Multiple sclerosis signs and symptoms Puns

Study link at the bottom

This was a retrospective study of patients with MS attending 2 tertiary centers in the New York City metropolitan area, who self-identified as White, African American (AA), or Hispanic American (HA). Disability was rated with Patient-Determined Disability Steps (PDDS) and symptom severity, with SymptoMScreen (SyMS), a validated battery for assessing symptoms in 12 domains. Analyses comparing race, sex, and age groups were performed using analysis of variance models and Tukey honestly significant difference tests to control the overall type I error. A multivariable model was constructed to predict good self-rated health (SRH) that included demographic variables, PDDS, and SyMS domain scores.

Results

The sample consisted of 2,622 patients with MS (age 46.4 years; 73.6% female; 66.4% White, 21.7% AA, and 11.9% HA). Men had higher adjusted PDDS than women (p = 0.012), but similar total SyMS scores. Women reported higher fatigue and anxiety scores, whereas men had higher walking and dexterity scores. AAs and HAs had higher symptom domain scores than Whites in each of the 12 domains and worse SRH. In a multivariable logistic model, only pain, walking, depression, fatigue, and global disability (PDDS), but not sex or race/ethnicity, predicted good SRH.

Conclusions

AA and HA race/ethnicity was associated with higher overall disability, higher symptom severity in each of the 12 domains commonly affected by MS, and worse SRH relative to Whites. However, only symptom severity and disability, and not demographic variables, predicted good SRH.

Much has been written about symptoms of multiple sclerosis (MS)1,2 but relatively little about how symptoms of MS vary by age, sex, and race/ethnicity. We have previously assessed symptom severity as a function of disease duration in MS.3 In this study, we compare MS symptom severity across the age spectrum in men and women of the 3 race/ethnic groups most represented in our practice—Whites, African Americans (AAs), and Hispanic Americans (HAs). Minority populations are increasingly affected by MS,4,5 but less than 1% of all MS studies have been devoted to them.6 A better underst

https://doi.org/10.1016/j.celrep.2016.05.009

>Highlights
>
>•FMD reduces pro-inflammatory cytokines and increases corticosterone levels
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>•FMD suppresses autoimmunity by inducing lymphocyte apoptosis
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>•FMD promotes regeneration of oligodendrocyte in multiple MS models
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>•FMD is a safe, feasible, and potentially effective treatment for MS patients
>
>Summary
>
>Dietary interventions have not been effective in the treatment of multiple sclerosis (MS). Here, we show that periodic 3-day cycles of a fasting mimicking diet (FMD) are effective in ameliorating demyelination and symptoms in a murine experimental autoimmune encephalomyelitis (EAE) model. The FMD reduced clinical severity in all mice and completely reversed symptoms in 20% of animals. These improvements were associated with increased corticosterone levels and regulatory T (Treg) cell numbers and reduced levels of pro-inflammatory cytokines, TH1 and TH17 cells, and antigen-presenting cells (APCs). Moreover, the FMD promoted oligodendrocyte precursor cell regeneration and remyelination in axons in both EAE and cuprizone MS models, supporting its effects on both suppression of autoimmunity and remyelination. We also report preliminary data suggesting that an FMD or a chronic ketogenic diet are safe, feasible, and potentially effective in the treatment of relapsing-remitting multiple sclerosis (RRMS) patients (NCT01538355).

First, off, main portion is a mouse study. So take with a spoon/shovel of salt. But the second part is human, n=60, with mixed but promising results. I'm not sure the FMD is the way to go, myself. Perhaps KD with intermittent or extended fasting would be better? I know I don't understand the entire thing, I'm a chemist, not a biochemist, but it looks like the KD helped to prevent a worsening and the FMD actually prompted some regeneration? (Likely due to autophagy?)

EDIT: This would imply that throwing fasting cycles (IF/EF) into the KD would provide the same to stronger performance than the FMD with MD?

This is my first time posting so please excuse any formatting issues. I stopped working and retired from my Federal job in 2013. At that time I was recently promoted to management and after a year of many health issues, including cognitive, I retired. I was 32 at the time. I have since adapted to some of my disabilities, but would not be able to do what I did prior. I have worked small, very party time (10-15 hours/wk) odd jobs that were temporary, but nothing steady. Anyway, my dream job at a florist just became available with hours I could do. It's my lucky day. I want to submit a resume, bit I'm unsure if how to address the last 6 years. I also expect a much lower income than what I earned and my degree (M.S.) would appear/ I am definitely no longer overqualified and I don't know how to address this. Is this something I put in the cover letter or resume. I am so grateful for any help on this.

This document says that Multiple Sclerosis causes the symptoms of anedonia. My neurologist suspects Multiple Sclerosis

https://journals.sagepub.com/doi/full/10.1177/1352458520972279

i don't think I've read about this before.

i highlighted what i thought were the most important points in bold - super intriguing points in there.

SOURCE: https://www.kpbs.org/news/2018/nov/02/parkinsons-patients-preparing-brain-cell-replaceme/

Parkinson’s Patients Preparing For ‘Breakthrough’ Clinical Trial To Reverse Symptoms
Friday, November 2, 2018

By Susan Murphy

A walk in the park can be exhausting for Chris Whitmer. His once athletic stride has been weakened by Parkinson’s disease.

“Outwardly, you probably notice the tremors the most. You know, the shaking, the stiffness, how somebody walks,” said Whitmer, 58, a married, father of two. “The biggest thing I feel is the fatigue,” he said. “It just makes you extremely tired.”

Over the past dozen years, his symptoms have progressed. The disease is not fatal but it can leave a person completely debilitated.

“I don’t want to think about what I’ll be like 10 years from now, and what it’s going to feel like. I want to be around for my kids,” he said, choking back tears.

Parkinson’s symptoms generally include tremors or shaking, weak or aching muscles, and difficulty walking and speaking, along with depression or apathy. While some symptoms can be eased for a while with medication, there is currently no cure.

Whitmer’s cells from his skin are his biggest hope. The former tech industry businessman is one of 10 people preparing to undergo a brain cell transplant in San Diego as part of a first-of-its-kind clinical trial.

“I think it’s going to be the first successful treatment of Parkinson’s because everything we’ve done to now with drugs and therapies and deep brain stimulation... just treats the symptoms,” he explained. “This will be the first treatment, I think, that will reverse the symptoms.”

If all goes well, his health will be restored, within months.

Replacing Brain Cells To Reverse Symptoms

Parkinson's kills brain cells that make a substance called dopamine. Dopamine allows nerve cells to communicate with muscles.

“So what we propose to do is replace those neurons in the brain with the people’s own dopamine neurons,” said Jeanne Loring, a stem cell scientist with Scripps Research Institute in La Jolla.

**The process starts with taking a small skin biopsy from a patient’s arm. The skin cells are transformed into master cells called “induced pluripotent stem cells,” which can make any cell or tissue in the body, including neurons. The cells can also regenerate

I am in a high risk population, and they refused. Also,I talked to government officials, doctors, and other professionals; and learned a lot about how poorly our system acting on this epidemic. Ask me anything if you want to know!

Brain lesion dynamics. Time-lapse MRI movies reveal bright spots, representing multiple sclerosis brain lesions, that form and then grow, shrink, or disappear over 12 months in a man with RRMS—who experienced no flare-ups of symptoms in that period.

So I'm 25 about to be 26 but before the diagnosis it was maybe a year-and-a-half For You Been 2 years of me just being totally confused I knew something wasn't right and it didn't show much but I wasn't able to be the productive workaholic I was and certain things just got difficult but I didn't pay mind to it in a sense that something was medically wrong because I've always tooken great care of myself and watch the things that I ate or did and always was active I've never been one to be on the couch. So long story short the past 3 years of my life has consisted of nothing but adjusting and accepting this because everything I aspired to do and had plans for in my future is almost just totally fantasies and it's like you've been thrown into a world you're not welcome in. I've always been a loner but I've never felt so alone and in the dark, people understand and yeah I have a few friends that are actually there but besides that few nobody wants the baggage I carry and it's nothing anyone's trying to keep up with. And being 25 years old I mean I had aspirations of being a father having a family and all that stuff and it just all seems totally Out Of Reach. And it's just a letdown because I'm unable to beat the same person I am everyday because some days are downright terrible and other days able to move in get around and do

Sorry for the impending wall of doom. Or text, depending on how you look at it. If you take the time to read this, I want to heartfully thank you in advance. I've always been the "it" girl. I'm pretty, I'm smart, I'm engaging. I'm relatively funny, kind, and I have consistently been reminded by people how great I am, so talking about my insecurities is a very rare thing. I feel like I must always be at the top of my game, and complaining when I have been blessed with so much is ridiculous. So here's the letter, and thank you for your advice.

I’ve always been a proud person. Not to be confused with prideful- I’m not prideful. I don’t gloat. I’m not arrogant. But I have immense respect for myself. I think I’m a solid individual for the most part. I do, however, have on glaring insecurity which I generally ignore as much and often as possible: I have Multiple Sclerosis. I know we’ve talked about it in the past, but I’m writing this to better convey my emotions and thoughts on the matter. I thought about just trying to sit down and talk about it with you, but I think it’ll be better if we both have something tangible we can refer to. Plus I’d likely cry, which becomes counter-productive, because we’ll just get distracted by what a hideously ugly crier I am. Seriously, I don’t know how girls cry prettily. It’s a talent I’ve yet to master.

FIRST THING IS FIRST: if you start to coddle me or treat me differently, you’re going to anger me. The reason I don’t talk about how I’m feeling physically and/or emotionally is because I loathe the idea of being treated like a porcelain doll. I don’t want your pity- just your understanding.

The lowdown on my most frequent symptoms: Exhaustion- not just tired like “I want to go to sleep because I’ve been up for 16 hours”, it’s deeper. Do you remember the first day of practice for a sport after being out of shape? Getting home and that encompassing tiredness of body and mind? I feel that nearly every day. The aching muscles, the desire to do nothing but go right back to bed, the sore joints. It’s all there almost all the time, even when I’m eating well. On my best days I’ll feel good for the morning and it’ll hit around 2-3.

Nerve pain- It ranges from just weird heightened sensitivity type tingling, to intense pins and needles. You know when your foot falls asleep and when you regain feeling it’s that tingly/burning pain? It’s pretty much that, but mixed with the pain of when you twist your neck funny and pinch a nerve.

Link

Just thought I'd drop this here in case anyone hasn't seen it or is interested. I'm glad to see MS is still being actively researched.