Just wondering if it's possible to have an inflammatory arthritic condition (such as rheumatoid arthritis) while having normal C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) bloodwork.
Using an erythrocyte fatty acid fingerprint to predict risk of all-cause mortality: the Framingham Offspring Cohort
Michael I McBurney, Nathan L Tintle, Ramachandran S Vasan, Aleix Sala-Vila, William S HarrisThe American Journal of Clinical Nutrition, nqab195, https://doi.org/10.1093/ajcn/nqab195
Published: 16 June 2021 Article history
ABSTRACT
Background
RBC long-chain omega-3 (n–3) fatty acid (FA) percentages (of total fatty acids) are associated with lower risk for total mortality, but it is unknown if a suite of FAs could improve risk prediction.
Objectives
The objective of this study was to compare a combination of RBC FA levels with standard risk factors for cardiovascular disease (CVD) in predicting risk of all-cause mortality.
Methods
Framingham Offspring Cohort participants without prevalent CVD having RBC FA measurements and relevant baseline clinical covariates (n = 2240) were evaluated during 11 y of follow-up. A forward, stepwise approach was used to systematically evaluate the association of 8 standard risk factors (age, sex, total cholesterol, HDL cholesterol, hypertension treatment, systolic blood pressure, smoking status, and prevalent diabetes) and 28 FA metrics with all-cause mortality. A 10-fold cross-validation process was used to build and validate models adjusted for age and sex.
Results
Four of 28 FA metrics [14:0, 16:1n–7, 22:0, and omega-3 index (O3I; 20:5n–3 + 22:6n–3)] appeared in ≥5 of the discovery models as significant predictors of all-cause mortality. In age- and sex-adjusted models, a model with 4 FA metrics was at least as good at predicting all-cause mortality as a model including the remaining 6 standard risk factors (C-statistic: 0.778; 95% CI: 0.759, 0.797; comp
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Background: 63F. ABVD chemo for CHL. 2.5 cycles/6 in for stage 2BS (since treatment theres been reduced B symptoms but still occasionally lymphoma-fevers). No active infection. Doctor thinks high ESR is cancer related.
Anyone have any experience with high ESR? And did you present with B symptoms? Was it high throughout treatment?
500mm/hr compared to the baseline <50. To me this 10x factor seems to be whopping - and very concerning.
Any comments with regard to this literature about ESR and prognosis.
I tried LT 150 last year. It gave me TSH 0.11 and it was terrible. I’m afraid LT 137 can do that too!
I’m female, 28 years old. And I have Hashimoto‘s since 2012.
What is it about the proton that prevents it from leaving the rbc where then an extra process of a chloride shift is required to get rid of the H+
