Abscess the result of a severe bone infection after total shoulder replacement surgery. Got 2 more surgeries in a 3 month period. The 1 month home IV drip of vancomycin and meropenem (twice a day) destroyed my gut garden. After the last shoulder surgery was diagnosed with 3rd stage colon cancer. reddit.com/gallery/s1hdqj
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๐Ÿ‘ค︎ u/MFG_666
๐Ÿ“…︎ Jan 11 2022
๐Ÿšจ︎ report
ESBL Escherichia coli with mucoid shape around meropenem and cefoxitin discs v.redd.it/k81mtomehsa81
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๐Ÿ‘ค︎ u/Lean_Id
๐Ÿ“…︎ Jan 10 2022
๐Ÿšจ︎ report
ESBL Escherichia coli with mucoid shape around meropenem and cefoxitin discs v.redd.it/qmh33sup9sa81
๐Ÿ‘︎ 18
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๐Ÿ‘ค︎ u/Lean_Id
๐Ÿ“…︎ Jan 10 2022
๐Ÿšจ︎ report
ESBL Escherichia coli with mucoid shape around meropenem and cefoxitin discs v.redd.it/aojzucui9sa81
๐Ÿ‘︎ 6
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๐Ÿ‘ค︎ u/Lean_Id
๐Ÿ“…︎ Jan 10 2022
๐Ÿšจ︎ report
Antibiotic meropenem as antidote for valproic acid toxicity

https://pubmed.ncbi.nlm.nih.gov/31980292/

A well documented drug interaction used rapidly clear VPA.

๐Ÿ‘︎ 45
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๐Ÿ‘ค︎ u/JohnChivez
๐Ÿ“…︎ Feb 20 2021
๐Ÿšจ︎ report
Intermittent Meropenem IV

How often do you change IV tubing when your institution does Meropenem 1g infusions? Resources state the drug is not stable after 1 hour at room temperature and there is always drug left over in the tubing between doses (I know they should be flushing before dose, after dose, and q shift - but lets be real) so my question is how would that affect the tubing? Would it need to be changed per dose? TIA.

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๐Ÿ‘ค︎ u/Grape_Vanc_Drank
๐Ÿ“…︎ Feb 05 2021
๐Ÿšจ︎ report
42 year old patient recovers from COVID-19, with a clear CT, after receiving antivirals ganciclovir and oseltamivir and anti-inflammatories meropenem and linezolid during a 25 day hospitalization

From Radiology, a medical journal published by the Radiological Society of North America:

"The patient was treated with antiviral drugs (ganciclovir, oseltamivir) and anti-inflammatory drugs (meropenem, linezolid), with supportive care from January 1, 2020, until his discharge on January 25, 2020. Serial imaging studies in the Figure illustrate the patientโ€™s improvement after therapy."

"Chest radiograph obtained on day 7 after the onset of symptoms shows opacities in the left lower and right upper lobes. B, C, CT scans obtained on day 9 show multifocal bilateral ground-glass opacities. D, CT scan obtained on day 15 shows evolution to a mixed pattern of ground-glass opacities and consolidation. E, CT scan obtained on day 19 shows healing of the consolidations and ground-glass opacities. F, CT scan obtained on day 31 shows complete resolution."

Link to full text: https://pubs.rsna.org/doi/10.1148/radiol.2020200269

"A new type of pneumonia caused by the 2019 novel coronavirus (2019-nCoV) broke out in December 2019 in Wuhan City, China (1,2). On January 1, 2020, a 42-year-old man was admitted to the emergency department of Union Hospital (Tongji Medical College, Wuhan, Hubei Province) due to a high-grade fever (39.6ยฐC [103.28ยฐC]), cough, and fatigue for 1 week. Bilateral coarse breath sounds with wet rales distributed at the bases of both lungs were heard on auscultation. Laboratory studies showed leukopenia (white blood cell count, 2.88 ร— 109/L) and lymphocytosis (lymphocyte cell count, 0.90 ร— 109/L). The white blood cell differential count displayed 56.6% neutrophils, 32.1% lymphocytes, and 10.2% monocytes. Several additional laboratory tests were abnormal, including C-reactive protein (158.95 mg/L; normal range, 0โ€“10 mg/L), erythrocyte sedimentation rate (38 mm/h; normal range, <20 mm/h), serum amyloid A protein (607.1 mg/L; normal range, <10 mg/L), aspartate aminotransferase (53 U/L; normal range, 8โ€“40 U/L), and alanine aminotransferase (60 U/L; normal range, 5โ€“40 U/L). Real-time รฑuorescence polymerase chain reaction of the patientโ€™s sputum was positive for the 2019-nCoV nucleic acid. The patient was treated with antiviral drugs (ganciclovir, oseltamivir) and anti-inflammatory drugs (meropenem, linezolid), with supportive care from January 1, 2020, until his discharge on January 25, 2020. Serial imaging studies in the Figure illustrate the patientโ€™s improvement after therapy."

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๐Ÿ‘ค︎ u/AnakinsFather
๐Ÿ“…︎ Feb 28 2020
๐Ÿšจ︎ report
Sepsis on admission clinically seems to better pseudomonas aeruginosa which is pansensitive the phone number chronic kidney disease plan number atrial fibrillation hypertension Parkinsonโ€™s disease Early dementia continue with IV antibiotic as ordered to meropenem recheck of blood cultures

I hate copy/paste and voice to text physician notes. This is literally an assessment/plan section of a finalized note for one of my patients.

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๐Ÿ‘ค︎ u/cobo10201
๐Ÿ“…︎ Jun 12 2019
๐Ÿšจ︎ report
How do I tell this doctor she found the meropenem already...?
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๐Ÿ‘ค︎ u/Jellotek
๐Ÿ“…︎ Jun 25 2019
๐Ÿšจ︎ report
Meropenem Staining

I take meropenem nebulised and sometimes intravenously and it stains fabric/clothes so badly. Does anyone have any cleaning tips on getting it out??

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๐Ÿ‘ค︎ u/kinesis105
๐Ÿ“…︎ Oct 19 2017
๐Ÿšจ︎ report
New molecule knocks out superbugs' immunity to antibiotics - "In all cases, the PPMO restored meropenem's ability to kill the bacteria in vitro, and also managed to kill off an NDM-1-expressing strain of E. coli in tests in mice." newatlas.com/molecule-weaโ€ฆ
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๐Ÿ‘ค︎ u/mvea
๐Ÿ“…︎ Jan 20 2017
๐Ÿšจ︎ report
Over a year later and one of the sickest rescue bettas I've had is going strong! When I brought him home I thought I was giving him a place to die... Be he was a fighter! This is Meropenem. imgur.com/a/wpbNn
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๐Ÿ‘ค︎ u/rmarkham
๐Ÿ“…︎ Dec 04 2014
๐Ÿšจ︎ report
Over a year later and one of the sickest rescue bettas I've had is going strong! When I brought him home I thought I was giving him a place to die... Be he was a fighter! This is Meropenem.(xpost) imgur.com/a/wpbNn
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๐Ÿ‘ค︎ u/rmarkham
๐Ÿ“…︎ Dec 04 2014
๐Ÿšจ︎ report
Meropenem turning yellow??

I received a week supply (3 doses a day for 7 days) of Meropenem in the home pump eclipse medicine balls. I pulled my next dose out of the fridge and noticed 7 of them have turned bright yellow instead of being clear. I donโ€™t feel comfortable taking these doses until Iโ€™m able to speak with my doctor in the morning. Iโ€™m just wondering if anyone knows why this has happened and what it means.

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๐Ÿ‘ค︎ u/ephemeral_harbinger
๐Ÿ“…︎ May 20 2018
๐Ÿšจ︎ report
Who doesn't love a good healthy transformation? Reddit, this is Meropenem's recovery! imgur.com/a/GOnxW
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๐Ÿ‘ค︎ u/rmarkham
๐Ÿ“…︎ Feb 02 2014
๐Ÿšจ︎ report
Anaphylaxis to penicillins isnโ€™t a contraindication to meropenem emcrit.org/pulmcrit/pulmcโ€ฆ
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๐Ÿ‘ค︎ u/Henipah
๐Ÿ“…︎ Nov 16 2016
๐Ÿšจ︎ report
FDA approves Vabomereยฎ (I.V. meropenem + vaborbactam combination) for adults with complicated urinary tract infections caused by specific Enterobacteriaceae bacteria [FDA news, 29 Aug 2017] fda.gov/newsevents/newsroโ€ฆ
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๐Ÿ‘ค︎ u/isosafrole
๐Ÿ“…︎ Sep 06 2017
๐Ÿšจ︎ report
Recovery of gut microbiota of healthy adults following antibiotic exposure ; meropenem, gentamicin and vancomycin [Nature, Oct 2018]

https://www.nature.com/articles/s41564-018-0257-9

Abstract

To minimize the impact of antibiotics, gut microorganisms harbour and exchange antibiotics resistance genes, collectively called their resistome. Using shotgun sequencing-based metagenomics, we analysed the partial eradication and subsequent regrowth of the gut microbiota in 12 healthy men over a 6-month period following a 4-day intervention with a cocktail of 3 last-resort antibiotics: meropenem, gentamicin and vancomycin. Initial changes included blooms of enterobacteria and other pathobionts, such as Enterococcus faecalis and Fusobacterium nucleatum, and the depletion of Bifidobacterium species and butyrate producers. The gut microbiota of the subjects recovered to near-baseline composition within 1.5 months, although 9 common species, which were present in all subjects before the treatment, remained undetectable in most of the subjects after 180 days. Species that harbour ฮฒ-lactam resistance genes were positively selected for during and after the intervention. Harbouring glycopeptide or aminoglycoside resistance genes increased the odds of de novo colonization, however, the former also decreased the odds of survival. Compositional changes under antibiotic intervention in vivo matched results from in vitro susceptibility tests. Despite a mild yet long-lasting imprint following antibiotics exposure, the gut microbiota of healthy young adults are resilient to a short-term broad-spectrum antibiotics intervention and their antibiotics resistance gene carriage modulates their recovery processes.

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๐Ÿ‘ค︎ u/ralaman
๐Ÿ“…︎ Oct 22 2018
๐Ÿšจ︎ report
New molecule knocks out superbugs' immunity to antibiotics - "In all cases, the PPMO restored meropenem's ability to kill the bacteria in vitro, and also managed to kill off an NDM-1-expressing strain of E. coli in tests in mice." newatlas.com/molecule-weaโ€ฆ
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๐Ÿ‘ค︎ u/mvea
๐Ÿ“…︎ Jan 20 2017
๐Ÿšจ︎ report
PulmCrit mythbusting- Anaphylaxis to penicillins isnโ€™t a contraindication to meropenem emcrit.org/pulmcrit/pulmcโ€ฆ
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๐Ÿ‘ค︎ u/emcrit
๐Ÿ“…︎ Oct 24 2016
๐Ÿšจ︎ report
New molecule knocks out superbugs' immunity to antibiotics - "In all cases, the PPMO restored meropenem's ability to kill the bacteria in vitro, and also managed to kill off an NDM-1-expressing strain of E. coli in tests in mice."

This is an automatic summary, original reduced by 56%.


> One of the most terrifyingly-plausible doomsday scenarios is the rise of superbugs, strains of bacteria that are evolving a resistance to our most powerful antibiotics.

> Now researchers have created a new molecule that can make previously antibiotic-resistant bacteria vulnerable to existing drugs again.

> &quot;Everything&#039;s resistant to them now. That&#039;s left us to try to develop new drugs to stay one step ahead of the bacteria, but the more we look the more we don&#039;t find anything new. So that&#039;s left us with making modifications to existing antibiotics, but as soon as you make a chemical change, the bugs mutate and now they&#039;re resistant to the new, chemically modified antibiotic."

> Some of the most devastating bacteria get their antibiotic resistance by producing an enzyme known as New Delhi Metallo-beta-lactamase.

> &quot;That is literally the last antibiotic that can be used on an NDM-1-expressing organism, and we now have bacteria that are completely resistant to all known antibiotics. But a PPMO can restore susceptibility to antibiotics that have already been approved, so we can get a PPMO approved and then go back and use these antibiotics that had become useless."

> The study combined the new PPMO with meropenem, a type of carbapenem antibiotic that&#039;s effective against a broad range of bugs, and pitted it against three different types of bacteria that make use of NDM-1.


Summary Source | FAQ | Theory | Feedback | Top five keywords: antibiotic^#1 bacteria^#2 new^#3 PPMO^#4 That&#039;s^#5

Post found in /r/Futurology and /r/Health.

NOTICE: This thread is for discussing the submission topic. Pl

... keep reading on reddit โžก

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๐Ÿ‘ค︎ u/autotldr
๐Ÿ“…︎ Jan 20 2017
๐Ÿšจ︎ report
My pretty rescue Meropenem's recovery! (x-post /r/aquariums) imgur.com/a/GOnxW
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๐Ÿ‘ค︎ u/rmarkham
๐Ÿ“…︎ Feb 03 2014
๐Ÿšจ︎ report
Can you store Meropenem + water stock solution at 4ยฐC?

Hello! I need to do daily experiments with Meropenem and I was wondering if I could store the stock solution and renew it once every few days.

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๐Ÿ‘ค︎ u/afroninja7
๐Ÿ“…︎ Jan 11 2017
๐Ÿšจ︎ report

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