I was taking a pharmaceutical NMDA/AMPA antagonist called topiramate AKA Dopamax/Topamax. It is notorious for making people stupid. Added to which I stopped it cold turkey.
Its symptoms include a sort of brain slowing and disruption similar to pseudo-ADHD, loss of words, loss of memory (confusion when waking up - not knowing where I live), inability to learn new things (maybe linked to long term potentiation), and of course depersonalization which is common with NMDA antagonists.
I don't know much about this stuff, but I'm looking for suggestions?
So far I have read about the TCA opioid Tianeptine helping regulate glutamate
Also, sarcosine might help upregulate NMDArs at the glycine site.
There's also nefiracetam - although it may well be toxic to the kidneys and more importantly the precious testes.
That's it. Any insight? I'd really appreciate it. I'm brain dead.
I have tried:
Noopept, NAC, aniracetam, oxiracetam, colouracetam, fasoracetam, lions mane, bacopa moneri, ginko, rhodolia rosea, sulbutiamine, b12, p-5-p, VD+VK2, LD Naltrexone, selegiline at both MAO-B and nonselective MAOI doses, modafinil for glutmate regulation.
GABA analogs like pregabalin now seem to ease depersonalization and actually increase verbal fluency.
There's also semax/selank for more BDNF, and also NSI-189 - but that could do anything, it's proven safe short term, but who knows what it activates something that causes tumours to grow 10 years from now.
I'd be grateful for any thoughts at all.
Edit: been of it for a year.
Please I beg the press to ask less obvious questions for Adam Driver. If you ask him what it was like to work with that director, he'll probably answer that "He gave a lot of freedom during shooting and that was really good for the actors." If you ask him what it was like to work on that character, he will probably answer that "As that script is very good and very clear, it made his job a lot easier!" Please ask smart questions! Does anyone have a suggestion for a question you want to leave here?
https://preview.redd.it/vxhf2fzqofw71.png?width=1169&format=png&auto=webp&s=e1f43e639d3d84506595f4a65a0a7ac136a98f64
so jadi gw bikin novel yang bernama "kitaro bizarre life"
pas di translate jadi "喜多郎奇妙な生活" yang berarti "kitaro strange life" tapi gw kurang puas gw translate lagi jadi "喜多郎不思議な生活" artinya "kitaro mysterious life" makin kurang puas karena malah beda jauh
yaudah gw pake teknik pisah pisah kayak gini
gw bahasa jepangnya kitaro yang mana itu "喜多郎"
lalu ambil bizarre yang mana itu "奇妙な"
dan ambil life yang mana itu "生活"
digabungin jadi "喜多郎奇妙な生活" yang artinya " The life of the Kitaro brothers " lah kok jadi gini bukannya dulu "hokuro strange life" ????????????
selagi mempost ini gw berkesimpulan . gw bakalan pake "喜多郎不思議な生活" aja karena agak lebih deket daripada tadi
novel :https://ncode.syosetu.com/n9564hb/
(masih on going , semoga gw dapet editor gratis dari syosetu karena gw gk tau tipografi yang bagus)
(sorry kalo gaje karena udah gw bilang tipografi gw kurang bagus
There were actually so many I couldn't fit in a someone else option but if you feel like it could have been someone just say who in the comments.
Diverse Business With Customer.Our To Commitment Competitive Who Mission Service, And
Unwanted Changes to our cells mechanisms of spreading glutamate, but Also Retentioning it Back in The cell. Might Explain Perhaps Excess Glutamate being spilled onto other local Synapses. Causing both neurotoxic environment and oxidative cellular stress.
https://www.dana.org/article/protecting-the-brain-from-a-glutamate-storm/
This condition might stem from The Modulation in Cell function induced by Psychedelics or Long term use of seritonergic Drugs/ or Glutamate Acting. like Weed. IN HPPD cases The Changes to Function is Properly in The Visual cortex and Thalamus.
Because of LSDs powerfull mechanisms in Neuroplasticity and induced modulatory changes In immune response, Gene expression and further on.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3073152/#!po=0.769231
The studies are in animal trials right now and this linked study cover two drugs: Huperzine A and IDRA 21. Their goal is to find if these drugs can help boost the congnition of both the cognitively impaired and non-cognitively impaired. Test are taken as baselines and those baselines tests are what they used in their research. I emplor you to read the journal, but I emphasized some this i took away from it. .
IDRA 21
In contrast, IDRA 21 has shown a consistent effect in improving performance on memory tasks in animals, even when the animals were not compromised by drugs, lesions, or age. Along with similar results using other ampakines, this suggests that this class of compounds is especially promising for augmenting memory beyond the normal level of functioning. In fact, the observation that IDRA 21 improved the performance of normal young animals more than that of aged subjects (Buccafusco et al., 2004) suggests that this type of cognitive enhancement may be best suited for use in normal subjects
huperzine A
The lack of a clear effect of huperzine A to improve cognitive function in normal young monkeys in our study is consistent with previous findings in animals from other laboratories. These findings are in contrast with the positive effect of huperzine A in patients with cognitive impairment and aged animals suggesting that huperzine A, as other AChE inhibitors, exerts its function in a system which does not function normally, because it has been compromised by the disease of aging, or by the experimental depletion of acetylcholine. Thus, huperzine A can be used to restore or ameliorate a compromised system back to a normal level of functioning, however, it may not be effective in enhancing cognitive function beyond normal levels
TL;TR: We might become Limitless or even find a treatment for degenerative diseases like Alzheimer's
Sí, han leído bien. Alegan que se falta a la neutralidad.
Tanto ruido aniquila la capacidad de las sociedades para discernir; se han quedado tan anchos, cuatro noticias en algunos medios y ya está.
¿Es neutralidad defender, promover y favorecer a la enseñanza concertada pagada con el dinero de todas? Eso es lo que llevan haciendo las instituciones desde 1985, cuando se publicó la LODE. La promulgó el PSOE con la justificación de que universalizar la educación, viniendo de las deficiencias del franquismo, no era posible sin contar con los recursos materiales y humanos que poseían las privadas. Algo había de cierto, pero casi todo era falso; la concertada es una forma de control político de las más eficaces.
Llaman neutralidad a que las instituciones paguen con dinero público a centros educativos privados, aproximadamente el 70% en manos de la Iglesia Católica española, esa que fue uña y carne con Franco. Centros privados con ideario propio por ley, no es difícil imaginar los idearios surgidos de esos directores. Centros privados pagados por todas y todos que eligen a su profesorado a dedo, sin más, con el clientelismo que ello genera -en contraposición al calvario que pasan las profesoras y profesores de la escuela pública, para ser interinos y para obtener una plaza en propiedad.
No se falta a la neutralidad ni a la justicia, cuando curso tras curso, se sigue financiando con el dinero de todas a esos centros privados que solo están donde hay mucha gente, en grandes poblaciones -en Segovia solo están en la capital, los pueblos segovianos tienen poca población, que se encargue la pública, en Madrid, con densidades de población enormes, los concertados ya escolarizan a más del 50%- No, eso no es faltar a la neutralidad, que un centro educativo anime a que se matricule la gente en él sí; seguro que los privados concertados no ponen carteles animando a la gente a matricularse en ellos.
No se falta a la neutralidad, no, cuando se equipara como iguales a los centros públicos educativos con los privados concertados, a sabiendas de que muchos, muchísimos de los concertados, obtienen financiación extra con recursos retorcidos sobre pagos por actividades complementarias y extraescolares o espantan a alumnos que ven en su ideario cuestiones relacionadas con la religión católica, y son de otra religión o de ninguna.
Qué decir del ejército de profesores/as de religión (católica, claro, sería pertinente conocer las excepciones absolutamente minoritarias) que han si
... keep reading on reddit ➡