change could spell disaster though.
Making it all the way home and realizing that they forgot one of the containers:
Riceless
That was the punchline
So I’ve had a few small tears in the past, one requiring some treatment by a proctologist to help the healing. It’s been a while but I got another one at the start of December because I didn’t take it slow enough when bottoming.
I laid off it for a few weeks and tried again with a mate on New Years but it seems to have triggered the fissure again. It’s gotten me pretty depressed because I can’t do something I really enjoy and feel pretty isolated not knowing if it’s a shared experience with other 20-something year olds.
Anyway, how long should I wait before I try again? Does anyone have much experience with fissures? This one seems pretty ‘up there’ so I can’t see anything or feel a sting, just a bit of an ache from time to time... but that could be because I train legs a lot too.
Frustrating af...
Without missing a beat he asks "Daddy, do you know how much room you need to grow Fungi like that?"
I did not know.
So he tells me "as Mushroom as possible!"
So proud.
Feyonce
He was so brave and even tried to encourage us, the family around him, with his last breaths. He kept whispering to us to Be Positive.
He said, “Change the batteries in your hearing aid”.
She was pretty mad when I only picked seven up
So far no one has given me a straight answer.
Alzheimer, Grandma, it's Alzheimer.
“ The endothelium is integral to the maintenance of vascular health in humans, and advancing age and low testosterone levels are associated with endothelial dysfunction in men. We compared the impacts of testosterone and exercise training, alone and in combination, on endothelium-dependent flow-mediated dilation % and endothelium-independent glyceryl trinitrate % responses. In this 2×2 factorial 12-week randomized controlled trial, 80 men aged 50 to 70 years with waist girth ≥95 cm and low-normal serum testosterone levels (6–14 nmol/L) were randomized to transdermal AndroForte5 (testosterone 5.0% w/v, 100 mg/2 mL; testosterone), or matching placebo; and to supervised centre-based exercise or no additional exercise. Testosterone increased serum testosterone levels (testosterone×time, P=0.003) to the extent that 62% of subjects in testosterone groups increased levels to >14 nmol/L, whereas placebo treatment had no impact on testosterone levels. Exercise training increased flow-mediated dilation % (exercise×time, P=0.033; testosterone+exercise: +0.5, placebo+exercise: +1.0 versus testosterone+no additional exercise: −0.7, placebo+no additional exercise: +0.2%), whereas testosterone did not impact flow-mediated dilation, nor was it additive to exercise (all P>0.05). There were no significant exercise or drug main effects on glyceryl trinitrate responses (all P>0.05). Exercise training improved endothelium-dependent vasodilator function, whereas administration of testosterone at therapeutic doses did not impact flow-mediated dilation % or add to the exercise benefit. Vascular smooth muscle sensitivity to nitric oxide was not modified by exercise, testosterone, or their combination. In middle-to-older-aged men with central adiposity and low/normal testosterone levels, we observed no evidence that testosterone added to the beneficial impact of exercise on vascular function and health.”
https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.120.16411
Hi all, I am a global supply chain exec at a electronics manufacturing firm and a fellow gout sufferer. I don't want to cause undue concern, I just want to inform. If you have been paying attention, you all know about the Coronasvirus pandemic (it's not really a pandemic yet) and the effects that it is having on the global supply chain. Gout suffers should be aware that China is a major producer of allopurinol for the world market and cannot and will not be shipping for at least another month possibly longer. If you prescription is low, I would consider refilling now.
edit: I SHOULD HAVE INCLUDED THIS TO BEGIN WITH, SORRY:
Here is a list of some of the drugs manufactured in China; this list does NOT include drugs that simply require ingredients made in China, but please understand that that supply chain will also likely be impacted. While any prescription drug may fall victim to shortages in the coming months, these are the most likely candidates. If necessary, please speak to your doctors if you require any of the listed below. If you know you depend on any of the OTC listed, the time to stock up is NOW.
Also, people with diabetes: Insulin is made in Europe and the US, however, the syringes, needles, pens, and pumps are made in China. Plan accordingly.
Aciclovir – (Zovirax) – antiviral drug
Advair – asthma medicine
Adrenaline Hcl – treatment for cardiac arrest
Albendazole – treatment for worms
Alfuzosin – (Uroxatral) treatment for enlarged prostate
Allopurinol – gout treatment
Alprazolam – (Xanax) – treatment for anxiety disorders
Amikacin sulfate – treatment for bacterial infections
Aminophyline -treatment for cerebral ischemia
Amiodarone Hydrochloride -treatment for irregular heartbeat
Amlodipine – treats high blood pressure & angina
Ampicillin – antibiotic
Amodiaquine – treatment of malaria
Amoxicillin – antibiotic
Aniracetam – (Draganon, Sarpul, Ampamet) a congnition enhancer
Artemether – treats drug resistant malaria
Artesunate – malaria treatment
Aspirin – anti-inflammatory painkiller
Artemether – treats malaria
Atenolol – high blood pressure medicine
Atropine – antidote against nerve agents
Avandia – (Avandia) treatment of diabetes
Budesonide – (Entocort) treatment of allergy & asthma
Bupropion (Wellbutrin) antidepressant
Calcifediol – treats vitamin D deficiency
Candesartan – (Blopress, Atacand, Amias, Ratacand) treats hypertension
Captopril – (Capoten, Inhibace) treatment for hypertension & conge
... keep reading on reddit ➡