Biological Half Life Puns

Edit: For some reason my account password was changed without me knowing. I found out when I was trying to update my password and it said my old password was incorrect. I’ve been using one very memorable password and tried multiple times. I’m assuming whoever changed my password did not select the “log out from all devices option” as I wasn’t logged out here. So now I won’t have access to this account anymore once I logout from Safari on my phone. This isn’t my first time having my password changed behind my back on a device or app. I will reset my iPhone and laptop now and hopefully be able to create another account and make a new post afterwards or in the near future. As suggested many times, I now have access to a VPN subscription and I’ll have it turned on for all my devices as soon as they are reset. Thank you so much for all your advices and suggestions. 🙏

Please feel free to delete this post and/or report this reddit account if I make a new thread with a different account later to avoid duplicate posts.

https://en.wikipedia.org/wiki/Zuranolone

Zuranolone (INN;[1] developmental code names SAGE-217, S-812217) is an investigational medication which is under development by SAGE Therapeutics for the treatment of depressive disorders and a variety of other indications.[2][3] It is a synthetic, orally active, inhibitory pregnane neurosteroid, and acts as a positive allosteric modulator of the GABAA receptor.[2][3][4] The drug was developed as an improvement of allopregnanolone (brexanolone) with high oral bioavailability and a biological half-life suitable for once-daily administration.[3] As of October 2019, zuranolone is in phase III clinical trials for major depressive disorder, postpartum depression, and insomnia and is in phase II clinical studies for bipolar depression, essential tremor, and [Parkinson's disease](https://en.wikipedia.org/wiki/Parkinson

I'm discontinuing pirlindole after 4 weeks of treatment (200mg/day). Anecdotally, I experienced no noticeable improvement in depression or anxiety symptoms over the course of treatment. I need to know how long pirlindole will be in active in my system, and the reports are frustratingly conflicting. One study that Wikipedia cites (but is otherwise locked behind a paywall) indicates an extremely long 185 hour half-life, almost 8 days! Other studies found online indicate pirlindole has a "relatively short half-life" and the indicates 0.7±0.3 for half-life, which I admit I have no idea what these figures mean.

Hoping someone can help me out, I appreciate it!

Wikipedia page: https://en.wikipedia.org/wiki/Pirlindole

DrugBank Page: https://www.drugbank.ca/drugs/DB09244

EDIT: a word

I apologize for the long title.. I'm fairly new to reddit and still getting used to the site. I have a situation that I don't have any clue of how to handle it...

Ok first, a little bit of backstory. I am 28 years old and my mother passed away in 2014. I was an only child and she was a single parent. I was devastated when she passed but this is not so much about that. Growing up, she acted as both parents because my "father" made it quite clear that he wanted her to have an abortion and also, he had a child with a previous girlfriend. My mom chose to keep me and took him to court for child support (i was around 3 or 4.. i have a memory or two of the dna testing) He was a police officer so once the test came back positive, he had to pay the child support and did so for many years (even back payment) Now, I assume his wife (the girlfriend with his other child) knew of all this, but he was big on keeping this under wraps from the rest of his family. He had asked my mom to not tell anyone (my grandparents and his family had all lived in the same area and knew of each other) and my mother kept it a secret from all of his family. (I respect her for this because I would probably not had been so nice)

Fast forward to when I was about 24 and I met my father ..for the first and last time. I won't go into detail..but I had found out where he was working and I happened to be there. I recklessly made a decision to ask to speak to him (really i was just acting out of curiosity.. to see his face.. no intentions or planning was in place) he of course didn't recognize me and i introduced myself. He was shocked. I immediately regretted ambushing him at work but it was too late. We talked. He pretty much blamed my mother for initiating everything and i decided then and there, that my mom was an amazing parent and I subconsciously deleted him and the occasion from my memory. We didn't exchange numbers or pleasantries. It was what it was. I moved on.

When my mom passed, my world changed. I lost my parent. My real family. She was my other half. I never minded being an only child before but having no siblings made this situation so much worse. I have never felt so alone. My grandparents have passed and i have one aunt who lives in another city. I feel like my family is extinct, in a way.

Okay! This is where things get interesting....

I recently was on facebook and ran across my father's page. I was in shock. When i was a kid, it was impossible to find such information a

Utah has passed a new law relating to fathers paying half the cost of pregnancy-related healthcare.

From the article: “Republican Utah Gov. Spencer Cox signed the legislation, which “requires a biological father to pay 50% of a mother’s insurance premiums while she is pregnant and pregnancy-related medical costs, including the hospital birth of the child, that are not paid by another person,” according to the bill’s text.” Additionally, there are exceptions to the required payments in cases of disputed paternity and abortion.

Supporters of the law argue that it decreases the financial burden of pregnancy on women. Supporters also claim that it may reduce the number of abortions in the state. Detractors argue that it will make pregnancy more dangerous for women in abusive relationships. Additionally, it is unclear how often the law will be utilized. Which side has the better argument? Is this fundamentally a good policy?

This law cannot be separated from the state and national environment surrounding the politics of abortion. Utah is attempting to enact abortion restrictions to challenge Roe v. Wade at SCOTUS. Does this law change the politics of abortion-related legislation for either the pro-life or pro-choice movements? Is there a larger end goal when Republican politicians sponsor legislation such as the Utah pregnancy law, which is tangentially related to abortion care?

Finally, pregnancy and delivery costs in the USA are very high compared to other nations with universal healthcare systems. Does this law relate to arguments for or against universal healthcare in any way?

For a program I'm writing I need to know the biological half-life (the "decay rate" of a substance in your body, the time it takes for you to poop/pee/sweat/... half of the ingested amount out) of the fatty acids.

I know there are quite a lot of them (there are 36 saturated fatty acids, I believe), I would love to find them all but if there is some kind of average available, that'll be fine too.

I searched through a bit of scientific records, but I couldn't really make heads or tails of it.

Background: I was a one night stand baby. Go mom? Anyways, I was raised by my mom alone and only just got in contact with my real dad. I ignored his calls for a while, but eventually gave in. His wife had apparently been bugging him for years to become part of my life. I can’t say I hold too much animosity towards him; I may have done the same thing in his shoes. Regardless, we’re back in touch, I’ve met my half-brother finally, and we’ve been seeing each other on a regular basis ever since.

My little brother idolizes me. He thinks it’s the coolest thing in the world to all of sudden have an older brother to ask questions to and copy mannerisms from. It’s all new to me, though. I grew up with two older brothers, so I only know what it’s like to be the “kid.” His birthday is coming up at the end of the month and I want to get him a really cool gift. The problem is, he’s so sheltered and protected from the cool things of this world that almost everything I want to get him he won’t be able to play with. For example, if I bought him Goldeneye for Wii, he probably wouldn’t be able to play it; it is considered too violent. I was playing Counter-Strike online when I was ten with people that were definitely a worse influence on me than the game ever was. I learned so much from online gaming: about computers, the internet, online communities, strategy, and I could go on and on. I’m sure you all would agree.

How do I pull my brother out from under the rock he is raised under? If I bring him over and play CoD or BF:BC2 he will just go home and tell his mommy all the cool shit he got to play with his bro. Then I get in shit for being the cool brother.

I don’t know what to do, Reddit. On one hand I want to corrupt him and let him have the life I had growing up, uncensored. On the other hand, I don’t want to interfere with how my dad and his mom want to raise him; he isn’t my kid after all.

Any cool gift ideas that might help me keep the cool brother image? If I had the money I’d love to just buy him a ps3 and a bunch of games, but I’m limited to about $100 at the moment.

Cheers

EDIT: I get that it's not my place to raise him any different than his parent's want. It's just an adjustment for me I guess. He is being raised on his own and I had two older brothers influencing me for years. I will just have to try and remain a good influence and wait for him to come out of his shell. That aside, gift ideas are still welcome! Thanks everyone.

How interested would you be in a relationship with them? Keep in mind, your estranged parent is actively involved in your half siblings’ lives. Would you want a relationship with them? What if they’re a minor, would you wait till they were adults and out of the house? If they contacted you on their own accord, would you be receptive to talking? This community is so helpful. Looking forward to your responses.

I'm a biologist who has spent over 40 years studying the diversity of life on planet Earth. I've written many books dealing with questions about this amazing biodiversity, but recently I've become fascinated by questions about life on other planets. The number of known planets is now well over 4000 - a very large number compared with the mere eight we knew of until recently, and yet only the tip of the suspected iceberg of about a trillion planets spread across our local galaxy. Some of these planets almost certainly host life. But how many, and what is it like? These are the central questions of my new book The Biological Universe, published by Cambridge University Press.

I began my scientific career with a PhD from Nottingham University in England, went on to teach and carry out research at several other British universities, and am now Emeritus Professor at the National University of Ireland in Galway. I have held visiting positions at Harvard and Cambridge universities. I was one of the founding editors of the scientific journal Evolution & Development. My previous books include Life through Time and Space (Harvard 2017). This was described as 'brilliant and thought-provoking in every way' by Sir Arnold Wolfendale, Britain's Astronomer Royal (only the 14th person to hold this position since its origin in the year 1675).

Ask me anything about:

• What alien life is likely to be like
• How widespread it is likely to be
• How soon we are likely to discover it
• How close is the nearest alien life to Earth
• What are the implications of discovering it

I'll be on at 12 noon Eastern (16 UT), AMA!

Username: /u/WallaceArthur

I've been with my fiance for years now and I'm really close to his family, as he is to my family. We are engaged and all set to get married this July. My fiance comes from a big close knit family with no divorces.

I, on the other hand , come from a typical divorced family background. My parents divorced when I was 5 years old and my father remarried almost immediately. My half sister was born the following year and then a year later my other half sister was born. I also had a half brother from my father's side who tragically passed away 2 years ago.

My mother married my stepdad,( who I just call dad ) when I was 8 years old. I have 4 siblings from my mom's marriage to my stepdad.

Till the age of 12, my father had me every alternate week. By the time I was 13 and about to step into high school, I begged my parents to change it to a weekend visitation schedule . After I turned 18, my father moved to a different state for my half brother's treatment. They moved back in our state after my half brother passed away.

Anyway, most of my acquaintances and colleagues don't know that my stepdad is my "stepdad". I call him dad and we have a typical father-daughter relationship. Only my close friends know that he isn't my biological father. In fact, before my fiance proposed, he sought my dad's (stepdad) blessings.

So my fiance's sister Lily and I were out shopping the other day, where we ran into my father and his wife with their daughters. Without thinking much, I quickly introduced them to each other. This is what I said.

"dad, meet Lily, my future SIL". " Lily, this is Eric, my biological father, his beautiful wife Lisa and their daughters Emily and Emma. " Now Lily knows my stepdad very well. She is a good friend of my (maternal half) sister Jess. She was meeting my dad for the first time so I didn't want to leave any room for confusion.

My father didn't know about my engagement and congratulated me. We had a pleasant conversation and everything. I didn't think much of it.

Later that night, my father called me drunk. He was crying and told me that he had no idea he lost another child after his son. He said he never thought our relationship would end up like this. He talked about my baby years and how I was his little girl and how he changed my diapers and watched me come out of the womb. I was really confused and asked him what the deal was. He then replied, "biological father? Really?" and hanged up.

I am honestly confused reddit. Did I mess up wi

My wife and I have had a complex history. We got married in 2008 after only dating for three months. My wife ( girlfriend) at the time told me that she was pregnant with my child (our first daughter). I found out when my daughter was five over Facebook that my wife was sending pictures of our daughter to her ex. That's when I discovered that I was not the biological father.

My wife started crying profusely, told me that she never got paternity testing but was 90% sure that her ex was the father but was scared. She said that she never saw a future with her ex, and that she slept with him out of a moment of weakness. That for her, she wasn’t sure about the relationship that I was moving so quickly and that she wasn’t used to be treated so well by a guy. That she just had a habit of sabotaging stuff.

I was heartbroken, I never thought my wife would have cheated on me. We had our fights before but they were never serious. At the end of the day, I viewed my daughter as my own. We both made an agreement to tell our daughter nor our family members.

Things now, have gotten tense, I found out that my daughter arguing with my wife, about Sumer camp. That she wasn’t able to see her ‘sister’… I found out that my wife and daughter had kept the secret. My wife told our daughter, that I wasn’t her real father that ____ was her dad. When I confronted my wife about this, she views it as some natural order, that this is the right thing to do that every child should know who her true father is. I got upset with my wife, and she told me that its selfish of me to want to keep our daughter in the dark. That, I as a father, got to have the young fun years of raising my daughter, but its wrong to do this to her. I was so upset, but then my daughter joined in too. My daughter views me as the bad guy because I kept her away from her real dad and siblings.

This whole ordeal has crippled me, I have had anxiety in the past but now it is unbearable. I feel that I am losing my family. My daughter thinks of her bio dad as a cool guy, because they have a pool and he never disciplines her. And I feel that in our relationship, I have been tough on her to do well in school since her grades have been slipping and she was rejected from GT classes. I don’t know what to do at this point. Had I known that life would be like this today, I would have divorced my wife the day I found out that my daughter wasn’t my own. At this point, I find myself in a terrible bind. My wife has convinced

My (20F) mom left my biological father when I was 2. She has been with my step dad now for about 17 years.

My bio dad had many kids with different women. So many that we don't know how many siblings there are. I have an older half sister (about 29) and older half brother (about 32-33). There's also two younger siblings who are a couple months about, and about 17-18 years old.

Two years ago, I got to meet my oldest sister for the first time, along with her daughter. We got along well. It was a bit strange, knowing that we were sisters but never had met before. Especially since my mom helped raise her and our older brother for about 5 years until she left our bio dad. I met my younger siblings briefly two years ago. The brother wasn't too interested but me and my younger sister got along great.

Now, our bio father did a lot of really bad things and got away with them. Hence why me, my mom and her family, and my older sister have no contact with him. So, as you can imagine, I don't want him finding me.

But, when I met my older sister, she mentioned that our younger sister came out as suicidal and lesbian to her parents and they won't believe her. They took away her phone when she did, punished her, and told her she was doing it all for attention and was lying. I'd love to reach out to her, form a relationship with her, but I don't want our bio dad finding me. And if he still has control over her, he could.

Any advice on what to do?

TLDR: I want to reach out to my younger sister without her/our father knowing.

My wife (25F) and I (24M) have recently discovered that we share the same dad. We have been together for 8 years and married earlier this year. We own our own home and we're expecting our first child in March 2020. Our bio father is still alive but we don't want anything to do with him because of this and because he was a shitty person.

From what I understand, my father who is persona non grata in both households did not remain in our mothers' lives for long and while I knew a brief bit of info about him my partner did not as he was an all around shitty person. Neither of our mums named him on the birth certificate as the father and in my wife's case she knew her mum's longterm boyfriend as a father while I gained a stepdad. Our parents do not know this and we aren't even sure if we should say anything. I will not disclose how we found out but I suppose I just wanted a bit of closure and her mum (who is one of my close friends) admitted to me at a rough moment that her daughter's dad was XX and how he was etc and this combined with other info made it clear. We have had a private DNA test taken and the results suggested we were half-siblings.

Despite this, our feelings for each other have not changed and we do not want to split. We have known each other since starting school and been through some hard times together. I am afraid what this means for us and our child, if that means he will have any health complications in life, my wife doesn't believe in abortion personally and does not wish to terminate her first pregnancy (nor do I want her to) so we mean to see it through and hope for the best. We are lucky in that we don't have a history of illness in our mum's families at least so hopefully that is better luck than some.

I know incest is against the law and I am terrified that we could be found out if anyone looked into our histories or if they (I heard they do this) take a DNA sample of our son for genetic testing to make sure he has no health problems and what could happen to us. I am not even sure what to do, except maybe ensure that we do not have more biological children even if our child turns out without a problem just to be safe and adopt or something instead. I don't want anyone to find out so I am keeping info to minimum and I will not let anything separate us and neither will she. What could happen to us, what can/should we do, should I just bury it? I am in england

My wife and I have had a complex history. We got married in 2008 after only dating for three months. My wife ( girlfriend) at the time told me that she was pregnant with my child (our first daughter). I found out when my daughter was five over Facebook that my wife was sending pictures of our daughter to her ex. That's when I discovered that I was not the biological father.

My wife started crying profusely, told me that she never got paternity testing but was 90% sure that her ex was the father but was scared. She said that she never saw a future with her ex, and that she slept with him out of a moment of weakness. That for her, she wasn’t sure about the relationship that I was moving so quickly and that she wasn’t used to be treated so well by a guy. That she just had a habit of sabotaging stuff.

I was heartbroken, I never thought my wife would have cheated on me. We had our fights before but they were never serious. At the end of the day, I viewed my daughter as my own. We both made an agreement to tell our daughter nor our family members.

Things now, have gotten tense, I found out that my daughter arguing with my wife, about Sumer camp. That she wasn’t able to see her ‘sister’… I found out that my wife and daughter had kept the secret. My wife told our daughter, that I wasn’t her real father that ____ was her dad. When I confronted my wife about this, she views it as some natural order, that this is the right thing to do that every child should know who her true father is. I got upset with my wife, and she told me that its selfish of me to want to keep our daughter in the dark. That, I as a father, got to have the young fun years of raising my daughter, but its wrong to do this to her. I was so upset, but then my daughter joined in too. My daughter views me as the bad guy because I kept her away from her real dad and siblings.

This whole ordeal has crippled me, I have had anxiety in the past but now it is unbearable. I feel that I am losing my family. My daughter thinks of her bio dad as a cool guy, because they have a pool and he never disciplines her. And I feel that in our relationship, I have been tough on her to do well in school since her grades have been slipping and she was rejected from GT classes. I don’t know what to do at this point. Had I known that life would be like this today, I would have divorced my wife the day I found out that my daughter wasn’t my own. At this point, I find myself in a terrible bind. My wife has convinced ou