https://pubmed.ncbi.nlm.nih.gov/31980292/
A well documented drug interaction used rapidly clear VPA.
How often do you change IV tubing when your institution does Meropenem 1g infusions? Resources state the drug is not stable after 1 hour at room temperature and there is always drug left over in the tubing between doses (I know they should be flushing before dose, after dose, and q shift - but lets be real) so my question is how would that affect the tubing? Would it need to be changed per dose? TIA.
From Radiology, a medical journal published by the Radiological Society of North America:
"The patient was treated with antiviral drugs (ganciclovir, oseltamivir) and anti-inflammatory drugs (meropenem, linezolid), with supportive care from January 1, 2020, until his discharge on January 25, 2020. Serial imaging studies in the Figure illustrate the patientโs improvement after therapy."
"Chest radiograph obtained on day 7 after the onset of symptoms shows opacities in the left lower and right upper lobes. B, C, CT scans obtained on day 9 show multifocal bilateral ground-glass opacities. D, CT scan obtained on day 15 shows evolution to a mixed pattern of ground-glass opacities and consolidation. E, CT scan obtained on day 19 shows healing of the consolidations and ground-glass opacities. F, CT scan obtained on day 31 shows complete resolution."
Link to full text: https://pubs.rsna.org/doi/10.1148/radiol.2020200269
"A new type of pneumonia caused by the 2019 novel coronavirus (2019-nCoV) broke out in December 2019 in Wuhan City, China (1,2). On January 1, 2020, a 42-year-old man was admitted to the emergency department of Union Hospital (Tongji Medical College, Wuhan, Hubei Province) due to a high-grade fever (39.6ยฐC [103.28ยฐC]), cough, and fatigue for 1 week. Bilateral coarse breath sounds with wet rales distributed at the bases of both lungs were heard on auscultation. Laboratory studies showed leukopenia (white blood cell count, 2.88 ร 109/L) and lymphocytosis (lymphocyte cell count, 0.90 ร 109/L). The white blood cell differential count displayed 56.6% neutrophils, 32.1% lymphocytes, and 10.2% monocytes. Several additional laboratory tests were abnormal, including C-reactive protein (158.95 mg/L; normal range, 0โ10 mg/L), erythrocyte sedimentation rate (38 mm/h; normal range, <20 mm/h), serum amyloid A protein (607.1 mg/L; normal range, <10 mg/L), aspartate aminotransferase (53 U/L; normal range, 8โ40 U/L), and alanine aminotransferase (60 U/L; normal range, 5โ40 U/L). Real-time รฑuorescence polymerase chain reaction of the patientโs sputum was positive for the 2019-nCoV nucleic acid. The patient was treated with antiviral drugs (ganciclovir, oseltamivir) and anti-inflammatory drugs (meropenem, linezolid), with supportive care from January 1, 2020, until his discharge on January 25, 2020. Serial imaging studies in the Figure illustrate the patientโs improvement after therapy."
I hate copy/paste and voice to text physician notes. This is literally an assessment/plan section of a finalized note for one of my patients.
I take meropenem nebulised and sometimes intravenously and it stains fabric/clothes so badly. Does anyone have any cleaning tips on getting it out??
I received a week supply (3 doses a day for 7 days) of Meropenem in the home pump eclipse medicine balls. I pulled my next dose out of the fridge and noticed 7 of them have turned bright yellow instead of being clear. I donโt feel comfortable taking these doses until Iโm able to speak with my doctor in the morning. Iโm just wondering if anyone knows why this has happened and what it means.
https://www.nature.com/articles/s41564-018-0257-9
Abstract
To minimize the impact of antibiotics, gut microorganisms harbour and exchange antibiotics resistance genes, collectively called their resistome. Using shotgun sequencing-based metagenomics, we analysed the partial eradication and subsequent regrowth of the gut microbiota in 12 healthy men over a 6-month period following a 4-day intervention with a cocktail of 3 last-resort antibiotics: meropenem, gentamicin and vancomycin. Initial changes included blooms of enterobacteria and other pathobionts, such as Enterococcus faecalis and Fusobacterium nucleatum, and the depletion of Bifidobacterium species and butyrate producers. The gut microbiota of the subjects recovered to near-baseline composition within 1.5 months, although 9 common species, which were present in all subjects before the treatment, remained undetectable in most of the subjects after 180 days. Species that harbour ฮฒ-lactam resistance genes were positively selected for during and after the intervention. Harbouring glycopeptide or aminoglycoside resistance genes increased the odds of de novo colonization, however, the former also decreased the odds of survival. Compositional changes under antibiotic intervention in vivo matched results from in vitro susceptibility tests. Despite a mild yet long-lasting imprint following antibiotics exposure, the gut microbiota of healthy young adults are resilient to a short-term broad-spectrum antibiotics intervention and their antibiotics resistance gene carriage modulates their recovery processes.
This is an automatic summary, original reduced by 56%.
> One of the most terrifyingly-plausible doomsday scenarios is the rise of superbugs, strains of bacteria that are evolving a resistance to our most powerful antibiotics.
> Now researchers have created a new molecule that can make previously antibiotic-resistant bacteria vulnerable to existing drugs again.
> "Everything's resistant to them now. That's left us to try to develop new drugs to stay one step ahead of the bacteria, but the more we look the more we don't find anything new. So that's left us with making modifications to existing antibiotics, but as soon as you make a chemical change, the bugs mutate and now they're resistant to the new, chemically modified antibiotic."
> Some of the most devastating bacteria get their antibiotic resistance by producing an enzyme known as New Delhi Metallo-beta-lactamase.
> "That is literally the last antibiotic that can be used on an NDM-1-expressing organism, and we now have bacteria that are completely resistant to all known antibiotics. But a PPMO can restore susceptibility to antibiotics that have already been approved, so we can get a PPMO approved and then go back and use these antibiotics that had become useless."
> The study combined the new PPMO with meropenem, a type of carbapenem antibiotic that's effective against a broad range of bugs, and pitted it against three different types of bacteria that make use of NDM-1.
Summary Source | FAQ | Theory | Feedback | Top five keywords: antibiotic^#1 bacteria^#2 new^#3 PPMO^#4 That's^#5
Post found in /r/Futurology and /r/Health.
NOTICE: This thread is for discussing the submission topic. Pl
... keep reading on reddit โกHello! I need to do daily experiments with Meropenem and I was wondering if I could store the stock solution and renew it once every few days.
