As in, would that destroy and prevent the spread of the adenovirus and thus render the vaccine useless and effectively make it as if the person pretty much received a placebo?
So I just found a link to an FDA conference where leading experts in gene therapy discussed the risks of chromosomal integration (permanent changes to DNA) with adenovirus viral vector gene therapies (J&J and AstraZeneca). If you go to the description of the conference at the link, they describe the consequences of chromosomal integration such as cancer and neurotoxicity. Can someone explain to me how these concerns would not apply to J&J and AstraZeneca?
Link to event materials from conference here: https://twitter.com/adaviesdhcg/status/1433429872748072977?s=21
Unfortunately my state is mandating vaccines for all healthcare workers as of October 1st. All exemptions have have been thrown out so I can't go that route. Which vaccine seems to be the safest? I was leaning towards j&j because it's just 1 shot and at least the technology has been used on the ebola vaccine.
I'm a 30 year old male with no preexisting conditions and in good shape to add context.
Relativamente às vacinas Astrazeneca, Jansen e Sputnik V, noto que têm havido muita confusão acerca do que se encontra efetivamente dentro dos frascos.
Colou a expressão "vector viral", ao detrimento de "vacina DNA". É fácil de perceber porque é que foi feito um esforço para abolir a última expressão, a fim de contas, mesmo a pessoa mais ignorante tende a saber que qualquer manipulação do DNA de um indivíduo pode ter consequências inesperadas.
O facto é que as 3 vacinas supracitadas são vacinas de DNA, sendo este introduzido nas células alvo via um vector viral (nestes casos adenovírus de chimpanzé, embora já tenha sido usado rabdovírus [raiva]) .
Atenção: o facto de as vacinas conterem DNA, não implica que este seja integrado nos cromossomas do vacinado, contudo, os estudos demonstram que tal tende a acontecer, embora em pequena escala (consequências a longo prazo desconhecidas).
Convido-vos a ver a seguinte entrevista da DW News:
https://www.youtube.com/watch?v=T7m4ovrjEfE
É uma atitude saudável desconfiar de qualquer "especialista" que afirme em relação a uma vacina "é impossível". A biologia não é uma ciência exacta uma vez que os fenómenos biológicos são infinitamente mais complexos do que os da matemática, por exemplo. Podem ouvir o virologista Friedemann Weber corroborar esta ideia ao minuto 3:48.
Pouco depois, Friedemann Weber esclarece a natureza das vacinas em questão.
My apologies if my question sounds convoluted. AAV vectors don't have the best PK parameters, despite higher target specificity than a small molecule drug. However, exceedingly large dosage can end up causing harmful effects (as with any drug) to the target tissue.
What methods do you guys use to optimize dosage?
Follow up: Could you do a brief overview of some of the math behind it?
Side Question: In what ways and how often do you interact w/ bioinformatics teams and biostatistics?
Hello good folks! I'm a soon-to-graduate PhD student, and while my PhD has focused on single-molecule imaging (biophysics), i'm super interested in working on viral vector tech (cell-specific gene delivery, to be more precise) going forward. I'm trying to put together a decent proposal to pitch to my university's tech transfer office, and while I have some ideas that are interesting, I'd like to interview someone directly working in this field (preferably in a company or startup) to understand what the *real* technological challenges are. If someone here is willing to spend half an hour or so to help out a naive PhD student on Skype or Zoom, I would really appreciate it. Please DM if you're interested, perhaps with a work email included, so I can set up something using my work email, just so you know you're not wasting your time. And thanks for taking the time to read this! Edit- if you know someone in this field who might be willing to help, that would be great too!
In May 2021 the mainstream media complained that the Ivory Coast population were suspicious of the AstraZeneca viral-vector Covid vaccines, causing low-uptake. So now a few months later, for the first time in decades, Ebola has appeared in Ivory Coast, interstingly Ebola vaccines are also ‘experimental’ viral-vector AKA Clotshots. It’s almost as if the agenda is about getting the viral-vector clotshot technology into the third world recipients under one guise or another.
It is concerning that early-on in the pandemic, Billy Goats said that the AstraZeneca Clotshots would be used on the third world, and years ago he told Forbes that he didn’t think poor people have a worthwhile existence, then more recently in 2010 he admitted in a TED talk that vaccines can be used to bring down the population, which he said would help the climate. So, the same viral-vector Clotshot technology which Gates wanted to use on the third world, is in both the Covid jabs sent to Ivory Coast and the Ebola vaccines which are no-doubt about be rolled out there. They are for the same third world people who Gates doesn’t value and views there existence as detrimental to the climate.
Fortunately, the people of Ivory Coast seem to have a fair idea that they are in the cross-hairs; they won’t be sitting ducks.
