Calcium hyperproficiency is a rare complication of vitamin D deficiency, where excess calcium from bone resorption forms complex structures resembling teeth. Neoformed teeth grow on different bones, such as this patient's hand, causing fractures and joint dysfunction. (Photoshop art by Valdevia)
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👤︎ u/Valdevia
📅︎ Nov 08 2021
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When bears hibernate, they avoid osteoporosis by turning off the genes for bone resorption and bone formation massivesci.com/notes/bone…
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📅︎ Jun 04 2021
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After age 50, bone breakdown (resorption) outpaces bone formation and bone loss often accelerates, particularly at the time of menopause.

This is another reason why after 50 it is more and hard work to Reverse Age a body, think of the work it takes to re-build the whole bone structure! not to forget the joints! Can't be done? Well, not by Billionaire and their dumb PETS! LOL

Downside? bloody "bone pain" that you forgot about for decades, re-visited! NOT NICE.

On women, menopause itself has to be paused! Done it too!

How is it that they can't do it?

https://preview.redd.it/89gtd9hk60t71.jpg?width=1200&format=pjpg&auto=webp&s=543afd9fd6ab71d51a5deb6f370011f6d3d72036

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📅︎ Oct 12 2021
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TIL In the first year of life humans replace 100% of their Skeleton through bone resorption and bone formation. wikipedia.org/wiki/Bone_r…
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📅︎ Mar 06 2021
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confused about bone decay vs bone resorption...a lose - lose situation?

Hello,

I'm getting a chipped tooth extracted, as it has been chipped for a year after a bicycle accident. Covid made seeing a dentist near impossible, and now its infected (molar 14) - the dentist I'm seeing now said I would need a 3 tooth bridge (more on this later)

I am confused about decay vs bone resorption after tooth extraction?

Seems like I will be losing bone regardless if I keep my tooth in, or get it extracted? My X rays show I have already lost some bone (the doc said its about 1mm). When I inquired about bone loss after extraction, he said don't worry about it since I am still fairly young (28 years old). And I would have to wait for the bone to rebuild itself after the extraction? But reading online, it says I will lose bone if I get my tooth extracted.... I am very confused....

As I am low income since losing my job during COVID, I got to think about all the money i've managed to save up during this entire pandemic. Which is about 5,000. So, it seems like the only difference is the 3,600.00 bill my dentist is charging me AND losing/destroying the additional teeth next to the infected one to put a bridge in...

It just feels like "damned if I do, and damned if I don't"

If I get it extracted and don't get the bridge, the dentist says I risk the back tooth shifting inward toward the gap, and bone loss will still happen on top of that? If I leave the tooth in, I risk bone loss via infection. I don't get it which is worse.

I suppose it would make my decision easier, if I could get a single implant done, but my dentist says an implant procedure cost as much as a house??....he also will not work with me on the costs/payment options since he got jibbed by previous patients.

So I've even looked at going to one of those "aspen dental" but heard nothing but bad things about them, and my dentists knows I am worried about the quality of service from aspen dental. Also every dentist in my area, including aspen dental - have a 4 - 6 week waiting period.

Any advice/experience/wisdom will be greatly appreciated.

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📅︎ Mar 20 2021
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When bears hibernate, they avoid osteoporosis by turning off the genes for bone resorption and bone formation massivesci.com/notes/bone…
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📅︎ Jun 05 2021
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Keratosis obturans discussed (bone resorption due to keratin plug in ear) youtu.be/MgNypDr7gMo
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📅︎ Jan 22 2021
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Partial Replacement of Animal Proteins with Plant Proteins for 12 Weeks Accelerates Bone Turnover Among Healthy Adults: A Randomized Clinical Trial [Partial replacement of animal proteins with plant-based proteins for 12 weeks increased the markers of bone resorption and formation]- a bad thing 2020 /r/ketoscience/comments/i…
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📅︎ Sep 21 2020
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Effects of Short-Term Dried Plum (Prune) Intake on Markers of Bone Resorption and Vascular Function in Healthy Postmenopausal Women: A Randomized Crossover Trial (2019) pubmed.ncbi.nlm.nih.gov/3…
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📅︎ Oct 07 2020
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This may be a very simple concept, but I always seems to get the terms confused. Could someone please explain bone resorption, mineralization and demineralization?

My understanding is that bone resorption is osteoclasts breaking down bone and bone mineralization is osteoblasts adding minerals and making bone. But then I don’t understand what the difference between resorption and demineralization is.

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👤︎ u/One_Pebble
📅︎ Nov 28 2020
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Partial Replacement of Animal Proteins with Plant Proteins for 12 Weeks Accelerates Bone Turnover Among Healthy Adults: A Randomized Clinical Trial [Partial replacement of animal proteins with plant-based proteins for 12 weeks increased the markers of bone resorption and formation]- a bad thing 2020

Partial Replacement of Animal Proteins with Plant Proteins for 12 Weeks Accelerates Bone Turnover Among Healthy Adults: A Randomized Clinical Trial

https://academic.oup.com/jn/advance-article-abstract/doi/10.1093/jn/nxaa264/5906634?redirectedFrom=fulltext

Full Text on Sci-Hub

Suvi T Itkonen, Essi Päivärinta, Tiina Pellinen, Hanna Viitakangas, Juha Risteli, Maijaliisa Erkkola, Christel Lamberg-Allardt, Anne-Maria PajariThe Journal of Nutrition, nxaa264, https://doi.org/10.1093/jn/nxaa264

Published: 16 September 2020

ABSTRACT

Background

Plant-based diets may reduce the risk of chronic diseases, but can also lead to low calcium and vitamin D intakes, posing a risk for bone health.

Objectives

We investigated whether partial replacement of animal proteins with plant-based proteins using a whole-diet approach affects bone and mineral metabolism in healthy adults in 3 groups fed diets differing in protein composition.

Methods

This 12-week clinical trial was comprised of 107 women and 29 men (20–69 years old; BMI mean ± SD, 24.8 ± 3.9) randomly assigned to consume 1 of 3 diets designed to provide 17 energy percent (E%) protein: “animal” (70% animal protein, 30% plant protein of total protein intake), “50/50” (50% animal, 50% plant), and “plant” (30% animal, 70% plant) diets. We examined differences in bone formation [serum intact procollagen type I amino-terminal propeptide (S-iPINP)], bone resorption [serum collagen type 1 cross-linked C-terminal telopeptide (S-CTX)], mineral metabolism markers (primary outcomes), and nutrient intakes (secondary outcomes) by ANOVA/ANCOVA.

Results

S-CTX was significantly higher in the plant group (mean ± SEM, 0.44 ± 0.02 ng/mL) than in the other groups (P values < 0.001 for both), and differed also between the animal (mean ± SEM, 0.29 ± 0.02 ng/mL) and 50/50 groups (mean ± SEM, 0.34 ± 0.02 ng/mL; P = 0.018). S-iPINP was significantly higher in the plant group (mean ± SEM, 63.9 ± 1.91 ng/mL) than in the animal group (mean ± SEM, 55.0 ± 1.82 ng/mL; P = 0.006). In a subgroup without a history of vitamin D supplement use, plasma parathyroid hormone was significantly higher in the plant than in the animal grou

... keep reading on reddit ➡

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📅︎ Sep 21 2020
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An Acid Activatable Fluorescence Probe for Imaging Osteocytic Bone Resorption Activity in Deep Bone Cavities

A rationally designed pH‐activatable fluorescent probe (pHocas‐RIS) has been used to measure localised pH levels in osteocytic lacunae in bone tissue. Conjugation of the moderate bone binding drug risedronate to a pH activatable BODIPY fluorophore enables the probe to penetrate osteocytic lacunae cavities that are embedded deep within the bone matrix. After injection of pHocas‐RIS, any osteocytic lacunae caused by bone‐resorbing osteocytes cause the probe to fluoresce in vivo , thus allowing imaging to be carried out using intravital two‐photon excitation microscopy. This enables this pH responsive probe to be used to visualize the bone mineralizing activities of acid producing osteocytes in real time, thus providing a valuable imaging method to explore their central role in remodeling bone‐matrix in health and disease.

https://ift.tt/2XmBDRt

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📅︎ Aug 04 2020
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Dental implant, bone infection, bone resorption - Second opinions

Dear Dentists,

I'm writing to you in hopes to get the opinion of the qualified Reddit crowd. This is a case that's bothered me for about a year now, although its history is longer.

I was born with a defect where tooth 3 was positioned on top of tooth 2. After some orthodontic treatment where they attempted to pull tooth 3 down, they decided to remove the tooth entirely. I was 15 at the time, now I'm 28 (female). I've been having one of those plastic prosthetic things that you can put off and on daily since then.

It worked well (still does), until my dentist saw an X-Ray last August and realised tooth 2's nerve was dead. She's not an implant person/oral surgeon, so she suggested I see an endodontist to do a root canal treatment on 2. The root canal was done in November 2019. The X-Ray below was taken today (June 2020). The dentist whom I had a consultation with told me there's an infection, and it hasn't subsided, despite the expectations of the endodontist. The dentist from today suggests a cleaning around the root of the tooth (not inside). I don't know how this works, but she assures me that it might help the infection if it's cleaned out. Is this true? She mentioned the 'cleaning' is mechanical, and not chemical. How is mechanical removal of any debris meant to heal an infection of the bone? How does this work?

Tooth 2 itself feels normal, however applying pressure to it (such as when I bite), feels a little off. It doesn't move, it just feels a little weird when I tap it from below (same direction as biting). It's enough to notice and cause concern.

My ideal scenario is to have the perfect smile. I want to do some straightening and whitening. I've been told to do any orthodontic treatment before any implant surgery or bone grafting, but this seems weird to me. What if tooth 2 is lost when it's being pulled in different directions to straighten it, when its bone integrity is compromised?

It seems to me there's different specialists whose opinions matter (endodonsist, orthodontist, implant surgeons, etc) and I can't really get them to talk to each other and discuss the whole case entirely. So, I'm here, asking the Reddit community of qualified professionals to shed some light, if possible.

Please share your thoughts and if possible, include a timeline of the procedures. How long between what to heal etc.

Thanks in advance.

[Panoramic x-ray](https://preview.redd.it/fhegooeg19451.png?width=3078&format=png&auto=webp&s=766e69a6d363c

... keep reading on reddit ➡

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👤︎ u/snoo2992
📅︎ Jun 11 2020
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Soy isoflavones prevent bone resorption and loss, a systematic review and meta-analysis of randomized controlled trials. [Akhlaghi et al., 2019] ncbi.nlm.nih.gov/pubmed/3…
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👤︎ u/dreiter
📅︎ Jul 18 2019
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"ATRAID" gene: Osteoporosis is commonly treated with Bisphosphonates, which inhibit bone resorption. But these drugs are associated with serious adverse effects, including osteonecrosis and fractures. Researchers have now identified a gene known as "ATRAID" that is linked with these adverse effects. nature.com/articles/s4157…
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📅︎ Jun 18 2020
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[Zanki] Why do high levels of vitamin D promote bone resorption?

zanki card i am referring to:

https://imgur.com/a/WDRRlRw

in my mind, vitamin D brings more calcium into the body due to increased absorption in the intestinal tract. this increase in calcium will be used to build the osteoid in the bone. so shouldn't high levels of vitamin D promote bone mineralization rather than resorption?

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👤︎ u/AlexPie2
📅︎ Sep 27 2019
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Alkaline mineral water lowers bone resorption even in calcium sufficiency:: Alkaline mineral water and bone metabolism

So recently one of my friends started talking about alkaline water and how it is ''beneficial'' for health and such, and he linked me this science article to support his claim, citing how it helps on bone metabolism and preventing osteoporosis

https://www.sciencedirect.com/science/article/pii/S8756328208007813 " Alkaline mineral water lowers bone resorption even in calcium sufficiency: Alkaline mineral water and bone metabolism "

Abstract

Background

Dietary acid charge enhances bone loss. Bicarbonate or alkali diet decreases bone resorption in humans. We compared the effect of an alkaline mineral water, rich in bicarbonate, with that of an acid one, rich in calcium only, on bone markers, in young women with a normal calcium intake.

Methods

This study compared water A (per litre: 520 mg Ca, 291 mg HCO3−, 1160 mg SO4−, Potential Renal Acid load (PRAL) + 9.2 mEq) with water B (per litre: 547 mg Ca, 2172 mg HCO3−, 9 mg SO4−, PRAL − 11.2 mEq). 30 female dieticians aged 26.3 yrs (SD 7.3) were randomized into two groups, followed an identical weighed, balanced diet (965 mg Ca) and drank 1.5 l/d of the assigned water. Changes in blood and urine electrolytes, C-telopeptides (CTX), urinary pH and bicarbonate, and serum PTH were measured after 2 and 4 weeks.

Results

The two groups were not different at baseline, and showed a similar increase in urinary calcium excrection. Urinary pH and bicarbonate excretion increased with water B, but not with water A. PTH (p = 0.022) and S-CTX (p = 0.023) decreased with water B but not with water A.

Conclusion

In calcium sufficiency, the acid calcium-rich water had no effect on bone resorption, while the alkaline water rich in bicarbonate led to a significant decrease of PTH and of S-CTX.

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Not sure if these are just snake oil cons defrauding stupid people with techno-babble or have some actual valid points into drinking alkaline water, so I came here.

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📅︎ Dec 28 2018
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Soy isoflavones prevent bone resorption and loss, a systematic review and meta-analysis of randomized controlled trials. [Akhlaghi et al., 2019] ncbi.nlm.nih.gov/pubmed/3…
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👤︎ u/dreiter
📅︎ Jul 18 2019
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Resorption/bone loss

Around two months ago, I started to have some pain around the area of my back two molars (wisdom teeth already removed). The gums inbetween the two teeth were inflammed and swollen. My dentist wasn't able to detect any cavity and/or abcess on either tooth, and deduced a faint lite gray line one of the molars could be resorption. The endodontist took a CT scan which revealed resorption in the first molar. I asked how could something contained within the tooth causes the gums to inflame, to which he replied I have bone loss in the space inbetween the back two molars. This is very confusing to me as no dentists I have been to over the past few years have claimed I have periodontal disease/ bone loss in this area, and I have kept up my dental hygeine.

Can resorption in a tooth cause gums to inflame around said tooth and cause this bone loss? The resorption I have is contained entirely within the tooth and is on the opposite side of the area with bone loss. I woke up with a lot of pain today, but don't want to get a root canal that will not fix said pain.

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📅︎ Mar 18 2020
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Implant post-placement for #33. Bone graft. Implant fully integrated into the bone matrix. Molar #33 removed due to root resorption.
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📅︎ Jul 09 2019
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Question on bone; isn't answer choice B true? (doesn't vitamin D decrease the resorption (breaking down) of bone?)
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👤︎ u/Eddweirdo
📅︎ Jun 27 2019
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damage to bone from tooth resorption/abscess?
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📅︎ Oct 14 2019
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Soy isoflavones prevent bone resorption and loss, a systematic review and meta-analysis of randomized controlled trials. [Akhlaghi et al., 2019] ncbi.nlm.nih.gov/pubmed/3…
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👤︎ u/dreiter
📅︎ Jul 18 2019
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abstract Mushroom Extracts Decrease Bone Resorption and Improve Bone Formation [animal study - 2016]

Mushroom extracts have shown promising effects in the treatment of cancer and various chronic diseases.

Osteoporosis is considered one of the most widespread chronic diseases, for which currently available therapies show mixed results.

In this research we investigated the in vitro effects of water extracts of the culinary-medicinal mushrooms Trametes versicolor, Grifola frondosa, Lentinus edodes, and Pleurotus ostreatus on a MC3T3-E1 mouse osteoblast-like cell line, primary rat osteoblasts, and primary rat osteoclasts

- https://www.ncbi.nlm.nih.gov/pubmed/27649725

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👤︎ u/Sorin61
📅︎ Dec 15 2019
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How does increased bone resorption lead to increased blood calcium levels? From the Kaplan bio book
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📅︎ Feb 21 2019
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THC and bone resorption

Several weeks ago i had part of my skull removed to relieve a swollen, pressurized brain. I had another surgery to put it back in, but my body doesn't like that. It's absorbing all the skeletal minerals because it doesn't recognize the skull flap. Some research says that THC can actually help bone metabolism, but I don't wanna take the risk that my favorite hobby will fuck me over. Will it?

I tried to post this to r/health, but it doesn't allow text posts

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📅︎ Aug 04 2017
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[Zanki] Why do high levels of vitamin D promote bone resorption?

zanki card i am referring to:

https://imgur.com/a/WDRRlRw

in my mind, vitamin D brings more calcium into the body due to increased absorption in the intestinal tract. this increase in calcium will be used to build the osteoid in the bone. so shouldn't high levels of vitamin D promote bone mineralization rather than resorption?

👍︎ 3
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👤︎ u/AlexPie2
📅︎ Sep 27 2019
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Alkaline mineral water lowers bone resorption even in calcium sufficiency?

So recently one of my friends started talking about alkaline water and how it is ''beneficial'' for health and such, and he linked me this science article to support his claim, citing how it helps on bone metabolism and preventing osteoporosis

https://www.sciencedirect.com/science/article/pii/S8756328208007813 " Alkaline mineral water lowers bone resorption even in calcium sufficiency: Alkaline mineral water and bone metabolism "

Abstract

Background

Dietary acid charge enhances bone loss. Bicarbonate or alkali diet decreases bone resorption in humans. We compared the effect of an alkaline mineral water, rich in bicarbonate, with that of an acid one, rich in calcium only, on bone markers, in young women with a normal calcium intake.

Methods

This study compared water A (per litre: 520 mg Ca, 291 mg HCO3−, 1160 mg SO4−, Potential Renal Acid load (PRAL) + 9.2 mEq) with water B (per litre: 547 mg Ca, 2172 mg HCO3−, 9 mg SO4−, PRAL − 11.2 mEq). 30 female dieticians aged 26.3 yrs (SD 7.3) were randomized into two groups, followed an identical weighed, balanced diet (965 mg Ca) and drank 1.5 l/d of the assigned water. Changes in blood and urine electrolytes, C-telopeptides (CTX), urinary pH and bicarbonate, and serum PTH were measured after 2 and 4 weeks.

Results

The two groups were not different at baseline, and showed a similar increase in urinary calcium excrection. Urinary pH and bicarbonate excretion increased with water B, but not with water A. PTH (p = 0.022) and S-CTX (p = 0.023) decreased with water B but not with water A.

Conclusion

In calcium sufficiency, the acid calcium-rich water had no effect on bone resorption, while the alkaline water rich in bicarbonate led to a significant decrease of PTH and of S-CTX.

__________________________________________________________________

Not sure if these are just snake oil cons defrauding stupid people with techno-babble or have some actual valid points into drinking alkaline water, so I came here.

👍︎ 3
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📅︎ Dec 29 2018
🚨︎ report

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