EMA Grants Accelerated Assessment for CSL Behring's Haemophilia B Gene Therapy prnewswire.com/news-relea…
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Freeline announces updated data for the first cohort of two patients in Haemophilia B study [gene therapy] freeline.life/investors-m…
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Haemophilia B: Royal Prince Alfred Hospital makes breakthrough in clinical trial to stop bleeding abc.net.au/news/2017-12-0…
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πŸ‘€︎ u/growleroz
πŸ“…︎ Dec 07 2017
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Novo Nordisk pauses the clinical trials investigating concizumab (anti-TFPI mAB) in haemophilia A and B with or without inhibitors globenewswire.com/news-re…
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πŸ‘€︎ u/Hemophiliac
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Haemophilia gene therapy shows early success: Just one injection could be enough to mean people with haemophilia B no longer need medication, according to an early study in the UK and the US. bbc.co.uk/news/health-161…
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πŸ‘€︎ u/davidreiss666
πŸ“…︎ Dec 12 2011
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Successful trial of Adenovirus as vector for gene therapy of Haemophilia B scienceblogs.com/erv/2015…
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πŸ‘€︎ u/SweetmanPC
πŸ“…︎ Apr 26 2015
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Gene therapy usually requires the use of engineered viruses, but the immune system gets rid of them. Now researchers have created decoy viruses to fool the immune system and deliver the treatment to cure haemophilia B. theconversation.com/cloud…
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πŸ‘€︎ u/azneo
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Scientists ingeniously use fake viruses to fool the immune system, in hunt for haemophilia B cure scilogs.com/mmmbitesizesc…
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πŸ‘€︎ u/notscientific
πŸ“…︎ Jul 18 2013
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Haemophilia B is clinically less severe than haemophilia A: further evidence bloodtransfusion.it/artic…
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2021 Endless Delve Primer/Discussion Megathread

Permanent Wiki Link || Old Reddit Wiki Link

Previous endless delve threads: December 2020

  • Fossil Locations: https://i.redd.it/i42pt6roebr21.png
  • Fractured Wall Guide: https://www.pathofexile.com/forum/view-thread/2204851
  • All Fractured Wall questions go in the most recent Questions Thread.

##General Info

Face the darkness of the Azurite Mine and forget everything else in this returning event. You begin the event in the Mine Encampment and cannot leave the Mine. All you can do is Delve. All sulphite costs have been removed, and the Mine scales from level 1 instead of its usual scaling.

We're not completely heartless, so you have some help. You start with a stack of Scrolls of Wisdom and some powerful unique items. Lilly Roth has shown up in the mine encampment to sell you gems, and she's running a special offer β€” all gems cost only a single Scroll of Wisdom. At level 1, and every 10 character levels until level 70, you gain 3 passive skill points to make up for the ones you'd normally get from quests. And of course the Altar of Ascendancy is available, granting you 2 Ascendancy passive skill points when you reach levels matching the area level of each Labyrinth. But you can't escape Kitava's curses either β€” you lose resistances and start incurring an experience penalty on death when you reach levels 40 and 70.

If you played last year's Endless Delve event, the main difference this time is the rework to the Azurite Mine from 3.16.0. However, there are a couple more changes. Firstly, Lilly Roth will now accept divination card turn-ins if you manage to gather a full set of a card. Secondly, early level scaling has changed to accommodate the changes to normal Delve scaling. The area level of the mines now matches the depth until depth 77, where it merges into normal Delve level scaling.


  • Starting at Noon December 3 (PST) which is Dec 03, 2021 12:00 PM (PST)
  • Ending at Noon December 13 (PST) which is Dec 13, 2021 12:00 PM (PST)
  • Standard Solo Self-Found, Hardcore Solo Self-Found versions ava
... keep reading on reddit ➑

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πŸ‘€︎ u/GR8B0-T
πŸ“…︎ Nov 29 2021
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Blind Girl Here. Give Me Your Best Blind Jokes!

Do your worst!

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πŸ‘€︎ u/Leckzsluthor
πŸ“…︎ Jan 02 2022
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Some thoughts on the Empress' Proclamation & the Bazaar (lots of spoilers)

I've been musing on the Empress' latest proclamation regarding the New Century, and how well it highlights that the Bazaar isn't just failing its mission, but has been actively undermining it since the beginning.


The Bazaar's ultimate mission is to save the Sun from potentially fatal heartbreak because of a message of rejection she carries from another star the Sun loves. To this end, she has been granted the duration of Seven Cities to find a love story sufficiently powerful to save the Sun.

The mechanism the Bazaar has chosen to exercise is in finding Great Loves stolen by death, and resurrecting them at the cost of a city, its people, and its stories. There's probably a degree of practicality to this, as Death is one of the most mutable Laws in the Neath, but it's hardly the only one capable of circumvented.


As in our timeline, Victoria and Albert's marriage was by all accounts one marked by deep love, and in the Roundworld timeline when he died in 1861 she would wear black in mourning for the remaining forty years of her life. Their story is known in our timeline as one of the great love stories of history. However, during that time she helmed one of, if not the, greatest Empire in history through its last Golden Age. Her children would go on to spread haemophilia throughout the royalty of Europe.

Compare to the Empress we saw today. The palace is shuttered. She lives in seclusion, rarely seen and yet still wears mourning, despite her husband being (somewhat) alive. She stubbornly holds on to things she can't control and it makes her look pathetic, standing athwart history yelling stop.

Almost all of her children have disappeared from public life. The Captivating Princess is a monster the Empress has entirely failed to raise or control, and of her other children only the Brooding Captain seems to be interested in working to counter the Princess' influence (eg. see Say it with Flowers, The Gift).


By saving Albert, the Masters and the Bazaar destroyed one of the best stories they could have used in order to save the Sun. Victoria's resiliency in our timeline in the face of tragic and catastrophic loss is exactly the kind of story that should help the Sun cope with the rejection and be able to continue doing its thing.

Evidence suggests that the Bazaar has been asleep at the wheel for a long time (eg. see the Grand Clearing Out, the Creditor) and not all of the Masters particularly care about the mission. Even those w

... keep reading on reddit ➑

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πŸ‘€︎ u/archlon
πŸ“…︎ Dec 31 2021
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Dropped my best ever dad joke & no one was around to hear it

For context I'm a Refuse Driver (Garbage man) & today I was on food waste. After I'd tipped I was checking the wagon for any defects when I spotted a lone pea balanced on the lifts.

I said "hey look, an escaPEA"

No one near me but it didn't half make me laugh for a good hour or so!

Edit: I can't believe how much this has blown up. Thank you everyone I've had a blast reading through the replies πŸ˜‚

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πŸ‘€︎ u/Vegetable-Acadia
πŸ“…︎ Jan 11 2022
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What starts with a W and ends with a T

It really does, I swear!

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πŸ‘€︎ u/PsychedeIic_Sheep
πŸ“…︎ Jan 13 2022
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Why didn't Tsar Nicolas II just name one of his daughters as the heir to the throne

Just a note, new to Russian history, so it may sound stupid.

I watched The Last Tsar on Netflix the other day. Like all history documentaries on modern Russia, Rasputin is mentioned, and we all know how he tarnished the fame of the Russian monarchy and nobility, ultimately causing the February Revolution (though of course not the sole cause). The reason why Rasputin, basically a nobody from the fringes of the Empire, was invited to the high society was because of his alleged ability to heal or alleviate the heir to the throne, Alexei's Haemophilia. The problem is as the topic states. There had been Empresses before Nicholas II, which means that there had been precedences, so why let the prestige of the monarchy be tarnished by a scandalous, sketchy, self-proclaimed holy man and insisted such a frail boy who might have been dead anytime to be the successor? The other four girls had no notable diseases as far as I am aware. What was or were the reason(s) behind such a gamble?

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πŸ‘€︎ u/hidehuman22
πŸ“…︎ Nov 24 2021
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What is a a bisexual person doing when they’re not dating anybody?

They’re on standbi

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πŸ‘€︎ u/Toby-the-Cactus
πŸ“…︎ Jan 12 2022
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Geddit? No? Only me?
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πŸ‘€︎ u/shampy311
πŸ“…︎ Dec 28 2021
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[Race thread] 2021 Alex Dowsett Hour Record attempt
Date Profile Course Distance Start
3 Nov ______ β¬­ ~55km 10pm GMT
Information Official announcement, official website (including option to donate to Little Bleeders, the charity encouraging haemophiliacs to do sports)
Previews BBC, Sporza, Guardian interview, Campenaerts gives his preview, Skinsuit and kit preview
Live Trackers #hourofbloodsweatandtears
TV BBC red button / BBC sport (starts 21:45 GMT), UCI livestream (starts 21:35 GMT), Alex Dowsett's YouTube channel

Distance to beat:

  • 55.089 km for Vocsnor Campenaerts' Hour Record
  • 54.723 km for Dan Bigham's British Hour Record
  • 52.937 km for a personal best

(and 56.375 km to write Chris Boardman's Best Human Effort out of the record books, but that's probably still a a step too far)

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πŸ‘€︎ u/epi_counts
πŸ“…︎ Nov 03 2021
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I wanna hear your best airplane puns.

Pilot on me!!

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πŸ‘€︎ u/Paulie_Felice
πŸ“…︎ Jan 07 2022
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E or ß?
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πŸ‘€︎ u/Amazekam
πŸ“…︎ Jan 03 2022
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No spoilers
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πŸ‘€︎ u/Onfour
πŸ“…︎ Jan 06 2022
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Covid problems
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πŸ‘€︎ u/theincrediblebou
πŸ“…︎ Jan 12 2022
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What do you call quesadillas you eat in the morning?

Buenosdillas

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πŸ‘€︎ u/FarronKeepSucks
πŸ“…︎ Jan 14 2022
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These aren't dad jokes...

Dad jokes are supposed to be jokes you can tell a kid and they will understand it and find it funny.

This sub is mostly just NSFW puns now.

If it needs a NSFW tag it's not a dad joke. There should just be a NSFW puns subreddit for that.

Edit* I'm not replying any longer and turning off notifications but to all those that say "no one cares", there sure are a lot of you arguing about it. Maybe I'm wrong but you people don't need to be rude about it. If you really don't care, don't comment.

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πŸ‘€︎ u/Lance986
πŸ“…︎ Dec 15 2021
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Spi__
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πŸ‘€︎ u/Fast_Echidna_8520
πŸ“…︎ Jan 11 2022
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I had a vasectomy because I didn’t want any kids.

When I got home, they were still there.

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πŸ‘€︎ u/demotrek
πŸ“…︎ Jan 13 2022
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I dislike karma whores who make posts that imply it's their cake day, simply for upvotes.

I won't be doing that today!

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πŸ‘€︎ u/djcarves
πŸ“…︎ Dec 27 2021
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The Ancient Romans II
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πŸ‘€︎ u/mordrathe
πŸ“…︎ Dec 29 2021
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How do you stop Canadian bacon from curling in your frying pan?

You take away their little brooms

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πŸ‘€︎ u/Majorpain2006
πŸ“…︎ Jan 09 2022
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School Was Clothed
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πŸ‘€︎ u/Kennydoe
πŸ“…︎ Jan 08 2022
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I did it, I finally did it. After 4 years and 92 days I went from being a father, to a dad.

This morning, my 4 year old daughter.

Daughter: I'm hungry

Me: nerves building, smile widening

Me: Hi hungry, I'm dad.

She had no idea what was going on but I finally did it.

Thank you all for listening.

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πŸ‘€︎ u/Sk2ec
πŸ“…︎ Jan 01 2022
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It this sub dead?

There hasn't been a post all year!

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πŸ‘€︎ u/TheTreelo
πŸ“…︎ Jan 01 2022
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The Undying CF KB Scion

Hey all, I've been experimenting a bit with an 'immortal' scion[pathfinder/gladiator] Aegis Aurora build take on my CF KB (corrupting fever/ kinetic blast )Glad.

pob : https://pastebin.com/TGP3r7sQ

I've been playing the Gladiator CF KB for a while with great success for farming nem3 and the like, but I've gotten increasingly annoyed with the occasional wipe especially with my shitty internet connection lagging me out in the middle of a pack and of course stopping=dying.

###^This ^lead ^me ^to ^fuck ^around ^with ^my ^Scion ^and ^came ^across ^this ^interesting ^setup ^:

  • max attack and spell block due to gladiator ascendancy and tempest shield and glancing blows, with +5 to max attack putting us at 80% which can be scaled to 82% with the Block Mastery

  • heal 4% of life on flask use from Pathfinder ascendancy + 5 flasks with 'gain [x] (ideally over 5) charges when hit'

  • Glorious vanity Doriyani = Corrupted soul for 15% of max life as ES and a big boost from Skin of the Lords = about 2k ES and 4-4.5k life

  • Aegis Aurora for amount of armor healed as ES, since we are stacking armor with determination and flasks you have around 70-80k armor most of the time, so you heal almost all of your ES back in one hit (or 3 out of every 4 incoming hits)

  • all of those combined means that basically almost every time you get hit you are either recovering a massive amount of life or a massive amount of ES or both.

  • since we are running magic flasks entirely, you can relieve a lot of pressure from gearing (for example i use amethyst flask to cap chaos resist) since they basically have 99% uptime, and you can be basically ailment immune since you get shock immunity from tempest shield, freeze/chill burning, bleeding from your flasks. Corrupted blood you can get on one of your many jewels

  • of course, we also cap endurance charges easily with Enduring Composure, have a shit ton of armor, and we take Prismatic Skin to bring ourselves to 79/80 all res and 84/5 Cold res, which pairs great with a Sapphire flask for damage taken as cold. this means we dont really get one shot by anything (though I havent tried shaper beams and the like yet)

I can finally stop for a breather in the middle of a map no matter how many mobs are in my face, in fact, usually the more the better (T15 Silo example at level 93 while im lagging out to all hell and cant move)

The rest is a pretty straightforward KB CF setup putting us at

... keep reading on reddit ➑

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πŸ‘€︎ u/neq
πŸ“…︎ Dec 12 2021
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Couch potato
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πŸ“…︎ Dec 31 2021
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Baka!
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πŸ‘€︎ u/ridi86
πŸ“…︎ Jan 09 2022
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What did 0 say to 8 ?

What did 0 say to 8 ?

" Nice Belt "

So What did 3 say to 8 ?

" Hey, you two stop making out "

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πŸ‘€︎ u/designjeevan
πŸ“…︎ Jan 03 2022
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